ライフサイエンスコーパス: sex difference

1 e mechanisms underlying this association and sex difference.

2 % baseline, P < 0.01, respectively), with no sex difference.

3 group analyses were conducted to examine the sex difference.

4 have the same genomic components except the sex difference.

5 identify factors that underlie the observed sex differences.

6 a-dihydrotestosterone abolished the observed sex differences.

7 but not the carotid arteries without between-sex differences.

8 ed on one sex, or include limited aspects of sex differences.

9 gastrointestinal cancers that often exhibit sex differences.

10 iatric disorders, many of which present with sex differences.

11 fferently, potentially causing or amplifying sex differences.

12 xposure that are instrumental to early brain sex differences.

13 o our understanding of the biologic basis of sex differences.

14 que drug-event combinations with significant sex differences.

15 l of placebo analgesia while controlling for sex differences.

16 e that is known to have marked developmental sex differences.

17 stem evolution and the fundamental nature of sex differences.

18 not in girls, thereby counteracting existing sex differences.

19 lity exhibits unique age-related effects and sex differences.

20 To accurately classify a sex difference along these dimensions, one may need to c

21 hippocampal CA3 neurons, we found remarkable sex differences and discovered that female mice displaye

22 The aim of this study was to assess sex differences and factors associated with 1-year rehos

23 Understanding the evolution of sex differences and their developmental emergence is nec

24 Sex differences are a common feature of human traits; ho

25 Sex differences are also ignored.

26 In humans, sex differences are apparent at every level of cardiovas

27 and tissues in a sexually dimorphic fashion, sex differences are caused by extragonadal and dosage ef

28 studies reveal that the root causes of PTSD sex differences are complex, and partly represent intera

29 Sex differences are highly species-specific, tied to the

30 Sex differences are less pronounced in cortical cultures

31 Qualitative genetic sex differences are observed in both samples.

32 Less appreciated as a contributor to sex differences are the fundamental genetic differences

33 spects of cardiovascular health in women and sex differences as they relate to clinical practice in t

34 m both sexes of rats and observed functional sex differences at all levels.

35 nvironmental variation, with rapid change in sex differences being more likely due to environmental c

36 In animals, sex differences between males and females are generally

37 risk and characteristics, which accounts for sex differences, but there is also evidence to support u

38 ment may, in part, explain such variation in sex differences, but whether the early-life environment

39 We found that androgens cause these sex differences by impeding the LT-biosynthetic 5-LO/FLA

40 These sex differences can be reduced in female-dominant specie

41 employ sex as a classification variable, as sex differences can generally be expected.

42 We suggest that 'sex differences' can be classified on four dimensions: (

43 peutic efficacy, whereas these posttreatment sex differences contribute to clinical treatment failure

44 Increasing evidence has shown that sex differences exist in Adverse Drug Events (ADEs).

45 Whether sex differences exist in macrophage polarization and the

46 may, in part, account for the persistence of sex differences following gonadectomy and selective invo

47 e were calculated to quantify the signals of sex differences for specific drug-event combinations.

48 Multivariable-adjusted models showed sex differences for the association of body mass index a

49 g-reducing strategies should incorporate the sex differences found in this study.

50 Traditionally, sex differences have been attributed to the differential

51 Sex differences have been reported in self-esteem as wel

52 Studies focusing on examining sex differences have demonstrated across many levels of

53 s, the underlying neural correlates of these sex differences have not been explained.

54 teralized than in rats, we did find that the sex difference in astrocyte number is only on the right

55 nce does not consistently favor the proposed sex difference in attractiveness preferences, nor the fi

56 fort, whereas accuracy exhibited the largest sex difference in circadian modulation.

57 e D2-type receptors in smokers and suggest a sex difference in how midbrain dopamine D2-type autorece

58 Sex difference in hypertension rate was not statisticall

59 Here we report a latent sex difference in molecular regulation of excitatory syn

60 an men (3.9% versus 2.4%; P<0.0001) while no sex difference in mortality was observed with MINOCA (1.

61 Sex difference in mouse metabolic response to erythropoi

62 A sex difference in neuronal soma size favoring males was

63 That an all-or-none apparent sex difference in neuronal types is controlled by experi

64 These findings point to a sex difference in NRF2 responsiveness that needs be cons

65 These results demonstrate that the famous sex difference in olfactory abilities likely originates

66 male than for male offspring, whereas little sex difference in risk was found for offspring suicide a

67 A sex difference in RV remodeling exists in obesity.

68 l cortex, insula, and precuneus, but the BEN sex difference in smokers was less pronounced.

