ライフサイエンスコーパス: sex determination

1 ge, especially in species with environmental sex determination.

2 ians, which are assumed to only have genetic sex determination.

3 testis development long after the period of sex determination.

4 te meristems, fasciation, and alterations in sex determination.

5 hromosome Y is important in processes beyond sex determination.

6 ametogenesis, developmental transitions, and sex determination.

7 nd yet, paradoxically, is essential for male sex determination.

8 As, which are hypothesized to participate in sex determination.

9 lecular pathways underlying the evolution of sex determination.

10 ome 4 and chromosomal regions that influence sex determination.

11 lopment, including stem cell maintenance and sex determination.

12 genesis, gonad differentiation, and possibly sex determination.

13 , particularly in species with plasticity in sex determination.

14 wing ancestral exposure during fetal gonadal sex determination.

15 iation for growth rate, vertebral number and sex determination.

16 wing ancestral exposure during fetal gonadal sex determination.

17 imal steroids, which are decisive factors of sex determination.

18 d then becomes testis-specific shortly after sex determination.

19 he genetics and hormonal regulation of plant sex determination.

20 e embryonic mouse gonad prior to, and after, sex determination.

21 and genotype-by-temperature interactions for sex determination.

22 ned no genes known to be involved in somatic sex determination.

23 everal amphibians and lizards with genotypic sex determination.

24 nesis implicate this pathway in normal human sex determination.

25 ions controlling several skeletal traits and sex determination.

26 critical for both embryonic development and sex determination.

27 related helicase vbh-1 function in germline sex determination.

28 ntaining gene 9), the key regulators of male sex determination.

29 d could mediate the impact of temperature on sex determination.

30 separate but linked genes as responsible for sex determination.

31 Chinese tongue sole is a marine fish with ZW sex determination.

32 ng model for studying this enigmatic mode of sex determination.

33 iggered a revolution in our understanding of sex determination.

34 g a central role of epigenetic regulation in sex determination.

35 ication of Notch activation, at the onset of sex determination.

36 rily responsible for the hormonal control of sex determination.

37 at short lifespan might have co-evolved with sex determination.

38 Anopheles gambiae appears to be involved in sex determination although very little is known about bo

39 These data suggest that during primary sex determination, an oocyte-derived signal acts on the

40 es, origin of new species, and mechanisms of sex determination and development.

41 he question of how the genes responsible for sex determination and differentiation are regulated.

42 ntial follow-up studies of genes involved in sex determination and differentiation in catfish.

43 elopment, Rspo1 is a key factor required for sex determination and differentiation of the follicular

44 nvestigations of the molecular mechanisms of sex determination and evolution in cichlid fishes.

45 al male functions in many species, including sex determination and fertility.

46 ic control of meiotic maturation to germline sex determination and gamete maintenance.

47 f the complex genetic network that underlies sex determination and identifies regions that potentiall

48 anscriptional repressor), which acts both in sex determination and in physiological demand control of

49 Despite its function in sex determination and its role in driving genome evoluti

50 addition, two genes, with critical roles in sex determination and micro RNA processing, Sxl and loqs

51 ells was blocked when Wt1 was deleted before sex determination and most genital ridge somatic cells d

52 cies, which are sensitive to hormones during sex determination and often use an increase in aromatase

53 activating genes normally involved in female sex determination and ovarian development and show that

54 nvestigate the impact of fatty acids (FA) on sex determination and reproductive development, we exami

55 which FA, an environmental factor, regulates sex determination and reproductive development.

56 ms to identify multiple loci responsible for sex determination and reproductively adaptive color phen

57 Medaka is an ideal model for sex determination and sex reversal, such as XY phenotypi

58 ors (DMRTs) are widely conserved in metazoan sex determination and sexual differentiation.

59 Although the basic tenants are shared, sex determination and sexual reproduction occur in myria

60 the diagnostic reliability of NIPD for fetal sex determination and single gene disorders.

61 sual plasticity in the bipotential system of sex determination and some of the diverse mechanisms tha

62 rovide evidence that JA is required for male sex determination and suppression of female reproductive

63 We mapped regions of the genome involved in sex determination and tail color by genotyping microsate

64 ure during embryonic days 8 to 14 of gonadal sex determination and the incidence of adult onset disea

65 and cetaceans), suggesting that this mode of sex determination and the subsequent evolution of live b

66 -linked markers, to understand mechanisms of sex determination and to investigate differences between

67 as the developmental switch gene for somatic sex determination and X-chromosome dosage compensation.

68 inbred populations exhibiting environmental sex determination and/or differentiation.

