ライフサイエンスコーパス: sexual differentiation

1 falciparum cell fate by repressing parasite sexual differentiation.

2 and SRD5A2 which are both required for human sexual differentiation.

3 tive splicing may be an important feature of sexual differentiation.

4 that SAGA has two opposing roles regulating sexual differentiation.

5 nal and gonadal steroidogenesis and for male sexual differentiation.

6 n kinase kinase kinase (MAPKKK) essential to sexual differentiation.

7 estrogens, dietary phytoestrogens can affect sexual differentiation.

8 by tra-1, the master regulator of C. elegans sexual differentiation.

9 for GATA4 and FOG2 transcription factors in sexual differentiation.

10 on of three known targets to mediate somatic sexual differentiation.

11 ng switch that is required during Drosophila sexual differentiation.

12 nes and characterized their phenotype during sexual differentiation.

13 l sheep brain during the critical period for sexual differentiation.

14 rmine whether these steroid hormones mediate sexual differentiation.

15 lop during the postnatal critical period for sexual differentiation.

16 y (P) 6, when the song circuit is undergoing sexual differentiation.

17 factor in Drosophila that regulates somatic sexual differentiation.

18 ion to affect a G0 cell-cycle checkpoint and sexual differentiation.

19 ting-type locus operates at telomeres during sexual differentiation.

20 d therefore may contribute to the process of sexual differentiation.

21 xpression are often associated with abnormal sexual differentiation.

22 r neural origin also likely played a role in sexual differentiation.

23 e is known about the initiation of germ cell sexual differentiation.

24 appearance of male gonads and thus for male sexual differentiation.

25 of brain cells contributes to the process of sexual differentiation.

26 and in testes where it plays a role in male sexual differentiation.

27 female reproductive tract during normal male sexual differentiation.

28 dentify a core regulatory mechanism in plant sexual differentiation.

29 ent of sex chromosomes may contribute to its sexual differentiation.

30 le fetuses is an essential step in mammalian sexual differentiation.

31 plicing factor in both vegetative growth and sexual differentiation.

32 n the global regulatory pathway and terminal sexual differentiation.

33 eptor maintenance, normal transcription, and sexual differentiation.

34 that one of them, nam1, regulates entry into sexual differentiation.

35 of the timing and hormonal cues that govern sexual differentiation.

36 ry information to one day reverse defects of sexual differentiation.

37 xposure to gonadal steroids results in brain sexual differentiation.

38 ells is independent of the somatic events of sexual differentiation.

39 ng samples and are applicable after embryos' sexual differentiation.

40 ct the developmental program leading to male sexual differentiation.

41 vely in the mammalian genital ridge prior to sexual differentiation.

42 ene of Drosophila plays an important role in sexual differentiation.

43 sential for mammalian gonadogenesis prior to sexual differentiation.

44 ibited a wild-type phenotype with respect to sexual differentiation.

45 y, doublesex and intersex, to control female sexual differentiation.

46 experience-dependent neural plasticity, and sexual differentiation.

47 on of the mullerian ducts during normal male sexual differentiation.

48 c splicing of multiple pre-mRNAs involved in sexual differentiation.

49 pecific genetic influences from any study of sexual differentiation.

50 iae STE11, is required for pheromone-induced sexual differentiation.

51 ullerian ducts, an essential process in male sexual differentiation.

52 s is one of the earliest indications of male sexual differentiation.

53 ets, and ELAV/Hu proteins can interfere with sexual differentiation.

54 d transposase-derived endonuclease vital for sexual differentiation.

55 t PfAP2-G function is essential for parasite sexual differentiation.

56 lated alternative splicing during Drosophila sexual differentiation.

57 uenced by unknown mechanisms associated with sexual differentiation.

58 l cycle progression in G1 phase and promoted sexual differentiation.

59 pc embryos, a developmental stage before the sexual differentiation.

60 play during the switch from proliferation to sexual differentiation.

61 l signals that induce gene expression during sexual differentiation.

62 response to nutritional signals that induce sexual differentiation.

63 fore be integrated into a realistic model of sexual differentiation.

