ライフサイエンスコーパス: severe impairment

1 t 1.447 [CI, 1.235 to 1.695] for moderate to severe impairment).

2 ny renal impairment, and 29% had moderate to severe impairment.

3 k ratios (RRs) and corresponding 95% CIs for severe impairment.

4 for future episodes than did those with less severe impairment.

5 e with scores of less than 16 as having less severe impairment.

6 tantial likelihood of developing moderate to severe impairment.

7 t, and 210 (78.7%) patients with moderate to severe impairment.

8 had mild impairment, and 267 had moderate to severe impairment.

9 ction: intact, mild-moderate impairment, and severe impairment.

10 y were up to 2.5 months old without signs of severe impairments.

11 normal (24-27), mild impairment (18-23), or severe impairment (0-17); cognitive decline was defined

12 nterval [CI] 1.30 to 1.77, p < 0.001; OR for severe impairment 3.73, 95% CI 2.55 to 5.45, p < 0.001;

13 2.06, 95% CI 1.59 to 2.66, p < 0.001; OR for severe impairment 3.81, 95% CI 2.57 to 5.65, p < 0.001).

14 s with scores of 16 or higher as having more severe impairment and those with scores of less than 16

15 and 5, be simply termed moderate impairment, severe impairment, and kidney failure, respectively.

16 nin I in enhancing force production, and the severe impairment associated with su195sd highlights imp

17 axons from the noninfarcted cortex predicted severe impairment at 2 years.

18 mes at 3 months, especially in patients with severe impairment at baseline.

19 orward, P=0.003 for observed cases), and the Severe Impairment Battery (P<0.001 with the last observa

20 o undertake normal daily activities were the severe impairment battery (SIB) and the seven-item minim

21 e secondary efficacy end points included the Severe Impairment Battery and other measures of cognitio

22 Standardised Mini Mental State Examination, Severe Impairment Battery.

23 significant absolute decrease in moderate to severe impairment between each week of gestation (6.5% [

24 This suggests that the severe impairment caused by inferotemporal ablations on

25 aired (CBI score=3-4), and 3 showed signs of severe impairment (CBI score > 4).

26 ymptom number and severity, role disability, severe impairment, comorbidity, and treatment compared w

27 d with a 1.5- to threefold increased risk of severe impairment compared with no CRT (eg, intelligence

28 , or cystatin-C >1.03 mg/dl) and moderate to severe impairment (creatinine > or =1.5, CrCl or eGFR <5

29 tion lesions of the amygdala that produced a severe impairment did so because they interrupted connec

30 ny renal impairment and 51% with moderate to severe impairment died versus 24% without impairment.

31 nd near vision impairment (DNVI), and 37 had severe impairment (distance or near worse than 20/200 [>

32 paired in emotional comprehension, with more severe impairment for emotions with negative valence, in

33 In patients with moderately severe impairment from Alzheimer's disease, treatment wi

34 to 4.19 million) than among those with more severe impairment (from 1.56 million to 2.28 million).

35 ental health services among youths with more severe impairment (from 26.2% to 43.9%) was larger than

36 d-moderate impairment group and 31.0% in the severe impairment group.

37 d-moderate impairment group and 56.3% in the severe impairment group.

38 group, and OR 1.99, 95% CI 1.12-3.55 for the severe impairment group.

39 group and OR 0.57, 95% CI 0.32-1.00 for the severe impairment group.

40 s were statistically significant only in the severe impairment groups.

41 risk in the co-twin, while index twins with severe impairment had a substantially higher risk for fu

42 te increase in service use, youths with more severe impairment had the greatest relative increase in

43 For women with severe impairment, however, those living alone had a gre

44 CI] 1.53 to 1.60, p < 0.001) and moderate to severe impairment (HR = 2.31; 95% CI 2.18 to 2.44, p < 0

45 The prevalence of severe impairment (ie, at least two standard deviations

46 e impairment in most areas of functioning or severe impairment in at least 1 area).

47 ng-term follow-up neurocognitive testing had severe impairment in at least 1 neurocognitive domain at

48 h or mutant TDP-43 in motor neurons caused a severe impairment in axon outgrowth, which was dependent

49 KE family, in which half of the members have severe impairment in both speech and language.

50 ified oligonucleotides, which contributed to severe impairment in cell proliferation.

51 ncies during double-strand break repair, and severe impairment in DNA end resection.

