ライフサイエンスコーパス: sexual development

1 on, cpsA is necessary for normal asexual and sexual development.

2 between yeast growth and filamentous asexual/sexual development.

3 hormone receptor HR39 is also essential for sexual development.

4 non-coding mutations underlying disorders of sexual development.

5 y from a paternal copy, that triggers female sexual development.

6 o secrete LHRH, the neuropeptide controlling sexual development.

7 d by glutamatergic neurons to control female sexual development.

8 transcriptional machinery controlling female sexual development.

9 -enriched transcripts, we focused on somatic sexual development.

10 ecific expression of AMD1 at later stages of sexual development.

11 d candidates to encode regulators of somatic sexual development.

12 e somatic gonad that regulates male germline sexual development.

13 NT4 has been shown to be important in female sexual development.

14 otein, Pum1, for hyphal morphogenesis during sexual development.

15 the single mating type locus (MAT) controls sexual development.

16 ntral role in coordinating hyphal growth and sexual development.

17 nstream of GprD-mediated negative control of sexual development.

18 hereas smaller transcripts accumulate during sexual development.

19 imary role of GprD is to negatively regulate sexual development.

20 and link nuclear export to the regulation of sexual development.

21 ific gene, the complex induces hermaphrodite sexual development.

22 and astroglial input to LHRH neurons during sexual development.

23 ike protein, in meiotic silencing and normal sexual development.

24 the hypothalamic neuropeptide that controls sexual development.

25 anches that play crucial roles in regulating sexual development.

26 hereas cats serve as the definitive host for sexual development.

27 may be an essential step in Aalpha-regulated sexual development.

28 ine in the wild could be at risk of impaired sexual development.

29 ha in a cells is sufficient to drive a/alpha sexual development.

30 in conidia and under conditions that favour sexual development.

31 gger a pathway of fertilization required for sexual development.

32 rectly or indirectly, all genes required for sexual development.

33 nalling molecule Wnt-4 is crucial for female sexual development.

34 hormone (LHRH), the neuropeptide controlling sexual development.

35 least some of the same mechanisms to control sexual development.

36 the neuroendocrine brain controls mammalian sexual development.

37 family member TRA-1 is necessary for normal sexual development.

38 Dmrt1 may also play a role in avian sexual development.

39 Primary safety measures were growth and sexual development.

40 l cycle and shown to be essential for normal sexual development.

41 otes results in abnormalities of somatic and sexual development.

42 ot reveal abnormalities during vegetative or sexual development.

43 n appropriately stressed that most resort to sexual development.

44 n factor complex that commits mated cells to sexual development.

45 e into gametocytes ready for continuation of sexual development.

46 r beyond their previously understood role in sexual development.

47 ed how this pathway may regulate alternative sexual development.

48 ociated with pathologies of reproduction and sexual development.

49 MID produced functional sperm packets during sexual development.

50 uency of switching from the asexual cycle to sexual development.

51 ondrial activity and lipid metabolism during sexual development.

52 associated with matA(HMG) regulation during sexual development.

53 A-1-binding sites results in defects in male sexual development.

54 ts is perhaps the least understood aspect of sexual development.

55 sion changes that occur over time throughout sexual development.

56 duction in conidiation, and complete loss of sexual development.

57 pathway operates to defend the genome during sexual development.

58 y quelling, in meiotic silencing, and normal sexual development.

59 produces steroid hormones that regulate male sexual development.

60 r vegetative growth, conidial production and sexual development.

61 n in fungi to specify cell types and control sexual development.

62 rucial role in regulating cGMP levels during sexual development.

63 omains of both Sxi proteins are required for sexual development, a departure from related fungi.

64 uberty, a complex biologic process involving sexual development, accelerated linear growth, and adren

65 major differences in the genetic control of sexual development among animal lineages, the doublesex/

66 o distinct phenotypes: nutrition-insensitive sexual development and a growth defect at high levels of

67 zygous-fertile phenotype uncouples MSUD from sexual development and allows us to demonstrate that bot

68 the ability of enkephalins to disrupt insect sexual development and also suggests the existence of co

69 in NCU09915 (fsd-1) were defective in female sexual development and ascospore maturation.

