ライフサイエンスコーパス: sex bias

1 loped DCM or the other phenotypes, including sex bias.

2 minantly affect females, indicating a strong sex bias.

3 resent muscle damage in soleus with a strong sex bias.

4 rom >4,100 cancers across 21 tumor types for sex bias.

5 Z chromosome, and shows other differences in sex bias.

6 genes, dosage compensation, and evolution of sex bias.

7 T does not seem to be affected by ethnic and sex bias.

8 r complex disorders that exhibit significant sex biases.

9 of mortality is the propensity for it to be sex-biased.

10 mber of genes that were female-biased or non-sex-biased.

11 owed functional clustering only if they were sex-biased.

12 are enriched for nearby and correspondingly sex-biased accessible chromatin regions, as well as sex-

13 sex bias, we demonstrate a rapid turnover of sex bias across this clade driven by sexual selection an

14 rtially migratory and that migration was not sex-biased across surveyed areas.

15 cultural populations, we find no evidence of sex-biased admixture during the migration that spread fa

16 We demonstrate increased power to detect sex-biased admixture in African-American individuals fro

17 duced arthritis (CIA) in mice is the lack of sex bias and autoantibodies in the animal model.

18 pproaches as well as the correlation between sex bias and expression breadth.

19 ntradictory, with some studies indicating no sex bias and others indicating either female or male bia

20 ss the island reveals that the admixture was sex biased and happened heterogeneously across Madagasca

21 lps; a freely adjustable sex ratio magnifies sex biases and promotes helping; and sib-mating, promisc

22 w that complex dispersal dynamics, including sex biases and strong density dependence, emerge natural

23 cross pregnancy for gene candidates that are sex-biased and stress-responsive in mice and translate t

24 significant differences in selection between sex-biased and unbiased genes, which relate primarily to

25 ptome shows switches between nonsex bias and sex bias, and just 0.9% of the transcriptome shows rever

26 However, mechanisms responsible for this sex bias are not clear.

27 n in men, but the mechanisms underlying this sex bias are unknown.

28 Sex biases are eliminated if both sexes evaluate mate av

29 that X chromosome dosage contributed to this sex bias as female pDCs have an enhanced TLR7-mediated I

30 utoreactive B cells and begin to explain the sex bias associated with the condition.

31 systems are implicated in diverse domains of sex-biased behavior and pathology, but we lack a basic u

32 sed accessible chromatin regions, as well as sex-biased binding sites for growth hormone-regulated tr

33 d developmental abnormalities leading to 1:2 sex biases, caused by lethality of half of the male or f

34 matin states are thus a major determinant of sex-biased chromatin accessibility and gene expression,

35 ined by miRNA-specific regulation, including sex-biased chromatin accessibility at promoters, rather

36 ng sex-biased genes by binding to sites in a sex-biased chromatin state.

37 females, with translational implications for sex biases commonly found in midbrain DA-associated diso

38 oof of principle that when CRF is in excess, sex-biased CRF1 coupling translates into divergent cell

39 es in male and female brains, as a result of sex-biased CRF1 signaling.

40 nervous system, locomotor abnormalities, and sex-biased defects in adult craniofacial morphology.

41 in the absence of these, also by historical sex-biased demographic events or other processes.

42 (iv) Sex-biased STAT5 binding is enriched at sex-biased DHS marked as active enhancers and preferenti

43 (i) Sex-biased DHS, but not sex-biased genes, are frequently

44 tic conflict caused by ancient admixture and sex-biased differences in genomic transmission.

45 f genes, respectively, exhibited strain- and sex-bias differential gene or exon expression.

46 We report greater sex-biased differential expression in the pituitary as c

47 tion model to explore interactive effects of sex-biased dispersal and demographic stochasticity.

48 Sex-biased dispersal and extra-pair mating may also have

49 erent host plants, potentially influenced by sex-biased dispersal and female philopatry.

