ライフサイエンスコーパス: sex-specific

1 inical response to these drugs appears to be sex specific.

2 at cellular pathways that regulate aging are sex specific.

3 comprising the maternal brain are innate and sex specific.

4 ting amino acids in children adolescents are sex-specific.

5 cluding the brain, outcomes that are largely sex-specific.

6 FMI results were sex-specific.

7 We also determined sex-specific 10th and 90th percentile limits for these m

8 was defined as a BMI at or above 120% of the sex-specific 95th percentile on the CDC BMI-for-age grow

9 After readjudication using sex-specific 99th percentile levels, diagnostic reclassi

10 hs-cTnI was measured (Abbott assay) using sex-specific 99th percentiles (women, 16 ng/L; men, 34 n

11 omosome genes may serve as novel targets for sex-specific AAA therapeutics.

12 Our results show that sex-specific additive genetic effects on breeding date c

13 dia) phenology and pedigree data to estimate sex-specific additive genetic variances in breeding date

14 Furthermore, we find evidence for sex-specific admixture patterns, resulting from predomin

15 e ancestry but whose ancestors had undergone sex-specific admixture with early farmers with Anatolian

16 That sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficit

17 Understanding sex-specific aging skeletal muscle will assist with the

18 Finally, we also identified sex-specific alterations in KOR binding density within t

19 Exploiting 52 sex-specific An. gambiae RNA-Seq datasets representing a

20 Sex-specific analyses found largely overlapping GWAS loc

21 All of the sex-specific analyses showed associations in opposite di

22 Sex-specific analyses were specified a priori.

23 In sex-specific analyses, we identified more CpGs with FDR<

24 reeding effects on breeding date can also be sex specific and that genetic effects can exceed phenoty

25 This finding highlights the need for sex-specific and cycle-specific approaches to pain manag

26 All phenotypes are non-sex-specific and rescued by a fosmid containing the enti

27 2025, by use of evidence-based age-specific, sex-specific, and year-specific transition probabilities

28 To estimate age, racial/ethnic, and sex-specific annual net transition probabilities between

29 Interestingly, we detect differential sex-specific association at LAMC1, with greater risk in

30 Our study indicated that there was a sex-specific association between serum UA and prognosis

31 ur knowledge, no study has examined age- and sex-specific associations between indoor tanning and mel

32 We investigated sex-specific associations between low birth weight (LBW;

33 Sex-specific associations for indoor tanning and melanom

34 Sex-specific associations have been reported between pht

35 We assessed sex-specific associations of particulate matter less tha

36 Therefore, we investigated sex-specific associations of self-esteem and stress reac

37 No sex-specific associations were found between BMI and DR

38 Sex-specific associations were seen for 3 SNPs in men (r

39 These sex-specific associations with pubertal development are

40 mes with a doubling in BPA concentration and sex-specific associations.

41 Heterogeneity analyses suggested some sex-specific associations.

42 s research, investigators routinely estimate sex-specific associations.

43 Genetic fine mapping of sex-specific asthma association signals was performed, a

44 defined as activity levels below the lower, sex-specific baseline quartile for more than two-thirds

45 ng that neurons unique to males trigger this sex-specific behavior.

46 We previously reported evidence of sex specific behavioral effects in rats resulting from d

47 involved in sex-specific behaviors with the sex-specific behavioral circuit identity marker fruitles

48 lfactory receptor neurons (ORNs) involved in sex-specific behaviors with the sex-specific behavioral

49 trait of neurons driving plastic aspects of sex-specific behaviors.

50 irs deliberately sampled to be discordant on sex-specific birth weight for gestational age (BW/GA) in

51 h chart data were used to calculate age- and sex-specific BMI percentiles, as measures of adiposity.