69 Overall there is a substantial sex difference in the Egfr pathways in mice.

70 Our data showed that there is a significant sex difference in the expression levels in kidney.

71 We found a significant sex difference in the IMS-UPRmt, because the spinal cord

72 We have uncovered a substantial sex difference in the pathology of the aging gut in Dros

73 ould partly explain the increasingly smaller sex difference in the prevalence of COPD, especially in

74 re likely to have airflow obstruction, but a sex difference in this association was not clear.

75 This indicates a latent sex difference in which different molecular mechanisms c

76 ers and whether such differences account for sex differences in 12-month health status, using data fr

77 nantly associated with a loss or reversal of sex differences in activity and anxiety-like behaviors.

78 Identifying those sex differences in ADEs could reduce the experience of A

79 egimens in the United States, 307 drugs have sex differences in ADEs.

80 he early-life environment is associated with sex differences in adult mortality and expected lifespan

81 scover which treatment regimens or drugs had sex differences in adverse events.

82 Sex differences in AF epidemiology are insufficiently un

83 We found that sex differences in age-specific mortality were primarily

84 differences in cerebral blood flow mediated sex differences in anxiety and depression symptoms by ca

85 e neurobiological characteristics underlying sex differences in anxiety and mood symptoms.

86 We, thus, aimed to assess sex differences in aortic valve fibrocalcific remodeling

87 lomeric euchromatin, which is reminiscent of sex differences in Arabidopsis recombination.

88 We did not find sex differences in aromatase expression and neither the

89 nto the neurobiological mechanisms mediating sex differences in ASD prevalence.

90 However, we did not find sex differences in astrocyte complexity or overall glial

91 of these behaviors is due in part to age and sex differences in AVP and OT synthesis within the SBNN.

92 odents, and discuss the relationship between sex differences in behavior and sexual dimorphism in the

93 influences spinal summation consistent with sex differences in behavioral pain thresholds.

94 anges in OT-sensitive networks contribute to sex differences in behavioral responses to stress.

95 These results are the first to demonstrate sex differences in BLA neuronal activity and the impact

96 Thus, sex differences in cerebellar physiology produce similar

97 We investigated whether developmental sex differences in cerebral blood flow mediated sex diff

98 thout addressing major gaps in the extent of sex differences in cerebrovascular pathology.

99 lence of ASD might partially be explained by sex differences in clinical symptoms, etiological models

100 e equal gender ratios in cases and controls, sex differences in CNV burden might have impacted on est

101 There is evidence for sex differences in cocaine addiction from both clinical

102 eir male colleagues and to determine whether sex differences in compensation exist after accounting f

103 Here we examined sex differences in context fear generalization and its n

104 We assessed sex differences in decision making using the rat version

105 In vitro sex differences in dendritic morphology are driven in pa

106 Sex differences in dioecious animals are pervasive and r

107 otification data are insufficient to measure sex differences in disease burden.

108 roductive hormones as well as illnesses with sex differences in disease expression and course.

109 This study supports the evidences that sex differences in DNA methylation of autosomes act as a

110 Sex differences in early mortality after myocardial infa

111 eption significantly in females such that no sex differences in ED50 were observed.

112 No obvious sex differences in either the pattern of AR immunoreacti

113 n vertebrates, one of the first recognizable sex differences in embryos is the onset of meiosis, know

114 erentiation pathways, and displays extensive sex differences in expression of genes with roles in gro

115 Therefore, we evaluated for sex differences in faculty rank among a comprehensive, c

116 Comprehensive evidence examining whether sex differences in faculty rank exist in academic cardio

117 ic PTSD vulnerability is partly regulated by sex differences in fear systems.

118 t a tractable PTSD biomarker in the study of sex differences in fear.