50 between mammals and birds, mating system and sex-biased dispersal are far from perfectly associated w

51 The hypothesis that patterns of sex-biased dispersal are related to social mating system

52 behavioral differences in mating system and sex-biased dispersal between mammals and birds, mating s

53 Sex-biased dispersal created spatial clines in the sex r

54 e fine-scale spatial genetic structuring and sex-biased dispersal have important implications for the

55 Additionally, tests for sex-biased dispersal imply that dispersal frequency is s

56 elationship between social mating system and sex-biased dispersal in birds when the effects of phylog

57 f the relationship between mating system and sex-biased dispersal in mammals and birds.

58 mes and the influence of sex chromosomes and sex-biased dispersal in post-speciation gene flow.

59 ulation structure and looked for evidence of sex-biased dispersal in smooth snakes (Coronella austria

60 ) the relationship between mating system and sex-biased dispersal in these vertebrate groups has not

61 t the relationship between mating system and sex-biased dispersal is more complex than a simple contr

62 st experimental evidence for an influence of sex-biased dispersal on invasion velocity, highlighting

63 laboratory mesocosms to test the effects of sex-biased dispersal on range expansion, and a simulatio

64 thers maintain that any kind of lineality or sex-biased dispersal only emerged much later.

65 , theoretical studies on mate finding and on sex-biased dispersal produce opposing predictions: in th

66 life history or behaviour (skewed sex ratio, sex-biased dispersal, and sex-specific mating behaviours

67 With sex-biased dispersal, the effective number of gametes is

68 nce in male reproductive success and limited sex-biased dispersal, which enables us to control to som

69 f male and female snakes showed evidence for sex-biased dispersal, with three of four analyses findin

70 eading-edge sex ratios, perhaps overwhelming sex-biased dispersal.

71 aphic stochasticity would weaken a signal of sex-biased dispersal.

72 l to diurnal activity patterns, but not with sex-biased dispersal.

73 trapolate dispersal frequencies and test for sex-biased dispersal.

74 mune-mediated disease of the CNS and shows a sex-biased distribution in which 60-75% of all cases are

75 ent STAT5 binding correlated positively with sex-biased DNase hypersensitivity and H3-K4me1 and H3-K4

76 We demonstrate how the close age- and sex-biased dyadic relationships are correlated with the

77 We tested the burden and the possible sex-biased effect of CNVs at 16p13.11 in a sample of 10,

78 with controls (OR = 2.59; p = 0.0005), and a sex-biased effect, with a significant enrichment of CNVs

79 ex ratio, one male per litter, revealing its sex-biased effect.

80 of human Dab2 as a tumor suppressor, and the sex-biased embryonic lethality suggests a genetic intera

81 al network and by the dynamics of changes in sex-biased epigenetic states.

82 se populations, quantifying the postcolonial sex-biased European gene flow across multiple regions.

83 Despite sex-biased eve expression, the gene networks downstream

84 transcription factor, giant (gt), we traced sex-biased eve patterning to gt dose, indicating that ea

85 specialties in which the greatest and least sex biases exist.

86 Objectives: To determine if sex bias exists in human surgical clinical research, to

87 Conclusions and Relevance: Sex bias exists in human surgical clinical research.

88 in preclinical studies, we explored whether sex bias exists in skin research.

89 That sex-biased exposure might translate to sex-specific adve

90 human brain, and we identified genes showing sex biased expression at major developmental stages (pre

91 in multiple outcrossing species with strong sex-biased expression are even more likely to be missing

92 Numerous studies have shown that genes with sex-biased expression are under- or over-represented on

93 Moreover, genes with sex-biased expression as revealed by comparing amounts i

94 s showing the same growth hormone-regulated, sex-biased expression as their mouse counterparts.

95 We show that averaged sex-biased expression changes accumulate monotonically o

96 Sex-biased expression characterized 247 liver lincRNAs,

97 identified several OR transcripts displaying sex-biased expression in adults, as well as larval-enric

98 About 80% of the expressed genes show sex-biased expression in each species.

99 We report tissue-specific and sex-biased expression in genes commonly investigated whe

100 rattlesnake to establish baseline levels of sex-biased expression in homomorphic sex chromosomes, an

101 To address this problem, we measured sex-biased expression in multiple Drosophila species and

102 lacking germline tissue to define genes with sex-biased expression in terminally differentiated somat

103 s been identified in a screen for genes with sex-biased expression in the head.