69 ation gene doublesex (DMRT proteins) control sex determination and/or sexual differentiation in diver

70 n formation, venom production, haplo-diploid sex determination, and host-symbiont interactions.

71 es of this complex in neuronal functions and sex determination, and implicate the nuclear YT521-B pro

72 m2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its

73 omplex transcription architecture underlying sex determination, and provide a mechanism by which indi

74 transcriptional repression during C. elegans sex determination, and provide evidence that this import

75 gamma and Map3k4 genetically interact during sex determination, and transgenic overexpression of Map3

76 n embryos, genes involved in the cell death, sex-determination, and RNAi pathways, and transposable e

77 Three principal types of chromosomal sex determination are found in nature: male heterogamety

78 ermatogenesis, testicular determination, and sex determination are poorly understood.

79 d its direct target gene Sf1 function during sex determination as well as in the specified testes and

80 t between germ cells at the onset of gonadal sex determination at embryonic day 13 (E13) and after co

81 indicate that each lineage evolved genotypic sex determination before acquiring live birth.

82 ir-35 family is required for not only proper sex determination but also viability, showing that a sin

83 Sex determination can be viewed as a battle for primacy

84 Sex determination cascade in insects terminates with the

85 he importance of alternative splicing in the sex determination cascade of the honeybee Apis mellifera

86 a molecular switch at the base of the insect sex determination cascade, and triggers male or female s

87 tis elegans hermaphrodite, the developmental sex-determination cascade specifies gamete sex in the di

88 ound that deletion of Wt1 in the ovary after sex determination caused ectopic development of steroido

89 inates sexual development by reinforcing the sex-determination decision and directing downstream sexu

90 of the testis that play an essential role in sex determination during embryogenesis and in spermatoge

91 Sry is believed to function primarily in sex determination during fetal life.

92 that will investigate the interplay between sex determination, ecology and behavior in additional di

93 In the mammalian model of sex determination, embryos are considered to be sexually

94 iological processes and phenomena, including sex determination, epigenetic chromosome-wide regulation

95 Environmental sex determination (ESD) - a change in sexual function du

96 SD) is the predominant form of environmental sex determination (ESD) in reptiles, but the adaptive si

97 vey our current understanding of how and why sex determination evolves in animals and plants and iden

98 sults provide crucial evidence for genotypic sex determination facilitating land-water transitions in

99 mo promotes expression of the canonical male sex determination factor DoublesexM (Dsx(M)) within CySC

100 nnections with neurons expressing the neural sex determination factor fruitless (fru), which have bee

101 nt regulation of alternative splicing of the sex determination factor Sex lethal (Sxl).

102 invasive prenatal diagnosis (NIPD) of fetal sex determination, fetal rhesus D status and some single

103 Crosses with sex-reversed strains uncoupled sex determination from sex chromosome identity and revea

104 longevity associated Hsp22 gene and the male sex-determination fruitless gene.

105 As with gld-1, no sex determination function for fbf or puf-2 orthologs is

106 nt maize, BRs have been coopted to perform a sex determination function not found in plants with bise

107 both the regulatory system and SXL protein's sex-determination function have remained largely unknown

108 netic analysis suggests that the SXL's novel sex-determination function in Drosophila is more likely

109 83, OR=1.37, P=1.12x10(-23)), containing the sex determination gene DMRT1, which has been linked to t

110 Knockdown of the sex determination gene intersex produced a partial femal

111 We analyzed a custom-built sex determination gene set consisting of 32 genes using

112 With the exception of DMRT1, genes in the sex determination gene set have not previously been iden

113 The sex determination gene set ranked highly compared with c

114 fter removal of DMRT1 from the gene set, the sex determination gene set remains associated with TGCT

115 ific expression of egl-5 requires the global sex determination gene tra-1 and the gonadal masculinizi

116 We show that the sex determination gene transformer (tra) acts in the dev

117 We demonstrate that the female sex determination gene, Sex-lethal (Sxl), functions in c

118 Here, we identify a novel sex determination gene, spenito (nito) that encodes a SP

119 we identified the mat1-Mc gene, a mammalian sex-determination gene (SRY) homolog, as the primary gen

120 Transcription factors related to the insect sex-determination gene doublesex (DMRT proteins) control

121 Here, we focus on the conserved sex-determination gene doublesex (dsx) and the mechanism

122 ential role played by neurons expressing the sex-determination gene doublesex (dsx) in regulating the

123 Here we show that the sex-determination gene doublesex (dsx) underlies importa

124 onses via sensory neurons that coexpress the sex-determination gene fruitless (fru) and the proprioce

125 The sex-determination gene set (false discovery rate, FDRM <

126 and processes, in addition to a custom-built sex-determination gene set, were subject to enrichment a

127 elegans, translational repression of the key sex-determination gene tra-2 (tra, transformer) is contr

128 when acting on loci linked to the ancestral sex-determination gene will inhibit an invasion.