119 ntal Cohort to study age-related effects and sex differences in four regional gray matter measures in

120 We estimated sex differences in full professorship, adjusting for the

121 which incomplete XCI manifests as detectable sex differences in gene expression and phenotypic traits

122 Identifying sex differences in gene expression within the brain is c

123 hundreds of genes in mouse liver, imparting sex differences in hepatic drug/lipid metabolism and dis

124 variants discovered in our study can inform sex differences in heritable disease prevalence, we inte

125 We also found no sex differences in heroin self-administration or the str

126 Sex differences in hippocampal expression of NLGN2, NRXN

127 While sex differences in hormonal regulation of development an

128 s, raising the question of whether there are sex differences in how the striatum is impacted by genet

129 and ryanodine receptors that contributes to sex differences in hyperalgesic priming.SIGNIFICANCE STA

130 hiectomy, but not ovariectomy, abolishes the sex differences in ILC2 development and restores IL-33-m

131 Sex differences in immune responses, especially during a

132 -specific factors also may contribute to the sex differences in infectious disease burden.

133 This variation may be linked to sex differences in inflammation.

134 Thus, our findings show novel sex differences in innate immunity and identify a common

135 ly dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise

136 Prior studies of sex differences in kidney graft survival showed conflict

137 ABSTRACT: Sex differences in left ventricular (LV) mechanics exist

138 KEY POINTS: Sex differences in left ventricular (LV) mechanics occur

139 Our current analyses indicate no sex differences in LIDS-derived sleep dynamics, whereas

140 ronmental change has the potential to affect sex differences in life-history traits in natural popula

141 whether the early-life environment mediates sex differences in life-history traits is poorly underst

142 two sexes result in the shifting patterns of sex differences in lifespan across human populations.

143 The causes underlying sex differences in lifespan are strongly debated.

144 Collectively, the data indicate that sex differences in light sensitivity might play a key ro

145 This may point to sex differences in limbic brain regions.

146 ncRNAs and their potential for regulation of sex differences in liver physiology and disease.

147 Sex differences in locomotor performance may precede the

148 in silica-induced SPP1 levels contribute to sex differences in lung fibrosis.

149 mic and adrenergic control may contribute to sex differences in LV mechanics and LV haemodynamics.

150 l challenges; however, it is unknown whether sex differences in LV mechanics are fundamentally regula

151 Accordingly, this study aimed to investigate sex differences in LV mechanics with altered adrenergic

152 We found no sex differences in methamphetamine self-administration o

153 These data implicate sex differences in microglial activation in the modulati

154 has been linked to addiction, we tested for sex differences in midbrain dopamine D2-type receptor BP

155 we were able to detect novel and consistent sex differences in modularity in both data sets.

156 s could be relevant for the understanding of sex differences in mood disorders and of the side effect

157 nhibition in the PAG of females reverses the sex differences in morphine responsiveness.

158 Sex differences in mortality are pervasive in vertebrate

159 We examined sex differences in mortality at 1 and 5 years after stro

160 There are sex differences in mortality while awaiting heart transp

161 Because of the known sex differences in neural and behavioral smoking charact

162 Here we demonstrate sex differences in neuronal activity in one key limbic r

163 These findings, which demonstrate sex differences in nicotine self-administration for dose

164 f NRXN3 mRNAs were observed WT mice, whereas sex differences in NLGN3, NRXN1, NRXN2, and NRXN3 mRNA e

165 The mechanistic underpinnings of sex differences in occurrence of depression and efficacy

166 ences of activating LC-MOR may contribute to sex differences in opioid abuse patterns and may guide s

167 In contrast to AVP, we observed no age or sex differences in OT-ir fiber fractional areas or cell

168 s, we examined whether orexins contribute to sex differences in outcomes relevant to stress-related p

169 Sex differences in physiology and disease susceptibility

170 We investigated sex differences in plaque features in patients with coro

171 METHODS AND We assessed sex differences in post-AMI inflammatory markers and whe

172 escribed, but little is known about race and sex differences in post-MI angina and long-term risk of

173 We examined race and sex differences in post-MI angina frequency and 1-year u

174 tic valve (BAV) registry aimed to define the sex differences in prevalence, valve morphology, dysfunc

175 Sex differences in probability of transplantation were p

176 This observation has led many to examine sex differences in PTSD risk factors.

177 These findings demonstrate clear sex differences in PVAT function in which PGF2alpha and

178 glodytes schweinfurthii) and find remarkable sex differences in rank dynamics, indicating that female

179 We examined sex differences in rates of IPD, and trends after the in

180 d focus on understanding the determinants of sex differences in rehospitalization risk among conditio

181 We compared sex differences in rehospitalization using a Cox proport

182 ata support growing evidence for significant sex differences in response to trauma, and support furth

183 a-dependent processes may thus contribute to sex differences in retrieval of context fear and greater

184 Temporal trends and sex differences in revascularization strategies, in-hosp

185 Our data contribute to understanding sex differences in risk for HPV-positive oropharyngeal S

186 racteristic age of onset in young adults and sex differences in schizophrenia.

