ライフサイエンスコーパス: severe congenital neutropenia

1 ted in leukemic progression in patients with severe congenital neutropenia.

2 e course in nearly half of all patients with severe congenital neutropenia.

3 ts with acute myeloid leukemia evolving from severe congenital neutropenia.

4 t of acute myeloid leukemia in patients with severe congenital neutropenia.

5 trophil numbers are cyclic hematopoiesis and severe congenital neutropenia.

6 ic neutropenia and most of the patients with severe congenital neutropenia.

7 myeloid progenitor cells in both cyclic and severe congenital neutropenia.

8 with acute myeloid leukemia associated with severe congenital neutropenia.

9 n linked to the development of monosomy 7 in severe congenital neutropenia and aplastic anemia.

10 ell functions was confirmed in patients with severe congenital neutropenia and autoimmune neutropenia

11 are present in approximately 50% of cases of severe congenital neutropenia and nearly all cases of cy

12 otease neutrophil elastase, cause cyclic and severe congenital neutropenia, and recent evidence indic

13 Severe congenital neutropenia as well as primary myelofi

14 stase are probably the most common cause for severe congenital neutropenia as well as the cause for s

15 se model of disease pathogenesis in cases of severe congenital neutropenia associated with ELA2 mutat

16 Among other genes, severe congenital neutropenia can also result from mutat

17 Certain patients with severe congenital neutropenia carry mutations in the GFI

18 Severe congenital neutropenia (CN) is a preleukemic bone

19 downregulated in granulocytic progenitors of severe congenital neutropenia (CN) patients.

20 in myeloid cells and plasma of patients with severe congenital neutropenia (CN).

21 The mutations causing severe congenital neutropenia consist of amino acid miss

22 Severe congenital neutropenia consists of static neutrop

23 RECENT FINDINGS: The category of severe congenital neutropenia continues to expand.

24 ts with acute myeloid leukemia evolving from severe congenital neutropenia, disrupted Gfi-1 up-regula

25 nia associated with ELA2 mutations and place severe congenital neutropenia in a growing list of human

26 ounts oscillate with a 21-day frequency, and severe congenital neutropenia, in which static neutropen

27 Severe congenital neutropenia is a heritable human disor

28 Severe congenital neutropenia is an inborn disorder of g

29 ases of cyclic neutropenia and most cases of severe congenital neutropenia result from heterozygous g

30 i-1 mutant, N382S, which was associated with severe congenital neutropenia, resulted in premature apo

31 own to be involved in apoptotic processes in severe congenital neutropenia (SCN) 3 (Kostmann disease

32 ase complex (chronic granulomatous disease), severe congenital neutropenia (SCN) and leukocyte adhesi

33 In patients with severe congenital neutropenia (SCN) and mice with growth

34 Severe congenital neutropenia (SCN) and Shwachman-Diamon

35 tor receptor (G-CSFR) in the pathogenesis of severe congenital neutropenia (SCN) and the subsequent d

36 Patients with severe congenital neutropenia (SCN) are at increased ris

37 the G-CSF receptor (G-CSFR) in patients with severe congenital neutropenia (SCN) are postulated to co

38 A subgroup of patients with severe congenital neutropenia (SCN) has been shown to ha

39 Severe congenital neutropenia (SCN) is a BM failure synd

40 Severe congenital neutropenia (SCN) is a rare disease di

41 Severe congenital neutropenia (SCN) is a syndrome charac

42 Severe congenital neutropenia (SCN) is an inborn disorde

43 Severe congenital neutropenia (SCN) is an inborn disorde

44 Severe congenital neutropenia (SCN) is characterized by

45 Severe congenital neutropenia (SCN) is characterized by

46 Severe congenital neutropenia (SCN) is characterized by

47 Severe congenital neutropenia (SCN) is often associated

48 The analysis of individuals with severe congenital neutropenia (SCN) may shed light on th

49 Severe congenital neutropenia (SCN) was first described

50 Severe congenital neutropenia (SCN) was originally descr

51 (G-CSFR) occur in a subset of patients with severe congenital neutropenia (SCN) who develop acute my

52 ion (HSCT) is the only curative treatment of severe congenital neutropenia (SCN), but data on outcome

53 Two hereditary human leukemia syndromes are severe congenital neutropenia (SCN), caused by mutations

54 In patients with severe congenital neutropenia (SCN), sepsis mortality is

55 identified in the majority of patients with severe congenital neutropenia (SCN).

56 e, ELANE, cause cyclic neutropenia (CyN) and severe congenital neutropenia (SCN).

57 s the only curative option for patients with severe congenital neutropenia (SCN).

58 on mutations are found in some patients with severe congenital neutropenia (SCN).

59 reditary neutropenia, cyclic neutropenia and severe congenital neutropenia (SCN).

60 stase (NE) are present in most patients with severe congenital neutropenia (SCN).

61 ich mislocates to the nucleus and results in severe congenital neutropenia (SCN).

62 ed with increased frequency in patients with severe congenital neutropenia (SCN).

63 in more than 15 genes are now known to cause severe congenital neutropenia (SCN); however, the pathol

64 and most cases of the pre-leukemic disorder severe congenital neutropenia (SCN; ref. 3) in humans.

65 utrophil elastase), the most common cause of severe congenital neutropenia (SCN; ref. 3).

66 ase-beta or G6PC3) deficiency, also known as severe congenital neutropenia syndrome 4, is characteriz

67 Kostmann disease is an inherited severe congenital neutropenia syndrome associated with l

68 ounts for the different clinical phenotypes (severe congenital neutropenia versus cyclic neutropenia)

69 ent studies of the molecular pathogenesis of severe congenital neutropenia, with an emphasis on those