52 One-year changes in age- and sex-specific BMI z score, child health-related quality o

53 ing to standardized procedures, and age- and sex-specific BMI z scores were computed based on the WHO

54 BMI on COWO, defined as the child's age- and sex-specific BMI z-score >/=85th percentile at the last

55 rived from birth weight and length; age- and sex-specific body mass index (BMI) z scores at 5 mo, 12

56 A more thorough understanding of sex-specific cardiovascular differences both at baseline

57 that sexual experience triggers lasting and sex-specific changes in MeA activity, which, in males, i

58 Similarly, current analyses revealed sex-specific changes in network connectivity and identif

59 Changes in sex-specific chromatin accessibility and histone modific

60 lity data through ATAC-sequencing to connect sex-specific chromatin accessibility to sex-specific pat

61 Adjusted incidence rate ratios (IRRs) for sex-specific community HIV incidence estimated using mul

62 Sex-specific comparative effectiveness of direct oral an

63 retrospective cohort study, we assessed the sex-specific, comparative effectiveness of direct oral a

64 We used sex-specific Cox proportional hazards regression methods

65 nical practice for more than 2 decades) or 2 sex-specific cutoff levels are preferable when using hig

66 hen using 2 alternative pairs of uniform and sex-specific cutoff values.

67 However, due to the sex-specific data structure of the X chromosome, it has

68 Sex specific de novo transcriptome assemblies generated

69 e (GGT) elevation was defined as the highest sex-specific decile.

70 Although CPMs hold promise for supporting sex-specific decision making in CVD clinical care, sex e

71 Here, we investigated sex-specific determinants for facial wrinkles.

72 dsx) and the mechanisms by which it mediates sex-specific development in a horned beetle species by c

73 developmental-genetic mechanisms underlying sex-specific development remain poorly understood.

74 ive propensity, bringing to light a possible sex specific difference in the cardiovascular protection

75 Furthermore, we identify a sex-specific difference in reconstitution efficiencies,

76 We show for the first time the existence of sex-specific differences between flower gender and colou

77 Sex-specific differences exist in the presentation, path

78 ns unclear which factors are responsible for sex-specific differences in adult pelvic morphology.

79 certain nonischemic conditions may also have sex-specific differences in clinical presentation and oc

80 Here we identify sex-specific differences in hypothalamic microglial acti

81 ite within the pri-miR-22 in vivo eliminates sex-specific differences in miR-22 expression.

82 eedback regulation is essential to establish sex-specific differences in muscle metabolism and body w

83 Sex-specific differences in response to antiplatelet the

84 nefits beyond cerebral palsy prevention with sex-specific differences in response.

85 However, sex-specific differences in sensitization history and hi

86 Secreted phosphoprotein 1 and sex-specific differences in silica-induced pulmonary fib

87 in human patients and animals have revealed sex-specific differences in susceptibility to renal dise

88 d colleagues present evidence that there are sex-specific differences in the effectiveness of certain

89 Sex-specific differences in the epidemiology, pathophysi

90 nce within the last several decades supports sex-specific differences in the prevalence, symptoms, an

91 adult offspring are not well known nor have sex-specific differences in therapeutic response been ex

92 Moreover, the sex-specific differences were independent of T and B cel

93 Although sex-specific differences were observed, histomorphometry

94 tructive (1%-49% stenosis) LM CAD, including sex-specific differences, has not been previously examin

95 oth transcription and directly or indirectly sex-specific differential splicing of its target genes t

96 erated only in one sex or a manifestation of sex-specific differentiation of neurons present in both

97 males, suggesting that these two factors are sex-specific disease modifiers and raising the possibili

98 We explored sex-specific DNA methylation in the cord blood of 39 fem

99 ng during reproduction revealed distinct and sex-specific dynamics for both contexts.

100 se haploid selective processes are typically sex-specific, e.g., gametic/gametophytic competition typ

101 en choosing an analytic approach to estimate sex-specific effects of endocrine disruptors on health.