187 Race and sex differences in silent myocardial infarction (SMI) ar

188 These sex differences in social behaviour may underpin male-bi

189 Here, we tested whether sex differences in social motivation emerge in infant mo

190 Studies suggest sex differences in somatic but not visceral pain percept

191 ng populations can arise through local-scale sex differences in survival and dispersal, with females

192 Sex differences in survival could influence this sex rat

193 o variation, but we find little evidence for sex differences in survival increasing with sex ratio sk

194 be more likely to have skewed sex ratios if sex differences in survival, recruitment or dispersal va

195 l practice, relatively little is known about sex differences in symptoms and quality of life and how

196 Wild-type mice showed sex differences in synaptic excitation, inhibition, and

197 We found substantial sex differences in the activity of neurons in lateral nu

198 tification by serum albumin level attenuated sex differences in the age group-specific hospitalizatio

199 Our study examined sex differences in the association between mood and anxi

200 We investigated whether there are sex differences in the association between pain and inci

201 These results suggest sex differences in the association between salivary oxyt

202 Observed sex differences in the association of body mass index an

203 We also raise the possibility that sex differences in the brain are canalized, which may ac

204 Some sex differences in the brain may be latent differences,

205 f sexual differentiation of the brain and on sex differences in the brain to conclude that the brain

206 ation of cognition could not be explained by sex differences in the circadian amplitude of plasma mel

207 The sex differences in the circadian modulation of cognition

208 rdial infarction, or pneumonia and estimated sex differences in the daily risk of rehospitalization/d

209 We report that, whereas no overall sex differences in the density of microglia were noted w

210 ation in SOD1 familial ALS, and suggest that sex differences in the disease phenotype could be linked

211 This study quantifies sex differences in the diurnal and circadian variation o

212 tion in a European population and to examine sex differences in the dose of acetylcholine leading to

213 Emerging evidence suggests sex differences in the early origins of adult metabolic

214 pharmacological mechanisms that may underlie sex differences in the effects of cannabis and cannabino

215 state cancer but also likely contributing to sex differences in the health and diseases of man.

216 gy, but we lack a basic understanding of how sex differences in the human cerebellum are distributed

217 These data indicate profound sex differences in the impact of a genetic lesion linked

218 Race and sex differences in the incidence and prognostic signific

219 There are profound sex differences in the incidence of many psychiatric dis

220 extensively evaluated, but studies examining sex differences in the influence of infant milk feeding

221 The mechanisms by which sex differences in the mammalian brain arise are poorly

222 iments using ER-selective agonists indicated sex differences in the mechanisms underlying E2-induced

223 Studies have suggested sex differences in the mortality rate associated with ty

224 in social engagement, little is known about sex differences in the neural mechanisms that underlie t

225 strongly indicate that there are fundamental sex differences in the neural regulation of dominance an

226 This model allows for investigation of sex differences in the neurobiological mechanisms of def

227 Sex differences in the number of neurons and astrocytes

228 Sex differences in the outcomes after percutaneous coron

229 The purpose of this study was to determine sex differences in the prevalence and clinical presentat

230 Sex differences in the prevalence of psychiatric disorde

231 no study has investigated whether there are sex differences in the regulation of blood vessel tone b

232 sponse and determined whether there were any sex differences in the regulation of vascular tone by PV

233 There are sex differences in the regulation of vascular tone, but,

234 To examine sex differences in the risk of airflow obstruction (a CO

235 These sex differences in the role of these prostanoids in the

236 Sex differences in the sensitivity to nicotine may influ

237 Together, these data suggest that sex differences in the susceptibility to SARS-CoV in mic

238 9 are expressed differentially in gonads, no sex differences in their expression were observed betwee

239 th male and female mice, enabling studies of sex differences in these infections.

240 Future studies should investigate putative sex differences in these phenotypic effects.

241 Whether sex differences in treatment decisions reflect patient p

242 ractable preclinical model for interrogating sex differences in UTI susceptibility and pathogenesis,

243 going debate about the mechanisms that drive sex differences in vital rates in vertebrates.