104 We give examples of genes where sex-biased expression is both disease-relevant and likel

105 sexual antagonism, and that the majority of sex-biased expression is due to adaptive changes in male

106 Sex-biased expression is explained by miRNA-specific reg

107 ormone (GH) secretory patterns determine the sex-biased expression of >1,000 genes in mouse and rat l

108 cific chromatin states appear not to explain sex-biased expression of genes.

109 osage compensation raises the possibility of sex-biased expression of key developmental genes, such a

110 ces between males and females arise from the sex-biased expression of nearly identical genomes can re

111 gned species-specific microarrays to examine sex-biased expression of orthologues and species-restric

112 We find that Dsx regulates sex-biased expression predominantly in males, that Dsx's

113 One model predicts that genes with sex-biased expression should be enriched on the X chromo

114 Comparative analysis of sex-biased expression should deepen our understanding of

115 bustness of the pattern to Gene Ontology and sex-biased expression suggest that partly recessive bene

116 Additionally, genes with sex-biased expression tend to be narrowly expressed in a

117 alleles to one sex, whereas ratites evolved sex-biased expression to confine the product of a sexual

118 ary, Nasonia accomplish a striking degree of sex-biased expression without sex chromosomes or epigene

119 ome is the result of selection on genes with sex-biased expression, narrowly expressed genes, or some

120 % of expressed genes displayed significantly sex-biased expression.

121 viding for direct and indirect regulation of sex-biased expression.

122 e-sensitive aneuploid effects also influence sex-biased expression.

123 0.9% of the transcriptome shows reversals of sex-biased expression.

124 in, loss, increase, decrease, or reversal of sex-biased expression.

125 ors that should be considered when analyzing sex-biased expression.

126 and evaluated ASD risk genes for evidence of sex-biased expression.

127 in the Drosophila genome may be spliced in a sex-biased fashion, raising the possibility that alterna

128 or protection from autoimmunity, creating a sex bias for autoimmune diseases.

129 nique opportunity to investigate a potential sex bias for different types of mutations.

130 Furthermore, a sex bias for severe sequelae from coxsackievirus infecti

131 strains, C and C57BL/6J (B), demonstrated a sex bias for susceptibility.

132 ver, levels of gene expression are generally sex-biased for all sex-linked genes relative to autosome

133 the X chromosome has acquired a paradoxical sex-biased function by redistributing gene contents [5,

134 o distinct co-expression networks, and shows sex-biased gene expression and exon usage.

135 m manipulation disproportionately influences sex-biased gene expression but show that the direction o

136 modifications accompanied these cGH-induced sex-biased gene expression changes.

137 test the links between sexual selection and sex-biased gene expression evolution in a comparative fr

138 Our results support a scenario in which sex-biased gene expression evolved during the evolution

139 We found that sex-biased gene expression has evolved in autosomal and

140 Separate sexes and sex-biased gene expression have repeatedly evolved in an

141 Here, we review our current knowledge of sex-biased gene expression in both model and nonmodel or

142 rate that previously unexplained patterns of sex-biased gene expression in Drosophila melanogaster mi

143 pidly evolved new gene networks and impacted sex-biased gene expression in Drosophila.

144 iver and WAT indicates that RSL1 accentuates sex-biased gene expression in liver but greatly diminish

145 sex-differential chromatin accessibility and sex-biased gene expression in mouse liver.

146 Such studies have revealed that sex-biased gene expression is abundant in many species,

147 Xenopus to provide an additional test of how sex-biased gene expression may contribute to differences

148 hanges cannot explain the extensive level of sex-biased gene expression observed.

149 ycle of the chicken to assess the pattern of sex-biased gene expression on the Z chromosome.

150 males and females are likely rooted from the sex-biased gene expression regulation during brain devel

151 Sexual dimorphism depends on sex-biased gene expression, but the contributions of mic

152 on, whereas other sex-specific signals cause sex-biased gene expression.

