ライフサイエンスコーパス: sex steroid

1 ness in songbirds and its fast modulation by sex steroids.

2 in older men, they were not associated with sex steroids.

3 ation of small, lipophilic molecules such as sex steroids.

4 eness of neurons to GABA can be modulated by sex steroids.

5 hat are regulated by physiological levels of sex steroids.

6 em is resistant to the modulatory effects of sex steroids.

7 validated by secretion of gonadotropins and sex steroids.

8 limits through negative feedback actions of sex steroids.

9 ified the unusual concentrations of measured sex steroids.

10 is not sex linked, we evaluated the role of sex steroids.

11 neurons and are differentially regulated by sex steroids.

12 s and 17,20 lyase activity needed to produce sex steroids.

13 intracellular levels of the active forms of sex steroids.

14 en treated with equivalent levels of various sex steroids.

15 chemic injury conferred by endogenous female sex steroids.

16 in human synthesis of androgen and estrogen sex steroids.

17 excitatory/inhibitory network influenced by sex steroids.

18 ), insulin-like growth factor-1 (IGF-1), and sex steroids.

19 oduction of fishes through the disruption of sex steroids.

20 Consistent with this, sex steroid ablation (SSA) led to increased expression o

21 keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic thymus restoration

22 s, with analysis of elderly males undergoing sex steroid ablation therapy for prostatic carcinoma, de

23 In this study, we demonstrate that sex steroid ablation using leuprolide acetate, a luteini

24 thymic rejuvenation efforts associated with: sex steroid ablation, cytokines, growth factors, and hor

25 LHRHa allows for reversible (and temporary) sex steroid ablation, has a strong safety profile, and h

26 dies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the gr

27 complex interaction between inflammation and sex steroids across development.

28 these findings suggest that temperature and sex steroids act upon a common neural substrate to influ

29 e HDACs, shown here for the antihypertrophic sex steroid acting at ERbeta.

30 We demonstrate herein a novel paradigm of sex steroid action on osteoblasts, osteocytes, embryonic

31 l parameters associated with male and female sex steroid action were assessed in the E6-AP null mouse

32 These results suggest that a sequential sex steroid activation of NPY and MOR circuits regulates

33 te a central role of MOR in the mediation of sex steroid activation of the CNS to regulate female rep

34 The mechanisms by which sex and sex steroids affect the immune system and autoimmunity a

35 ferrets were gonadectomized and treated with sex steroids, after which their nares were either bilate

36 19 months later, when serum sex steroid analysis confimed a postmenopausal state, tw

37 Administration of the female sex steroid and potent neuroprotective agent, 17beta-est

38 to a more tightly regulated producer of both sex steroids and glucocorticoids in mammals.

39 Because sex steroids and gonadotropins are both part of the HPG

40 in leuprolide acetate, which suppresses both sex steroids and gonadotropins.

41 Understanding how sex steroids and leptin regulate hypothalamic developmen

42 ure to undergo puberty in the setting of low sex steroids and low gonadotropins.

43 analyze the associations between endogenous sex steroids and mammographic density, the authors condu

44 urine bone marrow is negatively regulated by sex steroids and the aim of this study was to identify e

45 ble to examine regulatory pathways involving sex steroids and the periodontium.

46 teractive effects of growth hormone (GH) and sex steroids and their influence on strength and enduran

47 Sex steroids and their metabolites may also provide trea

48 Although sex steroids and their receptors are well characterized

49 unctionally, EC migration was induced by the sex steroid, and this was significantly reversed by NS-3

50 n and the insulin-like growth factor-I axis, sex steroids, and adipokines-but there are shortfalls to

51 ally differentiated as a result of postnatal sex steroids, and also specific neuronal populations in

52 sing MEDLINE with the keywords of menopause, sex steroids, and hormone replacement therapy.

