ライフサイエンスコーパス: severely

1 results as normal or mildly, moderately, or severely abnormal (for CAC: 0, 1-99 Agatston score [AS],

2 rred in patients with mildly, moderately, or severely abnormal FT (n=57 of 132, 43%; P<0.001).

3 Severely abnormal hemodynamics on echocardiograms were a

4 odel was associated with the lowest rates of severely abnormal test results (1.3% for CCTA; 5.6% for

5 ribution of normal or mildly, moderately, or severely abnormal test results was significantly differe

6 gs were stratified as mildly, moderately, or severely abnormal, hazard ratios for events in compariso

7 aneous transcriptome of patients suffering a severely active CSU refractory to antihistamine treatmen

8 atients, respectively, who had moderately to severely active ulcerative colitis despite previous conv

9 In patients with moderately to severely active ulcerative colitis, tofacitinib was more

10 that ignoring such developmental effects can severely affect inferences of trees' W i .

11 are plagued with systematic errors that may severely affect statistical analysis if the data are not

12 Natural freshwater systems have been severely affected by excess loading of macronutrients (e

13 The intestine is one of the organs most severely affected by GVHD and research has recently high

14 diate levels of EDA were detected, whereas a severely affected carrier had no active EDA in the serum

15 t the myriad clinical presentations in these severely affected children, it is also paramount to addr

16 or and a target gene of p53, which, in turn, severely affected chlamydial growth and had a marked eff

17 a major public health challenge in the most severely affected countries despite the sharp decline in

18 Environmental change across the extinction severely affected Devonian reef-builders, besides many o

19 normal oral epithelial adhesions in the most severely affected double mutant embryos ( Irf6(+/-);Tg(K

20 retinal guanylate cyclases GC1 and GC2 were severely affected in the Reep6 knockout animals, with al

21 ch-clamp and loose-patch recordings revealed severely affected inhibitory and excitatory synaptic tra

22 Mouse-derived Polbeta null fibroblasts had severely affected metabolic parameters.

23 Moreover, systemic ASO injection into severely affected mice leads to reversal of muscle patho

24 ration to form the prFMN(iminium) species is severely affected only for the R173A variant.

25 d treatment for long-term disease control in severely affected patients for whom hematopoietic stem c

26 marrow transplantation has been attempted in severely affected patients, but outcomes have been poor.

27 o quantify stiffness, especially in the less severely affected patients; or drug effectiveness in onl

28 ately affected gluteal muscle but not of the severely affected psoas muscle.

29 isease phenotype, enhancing mean survival in severely affected SMA model mice by approximately 40%.

30 ability in symptoms, with females being less severely affected than males and presenting a higher pro

31 drome (IC/BPS) suffer from chronic pain that severely affects quality of life.

32 Alternaria solani severely affects tomato (Solanum lycopersicum L.) yield

33 extremely poorly tolerated in the adult, and severely affects various organ systems demonstrating tha

34 at each of these processes acts more or less severely and at different times in each of the clinical

35 th continental climates were predicted to be severely and negatively affected (Berce, France), while

36 may contribute to callous-unemotionality in severely antisocial people.

37 Severely asthmatic horses (6 horses/group) were treated

38 h secondary major cardiovascular events in a severely atherosclerotic population.

39 surges in ovariectomized female monkeys were severely attenuated by systemic administration of the ar

40 optical induced waveguide is passive and is severely attenuated by the Doppler effect.

41 train lacking both SPN and SLO production is severely attenuated in ability to resist killing by huma

42 in lamina II neurons, but such currents were severely attenuated in gamma-2-lacking stargazer (stg/st

43 s, as the hyperfusogenic mutant gB[Y881F] is severely attenuated in human skin xenografts.

44 Specifically, the cheY2 mutants were severely attenuated in murine infection and disseminatio

45 failed to replicate in macrophages and were severely attenuated in their ability to generate cutaneo

46 ext feature from the pathologic reports was "severely atypical." Instead of surgical excision of all

47 as shown that this type of ascertainment can severely bias heritability estimates; we show here that

48 hat (i) GG causality estimates can be either severely biased or of high variance, both leading to spu

49 its, animal model parameter estimates can be severely biased.