52 0, Glu208, Glu241, Gly63, or Gly214 caused a severe impairment in eIF5A(Dhp) binding, with a complete

53 ust play an important part in generating the severe impairment in higher-order social, emotional and

54 Conditional removal of this myosin caused severe impairment in host cell invasion and parasite spr

55 attenuation in IFN-defective Vero cells but severe impairment in IFN-competent cells.

56 were not protected by immunization and had a severe impairment in IgG2c Ab production in response to

57 uman myoblasts, IR-Mut myotubes demonstrated severe impairment in insulin signaling and insulin-stimu

58 As a consequence, mutant mice displayed a severe impairment in lymphocyte homing and a compromised

59 for immune regulation is highlighted by the severe impairment in lymphoid cell function in IL-2Rbeta

60 ive analyses indicated a trend toward a less severe impairment in medicated than in unmedicated patie

61 However, Calhm1(-/-) mice showed a severe impairment in memory flexibility, assessed in the

62 argeted disruption of FRS2 alpha gene causes severe impairment in mouse development resulting in embr

63 However, among adults with more severe impairment in neuromuscular and movement-related

64 This knock-in mutation causes severe impairment in NMDAR synaptic incorporation and NM

65 A lesion in the OT caused a severe impairment in orientation discrimination specific

66 /s), which provides further evidence for the severe impairment in P-selectin-mediated rolling.

67 link (AB), which refers to the transient but severe impairment in perceiving the second of two tempor

68 ions into the hippocampus and PR resulted in severe impairment in performance.

69 In the chop -/- animals, in spite of the severe impairment in renal function, evidence of cellula

70 progressive infections are associated with a severe impairment in SIV-specific antibody production.

71 (Foxk1-/-) display growth retardation and a severe impairment in skeletal muscle regeneration follow

72 This severe impairment in synaptic development was associated

73 These abnormalities are associated with a severe impairment in the acquisition of classical eyebli

74 feline astrocytes that is associated with a severe impairment in the astrocytes' ability to uptake g

75 gfr2 (K5-R1/R2 mice) in the epidermis have a severe impairment in the epidermal barrier, which leads

76 of beta-arrestin2 preferentially leads to a severe impairment in the establishment and propagation o

77 KO mice showed a severe impairment in the functional and structural sharp

78 Base-line assessments documented severe impairment in the patients' health-related qualit

79 had disrupted glutamate co-transmission and severe impairment in the refinement of this inhibitory p

80 es of genes in the ventral telencephalon and severe impairment in the tangential migration of cortica

81 an neonatal cord blood monocytes demonstrate severe impairment in TNF-alpha production in response to

82 slightly elevated adenosine K(m) values, the severe impairment in transport resulted from drastically

83 We found that mice deficient in Raldh3 bear severe impairment in vestibular functions.

84 uman hepatoma cell line identified many with severe impairment in virion secretion, which can be resc

85 amygdala were found previously to produce a severe impairment in visual discrimination learning for

86 rtex underlying these structures, leads to a severe impairment in visual recognition.

87 n on chromosome 7q11.23, is characterized by severe impairment in visuospatial construction.

88 velop spontaneous ulcerated lesions due to a severe impairment in wound healing; their keratinocytes

89 ve been several successful investigations of severe impairments in a number of isolated families with

90 Arf4(+/-) mice at 4-5 months of age display severe impairments in a pattern separation task, as well

91 However, EF-hand mutants did show severe impairments in cellular resistance to detachment

92 t delta-cat(-/-) animals are viable and have severe impairments in cognitive function.

93 tion of liver glucose release in the face of severe impairments in MGU.

94 In conclusion, MCAO induced severe impairments in microcirculatory perfusion within

95 abnormal vision through closed lids produces severe impairments in neuronal selectivity, rendering th

96 re we report that Ophn1 deficiency generates severe impairments in performance at spatial working mem

97 Btk mutations lead to severe impairments in proinflammatory cytokine productio

98 In contrast, Myd88 null mice showed severe impairments in signal transducer and activator of

99 haracterized by a chronic illness course and severe impairments in social relationships and independe

100 bilateral ST cortex lesions also resulted in severe impairments in the ability to relearn the auditor

101 efrontal cortex and, as shown here, produces severe impairments in working memory.

102 months of age) Cln1(-/-) mice exhibited more severe impairments, including decreased locomotor activi

103 Among women without severe impairment, Instrumental ADL deterioration was si

104 The prevalence of severe impairment is greater than expected in the genera

105 We investigated whether their severe impairment might, in part, be caused by activity-

106 Two mutants that lead to severe impairment (mut0) are Gly-630 --> Glu and Gly-703

107 hydroxytryptamine for 3 h resulted in a more severe impairment of 15 mm glucose-induced secretion.