102 a has a critical role in the deleterious and sex-specific effects of maternal stress and other fetal

103 Sex-specific effects of organophosphate diazinon on the

104 ptor Y1 gene (Npy1r), which co-occurred with sex-specific effects of perinatal LPD on both Npy1r DNA-

105 Temporal- and sex-specific effects of perinatal stress have not been e

106 Sex-specific effects of smoking and BMI were found speci

107 of confounder relationships on estimates of sex-specific effects of the exposure of interest for thr

108 Here we report on the sex-specific effects of tobacco smoking on transcriptomi

109 ate that maternal BPA exposure has dose- and sex-specific effects on pancreatic islets of adult F1 an

110 in animals, but evidence in humans, of which sex-specific effects on pubertal development may be an i

111 isolation, but not acute physical stress has sex-specific effects on PVN CRH neurons.

112 and environmental factors interact to cause sex-specific effects that may help explain the male bias

113 ies had limited statistical power to examine sex-specific effects, and few examined child cognition.

114 how this compositional difference results in sex-specific effects, for example, the slower aging of t

115 of two traditional approaches for estimating sex-specific effects, stratification and product terms,

116 s that affect parental care, 8 of which have sex-specific effects, suggesting that parental care can

117 ty carrying low or high ASD probability were sex specific (eg, in inferior temporal regions, where AS

118 pplied statistical approaches for estimating sex-specific endocrine disruptor effects may produce div

119 al support for our hypothesis that differing sex-specific energy conservation strategies exist.

120 in association with restored occupancy of a sex-specific enhancer element in principal downstream ge

121 Further analysis revealed sex-specific enrichment of signaling pathways and key re

122 The sex-specific environment seems to play a role in changin

123 of how early life risk factors may generate sex-specific epigenetic effects relevant for mental diso

124 -independent regulatory changes in Egr1, and sex-specific epigenetic reprogramming of its effector ge

125 Sex-specific estimates from stratification and the augme

126 In simulations, sex-specific exposure effects estimated using the tradit

127 Sex-specific expression of alternative Lon isoforms was

128 hondrial Lon protease and is associated with sex-specific expression of Lon protein isoforms and prot

129 e sterility factor and additional genes with sex-specific expression.

130 est that cell-intrinsic (chromosome X and Y) sex-specific factors also may contribute to the sex diff

131 idence of autoimmunity in women, implicating sex-specific factors in disease development.

132 However, further investigations on sex-specific feeding and infant growth are warranted bef

133 onset in Krt16(-/-) females, coinciding with sex-specific fluctuations in footpad skin glutathione le

134 The expression and the effects of CR were sex-specific for several genes previously reported to be

135 dividuals, allows greater specialization for sex-specific functions and can be advantageous under var

136 primordial germ cells (PGCs), precursors of sex-specific gametes that produce an entire organism upo

137 This allowed us to study sex-specific gene expression and gonadal development.

138 en the sexes at a molecular level, including sex-specific gene expression and sex-specific impact of

139 nt with testosterone-propionate (TP) reveals sex-specific gene expression changes, causing 2854 and 7

140 Sex-specific gene expression could be observed during em

141 These data support the notion that sex-specific gene expression differences at baseline inf

142 We also observe increased sex-specific gene expression differences in neutrophils.

143 We identify key regulators of sex-specific gene networks underlying MDD and confirm th

144 erified European ancestry to investigate the sex-specific genetic architecture of gene expression mea

145 These data reveal sex-specific genetic determinants for aortic pulse wave

146 om over 100,000 meioses and have constructed sex-specific genetic maps at a previously unachievable r

147 Sex-specific genome resequencing in a recent species rad

148 viduals (BMI >/=30) in the lowest tertile of sex-specific grip strength (<35.3 kg for men and <19.6 k

149 as part of a relay that specifies the early sex-specific growth trajectories of larval but not imagi

150 Age- and sex-specific GS quintiles were used.

151 Finally, sex-specific GWAS analyses identified one locus near the

152 zygotic sex-ratios, we find that a period of sex-specific haploid selection generally favors recombin

153 additive genetic variances in breeding date (sex-specific heritabilities: 0.07 and 0.02, respectively

154 tion analyses reveal thousands of sites with sex-specific heritability as well as sites where the env

155 genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden of risk in

156 sexes, with only a small number of putative sex-specific hotspots.