53 ihydrotestosterone (DHT), a cocktail of four sex steroids, and inhibitors of sex steroid synthesis (a

54 are thought to be mediated by sensitivity to sex steroids, and the chromosomal rearrangement underlyi

55 least partially attributed to the effects of sex steroids, and their removal promotes enhanced thymop

56 axis; (3) parathyroid hormone signaling; (4) sex steroids; and (5) the OPG/RANKL/RANK cytokine system

57 esponses to trauma-hemorrhage, and that male sex steroids appear to be responsible for producing immu

58 The rapid, non-genomic actions of this sex steroid are attributed to membrane action, while gen

59 enopausal women, higher levels of endogenous sex steroids are associated with an increased risk of br

60 he purpose of this study was to determine if sex steroids are associated with periodontitis and tooth

61 Although male sex steroids are immunosuppressive, it remains unknown w

62 ations of luteinizing hormone, prolactin and sex steroids are low in these animals.

63 a compromised positive feedback response to sex steroids, as shown by significantly lower Kiss1 mRNA

64 ions, free testosterone was unaffected while sex steroid bioactivity on male and female reproductive

65 n variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk

66 The synthesis of DHEA and sex steroids, but not mouse glucocorticoids and mineralo

67 ypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tis

68 nto an endocytic mechanism for the uptake of sex steroids by mammalian cells.

69 rine, paracrine, and endocrine regulation of sex steroids by primary cultures of human skin epidermal

70 A number of sex steroids can be synthesized de novo in the brain, in

71 Sex steroids can both modulate and be modulated by behav

72 These results suggest that sex steroids can modulate the inflammatory response and

73 H) receptor antagonism bypassed the surge in sex steroids caused by LHRH agonists, the gold standard

74 rate), carnitine, prostaglandins, conjugated sex steroids, cGMP, odorants, and enterobiome metabolite

75 pothesis in vivo, we examined total and free sex steroid concentrations and bioactivity on target org

76 Serum sex steroid concentrations and the weights of the reprod

77 11-deoxycortisol implants reduced sex steroid concentrations and up-regulated gill Na+, K+

78 but by 9 months after the implantation, her sex steroid concentrations had returned to those seen wi

79 or the determination of free or bioavailable sex steroid concentrations in medicine, and clarify impo

80 Despite markedly raised total sex steroid concentrations, free testosterone was unaffe

81 es has been proposed as a mechanism by which sex steroid deficiency causes bone loss.

82 In germ-free (GF) mice, sex steroid deficiency failed to increase osteoclastogen

83 In murine models, sex steroid deficiency increased gut permeability, expan

84 ying mechanism of some of these effects, and sex steroid deficiency or glucocorticoid excess contribu

85 a modulates inflammatory responses caused by sex steroid deficiency, leading to trabecular bone loss.

86 rating that the gut microbiota is central in sex steroid deficiency-induced trabecular bone loss.

87 ove the depressed cardiovascular function in sex steroid-deficient female rats (i.e., ovariectomized

88 n of progesterone after trauma-hemorrhage in sex steroid-deficient females improved cardiovascular re

89 robiotics reversed hypogonadal osteopenia in sex steroid-deficient mice by preventing the disruption

90 demonstrated that twice-weekly treatment of sex steroid-deficient mice with the probiotics Lactobaci

91 that are critical for inducing bone loss in sex steroid-deficient mice.

92 uring the menopause and during treatment for sex-steroid dependent cancers.

93 cidating the receptor-mediated mechanisms of sex steroid-dependent growth and the clinical success of

94 This indicates a sex steroid-dependent plasticity of spinal KOR functiona

95 ategy may have arisen to mediate reversal of sex steroid-dependent repression of a limited cohort of

96 s associated with differential expression of sex steroid-dependent reproductive and aggressive behavi

97 The effect of sex steroids depends on the genetic background.

98 logical and psychological effects of 2 human sex-steroid derived compounds, 4.16-androstadien-3-one (

99 e (TH) in the male AVPV than the female, and sex steroids determine this sex difference, yet the role

100 whether different conditions of circulating sex steroids directly alter Kiss1 neuronal activity.

101 Alterations in sex steroids during pregnancy are associated with the de

102 ity to manipulation of circulating levels of sex steroids during the neonatal period.