108 nts was markedly reduced in association with severe impairment of activation of metalloproteinase-9 a

109 hin the catalytic loop of the enzyme, caused severe impairment of agrin-dependent MuSK phosphorylatio

110 says to reveal that loss of TgTic20 leads to severe impairment of apicoplast protein import followed

111 Lack of B and T cells resulted in a severe impairment of bacterial clearance in blood, splee

112 n content dropped 10- to 20-fold, suggesting severe impairment of beta-cell function.

113 63fsdelC IPF-1 mutation is associated with a severe impairment of beta-cell sensitivity to glucose an

114 In vivo physiological analyses show a severe impairment of both contractility and relaxation i

115 n using a working heart preparation revealed severe impairment of both contractility and relaxation i

116 KRAS(12V) mice show a severe impairment of both short- and long-term memory in

117 is thought to be indicative of an early and severe impairment of both the rod and cone photoreceptor

118 ast apoptosis was detected before indices of severe impairment of cardiac function became apparent.

119 of symptomatic transgenic mice documented a severe impairment of cardiac function evidenced by biven

120 The most severe impairment of catalysis occurred with the modific

121 directed knockdown of caspase-8 results in a severe impairment of CDIP-dependent cell death.

122 Embryonic lethality results from a severe impairment of cell proliferation that is not acco

123 -depleted primary and cultured cells reveals severe impairment of cell spreading and adhesion on fibr

124 Anaphylactic shock is associated with severe impairment of cerebral blood flow despite correct

125 for which substitution with uridine leads to severe impairment of cleavage but folding characteristic

126 placement by any other nucleotide results in severe impairment of cleavage, yet folding of the substr

127 Ate1 knockout cells have severe impairment of cytoskeletal organization throughou

128 n age, 4.1 year vs 2 months) and showed less severe impairment of degranulation and cytotoxic functio

129 re introduced in the kinase domain triggered severe impairment of downstream signaling.

130 y, and its genetic deletion in mice leads to severe impairment of eye, skeletal and kidney developmen

131 distress syndrome (ARDS) is characterized by severe impairment of gas exchange.

132 es that skeletal muscle IR in T2D involves a severe impairment of glucose transport and additional im

133 We show that mutation of Y145 leads to severe impairment of glycoprotein VI (GPVI)-mediated res

134 these same nutrient concentrations elicit a severe impairment of growth of nsd cells.

135 ulated intracellular fumarate and manifested severe impairment of HIF prolyl but not asparaginyl hydr

136 anced drug sensitivity was associated with a severe impairment of homologous recombination-directed D

137 This study provides evidence for a severe impairment of hypoxic pulmonary vasoconstriction

138 K-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling.

139 /+) mice, newborn NF90(-/-) mice demonstrate severe impairment of IL-2 expression.

140 GlcN infusion induced severe impairment of insulin action on Rd (39.4 +/- 3.2

141 icial effects, hyperinsulinemia also induces severe impairment of insulin-stimulated GS activity and

142 the LCx and LAD groups, along with early and severe impairment of LA function.

143 Both analyses showed moderate to severe impairment of left ventricular function and reduc

144 d by massive destruction of hepatocytes with severe impairment of liver function.

145 n in the dentate gyrus was normal, there was severe impairment of long-term potentiation (LTP) as a r

146 Moderate to severe impairment of lung function is an independent pre

147 Moderate to severe impairment of lung function related to complexity

148 Moderate to severe impairment of lung function was an independent pr

149 In contrast, there was a severe impairment of memory for autobiographical events

150 Severe impairment of methylation invariably led to a dra

151 density by dexamethasone is associated with severe impairment of mineralized extracellular matrix fo

152 gly polarized Th2 host immune response and a severe impairment of mitogen-driven proliferation and ty

153 d (90 mg/kg) over a 5-day period resulted in severe impairment of movement and loss of neurons in the

154 f CP47 (CP47 RR384385EE), exhibited the most severe impairment of MSP binding, whereas the Arg384Arg3

155 ular dystrophy in boys progresses rapidly to severe impairment of muscle function and death in the se

156 These defects stemmed from severe impairment of neurogenesis associated with uncont

157 riking decline in rod visual sensitivity and severe impairment of nocturnal vision.