70 In addition, it has a potential role in sexual development and bile acid transport, and it is as

71 ecific transcription factor involved in male sexual development and bone formation.

72 ype locus of Schizophyllum commune regulates sexual development and contains the code for two protein

73 ions about sexuality to help promote healthy sexual development and decision making.

74 pproach provides a new resource for studying sexual development and demonstrates that exploiting the

75 ypothalamic expression of genes required for sexual development and deregulation of a gene involved i

76 We present a unified model for alternative sexual development and discuss the implications for esta

77 o inhibit transcription of genes involved in sexual development and gluconeogenesis, including the fb

78 n receptor (AR) plays a central role in male sexual development and in normal and malignant prostate

79 QIP is crucial for sexual development and is shown to colocalize with other

80 o the insect gene doublesex, are integral to sexual development and its evolution in many metazoans.

81 ated with this axis can result in defects in sexual development and maturity.

82 cts of water temperature and EDC exposure on sexual development and population viability of inbred an

83 protein 1 (SMTNL1) is a key factor governing sexual development and pregnancy induced adaptations in

84 ings define a new conserved pathway in which sexual development and pregnancy mediate smooth and stri

85 androgen receptor (AR) is critical for male sexual development and prostate cancer.

86 Surprisingly, sexual development and reproduction in mutant animals we

87 The LHR has an essential role in sexual development and reproductive function, and its tr

88 POR mutation A287P presents with disordered sexual development and skeletal malformations.

89 Second, sexual development and Sry expression levels were determ

90 of a paternal genome is required for female sexual development and suggest a genomic imprinting mech

91 nrichment and pathway analyses shed light on sexual development and the biosynthesis of sesquiterpeno

92 Dmrt1 is likely to play a role in vertebrate sexual development and therefore that DM domain genes ma

93 slational repression of messenger RNA during sexual development, and a 47-base 3' untranslated region

94 pleiotropic effects on growth, conidiation, sexual development, and appressorium formation.

95 formation of female reproductive structures, sexual development, and meiosis.

96 These two genes control similar aspects of sexual development, and the male isoform of DSX can subs

97 oteins are essential for growth, asexual and sexual development, and virulence in both animal and pla

98 elated to invasion, asexual replication, and sexual development; and (iv) stage-specific.

99 Our findings suggest that genes involved in sexual development are also important in mammalian disea

100 The potential roles of ASW and Hint in avian sexual development are discussed elsewhere.

101 Commitment to and completion of sexual development are essential for malaria parasites (

102 served as dsx-related genes that function in sexual development are found throughout the animal kingd

103 he possible role of a rhamnogalacturonase in sexual development are presented.

104 rimary sex-determining signals that initiate sexual development are remarkably diverse, ranging from

105 master switch, is on in females and controls sexual development as a splicing and translational regul

106 on master switch, Sex-lethal (Sxl), controls sexual development as a splicing and translational regul

107 During sexual development ascomycete fungi produce two types of

108 of phoA resulted in a switch from asexual to sexual development (at pH 8), or the absence of developm

109 isits is recommended to allow discussions of sexual development, behavior, and risk reduction.

110 gin is a poorly understood disorder of human sexual development, brought about by the premature activ

111 mplicated in the control of several genes in sexual development, but its function in gonad formation

112 a conserved role(s) for Dmrt1 in vertebrate sexual development, but there has been no functional ana

113 hways through an interaction with Msa2p, and sexual development by modulating Ran1p/Pat1p.

114 In males, SF-1 participates in sexual development by regulating expression of the polyp

115 Thus, TRA-1 coordinates sexual development by reinforcing the sex-determination

116 th a variety of parasite processes including sexual development, cell invasion, antigenic variation a

117 d the transition from asexual development to sexual development compared to the wild-type strain.