103 pharmacologic approaches, we establish that sex steroid effects on human pigment synthesis are media

104 Limited prior data suggest that endogenous sex steroids either are not associated (total estradiol

105 Sex steroids exert anti-apoptotic effects on osteoblasts

106 Sex steroids exert profound effects on multiple immunolo

107 Ligated receptors for all sex steroids exist at the plasma membrane and rapidly si

108 ors tested the hypothesis that low levels of sex steroids facilitate the expression of pro-social beh

109 The negative sex steroid feedback was found to act specifically on ar

110 erving sex-typical behavior are dependent on sex steroids for both their organization early in life a

111 rophy, coincident with increased circulating sex steroids from puberty.

112 Sex steroid + GH increased muscle strength marginally an

113 les important in disease processes including sex steroids, glucocorticoids, eicosanoids, and neurotra

114 Serum gonadotropins, sex steroids, glucose, insulin, ghrelin, and leptin conc

115 ts in the form of thyroxine, hydrocortisone, sex steroids, growth hormone, and desmopressin.

116 Sex steroids have a significant effect on skeletal biolo

117 Both aging and loss of sex steroids have adverse effects on skeletal homeostasi

118 From these results we conclude that sex steroids have non-genomic actions in isolated intact

119 st cases, sex differences are induced by the sex steroid hormonal milieu during early perinatal devel

120 e data reveal mechanisms not only for female sex steroid hormone action but also in the regulation of

121 t correlations between urinary BPA and serum sex steroid hormone concentrations in adults.

122 e assessed pubertal staging, measured plasma sex steroid hormone concentrations, and analysed semen q

123 These results suggest that both absolute sex steroid hormone levels and the rates at which the le

124 Genetic variation in genes in the sex steroid hormone pathway is associated with differenc

125 rtium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to

126 P<5 x 10(-8)), implicating genes involved in sex steroid hormone pathways (FN1, CCDC170, ESR1, SYNE1

127 The sex steroid hormone progesterone (Pg) is critically invo

128 Sex steroid hormone receptors are expressed in the colon

129 in and support the important role of nuclear sex steroid hormone receptors in modulating social behav

130 near specific genes with important roles in sex steroid hormone signalling and function, and offer u

131 ed endogenous concentrations of estradiol, a sex steroid hormone that is known to influence UL risk.

132 Here, we used the cross-sex steroid hormone treatment of transsexuals seeking se

133 Together, sex steroid hormone-induced activation of WOX1 and WOX2

134 The sex-steroid hormone estradiol (E2) enhances the psychoac

135 ing and estradiol in the mechanisms by which sex-steroid hormone fluctuations provoke depressive symp

136 sical function, frailty, renal function, and sex-steroid hormone levels and seemed to be partially me

137 leotide polymorphisms (SNP) in genes for the sex-steroid hormone receptors are not strongly associate

138 hemicals (EDCs) due to their ability to bind sex-steroid hormone receptors.

139 The female sex steroid hormones 17beta-estradiol and progesterone m

140 In order to better understand where sex steroid hormones act to regulate social behavior in

141 suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (S

142 sequent nuclear translocation in response to sex steroid hormones and stress stimuli.

143 tions in endogenous postmenopausal levels of sex steroid hormones are not substantially related to th

144 sheep but not in monkeys or humans, although sex steroid hormones are still secreted.

145 in male 3xTg-AD mice depleted of endogenous sex steroid hormones by gonadectomy (GDX).

146 Sex steroid hormones contribute significantly to sex-bas

147 act symptoms (LUTS), and it is not clear how sex steroid hormones contribute to the rates of change i

148 oculture system was used to demonstrate that sex steroid hormones direct development of a sexually di

149 may be mediated by organizational actions of sex steroid hormones during development.

150 ns and songbirds is linked to the actions of sex steroid hormones during ontogeny but also in adultho

151 evaluated how the organizational effects of sex steroid hormones during postnatal development may af

152 brain regions develop under the influence of sex steroid hormones during the perinatal period, but ho

153 Sex steroid hormones exert a profound influence on the s

154 rain neurons are differentially regulated by sex steroid hormones in a dose-dependent manner.

155 sities of neurons that express receptors for sex steroid hormones in a pattern that is remarkably sim

156 Ovariectomy-induced depletion of sex steroid hormones in adult female 3xTg-AD mice signif

157 and clinical observations suggest a role of sex steroid hormones in the occurrence of meningioma.

158 and their relation to circulating levels of sex steroid hormones in women and to risk of endometrial

159 Sex steroid hormones influence the development of sex di

160 al. show that resistance (insensitivity) to sex steroid hormones is encountered in animals lacking m

161 different between men and women, and female sex steroid hormones likely have a role in this regulati

162 Despite the well-known influence of sex steroid hormones on the incidence of cardiovascular

163 stem provides a model for the important role sex steroid hormones play in mediating adult neural plas

164 Although age, genetics, and sex steroid hormones play prominent roles in the cause o

165 Sex steroid hormones regulate various neural functions t

166 Sex steroid hormones released from the gonads play an im

167 Sex steroid hormones such as estrogen and testosterone h

168 tional analyses of caregiving and endogenous sex steroid hormones were also conducted.

169 ine epinephrine output (but not cortisol and sex steroid hormones) correlated inversely with proinfla

170 use, it is becoming increasingly clear that sex steroid hormones, and in particular the principle fe

171 Vocal plasticity is linked to the actions of sex steroid hormones, but the precise mechanisms are unc

172 The female sex steroid hormones, estrogens and progesterone, are pr

173 Altered concentrations of sex steroid hormones, impaired reproductive performance,

174 rtility, with low levels of gonadotropic and sex steroid hormones, small testes or ovaries, impaired

175 07, to examine associations between baseline sex steroid hormones, the rate of change in these hormon

176 ke outcomes seen during life stages with low sex steroid hormones.

177 ence that likely results from the effects of sex steroid hormones.

178 ted with differences in circulating SHBG and sex steroid hormones.

179 Several endocrine factors, including sex-steroid hormones are known to influence adiponectin

180 lar and biochemical mechanisms through which sex-steroid hormones modulate memory, and a specific hyp

181 recent decades has demonstrated that ovarian sex-steroid hormones, particularly 17beta-estradiol (E2)

182 asonal fluctuations in circulating levels of sex-steroid hormones, which are known to be potent neuro

183 he rate-limiting step in the biosynthesis of sex-steroid hormones.

184 The phenotype depends on sex-steroid hormones: dihydrotestosterone treatment of g

185 lished data on circulating concentrations of sex steroids, IGFs, or IGFBPs and prostate cancer risk u

186 In this study, GH with or without sex steroids in healthy, aged women and men increased LB

187 fore have evolved from a general producer of sex steroids in lower vertebrates to a more tightly regu

188 d cell growth responses to gonadotropins and sex steroids in primary cultures of human OSE (HOSE) cel

189 underlying mechanisms, including the role of sex steroids in the etiology of ASD.

190 e more widespread neuroprotective actions of sex steroids in the mammalian nervous system, in the AVP

191 memory retrieval task, strongly implicating sex steroids in the regulation of this circuitry.

192 regulates the actions of glucocorticoids and sex steroids in these species.

193 To assess the role of sex steroids in this process, we studied mice deficient

194 Sex steroids, including testosterone, regulate the devel

195 stasis in a sexually dimorphic and partially sex steroid-independent manner; therefore, alterations i

196 Sex steroids influence the secretory dynamics of GH, but

197 We show that one mechanism by which sex steroids influence thymopoiesis is through direct in

198 nd IL-22), and hormonal modulation including sex steroid inhibition and growth hormone administration

199 including growth hormone administration and sex steroid inhibition.

200 ystem to investigate the complex pathways of sex steroid intracrinology in human skin.

201 s underlying the developmental activities of sex steroids involve interactions between nuclear hormon

202 Exposure to circulating sex steroids is felt to be a chief contributor to this p

203 ndrosterone (DHEA), a 19-carbon precursor of sex steroids, is abundantly produced in the human but no

204 Thus, in addition to sex steroids keratinocytes also actively metabolize cort

205 Moreover, there was no relationship between sex steroid levels and periodontitis progression or inci

206 FSH and sex steroid levels were not altered.

207 Endogenous sex steroid levels were unassociated with cognitive comp

208 evidence, the epidemiologic data correlating sex steroid levels with disease risk is inconsistent.

209 ts readily respond to and metabolize various sex steroid-like substrates, we find that they also gene

210 in responsiveness of hematopoietic cells to sex steroids may be essential for formation of the immun

211 ed male, and raise the possibility that yolk sex steroids may be part of the sex-determining process

212 ch hormone.) These results suggest that some sex steroids may increase the risk of breast cancer by s

213 RATIONALE: Sex steroids may play a role in plaque composition and i

214 and neurogenesis in songbirds indicate that sex steroids may provide crucial cues to newly divided c

215 ological studies indicate that the exogenous sex steroid medroxyprogesterone acetate (MPA) can impair

216 psilon4 and genetic polymorphisms related to sex steroid metabolism and AD risk need to be further in

217 eted, including multiple genes with roles in sex steroid metabolism, olfaction and drug response.

218 he SDR domain is predicted to be involved in sex-steroid metabolism and the WW domains are likely inv

219 Sex steroids modulate scent investigation and marking in

220 We tested the hypothesis that circulating sex steroids modulate single-unit responses in the avian

221 Sex steroids modulate vertebrate sensory processing, but

222 e two sexes and respond differently to adult sex steroids, modulate sensitivity to pheromonal stimula

223 Sex steroid modulation of MOR in the MPN acts through NP

224 Our results suggest that female sex steroids, most likely estrogen, have important effec

225 injections of 100 mg) (n = 35); GH + placebo sex steroid (n = 30); sex steroid + placebo GH (n = 35);

226 placebo GH (n = 35); or placebo GH + placebo sex steroid (n = 31) in a 2 x 2 factorial design.

227 Sex steroids negatively regulate B lymphopoiesis in adul

228 The available information indicates that sex steroids not only modulate the immune/cardiovascular

229 ones, and in particular the principle female sex steroid oestrogen, exerts potent effects upon the im

230 in sexual differentiation has contended that sex steroids of gonadal origin organize the neural circu

231 hip probesets, and showed similar effects of sex steroids on GABA receptor subunit gene expression in

232 rons mediate the negative feedback effect of sex steroids on gonadotropin secretion in mammals.

233 Furthermore, the differential action of sex steroids on the density of afferents from the BSTp i

234 To examine the acute effects of sex steroids on VZ cell proliferation, male and female a

235 ts significantly extend our understanding of sex steroid pathways in the cichlid brain and support th

236 (n = 35); GH + placebo sex steroid (n = 30); sex steroid + placebo GH (n = 35); or placebo GH + place

237 Sex steroids play a significant role in organizing male

238 Nonetheless, it is unclear what role sex steroids play in the maintenance of immune function

239 ysfunction, but it remains unknown if female sex steroids produce any salutary effects on the depress

240 dectomy, INH(-/-)-LH-CTP mice develop large, sex steroid-producing adrenal tumors that arise from the

241 ns in glucocorticoid, mineralocorticoid, and sex steroid production that require hormone replacement

242 ytes, although all other enzymes involved in sex steroid production were expressed almost entirely in

243 mal recessive Mendelian disorder of aberrant sex steroid production.

244 ogen and the expression of genes involved in sex steroid production/signaling (cyp19a1b, cyp17, hsd11

245 cing occurs through the action of the female sex-steroid progesterone.

246 Concentration levels of Delta4 sex steroids (progesterone, 17alpha-hydroxy-progesterone

247 of diabetes in females suggests that female sex steroids protect from beta-cell injury.

248 We show that sex steroids protect the adult murine skeleton through a

249 use of the H295R steroidogenesis assay, and sex steroid receptor binding activity using the yeast es

250 Thus, sex steroid receptor expression is significantly and dif

251 onferring more efficient functioning of this sex steroid receptor is associated with "masculinization

252 anation for the profound skeletal effects of sex steroid receptor ligands, including synthetic ones t

253 ovel targets to selectively inhibit membrane sex steroid receptor localization and function.