157 We pooled sex-specific HRs using random-effects meta-analysis.Over

158 ne networks underlying MDD and confirm their sex-specific impact as mediators of stress susceptibilit

159 , including sex-specific gene expression and sex-specific impact of genetic variation.

160 Investigation of sex-specific impacts on outcomes is needed to identify o

161 indicate that both BPA and EE have dose- and sex-specific impacts on the cellular and microanatomical

162 on and subsequent X-linked gene silencing is sex specific in embryos and in differentiating embryonic

163 tic variance while simultaneously estimating sex-specific inbreeding depression.

164 Sex-specific incidence rate ratios (IRRs; relative risks

165 by applying year-specific, age-specific, and sex-specific incidence to UK census mid-year population

166 ostic implications are significant, with key sex-specific inferences on physical function, frailty, d

167 he genetic and neuronal basis underlying the sex-specific interaction between sleep and sexual behavi

168 CAD (adjusted hazard ratio, 1.78; P=0.017); sex-specific interactions were not observed across other

169 The Lshid transgene contains a sex-specific intron and as a consequence only females pr

170 but whether responses to climate change are sex-specific is unknown.

171 date genes for future functional analyses of sex-specific isoform usage.

172 This sex-specific lethality benefits the bacteria because mal

173 Overall, we expand our view of the sex-specific life cycle stages that can drive sex chromo

174 Epidemiological data suggest that sex-specific life experiences such as pregnancy increase

175 t times among extant hominoids (apes), given sex-specific life histories.

176 cal pattern may be due to the combination of sex-specific life history challenges encountered by fema

177 the dynamics of finding mates interact with sex-specific life-history traits to influence the rate o

178 ovides novel insights into the expression of sex-specific lincRNAs and their potential for regulation

179 Our results reveal a pattern of sex-specific local life-history adaptation: Surface moll

180 In the sex-specific low quartile of midwall GLS (<18.8% in wome

181 Population and sex-specific lower and higher WHR tertiles were <0.91 an

182 ethylation abnormalities induced by ART in a sex-specific manner and plays a role in mediating poor e

183 exposure was associated with %H3K36me2 in a sex-specific manner but was not associated with %H3K36me

184 ed and cell surface proteins, expressed in a sex-specific manner, that mediate sperm-egg interactions

185 were associated with school performance in a sex-specific manner, we performed a Mendelian randomizat

186 ulatory variants of blw affect lifespan in a sex-specific manner.

187 harmacological antidepressant response, in a sex-specific manner.

188 cterial community assembly in a temporal and sex-specific manner.

189 al littermate control mice in a genotype and sex-specific manner.

190 es to the regulation of this plasticity in a sex-specific manner.

191 de C. elegans differentiates in a strikingly sex-specific manner.

192 nome, and associated metabolic profiles in a sex-specific manner.

193 ression and global methylation in a parental sex-specific manner.

194 Sex-specific mating behaviors occur in a variety of mamm

195 (skewed sex ratio, sex-biased dispersal, and sex-specific mating behaviours) amplify these effects.

196 r the urea cycle represent potentially novel sex-specific mechanisms for the development of atheroscl

197 y altered by letrozole, the findings suggest sex-specific mechanisms of E2 signaling.SIGNIFICANCE STA

198 A collaborative sex-specific meta-analysis was conducted of phase III or

199 re similarly hypomethylated, indicating that sex-specific methylation differences arise in culture.

