ライフサイエンスコーパス: sex hormone

1 Testosterone (T) is the principal male sex hormone.

2 ting factors, apolipoprotein E genotype, and sex hormones.

3 sal women, which may be attributed to female sex hormones.

4 echanism dependent on IL-6 and expression of sex hormones.

5 account for within-woman variation in these sex hormones.

6 that are directly or indirectly regulated by sex hormones.

7 which was dependent on the presence of adult sex hormones.

8 able evidence supports an important role for sex hormones.

9 ociated with epilepsy may alter responses to sex hormones.

10 nce in males, an effect that is dependent on sex hormones.

11 females after puberty, suggesting a role for sex hormones.

12 positively associated with SHBG but not with sex hormones.

13 d coffee nor tea was associated with SHBG or sex hormones.

14 compared to men, and is modulated by female sex hormones.

15 erences cannot be logically connected to the sex hormones.

16 ressors, even before the production of fetal sex hormones.

17 irrespective of their history of exposure to sex hormones.

18 bited by VNO signaling, independent of adult sex hormones.

19 otection) and the balance may be affected by sex hormones.

20 kin-6, C-reactive protein, homocysteine, and sex hormones.

21 differs in men and women and is sensitive to sex hormones.

22 C2 development is greatly influenced by male sex hormones.

23 nd also was related to the effects of female sex hormones.

24 e gender disparities suggest an influence of sex hormones.

25 females and are likely driven by changes in sex hormones.

26 ty, and can decrease serum concentrations of sex hormones.

27 ed (NZB x NZW)F(1) male mice with the female sex hormone 17beta-estradiol significantly increased ste

28 NK in lung cancer and may explain why female sex hormones accelerate lung cancer development.

29 pes are pituitary-dependent, suggesting that sex hormones act via the gonadal-hypophyseal axis.

30 nt investigation in vivo of the mechanism of sex hormone action on the development of colonic adenoma

31 disease are typically mediated through acute sex hormone actions, sex-specific differences in brain t

32 ical and disease processes sensitive to male sex hormone actions, thereby not only affecting the path

33 response; (3) the mechanisms by which gender/sex hormones affect the metabolic modulators; and (4) th

34 dermal adipose tissue, innate immune system, sex hormones, aging, circadian rhythm and seasonal rhyth

35 CC than females, an effect largely driven by sex hormones, albeit through still poorly understood mec

36 in metabolism, adipokines, inflammation, and sex hormones all contribute to the adverse effects of ob

37 ductive age and thus cannot be attributed to sex hormones alone.

38 tionally, the type I interferon response and sex hormones alter both CVB3 intestinal replication and

39 omen in adulthood, suggesting that shifts in sex hormones alter the course of the disease.

40 , and mineralocorticoid receptor, as well as sex hormone and corticosteroid binding globulins.

41 chanisms underlying the associations between sex hormones and AF in older men merit continued investi

42 Sex hormones and blood lipids were deviated in all subje

43 are prone to vitamin D deficiency, deviated sex hormones and blood lipids.

44 a variety of factors including age, gender, sex hormones and diabetes status.

45 experimental evidence indicates that female sex hormones and hormonal contraceptives regulate suscep

46 cell counts measured and blood analysed for sex hormones and inflammatory markers.

47 orononanoic acid (PFNA), may alter levels of sex hormones and insulin-like growth factor-1 (IGF-1) in

48 des the well-known associations of risk with sex hormones and insulin-regulated physiological axes, o

49 study was to assess the relationship between sex hormones and natriuretic peptide levels in community

50 influencing levels of circulating endogenous sex hormones and outcome in these various malignancies.

51 has been shown to mediate the metabolism of sex hormones and prostaglandin D(2) (PGD(2)), a lipid me

52 he association between physiologic levels of sex hormones and QT-interval duration in humans was eval

53 We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may

54 This study suggests that sex hormones and systemic inflammation may be mediating

55 f anaphylaxis and explore the role of female sex hormones and the mechanisms responsible.