129 ion) mutant alleles of the Drosophila master sex-determination gene, Sex-lethal (Sxl).

130 temperature-sensitive point mutation in the sex-determination gene, transformer-2 (tra-2), using CRI

131 to the nervous system via the actions of the sex determination genes doublesex (dsx) and fruitless (f

132 male-specific P1 neurons that coexpress the sex determination genes fru (M) and dsx, but does not af

133 Here the authors identify the sex determination genes fruitless and doublesex, and a s

134 ive neuronal marker pickpocket (ppk) and the sex-determination genes doublesex (dsx) and fruitless (f

135 ence that the neural circuits expressing the sex-determination genes fruitless and doublesex drive qu

136 on, linkage between the sex-antagonistic and sex-determination genes, and the amount of genetic varia

137 model to determine how degree of inbreeding, sex determination, genomic location, pattern of gene exp

138 those of a virtual population with genotypic sex determination (GSD) and fixed sex ratios.

139 tudy of sex chromosome evolution, as genetic sex determination has evolved repeatedly and is often ab

140 In flies, the sex-determination hierarchy terminates in the doublesex

141 nt of convergence of the two branches of the sex-determination hierarchy.

142 well established, the importance of genetic sex determination in adult lineages remains largely unex

143 e open ocean constrain temperature-dependent sex determination in amniote species.

144 Sex determination in animals and fungi is regulated by s

145 Molecular understanding of sex determination in B. tabaci, an emerging invasive ins

146 of reproduction and development such as male sex determination in branchiopod crustaceans.

147 Since sex determination in C. elegans requires zygotic gene ex

148 has pointed to an unusual 3-locus system of sex determination in dioecious populations.

149 The genes governing sex determination in dioecious species remain unknown, b

150 cate that PUF family genes were co-opted for sex determination in each hermaphrodite via their long-s

151 m subdaily temperature fluctuations and that sex determination in fathead minnows can be influenced b

152 resource for understanding the evolution of sex determination in insects.

153 Sex determination in maize is controlled by a developmen

154 We show that BRs control sex determination in maize revealed through characteriza

155 Sex determination in mammals requires interaction betwee

156 vation, both of which are essential for male sex determination in mice.

157 turally-evolved pigmentation differences and sex determination in N. furzeri are controlled by simple

158 Sex determination in papaya is controlled by a recently

159 l stress responses, but their involvement in sex determination in plants has been only speculative.

160 We studied sex determination in Psocodea-a species-rich order of in

161 Clearly, sex determination in reptiles is far more complex than i

162 Sex determination in the mosquito Aedes aegypti is gover

163 may underlie emergence of non-Sry-dependent sex determination in the radiation of Muroidea.

164 Sex determination in the social amoebae thus appears to

165 rization of the sup-26 gene, which regulates sex determination in the soma and encodes an RNA recogni

166 ndings therefore suggest that the outcome of sex determination in these reptiles is heavily influence

167 the existence of within-species variation in sex determination in this species, and underscore the po

168 Little is known about the genetic basis of sex determination in vertebrates though considerable pro

169 d to a better understanding of the origin of sex-determination in Drosophila and also raise some new

170 ethal (Sxl) functions as the switch gene for sex-determination in Drosophila melanogaster by engaging

171 ight of a model for the mechanism underlying sex-determination in seed plants, in which AP3/PI orthol

172 all crocodilians, has temperature-dependent sex determination, in which the sex of an embryo is dete

173 Here, we investigate sex determination, inbreeding depression and inbreeding

174 Here we assess whether the type of genetic sex determination influences the ASR using data from 344

175 Mammalian sex determination initiates in the fetal gonad with spec

176 n gynodioecious Beta vulgaris ssp. maritima, sex determination involves cytoplasmic male sterility (C

177 Sex determination is a fundamental developmental pathway

178 Sex determination is an important area of study in devel

179 Mammalian sex determination is controlled by antagonistic pathways

180 In many insect lineages, sex determination is either completely unknown or poorly

181 importance for organisms might suggest that sex determination is highly conserved.