158 These effects correlated with the severe impairment of normal, developmental sharpening, a

159 accumulation in HEK293 cells and caused more severe impairment of osteoblastic differentiation of MC3

160 We observe a surprisingly severe impairment of plus-end motion due to these altera

161 KCtheta, Bcl10, and Malt1 knockout mice show severe impairment of proliferation in response to TCR st

162 rain damage are frequently associated with a severe impairment of reading, called hemianopic dyslexia

163 from the full-length polypeptide resulted in severe impairment of Rep-Rep interaction.

164 e binding by substitutions was offset by the severe impairment of signal generation of cAMP and/or in

165 hat motor presymptomatic R6/1 HD mice show a severe impairment of somatosensory-discrimination learni

166 e non-restraint ApoE-deficient mice showed a severe impairment of spatial memory similar to that of t

167 Np73, results in male infertility because of severe impairment of spermatogenesis.

168 Downregulation of SON leads to severe impairment of spindle pole separation, microtubul

169 ncy of Foxo1, Foxo3, and Foxo4 resulted in a severe impairment of SSC self-renewal and a complete blo

170 enital lipoid adrenal hyperplasia results in severe impairment of steroid biosynthesis in the adrenal

171 a mutation in troponin I or tropomyosin show severe impairment of systolic function.

172 migration of cortical projection neurons and severe impairment of tangential migration by the ventral

173 parietal or frontal cortices often induces a severe impairment of the ability to redirect gaze to vis

174 te that overexpression of cPLA(2) results in severe impairment of the calcium and secretory responses

175 Furthermore, a severe impairment of the coupled activities occurred whe

176 ich progressed to loss of endothelial cells, severe impairment of the endothelial barrier function, a

177 isingly, these effects are evident despite a severe impairment of the immunoreceptor tyrosine-based a

178 Depletion of uDCs resulted in a severe impairment of the implantation process, leading t

179 Severe impairment of the kyphotic nursing posture in lac

180 residues of the beta7-beta8 loop results in severe impairment of the polymerase function of the hete

181 suggests the requirement for Rpn4p reflects severe impairment of the proteasome by UPR-M/C stress.

182 sing the downregulation of NKG2D and in turn severe impairment of the responsiveness of tumour-antige

183 We hypothesized that the severe impairment of these patients in real-life decisio

184 In MNGIE, severe impairment of TP enzyme activity leads to increas

185 with a surrogate misfolded protein revealed severe impairment of UPS function in CR-Csn8KO hearts.

186 This severe impairment of vasomotor tone after CTO reopening

187 nfectious molecular clone, HXB2, resulted in severe impairment of virus infectivity.

188 In 3-mo-old kittens, we show that a severe impairment of visual acuity is also fully reverse

189 r parietal region also results in an equally severe impairment of visually mediated redirection of ga

190 All five patients showed severe impairments of episodic memory (memory for events

191 cently reported on three young patients with severe impairments of episodic memory resulting from bra

192 Behavioral studies revealed severe impairments of fear-related associative learning

193 Deletion carriers present with severe impairments of phonology and of inhibition skills

194 radiofrequency lesions of the amygdala yield severe impairments on object reversal learning, a task t

195 airment ratings (mild/moderate impairment or severe impairment) on the three consent abilities.

196 r disruption of metabolism and can result in severe impairment or death.

197 All boxers with severe impairment possessed at least 1 APOE epsilon4 all

198 erall rates of survival and survival without severe impairment ranged from 5.1% (IQR, 0 to 10.6) and

199 l variation in survival and survival without severe impairment, respectively, among children born at

200 unction (78.9% versus 46.2% with moderate or severe impairment, respectively; P<0.001).

201 tencies were found in patients with the most severe impairment (rs = -0.57; P < 0.01, two-tailed).

202 ddition to panic phenomena contribute to the severe impairment seen in patients with panic disorder.

203 litudes were found in patients with the most severe impairment (Spearman rank correlation coefficient

204 Shank3(e4-9) male mice display more severe impairments than females in motor coordination.

205 ical injury to the carotid artery revealed a severe impairment to occlusion as a consequence of the P

206 0 to 52, with higher scores indicating more severe impairment); we classified youths with scores of

207 impairment, slight impairment, and moderate/severe impairment were defined, based on scores from the

208 gs (no impairment, mild/moderate impairment, severe impairment) were also identified for individual p

209 Social function scores showed severe impairment with only modest albeit statistically