56 Moreover, sex hormones and their metabolites can directly act on n

57 Possible synergism between female sex hormones and vitamin D on periodontitis pathology ha

58 ollected in 2005-2006 and analyzed for PFAS, sex hormones, and IGF-1.

59 Perfluoroalkyl substances, sex hormones, and insulin-like growth factor-1 at 6-9 ye

60 Striatal function is also modulated by sex hormones, and previous studies show that estradiol i

61 Inherited risks, developmental factors, sex hormones, and psychosocial adversity interact to inc

62 ease by removing alphabeta T cells, altering sex hormones, and reconstituting gammadelta T cells.

63 fluences of biological sex, gender identity, sex hormones, and sexual orientation on white matter mic

64 or equal to 28 days and not taking exogenous sex hormones answered a postal questionnaire regarding t

65 Sex hormones are essential for neural circuit developmen

66 tic study, strengthen evidence that SHBG and sex hormones are involved in the aetiology of type 2 dia

67 The authors examined whether sex hormones are involved in the production of sequentia

68 Sex hormones are linked to inflammation and bone turnove

69 Steroid sex hormones are potential neuroprotective candidates fo

70 We hypothesized that sex hormones are related to atrial fibrillation (AF) in

71 Female gonadal sex hormones are responsible for this sexual dimorphism,

72 ertension (PAH), but it is not known whether sex hormones are risk factors for PAH in men.

73 e is evidence implicating the role of female sex hormones as a major factor in determining migraine r

74 e include immunological pathways affected by sex hormones, as well as consequences of differential ex

75 nsure binding to the second laminin/neurexin/sex hormone binding (LNS2) domain of Nrxn1alpha, but thi

76 sport proteins human serum albumin (HSA) and sex hormone binding globulin (SHBG) as models.

77 Testosterone, estradiol, and sex hormone binding globulin (SHBG) concentrations were

78 In the sex hormone binding globulin (SHBG) gene, a pentanucleot

79 l studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in

80 ne, dehydroepiandrosterone sulfate (DHEAS)], sex hormone binding globulin (SHBG), and EOC risk by tum

81 e (FT), bioavailable testosterone (BAT), and sex hormone binding globulin (SHBG).

82 in resistance (P=6 x 10(-4)) and lower serum sex hormone binding globulin concentrations (P=5 x 10(-4

83 strone, progesterone, free testosterone, and sex hormone binding globulin measurements.

84 ; positive associations for progesterone and sex hormone binding globulin merit additional study.

85 unassociated with cognitive composites, but sex hormone binding globulin was positively associated w

86 one sulfate, androstanediol glucuronide, and sex hormone binding globulin).

87 ing serum levels of testosterone, estradiol, sex hormone binding globulin, and androstenediol glucuro

88 Serum testosterone, estradiol, sex hormone binding globulin, gonadotropins, and bone de

89 Both drugs bind to sex hormone binding globulin.

90 rations of high-density lipoprotein (9%) and sex-hormone binding globulin (SHBG) (21%), and lower con

91 ficant for several estrogens, androgens, and sex hormone-binding globulin (2-sided P <or= 0.01).

92 CI: 1.12, 1.68; P = 0.002) and a decrease in sex hormone-binding globulin (OR = 0.60, 95% CI: 0.45, 0

93 ation of known and unknown recombinant human sex hormone-binding globulin (rhSHBG)-binding designer s

94 one, free testosterone, androstenedione, and sex hormone-binding globulin (SHBG) concentrations (seco

95 lored associations of total testosterone and sex hormone-binding globulin (SHBG) concentrations at ag

96 , androstanediol glucuronide, estradiol, and sex hormone-binding globulin (SHBG) for 3,043 cases and

97 hydroepiandrosterone sulfate, prolactin, and sex hormone-binding globulin (SHBG) improved risk predic

98 Sex hormone-binding globulin (SHBG) is believed to play

99 Sex hormone-binding globulin (SHBG) is the high-affinity

100 Low plasma sex hormone-binding globulin (SHBG) levels are associate

101 ine increased and significantly decreased as sex hormone-binding globulin (SHBG) levels at follow-up