244 he covariates gestational age, birth weight, sex, difference in age at diet-diary completion, and app

245 is measure of transduction captures age- and sex-differences in the sympathetic regulation of DBP and

246 our fundamental understanding of cerebellar sex differences-including their spatial distribution, po

247 Variation in sex differences is affected by both genetic and environm

248 One case of rapid change in sex differences is human lifespan, which has become incr

249 The biological basis of these sex differences is poorly understood.

250 east partially involved in determining these sex differences, it is through their effect on the level

251 This sex difference may be regulated by estrogens, such as es

252 icity may contribute to our understanding of sex differences observed clinically in chronic pain synd

253 2 gene expression and thereby contributes to sex differences observed in asthma.

254 e with type 2 diabetes mellitus, significant sex differences occur in the risk of cardiovascular dise

255 ing the confounding effect from the baseline sex difference of the events, there are 266 combinations

256 ove the confounding effect from the baseline sex difference of the events.

257 t, history of psychosis, mood state, age and sex differences on cortical regions.

258 nfluence of inter-individual traits, such as sex-differences, on light sensitivity remains to be esta

259 of this study was to test whether there are sex differences or estrous cyclicity in rat BLA physiolo

260 .8 x 10(-11), effect -0.86 years per allele; sex difference P=0.075).

261 ally similar in fellow eyes and there was no sex difference (P > .05).

262 rnal life per imputed risk allele in parent; sex difference, P=0.011), and a locus near CHRNA3/5 diff

263 men and 1.37 (95% CI, 1.01 to 1.85) for men (sex difference: P = .63).

264 There were no significant sex differences regarding BAV morphology and frequency o

265 e common among men than among women, with no sex difference related to age-related macular degenerati

266 sychiatric disorders, yet the origins of the sex difference remain obscure.

267 nisms responsible for ASD symptoms and their sex differences remain mostly unclear.

268 Regional sex differences suggest that extrinsic factors, such as

269 tion of autosomes act as a primary driver of sex differences that are found in psychiatric outcomes.

270 es that examine nonbiological and biological sex differences that contribute to normal and pathologic

271 ene expression, in which there are important sex differences that need further exploration.

272 ociated behaviors with a particular focus on sex differences, the medial prefrontal cortex, social re

273 and treatment of MDD all point toward major sex differences, the molecular mechanisms underlying thi

274 a brain region not normally associated with sex differences, this work sheds light on ways that gene

275 imulation, which imparts clinically relevant sex differences to hepatic metabolism and liver disease

276 evance of dopaminergic- and stress-dependent sex differences to maladaptive decision making.

277 Here we investigated potential sex-differences to evening light exposure of 40 lx at 65

278 Allometric analysis restricts sex-differences to: (1) greater pallidal volume (PV) in

279 between the two mouse strains, combined with sex differences, urge caution in applying CR to improve

280 status levels than did blacks or Hispanics; sex differences varied by race/ethnicity.

281 e adverse outcomes, but the magnitude of the sex difference was greater in the ACS patients (P(intera

282 No sex difference was seen in the rectal Vdelta1/Vdelta2 ra

283 multivariable logistic regression model the sex difference was statistically significant with a fema

284 Striking sex differences were also identified in the neural mecha

285 These molecular and cellular sex differences were associated with sexually distinct e

286 Group and sex differences were found for normalized LV wall thicke

287 No sex differences were found in VCD, LT, and NOP after hei

288 Sex differences were found to be statistically significa

289 Tests were done in both sexes, and no sex differences were found.

290 In this cohort, the sex differences were greatest in the younger age groups

291 Sex differences were most apparent for biomarkers of adi

292 Sexes were pooled for analysis and sex differences were not studied.

293 These sex differences were observed in different race groups a

294 For equal doses of exposure, sex differences were present in both ex-smokers and curr

295 Sex differences were present in CRF2 receptor binding de

296 However, these pooled sex differences were reversed after adjustment for confo

297 No sex differences were seen for C-reactive protein and N-t

298 Few sex differences were seen in Env-specific memory B cell,

299 Sex differences were studied as a prespecified subanalys

300 Min lines for all the tested phenotypes, and sex differences with traits; Colon, body weight and inte