182 The mechanisms of sex determination is known for only a handful of such sp

183 We verified that sex determination is linked to the sex determining locus

184 it lacks heteromorphic chromosomes (instead, sex determination is polygenic) and has reduced opportun

185 rs, mosasaurs and sauropterygians, genotypic sex determination is present in all known fully pelagic

186 equent indirect selection on the old and new sex-determination loci are mediated by the strengths of

187 Sex determination mechanisms (SDMs) show striking divers

188 odel species have led to the impression that sex determination mechanisms are old and conserved.

189 Sex determination mechanisms differ among animal species

190 However, a range of sex determination mechanisms exists in nature, not alway

191 ions, but few systems with rapid turnover of sex determination mechanisms have been rigorously studie

192 However, genetic studies have shown that sex determination mechanisms, and the genes involved, ar

193 ikely related to differences in haplodiploid sex determination mechanisms, which in eusocial species

194 genes are conserved during the evolution of sex determination mechanisms.

195 nce, functional diploid males or alternative sex determination mechanisms.

196 Although transitions of sex-determination mechanisms are frequent in species wit

197 n (TSD), commonly found among reptiles, is a sex determination mode in which the incubation temperatu

198 entification of some key genes that regulate sex determination, most cases of disorders of sexual dev

199 ant strains carrying a temperature-sensitive sex determination mutation, along with a second null mut

200 for example, by an inversion that captures a sex-determination mutation and a gene under sex-antagoni

201 tic selection acting on loci linked to a new sex-determination mutation can cause it to invade, but w

202 pecific differentiated cell types long after sex determination occurs during development.

203 The application of this method will make sex determination of adults and, for the first time, juv

204 Here we present a method for sex determination of human remains by means of a minimal

205 Consequently, sex determination of juvenile remains is rarely undertak

206 aman spectroscopy enables contactless in ovo sex determination of the domestic chicken (Gallus gallus

207 el and non-model organisms that suggest that sex determination operates as an antagonistic network wi

208 mosome, such as its minor feminizing role in sex determination or its targeting by a chromosome-speci

209 show that this microRNA family regulates the sex determination pathway at multiple levels, acting bot

210 used elegant genetic studies to unravel the sex determination pathway in Caenorhabditis elegans He i

211 al (Sxl) encodes the master regulator of the sex determination pathway in Drosophila and acts by cont

212 The sex determination pathway is a well-established molecula

213 ermined in the gonadal primordium the global sex determination pathway is dispensable for gonadal sex

214 Localized repression of dac by the sex determination pathway is necessary for male-specific

215 r link between environmental temperature and sex determination pathway is yet to be elucidated.

216 egulatory subnetwork within the well-studied sex determination pathway of Caenorhabditis elegans Repr

217 t chinmo acts in parallel with the canonical sex determination pathway to maintain the male identity

218 the activity of at least four pathways: the sex determination pathway, the appendage patterning path

219 lternative splicing events in the Drosophila sex determination pathway.

220 oduced by recent duplication events into the sex-determination pathway to control hermaphrodite devel

221 f MPK-1/MAPK and key factors in the germline sex-determination pathway.

222 for TRA-1 feedback regulation of the global sex-determination pathway: TRA-1 binds its own locus and

223 Sexual dimorphisms are established by sex determination pathways and are maintained during reg

224 They also reveal that, even though the sex determination pathways in Drosophila and mammals are

225 ty between the mating-type specification and sex determination pathways of volvocine algae, and revea

226 We show that in contrast to the sex determination phase, which relies on the GATA4-FOG2

227 n feature of human traits; however, the role sex determination plays in human genetic variation remai

228 ion in animals and humans, and environmental sex determination potentially plays a role in the proces

229 ovides a critical link between the germ line sex determination program and gamete-specific gene expre

230 ons to negatively regulate expression of the sex determination protein TRA-2, and we find that the ab

231 egion of high divergence corresponded to the sex determination region and included a candidate male s

232 Finally, the expression of sex determination region of Y chromosome (SRY)-related h

233 antagonistic alleles in close linkage to the sex determination region.

234 the Hox protein Abdominal-B (Abd-B) and the sex-determination regulator Doublesex (Dsx).

235 ferentiation are modulated by the Drosophila sex-determination regulatory genes to produce nervous sy

236 nsufficient feminization (TIF) branch of the sex-determination regulatory pathway.

237 However, no sex determination-related genes have been functionally i

238 The genetics of sex determination remain mysterious in many organisms, i

239 nd Cbr-puf-1.2, do have a redundant germline sex determination role.

240 meiotic function of RA during the embryonic sex determination (SD) period and in mature gonads.

241 nd limits Hey and HES family activity during sex determination, segmentation and neurogenesis.