118 s within SF1 underlie different disorders of sexual development (DSD), including sex reversal, sperma

119 n are derepressed for fbp1 transcription and sexual development even while growing in a glucose-rich

120 this transcriptional activator functions in sexual development, filamentous growth, and pathogenicit

121 PBANKA_143750, which account for the loss of sexual development frequently observed in parasites tran

122 2-g (PF3D7_1222600), the master regulator of sexual development, from an epigenetically silenced stat

123 hormone (LHRH), the neuropeptide controlling sexual development, from hypothalamic neuroendocrine neu

124 es for male and female mating locus genes in sexual development, gamete fitness and reproductive succ

125 y of transcription factors whose function in sexual development has been well studied in invertebrate

126 y of transcription factors whose function in sexual development has been well studied.

127 xual regulator and suggest how regulation of sexual development has evolved in distinct ways in diffe

128 d regulatory pathways involved in Plasmodium sexual development have been of great interest in recent

129 Genes previously implicated in mammalian sexual development have either a male- or female-specifi

130 hway can have deleterious effects, including sexual development impairment, spontaneous abortion, and

131 y of the imprinted gene would result in male sexual development in a biparental diploid embryo.

132 a model in which Sxi1alpha and Sxi2a control sexual development in a homeodomain-dependent manner by

133 fore that DM domain genes may play a role in sexual development in a wide range of phyla.

134 etabolism and hyphal growth, while represses sexual development in A. nidulans.

135 to coordinate a balance between asexual and sexual development in A. nidulans.

136 We examined the effects of atrazine on sexual development in African clawed frogs (Xenopus laev

137 has been co-opted during evolution for male sexual development in amniotes.

138 ieve the filamentous morphotype required for sexual development in Cryptococcus.

139 ing factors repress translation and modulate sexual development in different tissues of C. elegans.

140 latory genes controls all aspects of somatic sexual development in Drosophila melanogaster.

141 demonstration that one gene family controls sexual development in Drosophila, C. elegans, and verteb

142 nservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one m

143 At birth, sexual development in males with a mutation in Wnt-4 app

144 A basic tenet of sexual development in mammals is that genetic sex--deter

145 with DM domains may therefore also regulate sexual development in mammals.

146 anding of the genetic programs that initiate sexual development in mosquitoes.

147 act downstream of these switches to control sexual development in most animal species.

148 positively as a transcriptional regulator of sexual development in Neurospora.

149 Rum1 act jointly to inhibit Cdc2 and promote sexual development in nitrogen-starved cells.

150 on factor MAT1-1-1 was discovered to control sexual development in P. chrysogenum.

151 commitment of asexually replicating forms to sexual development in Plasmodium berghei, a malaria para

152 pc1 also has an important role in regulating sexual development in S. pombe.

153 loci that determine mating type and regulate sexual development in Schizophyllum commune.

154 ities between the abnormalities of embryonic sexual development in Sfrp1(-/-)Sfrp2(-/-) embryos with

155 Northern analysis suggests that faster sexual development in the basA mutant might be due to a

156 t triggers asexual development and represses sexual development in the fungus Aspergillus nidulans.

157 Eight genes that are upregulated during sexual development in the heterothallic oomycete, Phytop

158 e velvet gene, veA, co-ordinates asexual and sexual development in the homothallic fungal species Asp

159 encode MAPKK kinases that are necessary for sexual development in these organisms.

160 es serve as a foundation for deeper study of sexual development in this pathogen and identification o

161 group (LG) 19, which controls male or female sexual development in threespine sticklebacks.

162 ls shown previously to synergistically alter sexual development in turtles also synergized in the YES

163 , nitrogen starvation initiates a program of sexual development in which cells express mating pheromo

164 and educational strategies to ensure healthy sexual development in young people.

165 ble of driving both early and late stages of sexual development, including gametogenesis.