200 The contrasting patterns of sex-specific migration during these two migrations sugge

201 The identification of sex-specific miRNA signatures has implications for trans

202 A key component in any sex-specific model is the "mating function" (the relatio

203 Sex-specific models indicated 4 trajectory classes for w

204 atory role via two distinct mechanisms: as a sex-specific modulator by regulating strictly sex-specif

205 Both pathways involve sex-specific molecular signals from the somatic cells of

206 SLaM records compared with age-specific and sex-specific mortality statistics for England and Wales.

207 ne the association in dietary intake between sex-specific mother-child dyads.

208 nstrate the novel role of placental InsRs in sex-specific neurodevelopment and reveal a potential mec

209 nt contributor and novel mechanistic link to sex-specific neurodevelopmental changes underlying disea

210 Further, we delineate a sex-specific neuronal circuit wherein the P1 neurons enc

211 Sex-specific neuronal ensembles gradually separated as t

212 Here, we identify key sex-specific neurons that mediate copulation in Drosophi

213 x, and partly represent interactions between sex-specific nonbiological and biological risk factors,

214 We report sex-specific normative values for RV measurements among

215 To evaluate molecular mechanisms driving sex-specific outcomes, we assessed genome-wide expressio

216 ination genes fruitless and doublesex, and a sex-specific P1-DN1 neuronal feedback that governs the i

217 dwelling population, we observed a distinct, sex-specific pattern of cardiac remodeling.

218 th increased offspring allergies following a sex-specific pattern.

219 e and physiological factors underlying these sex-specific patterns are relatively unknown.

220 DMRT1 might influence sex-specific patterns of childhood asthma, and its expre

221 nect sex-specific chromatin accessibility to sex-specific patterns of expression and regulatory varia

222 The observed allergy- and sex-specific patterns suggest multiple etiologic pathway

223 3, which is both required and sufficient for sex-specific PHC differentiation.

224 We have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(

225 Finally, we demonstrated sex-specific placental responses to chronic hypoxia.

226 e ecology of sex shapes patterns of helping: sex-specific preadaptation strongly influences who helps

227 predictors of wheeze, wheeze phenotypes, and sex-specific predictors of these phenotypes by using gen

228 We identified sex-specific predictors of wheeze and longitudinal wheez

229 We identified sex-specific predictors of wheeze, wheeze phenotypes, an

230 Objective: To determine the age- and sex- specific prevalence of AMD among Chinese Americans.

231 We examined the sex-specific prevalence of asthma and rhinitis as single

232 n method, which applies the age-specific and sex-specific prevalence of the health measure to a stand

233 Age-specific and sex-specific prevalences of the eight groups were determ

234 underlying pathophysiology and relevance to sex-specific prevention strategies.

235 We postulate that sex-specific primordial energy optimisation strategies e

236 Recognizing the sex-specific prognostic significance of nonobstructive L

237 Moreover, these studies suggest that sex-specific PTSD vulnerability is partly regulated by s

238 e evaluated height-mortality associations in sex-specific quintiles of increasing height (Q1-Q5) usin

239 to be between 6.1% and 24.7%, information on sex-specific recurrence patterns is lacking.

240 To estimate high-confidence sex-specific recurrence rates of ASD among siblings.

241 difference between groups, p=0.26), with no sex-specific reductions (HRs for men: 1.09 [95% CI 0.85-

242 n GMFCS group I did not differ from age- and sex-specific reference children with typical development

243 ce organs were defined manually, scaled to a sex-specific reference, and residence times were calcula

244 ce relative to females and that this enables sex-specific regulation of muscular lipid metabolism and

245 As sex-specific regulatory variants discovered in our study

246 In contrast, we discovered an enrichment of sex-specific regulatory variants on the X Chromosome.

247 We also found evidence for sex-specific relationships between telomeres and tarsus

248 glial TLR4 and illustrate the necessity for sex-specific research and individualized treatment strat

249 Importantly, this sex bias was mediated by a sex-specific response to the S. aureus-secreted virulenc

250 ors of inflammatory genes, but their role in sex-specific responses is unclear.