102 (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) levels were measured

103 ne whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the

104 concentrations of estrogens, androgens, and sex hormone-binding globulin (SHBG) was investigated in

105 udy were analyzed to examine whether ESH and sex hormone-binding globulin (SHBG) were associated with

106 serum concentrations of total testosterone, sex hormone-binding globulin (SHBG), dehydroepiandroster

107 ating hormone (FSH), total testosterone, and sex hormone-binding globulin (SHBG), were performed in 6

108 t-specific 6 chimeras, with either the whole sex hormone-binding globulin (SHBG)-like domain (Val243-

109 nent to circulating sex steroid hormones and sex hormone-binding globulin (SHBG).

110 inverse relations between serum insulin and sex hormone-binding globulin (SHBG).

111 l: 0.01, 0.03) and inverse associations with sex hormone-binding globulin and follicle-stimulating ho

112 Low circulating levels of sex hormone-binding globulin are a strong predictor of t

113 mproved and levels of C-reactive protein and sex hormone-binding globulin but not interleukin-6 incre

114 (decreased blood concentration and increased sex hormone-binding globulin concentration).

115 ide polymorphism (SNP) rs6259 had 10% higher sex hormone-binding globulin levels (P=0.005), and carri

116 Circulating sex hormone-binding globulin levels are inversely associ

117 A dramatic 45-fold increase in sex hormone-binding globulin levels during hibernation d

118 free testosterone (FT) levels decreased and sex hormone-binding globulin levels increased in tandem

119 Testosterone, estradiol, and sex hormone-binding globulin levels were measured in ser

120 directions corresponding to their associated sex hormone-binding globulin levels.

121 .58) among men, a finding that suggests that sex hormone-binding globulin may have a causal role in t

122 peptide (NT-proBNP), total testosterone, and sex hormone-binding globulin plasma levels in 4,056 men

123 rd-deviation increase in the plasma level of sex hormone-binding globulin was 0.28 (95% CI, 0.13 to 0

124 Plasma levels of sex hormone-binding globulin were measured; two polymorp

125 Among women, higher plasma levels of sex hormone-binding globulin were prospectively associat

126 ween the fifth LNS (laminin-alpha, neurexin, sex hormone-binding globulin) domain and the third EGF-l

127 by gamma-glutamyltransferase, fetuin-A, and sex hormone-binding globulin), markers of dyslipidemia (

128 There were no differences in testosterone, sex hormone-binding globulin, and blood lipids between t

129 ostenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-pept

130 izing hormone, follicle-stimulating hormone, sex hormone-binding globulin, F(2)-isoprostanes, and thi

131 ured; two polymorphisms of the gene encoding sex hormone-binding globulin, SHBG, that were robustly a

132 ata demonstrate that higher androgens, lower sex hormone-binding globulin, surgical menopause, and ea

133 Other antiepileptic drugs increase sex hormone-binding globulin, which reduces the bioactiv

134 the single LNS-domain (for laminin/neurexin/sex hormone-binding globulin-domain) of neurexin-1beta o

135 analogs, we demonstrated that the C terminus sex hormone-binding globulin-like (SHBG) domain of PS is

136 s were assayed for estrogens, androgens, and sex hormone-binding globulin.

137 rostane-3alpha, 17beta-diol-glucuronide, and sex hormone-binding globulin.

138 d by hormonal contraceptives and mediated by sex hormone-binding globulin.

139 minase (beta = 0.002; P = 3 x 10(-5)), lower sex-hormone-binding globulin (beta = -0.010; P = 9 x 10(

140 main that we term Pentraxin/Laminin/neurexin/sex-hormone-binding-globulin-Like (PLL).

141 are not simply reflective of differences in sex hormones, but also reflect distinctions in synaptic

142 f some haematopoietic cells are regulated by sex hormones, but haematopoietic stem-cell function is t

143 ound that the type I interferon response and sex hormones can alter both viral replication and lethal

144 Steroid sex hormones can induce prostate carcinogenesis, and are

145 ale and female mice, and we show that female sex hormones can promote lung cancer progression via the

146 Sex hormones cause differences in cardiac electrophysiol

147 perimental studies and the known physiologic sex hormone changes that occur after menopause in women.