50 monstrate that impairment of DNA replication severely blocks transcriptional switch to primed pluripo

51 ly selective small molecule PRMT5 inhibitors severely blunted memory Th expansion, with preferential

52 retic response to furosemide and exhibited a severely blunted response to thiazide.

53 ar target to improve the clinical outcome of severely burned patients.

54 nas aeruginosa is a major cause of sepsis in severely burned patients.

55 PP_PA14 (PA14) was grown in whole blood from severely burned patients.

56 ondary and tertiary structures were affected severely by higher pressures (450MPa), which reduced enz

57 However, challenging lesions, such as severely calcified, remain difficult to treat with DCB a

58 mean lesion length was 8.3 cm, and 44% were severely calcified.

59 RS morphology appeared severely changed in averaged cryo-electron tomograms, su

60 Although this dual dependence has until now severely complicated analysis of DCs from highly dynamic

61 substrate carboxylate, and R245E/L mutations severely compromise activity and heme content, although

62 ix motifs, and mutations within any of these severely compromise biological activity.

63 histone retention, abnormal morphology, and severely compromised activity, which can be functionally

64 f the NAM protection network is likely to be severely compromised by a changing climate.

65 dently of other pCF10-encoded proteins, have severely compromised cell envelopes and strong growth de

66 ction, which attenuated both NHEJ and HR and severely compromised DSB repair resulting in chromosomal

67 result in the production of an antibody with severely compromised efficacy.

68 to cause mortality in a mouse model and were severely compromised for neuroinvasion.

69 g cyclic guanine adenine synthase (cGAS) was severely compromised for the pUL25 mutant.

70 trate that HR repair of conventional DSBs is severely compromised in DEK-deficient cells.

71 ation-promoting factor (MPF) activation, and severely compromised meiotic resumption.

72 on with saracatinib in these CTL clones also severely compromised their functional activities toward

73 their vegetative and reproductive growth was severely compromised under chilling conditions.

74 aired at synapses and (2) AP propagation was severely compromised with >40% of axonal branches no lon

75 patients with multiple risk factors, TFS was severely compromised, regardless of the timing of S2P an

76 subsets or even when TH2 cell functions were severely compromised.

77 Loss of both RECQL5 and WRN severely compromises DNA replication, accumulates genomi

78 mphoma progression or unacceptable toxicity (severely compromises organ function, quality of life, or

79 lexity basal dendrites of CA1 neurons, which severely compromises the animals' consolidation of both

80 or-binding site and the stem region on HA is severely constrained by their functional roles in engagi

81 ity of such a C-H activation reaction can be severely curtailed by the distance of the C-H bond in qu

82 Drought can severely damage crops, resulting in major yield losses.

83 ADB), caused by Hymenoscyphus fraxineus, has severely damaged a large proportion of ash trees (Fraxin

84 IMPORTANCE Immune tissues within the gut are severely damaged by HIV-1, and this plays an important r

85 swimming movement, and reduced percentage of severely damaged muscle cells.

86 of Pseudomonas syringae pv. actinidiae (Psa) severely damaged the New Zealand kiwifruit industry, whi

87 ached outbreak levels and subsequent feeding severely damaged tree fruit as well as other crops.

88 Pulse volume recording was moderate to severely dampened in 54 of 119 (45.4%) limbs.

89 KGROUND DATA: HO in burns is an uncommon but severely debilitating problem with a poorly understood m

90 owever, ubiquitous deleterious mutations may severely decrease its fitness.

91 Msh3-/- cells are severely defective for CTG*CAG repeat expansions but sho

92 bcr1Delta/Delta mutant, which is known to be severely defective in biofilm formation when grown as si

93 Furthermore, both viruses were severely defective in cell-to-cell spread and produced f

94 es but also SPO11-deficient oocytes that are severely defective in homolog synapsis.

95 Yeast cells lacking LDs are severely defective in PSM growth and organization and di

96 nsion led to haploinsufficiency resulting in severely defective intracellular and extracellular vesic

97 Those with a structurally defective or severely defective LES improved to a normal LES in 77% a

98 Lrrc8a(-/-) mice have severely defective T-cell development and function.

99 most IDH1 mutations identified in tumors are severely deficient in catalyzing the normal oxidation re

100 3 scaffold protein of immature virions, were severely deficient in the transmembrane proteins that co

101 h, development, and high parasite density in severely deficient samples.

102 with composition Fe50Mn30Co10Cr10 (at.%) was severely deformed by FSP and evaluated for its microstru

103 % of male and female Erk5 (fl/fl) mice had a severely deformed curved thoracic spine, with an associa

104 many proteins and protein complexes but can severely degrade performance of native mass spectrometry

105 ance of GaN-on-Silicon electronic devices is severely degraded by the presence of a parasitic conduct

106 M), a moderately degraded meadow (MDM) and a severely degraded meadow (SDM) from April to October 201

107 potential prophylaxis therapy for cholera, a severely dehydrating disease caused by Vibrio cholerae.

108 that the presence of a latent reservoir can severely delay evolutionary dynamics within a single hos

109 ) tomato (Solanum lycopersicum) mutant shows severely delayed flowering and precocious doming of the

110 392 rural fishers, we show that fishing has severely depleted a large-bodied keystone fish species,

111 athogens, but microbiota analysis revealed a severely depleted gut microbiota with concomitant opport

112 In the absence of Cluh, mitochondria are severely depleted of crucial enzymes involved in catabol

113 trusts in the North of England, we recruited severely depressed patients, who were diagnosed as havin

114 sses, and even the rather mild L28A mutation severely destabilized the NTD, drastically reducing TDP-

115 entify a sub-bandgap optical transition that severely deteriorates the carrier lifetime.

116 accuracy of intended sequence changes can be severely diminished by CRISPR/Cas9's propensity to re-ed

117 The activity of PEI is also severely diminished by substitution of DNA for shorter n

118 micking NP hyper-acetylation at K77 and K229 severely diminishes viral polymerase activity, while mim

119 t volume adjustments and management of these severely disabled patients.

120 is often favorable, but some patients remain severely disabled, requiring long-term immunotherapy and

121 Fifty-five patients with severely disabling, treatment-refractory OCD received bi

122 on, Tsc1 conditional knockout mice presented severely disorganized collagen fibers and neovasculariza

123 deletion, the MG form large aggregations and severely disrupt normal retinal architecture and functio

124 rstood symptom of Parkinson disease, and can severely disrupt the locomotion of affected patients.

125 Although these methods severely disrupt the mitochondrial electron transport ch

126 s in their judgments, this spatial prior was severely disrupted among a large subset of ASD participa

127 verge but their architecture and function is severely disrupted during S. Typhimurium infection.

128 pared with 20 other cancer types, OV is most severely disrupted in autophagy and in compensatory prot

129 In contrast, reducing dEaat1 expression severely disrupted sleep.

130 p consumer and affect its behaviour, thereby severely disrupting the function of natural ecosystems.

131 n (CHIN-1)- Furin (KPC-1) double-mutant that severely disrupts assembly.

132 tric risk gene transcription factor 4 (TCF4) severely disrupts the columnar organization of medial pr

133 s demonstrate that removing descending input severely disrupts the development of spinal circuits and

134 oduced large spine head depolarizations that severely distorted measurements and recruited voltage-de

135 on of Shh effectors and ciliary proteins are severely disturbed in Npc1-deficient mice.

136 c switch in nonpigmented melanoma cells, was severely down-regulated in vitiligo cell line PIG3V and

137 rain has revealed miR-132 as one of the most severely down-regulated miRNAs at the intermediate and l

138 Nutrient deprivation further severely down-regulated the conversion of 18:3 to 18:4,

139 The true knock-out mutants of MPK1 were severely dwarfed and sterile, and homozygous mpk1 seeds

140 , 90% to 99%), and detected 95% of malignant/severely dysplastic lesions, compared with 35% and 50% f

141 as co-inhibitory molecules-double-positive, severely exhausted PD-1(+)CD8(+) T cells, leading to red

142 cal Frailty Scale (range, 1 [very fit] to 7 [severely frail]).