153 and transcriptional dimorphism, often termed sex-biased gene expression.

154 ferences in gene expression is the result of sex-biased gene expression.

155 ying the transcription factors that regulate sex-biased gene expression.

156 ences gene expression, including patterns in sex-biased gene expression.

157 h as dosage compensation, also may influence sex-biased gene expression.

158 In addition, various degrees of sex-biased gene flow exhibiting disproportionately highe

159 Results indicate a sex-biased gene flow from Europeans, the male contributi

160 ng that sex biases in expression may reflect sex-biased gene regulatory structures.

161 Thus, the temporal, sex-biased gene responses to persistent GH stimulation a

162 , these analyses reveal an important role of sex biased genes in brain development and neurodevelopme

163 fectors expressed in the head, and report 46 sex-biased genes (>4-fold/P < 0.01).

164 However, there are little overlap of sex-biased genes among the major developmental stages, a

165 opening and STAT5, but not BCL6, regulating sex-biased genes by binding to sites in a sex-biased chr

166 h contributes to a nonrandom distribution of sex-biased genes compared to the remainder of the genome

167 We find that sex-biased genes do change in expression but, contrary t

168 rgence in the alternate sex, suggesting that sex-biased genes endure stronger selection when expresse

169 tion of dynamic expression regulation of the sex-biased genes in the brain during development.

170 on divergence than non-sex-biased genes, and sex-biased genes show higher levels of expression diverg

171 l expression can be achieved for hundreds of sex-biased genes simply based on the GH input signal pat

172 Sex-biased genes were clustered by chromatin environment

173 active enhancers and preferentially targets sex-biased genes with sex-differences in local chromatin

174 her levels of expression divergence than non-sex-biased genes, and sex-biased genes show higher level

175 (i) Sex-biased DHS, but not sex-biased genes, are frequently characterized by sex-di

176 Sex-biased genes, especially those with male-biased expr

177 e chromosomal locations and the evolution of sex-biased genes.

178 e the genomic and evolutionary properties of sex-biased genes.

179 utionary forces that govern the evolution of sex-biased genes.

180 We confirm recent reports of sex-biased genetic effects in 17q by showing highly sign

181 ctivating) marks, correlated negatively with sex-biased H3-K27me3 (repressive) marks, and was associa

182 l common variants largely do not explain the sex bias in ADHD prevalence.

183 variation, we find evidence of a significant sex bias in admixture proportions consistent with dispro

184 is relatively favoured when there is a small sex bias in adult dispersal in favour of the sex with th

185 Our findings identify a natural sex bias in appendage regenerative capacity and indicate

186 The sex bias in AS is not explained by X-chromosome-encoded

187 There is a significant sex bias in AS, and there are differences in recurrence

188 mit moth dispersal and whether there was any sex bias in attraction to light.

189 -estradiol is crucial in the pathogenesis of sex bias in cancer and autoimmunity.

190 ase-hypersensitive sites (DHS) classified by sex bias in chromatin accessibility and enhancer modific

191 in these strains, revealing or abrogating a sex bias in disease expression depending on the genotype

192 esented within a social group (when there is sex bias in dispersal and/or variance in reproductive su

193 ate-finding difficulties can select for less sex bias in dispersal when mate finding occurs after dis

194 and IL-6 may act synergistically to promote sex bias in experimental DILI by reducing Tregs.

195 An established sex bias in HIV pathogenesis is linked to immune respons

196 ulating the spatial pattern of dysbiosis and sex bias in IBD.

197 Numerous studies have reported sex bias in infectious diseases, with bias direction dep

198 Strong sex bias in laying order and growth patterns enabled mit

199 The disease model best explaining the sex bias in occurrence and transmission of AS is a polyg

200 ever, a possible molecular mechanism for the sex bias in physiological adaptation to oxidative stress

201 ot differ by sex, as evidenced by absence of sex bias in programmed death receptor-1 and responses to

202 rstand the role of DR4 in susceptibility and sex bias in RA.