148 Sensory cues and sex hormones control the entire repertoire of sexually d

149 Sex hormones, cortisol, and insulin levels were measured

150 Circulating levels of sex hormones, cortisol, and insulin were also determined

151 mere diseases, we administered the synthetic sex hormone danazol orally at a dose of 800 mg per day f

152 bserved skeletal phenotype is secondary to a sex hormone deficiency.

153 The adrenal sex hormone dehydroepiandrosterone (DHEA), which is pres

154 er the mechanisms that control the growth of sex hormone-dependent cancers started more than 100 year

155 EFNB3 regulates blood pressure in a sex- and sex hormone-dependent way.

156 er by existing cancer treatments, especially sex hormone deprivation.

157 vations demonstrate that the female and male sex hormones differentially regulate the expression of I

158 explore NK3R antagonists as therapeutics for sex-hormone disorders that can potentially benefit from

159 between the 90th and 10th percentiles of the sex hormone distributions were estimated by using propor

160 either older or younger men, suggesting that sex hormones do not modulate sequential movement in men,

161 Steroid sex hormones drive changes in the nervous system and beh

162 Sex hormone dysregulation and altered end-organ hormone

163 span (e.g. puberty and menopause), exogenous sex hormones (e.g. hormonal contraception or hormone the

164 urface trafficking and its modulation by the sex hormone E2 is a cellular mechanism critical for a ma

165 ons for understanding the pathophysiology of sex hormone effects in diverse CNS disorders.

166 studied predominantly within the context of sex hormone effects.

167 It remains unclear whether endogenous sex hormones (ESH) are associated with risk of type 2 di

168 k suggests that sex chromosomal genes and/or sex hormones, especially testosterone, may modulate the

169 axis that is required for production of the sex hormones estradiol, progesterone, and testosterone.

170 ntensive care unit admission and assayed for sex hormones (estradiol, testosterone, prolactin, and pr

171 indings were significant while adjusting for sex hormones (estradiol-to-progesterone ratio in women a

172 one and dihydrotestosterone), but not female sex hormones (estrogen and progesterone), were able to s

173 Together, these results indicate that female sex hormones, estrogens, and X chromosome complement ind

174 eproductive factors reflective of endogenous sex hormone exposure might have an effect on cardiac rem

175 = 3 x 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.

176 ata reveal an unrecognized role of transient sex hormone exposures during neonatal development as lon

177 Here, we modeled a biphasic ovarian sex hormone fluctuation using a gonadotropin-releasing h

178 effect of genomic and nongenomic pathways of sex hormones following trauma.

179 ) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative e

180 Female sex hormones have been hypothesized to play a role in th

181 Sex hormones have been implicated in experimental and cl

182 Both systemic inflammation and sex hormones have been proposed as potential mediators o

183 Endogenous sex hormones have been related to cardiovascular outcome

184 Although sex hormones have been shown to modulate some end-organ

185 Sex hormones have potent immunoregulatory abilities.

186 topoietic cell types are known to respond to sex hormones, hematopoietic stem cells (HSCs) are genera

187 glucocorticoid overtreatment and control of sex hormone imbalances.

188 pellets validates an important role of male sex hormone in castration-induced nigrostriatal patholog

189 pecific ILP was identified as the androgenic sex hormone in Crustacea.

190 Gender bias and the role of sex hormones in autoimmune diseases are well established

191 Epidemiologic data on the effects of female sex hormones in cataract formation are conflicting.

192 We further investigated the role of sex hormones in kras(V12) transgenic fish.

193 ntrations of adipokines, growth factors, and sex hormones in male and female mice.

194 lorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal wome

195 Prospective cohort studies examining sex hormones in relation to cancer risk have generally c

196 This has suggested an etiologic role of sex hormones in the development of these conditions.

197 an in elderly females, suggesting a role for sex hormones in the healing process.