143 lude high-dose treatment of other cancers is severely hampered by serious side effects on healthy org

144 ay crystallography of these intermediates is severely hampered by the difficulty in obtaining well-di

145 system that uptake by splenic APC subsets is severely hampered in mice lacking complement factor C1q

146 iofilm, suggesting that biofilm formation is severely hampered in the natural environment where most

147 These limits have severely hampered innovations and applications of DIW 3D

148 The limitations of peptides have severely hampered their use in pharmacology, thus prompt

149 Data availability severely hampers modeling the most extensive land manage

150 d algorithm definitions and image processing severely hampers reproducibility and comparability of re

151 osen for removal of lead since the latter is severely hazardous to human health even in small amounts

152 development of solar-energy technologies is severely hindered by poor energy-conversion efficiencies

153 ur reaction in the Mg cation environment has severely hindered our understanding and prevents effecti

154 and clearly show that Li-ion conductivity is severely hindered through the grain boundaries.

155 at glands appeared mature, but the mice were severely hypohidrotic.

156 opment, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pre

157 ue-specific genetic ablation of HDAC3 become severely hypothermic and succumb to acute cold exposure.

158 tes for triglyceride esterification protects severely hypothyroid mice against NAFLD.

159 In contrast, severely hypothyroid mice show down-regulation of TH sig

160 In more severely hypoxaemic patients with ARDS, neuromuscular bl

161 Less severely ill patients seem to benefit less in terms of o

162 ill experience the same side-effects as more severely ill patients.

163 tients with cellulitis were found to be less severely ill than patients with necrotizing fasciitis.

164 reasing reactivation of chronic infection in severely immunocompromised mice.

165 asthma, pre-existing pulmonary lesions, and severely immunocompromised patients are susceptible to d

166 hes affect 70% of menopausal women and often severely impact physical, psychosocial, sexual, and over

167 production with about 27% of the production severely impacted by 2030s.

168 While the crude oil severely impacted the phytoplankton population and was l

169 t small electrolytic lesions in the midbrain severely impair a chicken's ability to discriminate orie

170 ic nucleotide and DNA binding defects, which severely impair catalytic activity and correlate with pr

171 at disrupt either interface in solution also severely impair evoked synchronous release in neurons, s

172 Sleep loss can severely impair the ability to perform, yet the ability

173 oderately impaired (N=148; 17th percentile), severely impaired (N=181; 3rd percentile), and profoundl

174 he photoreceptor outer segment structure was severely impaired at 4 weeks of age, although a full-fie

175 of the truncated GLI1 factor was found to be severely impaired by cell culture and in vivo assays, in

176 velopment of motile ookinetes that exhibit a severely impaired capacity to traverse the mosquito midg

177 n stratified by sex and CFR, only women with severely impaired CFR demonstrated significantly increas

178 The LQT mutant K526E revealed a severely impaired channel function with a right shift in

179 ng resulted in a halt of cell proliferation, severely impaired EGFR signaling and the onset of cellul

180 51%-57% with normal function to 27%-42% with severely impaired function and 15%-32% on dialysis.

181 Furthermore, LMP1 packaging was severely impaired in CD63 knockout cells, concomitant wi

182 ter knockdown in Drosophila also resulted in severely impaired locomotor activity and reduced lifespa

183 Furthermore, KIFC1 knockdown more severely impaired migration in AA TNBC cells than White

184 Moreover, loss of SEP4 severely impaired mutant conidiation, melanin and chitin

185 Primary cells revealed one substitution severely impaired OGFOD1-dependent hydroxylation of a ne

186 The presence of Retro94 results in severely impaired production of infectious virions, with

187 uced p53, yet reduction of MDM2 but not MDM4 severely impaired proliferation and survival through a p

188 as a therapeutic strategy for diseases with severely impaired redox balance.

189 immunodeficiency (SCID) is characterized by severely impaired T-cell development and is fatal withou

190 ficant loss of binding to Jurkat T-cells and severely impaired their cytotoxicity.

191 n n1-src-knockdown embryos, accompanied by a severely impaired touch response in later development.

192 xcessive miR-27 expression in murine T cells severely impaired Treg differentiation.

193 inhibition, increased SOCS-1 expression, and severely impaired tTreg cell development in embryos, adu

194 from the wild type under constant light, but severely impaired under fluctuating light due to PSI pho

195 ur results revealed that pollen hydration is severely impaired when multiple PCP-Bs are lost from the

196 bronectin and ICAM1, 2 integrin ligands, was severely impaired, and CYTH1-deficient cells showed a re

197 the nucleotide selectivity of the enzyme is severely impaired, providing a mechanistic explanation f

198 ents continue to be treatment-refractory and severely impaired.

199 Knockdown of Shrm4 in rat severely impairs GABABR activity causing increased anxie

200 ically disrupts the structure of the conoid, severely impairs host-cell invasion, and slows growth.

201 Painful palmar-plantar keratoderma (PPK) severely impairs mobility in pachyonychia congenita.

202 in3-histone deacetylase corepressor complex, severely impairs the competitive repopulation capacity o

203 This limited swelling severely impairs their application as delivery vehicles

204 ere side reactions, and limited power output severely impede their practical applications.

205 s fumigatus and found that calcium chelation severely impedes hyphal growth indicating a critical req

206 be attributed to the TiBw architecture that severely impedes the movements of dislocation and grain

207 Jewish women, 3 mutations in BRCA1 and BRCA2 severely increase the risk of breast and ovarian cancer.

208 to 22.6 percentage injected dose per gram in severely inflamed joints.

209 parts of the Tropics, but photosynthesis is severely inhibited for the first 1 y to 2 y, and freezin

210 ye, we found that partial APC/C inactivation severely inhibits retinal differentiation independently

211 Prospective study of severely injured children at a level 1 pediatric trauma

212 cessary to unmask distinguishing features of severely injured DCD hearts.

213 A novel gene expression signature identified severely injured hearts during EVHP (upregulation of c-J

214 Histochemical assessment identified severely injured hearts during EVHP.

215 Severely injured human blunt trauma patients (n = 472, a

216 HS is still a common cause of death in severely injured patients and is characterized by impair

217 Severely injured patients frequently suffer compromised

218 This report of a severely injured trilobite from the Middle Ordovician (

219 Sequencing of ARL15 in 375 severely insulin resistant patients identified four rare

220 luorophore-appended boronic acids, but these severely lack discriminatory power and their response is

221 uantitative data on most of these parameters severely limit attempts to accurately predict trajectori

222 embranes employed in contemporary fuel cells severely limit device design and restrict catalyst choic

223 suggest that changes in stopover habitat can severely limit migratory populations.

224 Food and Drug Administration regulations may severely limit the ability of plastic surgeons to contin

225 ignatures in the tumor microenvironment, can severely limit the utility of nanomedicine in the oncolo

226 wide-spread investigation has, however, been severely limited by challenging synthetic requirements t

227 However, this approach is severely limited by the poor survival of donor cells.

228 discriminate the locus of focal attention is severely limited.

229 invasive imaging of nanodiamonds in vivo are severely limited.

230 lationships contributes to human disease, is severely limited.

231 e rapidly deaminates/inactivates decitabine, severely limiting its half-life, tissue distribution, an

232 P deficiency severely limits crop yield, and regular fertilizer appli

233 This extremely low capacity severely limits execution of many cognitive tasks, but i

234 vents orthogonal verification of results and severely limits interpretation of the data.

235 ming and requires a technical expertise that severely limits the development of new contents of poten

236 This law severely limits the generic capabilities of all types of

237 This assumption severely limits their applicability to cancer samples wi

238 e with appropriate dispersion, which in turn severely limits their catalytic functions.

239 sity inherent to traditional supercapacitors severely limits their widespread applications, triggerin

240 Electrodiagnostic examination showed severely low compound muscle action potentials and presy

241 iciency for nucleic acids (>10 bases), which severely lowers the sensitivity of an aerolysin-based ge

242 ones of adaptation (adapted, maladapted, and severely maladapted) were identified based on the RVESRI

243 s suggest that the ground state of SiH2OO is severely multireference in nature.

244 ardless of plant diversity, and legumes were severely negatively affected regardless of plant diversi

245 We enrolled 11 severely obese and 12 nonobese patients and obtained 294

246 2 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls.

247 Five severely obese patients (four women, one man) who were 3

248 excretion were measured simultaneously in 26 severely obese patients before and 1 year after RYGB, wh

249 n correlates with elements of fat balance in severely obese patients before and after RYGB.

250 Severely obese patients, prior to bypass, ingest excess

251 feasible and appears to be well tolerated in severely obese patients.

252 overweight people to more than ten times in severely obese people compared with individuals with a h

253 Eight healthy volunteers and eight severely obese subjects with insulin resistance were stu

254 adulthood, especially for children who were severely obese.

255 AD, whereas men showed a higher frequency of severely obstructive CAD (P=0.002).

256 Concurrently, herbivorous fishes have been severely overfished in many locations worldwide, contrib

257 optimized with respect to the resolution of severely overlapping chromatographic peaks and the total

258 ability, disrupted muscle proteostasis, and severely perturbed IFM structure.

259 Furthermore, muscle repair was severely perturbed when Ptpn11 was ablated in stem cells

260 ereas approximately one-third of moderate to severely poisoned patients exhibit cardiac dysfunction,

261 ations as the large molecular size of pectin severely prevents its bioavailability in vivo.

262 -20 million individuals worldwide and causes severely progressive hepatitis.

263 Fc receptor gamma chain (FcRgamma) produced severely reduced amounts of granulocyte colony-stimulati

264 in a switching B cell line, DSB formation is severely reduced and CSR frequency is impaired.

265 89 patients with new-onset heart failure and severely reduced ejection fraction not caused by valvula

266 cells, we find that ATM inhibition leads to severely reduced HDR in Brca1(S1598F) cells.

267 .e. granule-to-granule homotypic fusion) was severely reduced in the absence of Munc13-4.

268 participating in chlorophyll synthesis were severely reduced in the tsv mutant under cold stress, bu

269 In type-2 diabetes (T2D), severely reduced islet syntaxin-1A (Syn-1A) levels contr

270 tervention (PCI), particularly in those with severely reduced left ventricular ejection fraction.

271 o non-PM membranes or the actin cytoskeleton severely reduced net virus particle production.

272 Tshz1 mouse mutants exhibit severely reduced numbers of ITCs as a result of abnormal

273 ariable immunodeficiency (CVID) present with severely reduced switched memory B-cell counts, and some

274 The deletion of misR or misS severely reduced the capacity of N. gonorrhoeae to colon

275 ional regulators, Pumilio 1 (Pum1) and Pum2, severely reduced the number of neural stem cells (NSCs)

276 In FtsZ mutants with severely reduced treadmilling, the spatial distribution

277 Growth of a sitA mntH double mutant was severely reduced under Mn(2+) limitation and sitA and mn

278 ir vision from only S-cones and rods, suffer severely reduced visual acuity and impaired color vision

279 duced, but, paradoxically, not when they are severely reduced.

280 tation of E73 to either alanine or glutamine severely reduces oligomerization, demonstrating the role

281 n insoluble and unprocessable powders, which severely restrict their widespread applicability.

282 RNA levels demonstrate that PLVA fitness is severely restricted in mountain lions compared to that i

283 ength, ductility and low melting temperature severely restricts practical applications of Mg.

284 esence of a water-impenetrable coating which severely restricts the proximity of protons to the magne

285 GS, FIC1, and BSEP patients experienced less severely scored pruritus after PEBD (ALGS, 100% vs. 9% s

286 sprouted wheat, the potential of eliminating severely sprouted kernels based on density differences i

287 scarding lower density kernels of mildly and severely sprouted wheat batches (11% and 16%, respective

288 second laser technology in the management of severely subluxated cataracts.

289 For acute or severely symptomatic hyponatremia, both guidelines adopt

290 and efficacy of masitinib versus placebo in severely symptomatic patients who were unresponsive to o

291 ants and typically presents more rapidly and severely than illness caused by types A and B botulinum

292 Moreover, the uniform-flow algorithm severely underestimates the network throughput of conges

293 Even so, AIT is still severely underused.

294 Obese (odds ratio, 1.28; P=0.008), severely underweight (odds ratio, 1.29; P<0.0001), and u

295 composite outcome (P<0.0001) were higher in severely underweight and obese subjects.

296 Severely underweight BMI was associated with increased u

297 mal weight, 7% were underweight, and 9% were severely underweight.

298 fference=-0.5, 95% CI=-0.8, -0.1) and as not severely unwell (CGI-S: treatment difference=-0.3, 95% C

299 normal systems where the anomeric effect is severely weakened by polar solvents.

300 ed, regardless of the timing of S2P and most severely when S2P was performed early.