242 In species with genetic sex determination, sex chromosome-specific processes, su

243 evolution of the genetic pathways underlying sex determination, sex chromosomes and sexual reproducti

244 ism appears to be single-locus complementary sex determination (sl-CSD), in which individuals that ar

245 n mechanism resembles that of the Drosophila sex-determination Slx gene.

246 vast influence on invertebrate reproduction, sex determination, speciation, and behavior worldwide.

247 maleness, as it encodes a gene driving male sex determination, Sry, as well as a battery of other ge

248 th proteins in testis development beyond the sex determination stage; their roles in the postnatal ov

249 The 20th-century theory of mammalian sex determination states that the embryo is sexually ind

250 and studies of ongoing major transitions in sex determination (such as the establishment of new sex

251 omosome dose by repressing the masculinizing sex determination switch gene xol-1 (XO lethal) in a dos

252 Primary sex-determination "switches" evolve rapidly, but Doubles

253 brown alga Ectocarpus sp. that has a haploid sex determination system (UV system) recovering the sex

254 The XX/XO sex determination system found in many nematodes [1] fac

255 onment interactions that support a polygenic sex determination system in domesticated (laboratory) ze

256 es originated from the anomalous Hessian fly sex determination system in which postzygotic chromosome

257 rkers revealed that N. furzeri has a genetic sex determination system with males as the heterogametic

258 the Z chromosome in an organism with the ZW sex determination system, Bombyx mori.

259 Catfish has a male-heterogametic (XY) sex determination system, but genes involved in gonadoge

260 raction with either X-chromosome dose or the sex determination system.

261 Both have an XO sex determination system.

262 rol of any pest or vector species with an XY sex-determination system by targeting sequences exclusiv

263 The genetic sex-determination system explains 24% of interspecific v

264 em to ascertain the extent to which the same sex-determination system has been conserved following ge

265 of the mechanism, the effects of the genetic sex-determination system on the adult sex ratio are like

266 sarcomere morphology, but the hermaphrodite sex-determination system promotes more growth.

267 been conducted in species with conventional sex determination systems (XY and ZW) and exceptions to

268 a model to study evolutionary transitions in sex determination systems and pave the way to molecularl

269 Sex determination systems are highly variable in many ta

270 eny revealed between 3 and 13 transitions of sex determination systems during the evolution of these

271 werful agents of evolutionary transitions in sex determination systems in animals.

272 dosymbionts triggered recurrent turnovers of sex determination systems in terrestrial isopods.

273 mologous autosomes which differentiated into sex determination systems, such as XY or ZW system, as a

274 e changes that have occurred among different sex determination systems.

275 ther distorted sex ratios, understanding the sex-determination systems in X. tropicalis is critical f

276 A common feature of most genetic sex-determination systems studied so far is that sex is

277 ion promotes establishment of new vertebrate sex-determination systems.

278 to recruit the KAP1 repression machinery to sex determination target genes.

279 genome elimination (PGE), an unusual mode of sex determination that involves genomic imprinting.

280 estating female rat during embryonic gonadal sex determination, the F1 and F3 generation progeny adul

281 Despite its variable roles in sex determination, the function of gld-1 in female meiot

282 In organisms with temperature-dependent sex determination, the incubation environment plays a ke

283 ested the effect of gibberellic acid (GA) on sex determination through exogenous applications of GA a

284 onserved Dmrt gene family, are important for sex determination throughout the animal kingdom.

285 extend from a focus on temperature-dependent sex determination to a focus on temperature-linked hatch

286 r mechanism underlying temperature-dependent sex determination (TSD) has been a long-standing mystery

287 The study of temperature-dependent sex determination (TSD) in vertebrates has attracted maj

288 Temperature-dependent sex determination (TSD) is the predominant form of envir

289 Temperature-dependent sex determination (TSD) was first reported in 1966 in an

290 Temperature-dependent sex determination (TSD), commonly found among reptiles,

291 Australian lizard with temperature-dependent sex determination under three thermal regimes; some eggs

292 s important to characterize diverse modes of sex determination utilized by metazoans.

293 To identify regulatory sites during sex determination, we subjected Sertoli cells from mouse

294 idate the transcriptional network underlying sex determination, we took the first expression quantita

295 he molecular basis of gender differences and sex determination, we used RNA-sequencing (RNA-Seq) to i

296 Non-genetic maternal effects on sex determination were negligible in comparison with add

297 species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolu

298 this article, I propose a general theory of sex determination, which recognizes multiple parallel pr

299 Snakes exhibit genetic sex determination, with female heterogametic sex chromos

300 re are no reliable morphological methods for sex determination without resorting to DNA analysis, whi