198 ized mice, we highlighted the role of female sex hormones in the phenotype.

199 These results highlight a possible role of sex hormones in the regulation of ABCG2 urate transporte

200 re associated with lower levels of IGF-1 and sex hormones in young children.

201 r among younger women, supporting a role for sex hormones in younger onset of T2DM, in addition to BM

202 Sex hormones, in particular estrogen, can influence CD4

203 Steroid sex hormones induce dramatic seasonal changes in reprodu

204 time exposure to increased concentrations of sex hormones is associated with the risk of some cancers

205 study is to explore the association between sex hormone levels and periodontitis in men using data f

206 Plasma sex hormone levels in men with idiopathic, heritable, or

207 tal, half the TCSs had at least one of three sex hormone levels outside the reference range at SII.

208 The association of sex hormone levels with mortality over a median of 16 ye

209 ence of an association of periodontitis with sex hormone levels, especially testosterone, in men.

210 sociations were not driven by differences in sex hormone levels, sexually transmitted infections, or

211 ogical pathways, including the regulation of sex hormone levels.

212 nied by disruption of the oestrous cycle and sex hormone levels.

213 response to acute and pronounced changes in sex-hormone levels during, for example, the perimenopaus

214 nd irregular periods, among other markers of sex-hormone levels, have been associated with a higher r

215 d low prevalence in childhood reinforce that sex hormones, like estrogen, play an important, complex

216 Removing circulating sex hormones makes these signals slower and less discrim

217 Sex hormone manipulation with GnRHa significantly trigge

218 hese results suggest that factors other than sex hormones may be responsible for gender-based differe

219 ight to explain the molecular basis by which sex hormones may be responsible for the female predispos

220 Sex hormones may contribute to the symptomatology of fem

221 Sex hormones may play a role in predisposing to gastric

222 inantly affect women, suggesting that female sex hormones may play a role in the pathogenesis of such

223 here is some evidence suggesting that female sex hormones might be protective of the optic nerve.

224 sordellii infections suggests that steroidal sex hormones might regulate its capacity to germinate.

225 ing mechanisms, with particular focus on how sex hormones modulate the immune responses necessary for

226 Sex hormones modulating serotonergic transmission are pr

227 nfluence of tissue and circulating levels of sex hormones more recently in conjunction with gene expr

228 ssess mechanisms behind the impact of female sex hormones on host immune responses to P. aeruginosa W

229 sers suggests a possible influence of female sex hormones on host response to HPV infection.

230 or histocompatibility antigens, influence of sex hormones on immune activation, sex- and age-related

231 Because actions of female sex hormones on normal renal tissue might protect agains

232 model and present evidence for the action of sex hormones on pancreatic beta-cell function and the va

233 fluence of sensory cues, social context, and sex hormones on progesterone receptor (PR)-expressing ne

234 the protective effects of testicular-derived sex hormones on the development of joint and lung diseas

235 To review the influence of sex hormones on the progression of breast, prostate, gyn

236 The impact of sex hormones on the T-helper 1/T-helper 2 cytokine balan

237 fied by circulating concentrations of IGF-1, sex hormones, or their major binding proteins.

238 tudy was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemi

239 he naturally occurring changes in endogenous sex hormones over the lifespan (e.g. puberty and menopau

240 the current evidence for the involvement of sex hormones, particularly estrogens and androgens in th

241 nted for over two millennia, suggesting that sex hormones play a role in regulating epidermal melanoc

242 Steroidal sex hormones play an important role in the neural contro

243 ronment and show that, depending on prenatal sex hormone priming, testosterone administration in wome

244 Sex-based differences in sex hormone processing and signaling may contribute to u

245 genes, notably those involved in retinol and sex hormone processing as well as in detoxification.

246 cm(2)), weekly) for 10 weeks, and endogenous sex hormone production was abrogated by ovariectomy.

247 ntagonist for 16 days to suppress endogenous sex hormone production.

248 The sex hormone progesterone has been shown to improve outco

249 throughout the body, mediated by the female sex hormones progesterone and estrogen.