64 ng for Mullerian duct regression during male sexual differentiation.

65 ve opposing regulatory roles during S. pombe sexual differentiation.

66 e homozygotes fail to develop ovaries during sexual differentiation.

67 conserved in metazoan sex determination and sexual differentiation.

68 s, but also a model to understand defects in sexual differentiation.

69 s required continuously through the onset of sexual differentiation.

70 ivation of the Galpha protein Gpa1 to signal sexual differentiation [3, 5, 6].

71 SDC-2 was shown to induce hermaphrodite sexual differentiation and activate X chromosome dosage

72 n of Drosophila TRA-2, affecting both female sexual differentiation and alternative splicing of dsx p

73 n about the molecular basis of this abnormal sexual differentiation and any associated sexual dysfunc

74 ng a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappro

75 indicates that in utero BPA exposure affects sexual differentiation and behavior; however, the mechan

76 in studies of the molecular neurogenetics of sexual differentiation and behaviour has come from the u

77 d light on the pathogenesis of a disorder of sexual differentiation and brainstem-mediated sudden dea

78 fic cell types of the animal fetus to induce sexual differentiation and concentration peaks of the pl

79 f autophagy genes were necessary for asexual/sexual differentiation and deoxynivalenol (DON) producti

80 e causative agent of malaria, has to undergo sexual differentiation and development in anopheline mos

81 estosterone and 11-ketotestosterone, control sexual differentiation and development in juveniles and

82 ts suggest that PfPufs might function during sexual differentiation and development in Plasmodium thr

83 utilization exist, suggesting that complete sexual differentiation and development likely involve ad

84 New findings have suggested that the sexual differentiation and development of kisspeptin neu

85 on factor that plays important roles in male sexual differentiation and development.

86 ctor that regulates genes important for male sexual differentiation and development.

87 natomic and cellular changes that constitute sexual differentiation and discusses SRY and other genes

88 t through control of downstream effectors of sexual differentiation and dosage compensation [1, 4].

89 r GHMP kinase family members as mediators of sexual differentiation and dosage compensation and, poss

90 cripts, the Sex-lethal protein (SXL) governs sexual differentiation and dosage compensation in Drosop

91 bryogenesis at three time points surrounding sexual differentiation and female meiotic initiation, an

92 d hormones exert a profound influence on the sexual differentiation and function of the neural circui

93 f perinatal GnRH signaling for driving brain sexual differentiation and indicate that kisspeptin inpu

94 in the Drosophila LAMMER kinase, Doa, alter sexual differentiation and interact synergistically with

95 the genital ridge and Wolffian duct prior to sexual differentiation and is expressed at higher levels

96 ne doublesex, which controls many aspects of sexual differentiation and is necessary for normal court

97 Thus, sexual differentiation and meiotic entry of germ cells i

98 participates in signaling pathways including sexual differentiation and morphogenesis.

99 gen; this event is essential for proper male sexual differentiation and occurs between embryonic days

100 arasite Plasmodium berghei, Pbmap-2, in male sexual differentiation and parasite transmission to the

101 or superfamily, plays a central role in male sexual differentiation and prostate cell proliferation.

102 rfamily that plays an important role in male sexual differentiation and prostate cell proliferation.

103 Despite their importance in sexual differentiation and reproduction, Y chromosome ge

104 E-47 during early life stages can alter both sexual differentiation and reproductive function.

105 aditional concepts about mechanisms of brain sexual differentiation and reveal a significant function

106 ion factors doublesex and fruitless controls sexual differentiation and sexual behavior.

107 three, differential cell death is central to sexual differentiation and shared molecular mechanisms h

108 endogenous tra-2 gene for both normal female sexual differentiation and spermatogenesis.

109 be MAP kinases are known, Spk1, required for sexual differentiation and sporulation, and Spc1/Sty1/Ph

110 omes linked to DMRT1, including disorders of sexual differentiation and testicular cancer.

111 This paper reviews sexual differentiation and the role of gonadal steroids

112 Roles in development, sexual differentiation, and long-term neuronal survival

113 r Shk1 in the regulation of cell morphology, sexual differentiation, and mitosis in S. pombe.

114 quired for cell cycle control, initiation of sexual differentiation, and protection against cellular

115 nd anti-Mullerian hormone which mediate male sexual differentiation, and the female developmental pat

116 lpha components are insufficient to regulate sexual differentiation, and we identify a novel alpha-sp

117 icating different aspects of C. elegans male sexual differentiation are coordinated among DM domain f

118 om mice at d 10.5 postconception (PC) before sexual differentiation, at d 17.5 PC after the first emb

119 inally, the set of genes induced late during sexual differentiation, at the time of spore formation,

120 Sex-lethal (Sxl) controls autoregulation and sexual differentiation by alternative splicing but regul

121 ides have recently been reported to modulate sexual differentiation by interacting with nuclear stero

122 Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic in

123 ncerted molecular mechanisms that govern the sexual differentiation developmental decision.

124 le or female cells, even from embryos before sexual differentiation, differ in gene expression and se

125 ndirect effects, notably the consequences of sexual differentiation, display complex dependencies.

126 mpromised in splicing functions required for sexual differentiation, displaying only partial autoregu

127 xpression during a sensitive period of brain sexual differentiation disrupts the organization of sex

128 of female isoforms of two key regulators of sexual differentiation: doublesex and fruitless.

129 tate in the germ line from the initiation of sexual differentiation during fetal development and into

130 . elegans is well studied, but regulation of sexual differentiation, especially later in gonadal deve

131 te global sexual fate into appropriate local sexual differentiation events is perhaps the least under

132 ermination decision and directing downstream sexual differentiation events.

133 ency but is not essential for female or male sexual differentiation, fertility, or lactation.

134 atching day 25 during a heightened period of sexual differentiation (following BrdU injections on day

135 Our findings demonstrate how a sexual differentiation gene can build a sex-specific cir

136 s and the hg1 motoneuron is regulated by the sexual differentiation gene doublesex.

137 orted here, we have examined the role of the sexual differentiation genes transformer (tra) and doubl

138 cooperate to silence diverse loci, including sexual differentiation genes, genes encoding transmembra

139 The central dogma of mammalian brain sexual differentiation has contended that sex steroids o

140 of specific genes involved in the process of sexual differentiation has made it possible to determine

141 nsively studied, the actual mechanism of its sexual differentiation has not been established.

142 the classical estrogen receptor (ERalpha) in sexual differentiation has remained elusive.

143 several components of the pathway regulating sexual differentiation have been elucidated, the mechani

144 Consistent with such a terminal function in sexual differentiation, her encodes a protein with C2H2-

145 hese X-linked brain genes may play a role in sexual differentiation if they are expressed at a higher

146 cates a role for environmental modulation of sexual differentiation in amphibians, which are assumed

147 4 develop essentially normally, undergo full sexual differentiation in both sexes, and are fertile.

148 mple of a key regulator of cell identity and sexual differentiation in C. neoformans, and its identif

149 nt Drosophila species supports the idea that sexual differentiation in D. melanogaster and D. virilis

150 e DNA binding motif, have been implicated in sexual differentiation in diverse metazoan organisms.

151 T proteins) control sex determination and/or sexual differentiation in diverse metazoans and are impl

152 elated to MAB-3 (DM domain proteins) control sexual differentiation in diverse metazoans.

153 Sexual differentiation in Drosophila is regulated throug

154 x determination hierarchy to control somatic sexual differentiation in Drosophila melanogaster.

155 esex) transcription factor regulates somatic sexual differentiation in Drosophila.

156 (DSX) transcription factor regulate somatic sexual differentiation in Drosophila.

157 he hermaphrodite (her) gene is necessary for sexual differentiation in Drosophila.

158 cascade, and triggers male or female somatic sexual differentiation in Drosophila.

159 f sex-specific splicing events that controls sexual differentiation in Drosophila.

160 nd mab-3 of Caenorhabditis elegans, regulate sexual differentiation in multiple phyla.

161 Brain sexual differentiation in rodents results from the perin

162 Analyzing over 500 genes important for sexual differentiation in S. cerevisiae, we find many ho

163 ch to the 'function' question is to contrast sexual differentiation in standard laboratory animals wi

164 proteins) are also central to the control of sexual differentiation in the ascomycetes.

165 iae STE11, is required for pheromone-induced sexual differentiation in the fission yeast Schizosaccha

166 bility, polarized growth and cell shape, and sexual differentiation in the fission yeast, Schizosacch

167 n hormone (AMH) is an essential messenger of sexual differentiation in the foetus and is an emerging

168 physiological functions including secondary sexual differentiation in the male and the induction of

169 Here, we traced the initiation of germ cell sexual differentiation in XX gonads using the Stra8 gene

170 ggesting that different song nuclei initiate sexual differentiation independently of transsynaptic ma

171 own of DMRT1 expression during the period of sexual differentiation induces feminisation of male embr

172 Conversion from asexual proliferation to sexual differentiation initiates the production of the g

173 he Ser2 requirement for transcription during sexual differentiation is bypassed by subtracting Ser7,

174 Sexual differentiation is essential for this process, as

175 sence of testicular hormones, the pathway of sexual differentiation is female.

176 Exposure to estrogens during the period of sexual differentiation is known to adversely affect the

177 e role of the androgen receptor (AR) in male sexual differentiation is revealed in part by the analys

178 We have also determined that testis sexual differentiation is sensitive to the timing of GAT

179 an inherent sex identity and that, in birds, sexual differentiation is substantively cell autonomous.

180 A major advantage of the rat as a model of sexual differentiation is that treatment of neonatal fem

181 e most common process implicated in neuronal sexual differentiation, it is currently unknown how deve

182 hown that DOA kinase is essential for normal sexual differentiation, levels of both kinase isoforms a

183 Current theories of sexual differentiation maintain that ovarian estrogen pr

184 y individuals do better if female; secondary sexual differentiation may be important for understandin

185 We examined whether sexual differentiation of an androgen receptor-dependent

186 that these ribosomal proteins may influence sexual differentiation of Area X and RA, potentially reg

187 eam of tra-1 and is known to be required for sexual differentiation of at least two tissues.

188 Estrogenic effects have been implicated in sexual differentiation of brain and behavior, in part by

189 on the sex chromosomes play a direct role in sexual differentiation of brain and behavior.

190 tems during development, and are crucial for sexual differentiation of brain and behavior.

191 us, Bax-dependent cell death is required for sexual differentiation of cell number, regardless of whe

192 Thus, the sexual differentiation of dopamine neurons in the AVPV a

193 (DSDs) are congenital anomalies that affect sexual differentiation of genitourinary organs and secon

194 Sexual differentiation of malaria parasites into gametoc

195 anos family protein, NANOS2, is required for sexual differentiation of male (XY) germ cells in mice,

196 ired for stress responses, reproduction, and sexual differentiation of male fetuses, exerts its activ

197 tal testosterone surge, and disordered brain sexual differentiation of male mice in which the kisspep

198 from testicular androgens promotes masculine sexual differentiation of neuroanatomy and sexual behavi

199 sed whether GPR54 signaling is essential for sexual differentiation of other sexually dimorphic trait

200 hesis that hormones and genes play a role in sexual differentiation of partner preferences, as in the

201 One family member, Ste11p, directs sexual differentiation of Schizosaccharomyces pombe by b

202 se findings form the basis of a new model of sexual differentiation of the AVPV that may also apply t

203 o identify upstream pathways responsible for sexual differentiation of the AVPV, we used targeted apo

204 s of doublesex (dsxF and dsxM), that control sexual differentiation of the body, also contribute to s

205 in male rodents plays a significant role in sexual differentiation of the brain and adult behaviors.

206 raises interesting questions with respect to sexual differentiation of the brain and behavior.

207 xt discuss current data on the mechanisms of sexual differentiation of the brain and on sex differenc

208 on by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic re

209 Sexual differentiation of the brain is determined in par

210 rmones undoubtedly play an important role in sexual differentiation of the brain, they are not the on

211 sterone release in male rats is critical for sexual differentiation of the brain.

212 consequence of reducing SRC-1 protein during sexual differentiation of the brain.

213 idual's genetic constitution, can affect the sexual differentiation of the brain.

214 n exhibiting sex-different expression during sexual differentiation of the hypothalamic sexually dimo

215 Sexual differentiation of the malaria parasite is a pre-

216 Although alternative mechanisms exist, sexual differentiation of the male mammalian brain is in

217 ital representations might tell us about the sexual differentiation of the mammalian brain.

218 death is not a primary mechanism leading to sexual differentiation of the oSDN.

219 related to their unique social organization, sexual differentiation of the prairie vole spinal cord d

220 ted that the GABAergic system is involved in sexual differentiation of the rodent hypothalamus.

221 ptosis by T is one mechanism involved in the sexual differentiation of the SDN-POA.

222 Development of the vagina depends on sexual differentiation of the urogenital sinus ridge, an

223 Sexual differentiation of the zebra finch (Taeniopygia g

224 Mechanisms regulating sexual differentiation of the zebra finch song system ap

225 s evaluating the role of steroid hormones in sexual differentiation of the zebra finch song system ha

226 One model of the sexual differentiation of the zebra finch song system ho

227 The exact mechanism(s) responsible for sexual differentiation of the zebra finch song system re

228 estrogen, indicating a role for aromatase in sexual differentiation of these neurons.

229 ed male mice as in WT males, indicating that sexual differentiation of this population of neurons is

230 ure to 17alpha-ethynylestradiol (EE2) during sexual differentiation of X. laevis were evaluated by us

231 n as a pivotal molecular mechanism promoting sexual differentiation of XY germ cells.

232 ypothalamus (AVPV) to test the dependence of sexual differentiation on a functional ERalpha by compar

233 directing all aspects of Drosophila somatic sexual differentiation outside the nervous system.

234 The sexual differentiation paradigm contends that the female

235 ology and introduce a major component of the sexual differentiation pathway in Plasmodium that may pr

236 ependent phase and a late androgen-dependent sexual differentiation phase.

237 nknown and thought to mediate all aspects of sexual differentiation, physiology and behavior.

238 In Drosophila, sexual differentiation, physiology, and behavior are tho

239 al inhibition during the critical period for sexual differentiation prevented sex differences in micr

240 hophysiologic effects of androgens including sexual differentiation, prostate development, and cancer

241 ptor function is required for male embryonic sexual differentiation, pubertal development and the reg

242 Male sexual differentiation relies upon testicular secretion

243 have demonstrated previously that mammalian sexual differentiation requires both the GATA4 and FOG2

244 Thus normal sexual differentiation requires exquisite timing of feta

245 Human male sexual differentiation requires production of fetal test

246 s, including a fundamental conserved role in sexual differentiation, species-specific morphology and

247 wide array of biological processes including sexual differentiation, spermatogenesis, and prostate ca

248 the twentieth century, the dominant model of sexual differentiation stated that genetic sex (XX versu

249 STE50, an S. cerevisiae protein required for sexual differentiation that we show can bind to STE11.

250 onads will develop as testes or ovaries; and sexual differentiation, the subsequent events that ultim

251 During male sexual differentiation, the transforming growth factor-b

252 use forebrain that show opposite patterns of sexual differentiation: the principal nucleus of the bed

253 How these genes coordinate sexual differentiation throughout the body is a key unan

254 single gonadal cell type ultimately controls sexual differentiation throughout the body.

255 quivalent between XO and XX animals, causing sexual differentiation to be controlled by genes downstr

256 nt predisposition at the PvT and (ii) by the sexual differentiation trajectory established early in g

257 he PvT further indicate that embryos adopt a sexual differentiation trajectory many days prior to the

258 Although central for sexual differentiation, very little is known about the e

259 such as an antigen-coated surface, parasite sexual differentiation, virulence, and drug resistance,

260 in inputs to GnRH neurons for the process of sexual differentiation was demonstrated by the lack of a

261 fferent splicing forms of Dsx in controlling sexual differentiation was present in the common ancesto

262 This serial model of sexual differentiation was simple, unifying and seductiv

263 Specific environmental conditions trigger sexual differentiation, which leads to an internal progr