203 izophrenia and autism, which often exhibit a sex bias in rates of presentation, age of onset, and sym

204 Although a significant sex bias in seropositivity was detected in adult deer mi

205 detected in adult deer mice, no significant sex bias in seropositivity was detected in juvenile anim

206 ex bias observed in human disease.IMPORTANCE Sex bias in severe sequelae from enteric viral infection

207 odevelopmental disorders, which often have a sex bias in severity and prevalence.

208 providing support for the role of Ifi202 in sex bias in SLE.

209 Sex bias in susceptibility to autoimmune diseases is evi

210 IFNgamma/IL-26 gene region may contribute to sex bias in susceptibility to RA, by distorting the prop

211 skin and soft tissue infections (SSTIs), yet sex bias in susceptibility to S. aureus SSTI has not bee

212 The existence of sex bias in the delivery of cardiac care is controversia

213 Here, we have revealed a sex bias in the efficiency of clinically relevant LT bio

214 ty of HSV-1 0DeltaNLS and uncover a probable sex bias in the induction of IFN-alpha/beta in the corne

215 nvestigated the genetic aspects of the large sex bias in the prevalence of autism spectrum disorder b

216 Most neuropsychiatric diseases have a sex bias in their presentation, age of onset, or treatme

217 The sex bias in urine testing is not clinically supported an

218 Sex biases in autoimmunity and infection suggest that st

219 uences, and provide evidence suggesting that sex biases in expression may reflect sex-biased gene reg

220 demonstrate that escape from XCI results in sex biases in gene expression, establishing incomplete X

221 identifying several traits with significant sex biases in genetic susceptibilities.

222 gnificant mechanistic implications regarding sex biases in NDDs.

223 host and pathogen genetic data can identify sex biases in pathogen spatial spread, which may be a wi

224 pmental disorders (NDDs), many of which show sex biases in prevalence, onset and/or severity.

225 mbined with cellular aging processes promote sex biases in stress dysregulation.

226 and highlight new avenues for research into sex biases in stress-related disorders.

227 s and found evidence for different levels of sex-bias in these areas: the strongest male-bias was obs

228 We test the hypothesis that sex-biases in infection are related to variation in mult

229 chronic oxidative stress show a significant sex bias, including neurodegenerative diseases, cancer,

230 In mouse, but not opossum and chicken, sex bias is coordinated across tissues such that autosom

231 The etiology of this sex bias is far from known, but pivotal for understandin

232 ess, and is relatively disfavoured when this sex bias is large or in the opposite direction.

233 men, although the mechanistic basis for this sex bias is not well understood.

234 A combination of heavily sex-biased laying order and sex differences in growth pa

235 The basis for this sex bias lies in the X chromosome, which contains many i

236 The sex-biased lincRNA genes are enriched for nearby and cor

237 tors implicated in growth hormone-regulated, sex-biased liver gene expression, leading to the followi

238 s assigned a physiological role, accentuates sex-biased liver gene expression, most dramatically for

239 esity, and increased leptin sensitivity in a sex-biased manner.

240 and many inflammatory diseases present in a sex-biased manner.

241 ng the molecular mechanisms controlling this sex bias may reveal novel targets to promote host innate

242 change over adolescence--with relevance for sex-biased mental disorders emerging in youth.

243 rough both severe population bottlenecks and sex-biased migration.

244 analyses uncovered numerous cases of somatic sex-biased miRNA expression, with the largest proportion

245 Sex-biased miRNAs also targeted genes related to Wnt and

246 l. applied a pan-cancer analysis to identify sex-biased molecular signatures and revealed two sex-eff

247 whereas the other shows much more extensive sex-biased molecular signatures.

248 f this more vulnerable sex in expectation of sex-biased mortality.

249 o Y chromosomal translocation has revealed a sex bias much lower than previous estimates.

250 hromosome population datasets emphasizes the sex-biased nature of recent demographic transitions in E

251 Studies have linked sex-biased neurodevelopmental disorders, including autis

252 ss during pregnancy predisposes offspring to sex-biased neurodevelopmental disorders, including schiz

253 et and penetrance of disease, abrogating the sex bias normally seen in the NOD model.