250 Some sex hormone receptor modulators with bone sparing effect

251 on-coding RNA that coactivates several human sex hormone receptors and is strongly associated with br

252 ators; and (4) the tissue-specific effect of sex hormone receptors and the effect of genomic and nong

253 SMC markers, expression of VEGF-D and female sex hormone receptors, reduced autophagy, and metabolic

254 In tissue culture and animal models, sex hormones regulate expression of the telomerase gene.

255 We find that adult sex hormones regulate these expression patterns in a sex

256 Thus, sex hormone regulation of a neurotrophic factor signal d

257 nature was independent of biological age and sex-hormone regulation and was regulated by the transcri

258 While such stress and sex hormone-related alterations occur in regions mediati

259 cal ingredient used to treat a wide range of sex hormone-related disorders, including advanced prosta

260 eptor (PR) as an approach to avoid potential sex-hormone-related adverse effects and improving biopha

261 oid gonad tumours in later life, appropriate sex-hormone replacement at puberty and beyond, and an em

262 he elucidation of complex interactions among sex hormones, sex chromosomes, and immune response genes

263 This may be caused by differences in sex hormones, sex chromosomes, or both.

264 s model to investigate the influence of male sex hormone signaling on infectious hepatitis.

265 f BK channels in smooth muscle and has shown sex hormone specific regulation.

266 lating NT-proBNP levels were associated with sex/hormone status (overall p < 0.0001).

267 markedly attenuated the association between sex/hormone status and NT-proBNP concentrations.

268 Across sex/hormone status groups, free testosterone (FT) levels

269 Sex/hormone status was grouped as: 1) men; 2) post-menop

270 onadotropin receptors and several enzymes of sex hormone steroidogenesis were greater than in control

271 ssed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, al

272 Sex hormones such as estrogen and testosterone are essen

273 nhibition of the transcriptional activity of sex hormones, such as estrogens and androgens, and the a

274 red with men, has been reported, but whether sex hormones, such as estrogens, are involved in this se

275 based disparity are unknown and the specific sex hormone target for therapeutic manipulation has not

276 Furthermore, we show that male sex hormones (testosterone and dihydrotestosterone), but

277 linear relationship with the level of a male sex hormone, testosterone, using the Pearson correlation

278 The estrogens are female sex hormones that are involved in a variety of physiolog

279 ether progesterone (P4), one of the dominant sex hormones that regulates multiple biological function

280 Various factors, including sex hormones, the presence or absence of a second X chro

281 In addition to sex hormones, the X and Y sex chromosomes, and their uni

282 s in transgender populations receiving cross-sex hormone therapy (CSHT) limits appropriate primary an

283 in women and has potential implications for sex hormone therapy.

284 ng women suggests important contributions of sex hormones to differential responses of MSNA to fallin

285 , epidemiological studies have linked female sex hormones to lung cancer in women; however, the under

286 Sex hormone treatments did not affect protein levels of

287 these studies establish that female gonadal sex hormones underlie the sexual dimorphic differences i

288 all ages, suggesting that factors other than sex hormones underlie this discrepancy.

289 Whether exposure to endogenous sex hormones underlies this relationship should be inves

290 tive contribution of X chromosome dosage and sex hormones using a humanized mouse model in which male

291 Levels of sex hormones were categorized according to quartiles and

292 and severity of periodontitis and levels of sex hormones were determined and expressed as odds ratio

293 Sex hormones were evaluated as categorized and continuou

294 gonadal secretions (commonly referred to as sex hormones), which substantially influence many aspect

295 ALE: Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and o

296 with increased circulating concentrations of sex hormones, which in turn may increase hormone-depende

297 ulating concentrations of growth factors and sex hormones, which may be important in prostate cancer

298 IL2Cs, uterine ILC2s are regulated by female sex hormones, which may specialize them for specific phy

299 Progesterone, a key female sex hormone with pleiotropic functions in maintenance of

300 igraine and estrogen, the predominant female sex hormone, with a focus on studies published in the la

301 and adolescent mice to the stressors and/or sex hormones yielded expression patterns that reflected