166 domain and they regulate similar aspects of sexual development, including yolk protein synthesis and

167 Sexual development is controlled by the homeodomain tran

168 aled that the regulatory pathway controlling sexual development is far from linear and that it contai

169 Here we show that under conditions where sexual development is inhibited, a approximately 17-fold

170 In homozygous asd-I crosses, sexual development is initiated and large numbers of nor

171 Early sexual development is normal in ob/ob females; however,

172 eleasing hormone (GnRH) gene, which controls sexual development, is regulated by the POU protein SCIP

173 different mating types regulate a pathway of sexual development leading to mushroom formation and mei

174 ing fungal pathogen Cryptococcus neoformans, sexual development leads to the production of spores (su

175 al for an understanding of how they regulate sexual development, morphogenesis, differentiation and a

176 During sexual development, Neurospora crassa inactivates genes

177 t Axl2 is also involved in the regulation of sexual development, not only in A. nidulans, but also in

178 I highlight a number of common themes in the sexual development of different taxa, discuss how Dmrt g

179 Here we have determined that the sexual development of female mice is profoundly affected

180 ity and dynamics at the isoform level in the sexual development of fission yeast.

181 Starvation-independent sexual development of ncs1Delta was also complemented by

182 quence similarity to genes that regulate the sexual development of nematodes and insects.

183 transcription-factor characterization during sexual development of the human fungal pathogen Cryptoco

184 undant role for Sfrp1 and Sfrp2 in embryonic sexual development of the mouse.

185 ng transcription at those loci involved with sexual development of the parasite.

186 is suggests a critical role for Pfg27 in the sexual development of the parasite.

187 ation gene tra-3 is required for the correct sexual development of the soma and germ line in hermaphr

188 eparate roles for GATA4 and FOG2 proteins in sexual development of the testis we have ablated the cor

189 DM domain proteins may also play a role in sexual development of vertebrates.

190 R3/R3) mice show no adverse effects in their sexual development or fertility or in the attenuation of

191 ex determination, most cases of disorders of sexual development remain unexplained.

192 Elimination of sexual development rescues both growth and developmental

193 se repression of both fbp1 transcription and sexual development, resembling cells lacking either the

194 l germination and uncontrolled activation of sexual development resulting in a small colony covered b

195 Transfectants lacking Pfg27 abort early in sexual development, resulting in vacuolated, highly disa

196 f strains during growth and both asexual and sexual development revealed phenotypes for 43% of the de

197 sensitive to osmotic stress and impaired for sexual development, showing that fission yeast uses a co

198 o profound defects in growth and asexual and sexual development, similar to those observed for a muta

199 ge development, whereas six are required for sexual development/sporogony in mosquitoes.

200 certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in

201 havior are similar to those controlling body sexual development, suggesting biological advantages of

202 lso caused faster transition from asexual to sexual development, supporting the involvement of sphing

203 act that environmental conditions inhibiting sexual development suppress growth defects of the Delta

204 Exogenous cAMP, a key regulator for sexual development, suppressed conjugation and sporulati

205 factors Sxi1alpha and Sxi2a are required for sexual development that produces infectious spores, but

206 iated with earlier, and others with delayed, sexual development; these genetic results mimic the cont

207 e overrepresented among genes induced during sexual development; they were particularly enriched in a

208 expression in nascent merozoites to initiate sexual development through a hitherto unknown mechanism.

209 e) or off (male) state, Sxl controls somatic sexual development through control of downstream effecto

210 all proportion of these parasites commits to sexual development to mediate mosquito transmission.

211 t work on the signalling pathways regulating sexual development, together with transcriptomic and pro

212 GprH also represses sexual development under conditions favouring sexual fru

213 first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (

214 he molecular pathways they employ to control sexual development vary considerably.

215 ete fungus, Schizophyllum commune, regulates sexual development via proteins Y and Z.

216 le of the A alpha genes in the regulation of sexual development, we transformed various A alpha Y and

217 ting-type genes are the master regulators of sexual development; we are just beginning our search for

218 bias is less pronounced in cells undergoing sexual development, when many pombe-specific genes becom

219 , but little is known about how dsx controls sexual development, whether DSX(F) and DSX(M) bind diffe

220 Androgens are important for male sexual development, which depend on the cognate receptor

221 ated signalling cascade negatively regulates sexual development, which is required for proper prolife

222 onditions, the An-PHO80 cyclin also promotes sexual development while having a negative effect on ase