254 ollectively, these data provide insight into sex steroid receptor-mediated regulation of androgen-ina

255 Classical sex steroid receptors (SRs) localize at the plasma membr

256 nucleus (PMV) expresses dense collections of sex steroid receptors and receptors for metabolic cues,

257 The classical genotropic actions of sex steroid receptors are dispensable for their bone pro

258 ing that the classical genotropic actions of sex steroid receptors are dispensable for their bone-pro

259 dition to the well-characterized role of the sex steroid receptors in fertility and reproduction, org

260 Sex steroid receptors were also expressed in a stage- an

261 rminal L/HX7LL motif, selectively present in sex steroid receptors, that causes recruitment of TAB2 a

262 rane translocation and function of classical sex steroid receptors.

263 refrontal cortex, are densely populated with sex steroid receptors.

264 7 and -21 proteins as conserved PATs for the sex steroid receptors.

265 Additionally, sex steroids regulate inflammatory cytokines that cause

266 Because sex steroids regulate the life span of bone cells by mod

267 onclude that in aging men, E is the dominant sex steroid regulating bone resorption, whereas both E a

268 e of placental mammals and could account for sex steroid regulation of LGALS1 expression, thus provid

269 ether GnIH serves as a signaling pathway for sex steroid regulation of the reproductive axis, we used

270 othalamic arcuate nucleus participate in the sex-steroid regulation of reproduction.

271 is a common molecular feature in subsets of sex-steroid-related tumors including endometrium and bre

272 ifferential gene regulation, particularly in sex steroid-responsive genes, may contribute to a sexual

273 lation in males and females, particularly in sex steroid-responsive genes.

274 h part of the HPG feedback loop, any loss in sex steroids results in a proportionate increase in gona

275 ial for metabolic and endocrine processes in sex steroid-sensitive uterine cells.

276 he posterodorsal medial amygdala (MePD) is a sex-steroid-sensitive area that modulates reproductive b

277 ymphatic circulation, infiltration/invasion, sex steroid sensitivity, and local and remote tissue des

278 nts, and suggest that in humans too, sex and sex steroids shape brain development in a spatiotemporal

279 ness in songbirds and its fast modulation by sex steroids.SIGNIFICANCE STATEMENT Neuroestrogens can a

280 Sex steroids such as androgens and estrogens have trophi

281 t is distinguished by its ability to secrete sex steroids such as estrogen.

282 tail of four sex steroids, and inhibitors of sex steroid synthesis (aminoglutethimide, ketoconazole,

283 P450c17-knockout mice would have disordered sex steroid synthesis and disordered brain DHEA producti

284 a HIF-1-induced leptin expression, modulates sex steroid synthesis by acting directly on steroidogeni

285 Peripheral intracrine sex steroid synthesis from adrenal precursors dehydroepi

286 one (LH), a pituitary hormone that regulates sex steroid synthesis in the testes.

287 pment, all of the genes required for de novo sex steroid synthesis would be expressed in regions that

288 ed the role of CYP17, a key enzyme mediating sex steroid synthesis, in Xenopus ovarian androgen produ

289 is and the 17,20 lyase activity required for sex steroid synthesis.

290 followed by 17,20 lyase activity needed for sex steroid synthesis.

291 These cells secrete sex steroids that control the ovulatory cycle and influe

292 , the gold standard for clinical ablation of sex steroids, thereby facilitating increased Dll4 expres

293 ncluding nutrient and fat status, stress and sex steroids, thus providing a link between these factor

294 eedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differenti

295 Sex steroid treatment led to numerous alterations in gen

296 of reproductive function involves actions of sex steroids upon their nuclear receptors in the hypotha

297 the bone anabolic, nongenotropic effects of sex steroids while having no effect on the uterus or sem

298 deficiencies in growth hormone (GHD) and/or sex steroids with low BMD and frailty.

299 that reproduces the nongenotropic effects of sex steroids, without affecting classical transcription,

300 20 micro g/kg, subcutaneously 3 times/wk) + sex steroids (women: transdermal estradiol, 100 micro g/