254 ine and should be considered in light of the sex bias observed in human disease.IMPORTANCE Sex bias i

255 iation in length of aganglionic segment, and sex bias observed in human HSCR patients.

256 response, specifically in the context of the sex bias observed in susceptibility to infectious and au

257 Sex bias occurrence of HCC associated with EGFR was conf

258 Sex bias occurrence was conserved in our model, with mal

259 dy provides evidence for the role of EGFR in sex bias occurrences of liver cancer and as the driver m

260 tterfly Hypolimnas bolina the suppression of sex biases occurs extremely fast, with a switch from a 1

261 the chicken and zebra finch, with regard to sex bias of autosomal versus Z chromosome genes, dosage

262 not affect the time of onset, incidence, or sex bias of type 1 diabetes in NOD/ShiLtJ mice.

263 Although several of these domains are sex biased, our fundamental understanding of cerebellar

264 maternal stress exposure that may relate to sex-biased outcomes in neurodevelopment.

265 study a species with an unusual, apparently sex-biased pattern of distribution, and test the hypothe

266 evels of African ancestry, consistent with a sex-biased pattern of gene flow with an excess of Europe

267 ly controlled at least in part by genes with sex-biased patterns of expression.

268 ch varied in density, genetic diversity, and sex-biased philopatry.

269 We conclude that a sex-biased process that reduced the female effective pop

270 evolutionary history, a coherent picture of sex-biased processes has yet to emerge.

271 rently contradictory evidence on the role of sex-biased processes in human evolutionary history and s

272 ther than piggybacking of intronic miRNAs on sex-biased protein-coding genes.

273 ons, and further specifying their timing and sex-biases, provides potent new research targets for bas

274 male and female affected persons without any sex bias, replicating recent findings, though the author

275 n of histone H3 at K27 (H3K27me3) is a major sex-biased repressive mark at highly female-biased but n

276 Of the 20 QTL, 8 were sex biased, sex specific, or sex antagonistic.

277 putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden o

278 1 to Gs-independent signaling pathways, this sex-biased signaling is proposed to result in distinct c

279 of clinically actionable genes (60/114) show sex-biased signatures.

280 nge of biological functions showed that most sex-biased splicing occurs in the gonads.

281 To investigate potential mechanisms of sex-biased splicing, we used real-time PCR to examine th

282 Most of these loci showed sex-biased splicing, whereas genotype-specific splicing

283 (iv) Sex-biased STAT5 binding is enriched at sex-biased DHS m

284 males and persistent in females-regulate the sex-biased, STAT5-dependent expression of hundreds of ge

285 minant gene, resistance to HSV-1 is strongly sex biased such that female mice are significantly more

286 tion between sex-dependent STAT5 binding and sex-biased target gene expression.

287 iod of multiple generations, with a level of sex bias that excludes a pulse migration during a single

288 development of SLE is known to have a strong sex bias, the molecular mechanisms remain unknown.

289 suggested that 17beta-estradiol may enhance sex bias through IL-6 induction, which subsequently disc

290 The degree of sex bias to SARS-CoV infection increased with advancing

291 remain viable, though flightless, and show a sex bias towards maleness.

292 n, for example when using mixed controls for sex-biased traits.

293 Here, we present analyses of sex-biased transcriptome divergence in sexually mature a

294 Five newly identified sex-biased transcripts in Drosophila are full of surpris

295 X (or Z) chromosomes also show sex-biased transmission (i.e., X chromosomes show female

296 The sex-biased transmission of the Z and its hemizygosity in

297 Recently we reported a vaccine-induced sex bias: vaccinated female but not male rhesus macaques

298 Importantly, this sex bias was mediated by a sex-specific response to the

299 Through ancestral reconstruction of sex bias, we demonstrate a rapid turnover of sex bias ac

300 ously found that the CRF1 receptor (CRF1) is sex biased whereby coupling to its GTP-binding protein,