251 We document sex-specific responses to climate change in the plant Va

252 However, factors contributing to sex-specific risk and the pattern of dysbiosis are large

253 ional studies reporting associations between sex-specific risk factors and stroke were selected.

254 tinct longitudinal wheeze phenotypes and the sex-specific risk factors associated with these phenotyp

255 Consideration of sex-specific risk factors can improve individualized str

256 e and asthma prevalence are well documented, sex-specific risk factors for wheeze and longitudinal wh

257 rebirth cohort, this study aimed to identify sex-specific risk factors for wheeze from birth through

258 The influence of sex-specific risk factors on stroke incidence and mortal

259 Thus, sex-specific risk in TAVR is the opposite of that in SAV

260 comes in men and women and to assess whether sex-specific risk scores better estimate all-cause morta

261 Sex-specific risk scores better estimate mortality in pa

262 In particular, these sex-specific risk scores help to identify patients at th

263 C statistics for the sex-specific risk scores in the CCF validation sample we

264 The sex-specific risk scores in the FIT cohort demonstrated

265 d calibration were also evaluated with these sex-specific risk scores in the FIT cohort.

266 ination improvement were used to compare the sex-specific risk scores with other tools that have all-

267 imination improvement were superior with the sex-specific risk scores, mostly owing to correct reclas

268 heterozygous mice: a possible modality- and sex-specific role for PMCA2 in nociception.

269 Thus Gck in the VMN plays a sex-specific role in the glucose-dependent control of au

270 sential for clearing S. aureus, demonstrated sex-specific S. aureus bactericidal capacity ex vivo.

271 ntiation into such a hub neuron involves the sex-specific scaling of several components of the synapt

272 ex chromosomes, as has been demonstrated for sex-specific selection among diploids.

273 We use models to investigate whether sex-specific selection on haploids could drive the evolu

274 We discuss the potential roles of sex-specific selection on the immune system and behaviou

275 s a critical role in processing species- and sex-specific signals that trigger social and defensive b

276 This work suggests that sex-specific skin innate responsiveness to Hla and neutr

277 exhibit strong concentration preferences for sex-specific small molecule cues secreted by hermaphrodi

278 which enhances KDR expression, contribute to sex-specific Sox9 expression in developing murine gonads

279 mework to systematically explore tissue- and sex-specific splicing to document its conservation throu

280 This argues that sex-specific stem cell fate together with differential p

281 ation since mice lacking either gene exhibit sex-specific sterility, making these proteins promising

282 velop Drosophila melanogaster as a model for sex-specific stress adaptation regulated by the Lon prot

283 gs add to the recent but growing evidence of sex-specific T-cell involvement in chronic pain processi

284 ex-specific modulator by regulating strictly sex-specific targets, or as a switch by regulating the s

285 ion is ensured by its collaboration with non-sex-specific terminal selector-type transcription factor

286 RTRs in the lowest sex-specific tertile of UKV (women, <55 mmol/24 h; men,

287 cers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer ty

288 ences in opioid abuse patterns and may guide sex-specific therapies.

289 y was twofold: to explore potential age- and sex-specific thresholds of MS, for optimal cardiometabol

290 lucidate the molecular mechanisms underlying sex-specific traits and diseases.

291 quantitative genetic analyses of interacting sex-specific traits in D. melanogaster with comparative

292 Trim28(hep-/-) mice display sex-specific transcriptional deregulation of a wide rang

293 MDD and highlight the importance of studying sex-specific treatments for this disorder.

294 AFA and AMA growth patterns exhibited sex-specific trends including multiple distinct age-rela

295 Significant sex-specific trends were also apparent, with a preponder

296 result in evolution favouring pathogens with sex-specific virulence.

297 stic reclassification in women and men using sex-specific vs the uniform cutoff level in the diagnosi

298 lation was dose dependent, and in some cases sex specific, with the brominated components reaching th

299 Functional trajectories were sex-specific, with a benefit of high education that pers

300 At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC),