ライフサイエンスコーパス: sham surgery

1 (3 subjects receiving TF and 1 receiving the sham surgery).

2 r, minicircle carrying microRNA-scramble, or sham surgery.

3 es) injected bilaterally into the putamen or sham surgery.

4 ived a mild fluid percussion injury (FPI) or sham surgery.

5 middle cerebral artery occlusion (MCAO), or SHAM surgery.

6 bjected to transverse aortic constriction or sham surgery.

7 nutes of either unilateral renal ischemia or sham surgery.

8 y prepared for CCI injury (4 m/s, 3.2 mm) or sham surgery.

9 kg) only showed an am to pm difference after sham surgery.

10 of 127 rats that survived experimental MI or sham surgery.

11 lesions, and six control subjects underwent sham surgery.

12 either an 18-(CLP18) or a 21-gauge needle or sham surgery.

13 ere TCP/HA/ACS and ?-BSM without rhBMP-2 and sham surgery.

14 e 24 hours after bile duct ligation (BDL) or sham surgery.

15 eral putaminal implantation of hRPE cells or sham surgery.

16 assigned to receive either the transplant or sham surgery.

17 pal lesions, and controls that had undergone sham surgery.

18 otoreceptor survival than the parent line or sham surgery.

19 Five rats underwent sham surgery.

20 ol animals received grafts of fibroblasts or sham surgery.

21 ter unilateral ureteral obstruction (UUO) or sham surgery.

22 nificantly enhanced compared with that after sham surgery.

23 Controls underwent sham surgery.

24 randomized to cecal ligation and puncture or sham surgery.

25 or 72 hours after subarachnoid hemorrhage or sham surgery.

26 ression after L5 spinal nerve transection or sham surgery.

27 Dawley rats received adrenalectomy (ADX) or sham surgery.

28 about 4 days after bilateral enucleation or sham surgery.

29 e-matched untransplanted rats, and rats with sham surgery.

30 al naris closure on postnatal day 1 (PN1) or sham surgery.

31 RRM + candesartan (Can, 10 mg/kg per d), or sham surgery.

32 Performance was unchanged following sham surgery.

33 '-triiodothyronine replacement (3 ng/hr), or sham surgery.

34 ni (GLX + CTX) transection, as well as after sham surgery.

35 mly assigned to APM, and 76 were assigned to sham surgery.

36 ter hRPE cell implantation compared with the sham surgery.

37 and putamen (1.0 x 10(12) vector genomes) or sham surgery.

38 nigra bilaterally in PD was not superior to sham surgery.

39 nded with long-term motor improvements after sham surgery.

40 r controlled cortical impact (CCI) injury or sham surgery.

41 ization, then again at 6 and 12 months after sham surgery.

42 bjected to transverse aortic constriction or sham surgery.

43 The diabetic animals underwent DJB or sham surgery.

44 only; and in the final group three underwent sham surgery.

45 induced obesity received AGB implantation or sham surgery.

46 f adult male rats after gonadectomy (Gdx) or sham surgery.

47 gned to arthroscopic partial meniscectomy or sham surgery.

48 cecal ligation and double puncture (2CLP) or sham surgery.

49 ed randomly to groups that received BES or a sham surgery.

50 e subjected to controlled cortical impact or sham surgery.

51 permanent myocardial infarction protocol or sham surgery.

52 hort term (4 weeks), compared with mice with sham surgery.

53 ts, 35 underwent cell transplantation and 36 sham surgery.

54 derwent cecal ligation and puncture (CLP) or sham surgery.

55 grees C stimulation after QUIS injections or sham surgery.

56 ned to receive a high-or low-dose implant or sham surgery.

57 d no antiparkinsonian benefits compared with sham surgery.

58 , 15, and 30 days after aortic denudation or sham-surgery.

59 Mice underwent PH or sham surgeries.

60 onditioning, at levels similar to those with sham surgeries.

61 r dorsal or ventral hippocampus or underwent sham surgeries.

62 cifically in autonomic neurons after RYGB or sham surgeries.

63 rats underwent subdiaphragmatic vagotomy or sham surgery 1 week prior to study.

64 +/- 5.6%), compared with animals undergoing sham surgery (1.2 +/- 1.4%).

65 155 IU, p < .05), and lactate dehydrogenase (sham surgery: 160 +/- 18, control: 1499 +/- 311, PUGNAc:

66 ach): 1) control = non-ingestion of caffeine/sham surgery; 2) caffeine = ingestion of caffeine/sham s

67 surgery; 2) caffeine = ingestion of caffeine/sham surgery); 3) ovariectomized (OVX) = non-ingestion o

68 ct sites in two animals receiving ACS versus sham surgery (4-week healing interval) were not evaluate

69 +/- 21 IU, p < .05), aspartate transaminase (sham surgery: 536 +/- 110, control: 1661 +/- 215, PUGNAc

70 age-induced increase in serum interleukin-6 (sham surgery: 8 +/- 6, control: 181 +/- 36, PUGNAc: 42 +

71 ng aortic banding (16 males, 18 females), or sham surgery (9 males, 9 females).

72 /- 22 pg/mL, p < .05), alanine transaminase (sham surgery: 95 +/- 14, control: 297 +/- 56, PUGNAc: 12

73 on via endovascular perforation technique or sham surgery, a breathing gas mixture containing 50 vol%

74 udied: RYGB, sham surgery pair-fed (PF), and sham surgery ad libitum (AL) fed rats.

75 er moderate fluid-percussion brain injury or sham surgery, adult male Sprague Dawley rats received ve

76 s) to receive a transplant of nerve cells or sham surgery; all were to be followed in a double-blind

77 Sham surgery also resulted in photoreceptor rescue but a

78 or eligibility, 23 were randomly assigned to sham surgery and 22 to AAV2-GAD infusions; of those, 21

79 en received 6 months of placebo (n = 87), or sham surgery and 6 months of once- or twice-daily omepra

80 le of rats after bile duct ligation (BDL) or sham surgery and applied to normal primary liver SEC wit

81 corticosterone recovered most rapidly after sham surgery and least rapidly after CLP18.

82 at underwent adrenalectomy (ADX) or received sham surgery and performed immunohistochemistry for 3alp

83 mia decreased laser-Doppler flux in both the sham surgery and postarrest groups.

84 Additional rats underwent ADX or sham surgery and received a corticosterone pellet (10 or

85 Additional rats underwent ADX or sham surgery and received a corticosterone pellet (10 or

86 underwent hypoxic-asphyxic cardiac arrest or sham surgery and recovered for 2 hrs with normothermia f

87 ale rats were catheterized 13 d after BDL or sham surgery and studied while awake 18 to 24 h later.

88 ed to either remote preconditioning (RPC) or sham surgery and then subsequently underwent 2 h MCAo 24

89 ybrid mice were given hippocampal lesions or sham surgery and then tested.

90 s then underwent either ovariectomy (OVX) or sham surgery and thereafter either continued to be fed a

91 Two and seven patients died in the sham surgery and transplantation group, respectively; on

92 wild-type (WT) littermates underwent GIBP or sham surgery and were culled 10 days postoperatively.

93 ) received electrolytic lesions of the Me or sham surgery and were tested for their ability to (a) di

94 Sham-surgery and SCNX mice were treated with either Meth

95 serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neurosurgery

96 heres, TRH microspheres, blank microspheres, sham surgeries) and underwent stereotactic neurosurgery

97 .2-2.7 atm) fluid percussion (FP) injury (or sham surgery) and processed for hippocampal electrophysi

98 ion (GLX), chorda tympani transection (CTX), SHAM surgery, and combined transection (CTX + GLX).

99 ere subjected to bile duct ligation (BDL) or sham surgery, and liver and kidney RNA and protein were

100 procedure trials, including those involving sham surgery, and provide an ethical framework for asses

101 ormed 14-18 d after spinal nerve ligation or sham surgery, and the effects of the FAAH inhibitor cycl

102 rats received either estrogen replacement or sham surgery, and then received either a unilateral inje

103 s underwent bilateral adrenalectomy (ADX) or sham surgery, and were killed after 1, 3, 7 or 14 days.

104 s underwent bilateral adrenalectomy (ADX) or sham surgery, and were killed after 1, 3, 7, or 14 d.

105 Sham-surgery animals received injections of carrier medi

106 Three control groups were used: One received sham surgery, another received no surgery or testosteron

107 Sham surgeries are difficult to justify ethically, yet t

108 placebo effects in PD subjects randomized to sham surgery as part of a double-blind gene therapy tria

109 Lesioned animals with ectopic grafts or sham surgery as well as animals that received intra-nigr

110 fferences between sites receiving ACS versus sham surgery at 4 or 8 weeks.

111 ice received a controlled cortical impact or sham surgery at postnatal day 21, approximating a toddle

112 were subjected to traumatic brain injury or sham surgery at postnatal day 21.

113 th an active or inactive device or underwent sham surgery before photoreceptor degeneration.

114 Six weeks following the obstructive or sham surgery, bladder function was evaluated by awake cy

115 onses were recorded in 6 of 13 RCS rats with sham surgery, but these responses were significantly dif

116 ssible roadmap for the ethical assessment of sham surgery clinical trials (CTs), focusing on methodol

117 ether ineffective as a neuroprotectant after sham surgery compared to OVX or after OVX plus estrogen

118 ), ethanol increased 3alpha,5alpha-THP after sham surgery, compared with saline controls, with no eth

119 A sham surgery control group (n = 10) was also included.

120 microcarrier-bound human RPE cells versus a sham surgery control in patients with advanced Parkinson

121 e-aged mice showed more severe deposits than sham-surgery control animals.

122 was significantly higher (P =0.001) than the sham-surgery control group (1.7 +/- 1.9 mm).

123 ls with orbital frontal cortex ablations and sham-surgery control squirrels were presented with a cag

124 at least 4 months of age, over and above the sham-surgery control.

125 We did a multicentre, double-blind, sham-surgery controlled trial in patients with advanced

126 This study was part of a large double-blind sham surgery-controlled trial designed to determine the

127 A 12-month double-blind sham-surgery-controlled trial assessing adeno-associated

128 evels when compared with chronically hypoxic sham surgery controls (P > 0.05).

129 g from 9.8+/-0.9 to 0.8+/-0.4 ml/100 mg/min (sham surgery controls vs. LPA stenosis, P < 0.05), but t

130 from 5.8+/-0.5 to 10.0+/-1.4 ml/ 100 mg/min (sham surgery controls vs. LPA stenosis, P < 0.05).

131 ed with DHA (LDL-DHA), triolein (LDL-TO), or sham surgery controls.

132 eated SCI animals were smaller than those of sham-surgery controls, and these reductions were both pr

133 roup back to baseline expression observed in sham-surgery controls.

134 atment, and the remaining 12 sites served as sham-surgery controls.

135 orn (DH) neurons in adult rats 1 month after sham surgery, contusion SCI, and SCI treated with a sele

136 cy of trial methodology/design adopted for a sham surgery CT; specific informed consent, and economic

137 Sham surgery did not impact either proliferation or surv

138 Sham surgery did not reduce the regional blood volume ch

139 Resection or sham surgery elevated IgG and IgA in serum and in lavage

140 rolytic cerebellar dentate nuclei lesions or sham surgery followed by a 30-day recovery.

141 In animals undergoing sham surgery followed by bacterial challenge, PSEUDOMONA

142 pectively, whereas 95% of animals undergoing sham surgery followed by P. aeruginosa administration su

143 induce HF, confirmed by echocardiography, or sham surgery, followed by 6 weeks treatment with epleren

144 gation and 26-gauge needle puncture (CLP) or sham surgery, followed by the intratracheal (i.t.) admin

145 Sham surgery, GL transection, and sublingual and submaxi

146 -surgery, sham surgery, glucan + no-surgery, sham surgery + glucan, and CLP groups were employed as c

147 No-surgery, sham surgery, glucan + no-surgery, sham surgery + glucan

148 s in the AAV2-neurturin group and two in the sham surgery group developed tumours.

149 s (46%) in the APM group and 37 (49%) in the sham surgery group reported catching or locking before s

150 my group as compared with 23.3 points in the sham-surgery group (between-group difference, -1.6 point

151 e transplantation group as compared with the sham-surgery group when patients were tested in the morn

152 e partial-meniscectomy group and five in the sham-surgery group) or serious adverse events (one and z

153 transplantation group and -0.4+/-1.7 in the sham-surgery group.

154 Comparison among the 3 sham surgery groups reveals that CryAB overexpression is

155 s or changes over time in the transplant and sham surgery groups.

156 Sham surgery had little effect on the ERG.

157 Sham surgery had no effect.

158 ived BES and 11.1% of those who received the sham surgery had recurrent acute pancreatitis (95% confi

159 feeding and after either RDN (HFD + RDN) or sham surgery (HFD + sham).

160 In the patients who received sham surgery, holes were drilled in the skull but the du

161 Control rats underwent sham surgery, implantation with inactive prosthetics, or

162 roximately 50% partial pancreatectomy versus sham surgery in 14 dogs.

163 coronary artery was performed in 12 mice and sham surgery in 7.

164 is intervention would be more effective than sham surgery in a controlled trial is not known.

165 Twelve animals received ACS alone versus sham surgery in contralateral defects.

166 GAD in the subthalamic nucleus compared with sham surgery in patients with advanced Parkinson's disea

167 lated cell technology implant in one eye and sham surgery in the contralateral eye.

168 ive a high- or low-dose implant in 1 eye and sham surgery in the fellow eye.

169 ive a high- or low-dose implant in 1 eye and sham surgery in the fellow eye.

170 Grafts of Schwann cells or fibroblasts and sham surgery induced a reactive Muller glial response.

171 The use of sham surgery is controversial from an ethical point of v

172 ed to ischemic strokes, hemorrhagic strokes, sham surgeries, kainate-induced seizures, hypoxia, or in

173 sity was observed at day 2, with recovery to sham-surgery levels by day 7.

174 ore and 6.3% after; P < .001), but not after sham surgery (mean 8.6% before and 8.9% after).

175 lete subdiaphragmatic vagotomies (n = 18) or sham surgeries (n = 12).

176 e subjected to lateral FP injury (n = 18) or sham surgery (n = 12).

177 Control animals underwent sham surgery (n = 12).

178 ecal ligation and puncture (CLP) (n = 34) or sham surgery (n = 13) was performed in female ND4 mice a

179 T and B cells also underwent CLP (n = 14) or sham surgery (n = 14) and had examination of tissues for

180 Renal artery stenosis surgery (n = 10) or sham surgery (n = 5) was performed, and the stenotic and

181 21 days after coronary ligation (n = 11) or sham surgery (n = 5).

182 Adult female rats underwent sham surgery (n = 6), bilateral L5-S2 ventral root avuls

183 ter unilateral ureteral obstruction (UUO) or sham surgery (n = 8 mice per group).

184 jected to unilateral ureteral obstruction or sham surgery (n = 8/group; sham, days 3, 7, 14, and 21).

185 Mice were randomized to one of three groups: Sham surgery (n=18), surgical brain injury without treat

186 eral renal wrapping to produce HTN (n=12) or sham surgery (n=6) was performed in adult dogs.

187 us aldosterone; n=9) and young control dogs (sham surgery; n=13).

188 pocampectomy, bilateral neocortical removal, sham surgery, no surgery).

189 After MI but not after sham surgery, OIM/OIM animals exhibited significantly in

190 We performed bile-duct ligations or sham surgeries on C57BL/6 or toll-like receptor 4 (TLR4)

191 rats underwent unilateral naris occlusion or sham surgery on either post-natal day (PN) 1 or after PN

192 rom rats that had undergone naris closure or sham surgery on either postnatal day 1 (P1) or P30 and w

193 Adult NZW rabbits underwent ACLT or sham surgery on one hind limb, while each contralateral

194 that received bilateral freezing lesions or sham surgery on postnatal day (P) 1, 3 or 5.

195 e subjected to subdiaphragmatic vagotomy (or sham surgery) on day 0 and had a cannula implanted into

196 more prominent than similar timepoints after sham surgery or 30 min of ischemia.

197 l Pik3r1 (p85alpha)-deficient mice underwent sham surgery or 30% resection.

198 /+)) or SR knockout (SR(-/-)) mice underwent sham surgery or BDL for 3 or 7 days.

199 LJ wild type (WT) controls were subjected to sham surgery or bile duct ligation.

200 preparations obtained from rats subjected to sham surgery or cecal ligation and puncture (CLP).

201 ncompetent NOD-Scids and diabetic NODs given sham surgery or empty microcapsules.

202 Animals received sham surgery or excitotoxic BLA lesions and were given i

203 Wistar rats underwent control sham surgery or ligation of the left coronary artery and

204 sis, adult male Sprague-Dawley rats received sham surgery or moderate parasagittal fluid-percussion b

205 Subsequently, the rats underwent either sham surgery or neurotoxic lesions of the hippocampus (H

206 ore testing outperformed aged rats receiving sham surgery or ovx 21 days before testing.

207 Sprague-Dawley rats had either sham surgery or tight ligation of L5 and L6 spinal nerve

208 ight fasted animals were subjected to either sham surgery or trauma-hemorrhage and during the resusci

209 ar nuclei (MVN) of rats, 1 week after either sham surgery or unilateral labyrinthectomy (UL).

210 All tracked longer than sham-surgery or nonsurgical dystrophic eyes.

211 A) active MPA, (M) minimally active MPA, (S) sham surgery, or (C) no surgery and the opposite eye was

212 ere randomized to no manipulation (control), sham surgery, or cecal ligation and puncture.

213 ter ligation of the L5 and L6 spinal nerves, sham surgery, or no surgery.

214 Following either sham surgery, or spinal nerve ligation, spinal muscimol

215 nted with inactive devices, those undergoing sham surgery, or the nonsurgical control eyes.

216 erone and ACTH increased from am to pm after sham surgery (p < .05) but not after CLP.

217 betes onset by 120 +/- 49 days compared with sham surgery (P < .05) without a difference in body weig

218 CLP but not in control mice or in mice after sham surgery (p < .05).

219 for transplantation vs -10.1 [SD 12.26] for sham surgery, p=0.9).

220 ically obese Zucker rats were studied: RYGB, sham surgery pair-fed (PF), and sham surgery ad libitum

221 e injected into the postcommissural putamen; sham surgery patients received partial burr holes.

222 ine HCl (CGS21680), 10-14 d after CCI versus sham surgery, produced a long-duration reversal of mecha

223 HDA) into the medial forebrain bundle, while sham surgery rats received saline injections.

224 Approximately 24 h after CLP or sham surgery, rats were anesthetized and myocardial func

225 Following ischemic or sham surgery, rats were randomized to either complex env

226 Following ischemic or sham surgery, rats were randomized to either EC, EX, or

227 , a unilateral cortical lesion compared with sham surgery reduced hippocampal GluA2, GluA1, and A1R s

228 subjecting juvenile RMs to thymectomy versus sham surgery, respectively, followed by total CD4(+) T c

229 , moderate, and mild spinal cord injury, and SHAM surgery, respectively.

230 Mice that underwent sham surgery served as sham controls.

231 Hamsters underwent sham surgery (SH), bilateral BX, or electrolytic or radi

232 thoracic 7 (T7X), lumbar 5 (L5X) levels, or sham surgery (Sh), responses to VS were measured, the va

233 y (LAD) ligation (post-MI group [n = 10]) or sham surgery (sham group [n = 10]).

234 ere grouped (six animals in each group) into sham surgery (sham group), left anterior descending (LAD

235 oups: sedentary (Sed) or exercise (Exc) with sham surgery (Sham) or FPI: Sham/Sed, Sham/Exc, FPI/Sed,

236 Young male and female F344 rats underwent sham surgery (SHAM), gonadectomy (GX), or GX plus suprap

237 underwent coronary ligation to induce MI or sham surgery (SHAM).

238 a with G-CSF treatment (GI+G-CSF, n=42), and sham surgery (Sham, n=26).

239 coronary artery ligation (HF group; n=17) or sham surgery (sham-operated control group, n=15).

240 The effect of sham surgery suggests that female rats are vulnerable to

241 Three days after administration of LDL-TO or sham surgery, the control rats had large, highly vascula

242 More than one year after ovariectomy or sham surgery, there were few differences in the histomor

243 of a torn meniscus has no added benefit over sham surgery to relieve knee catching or occasional lock

244 At 3 months, sheep were randomized to sham surgery versus isolated undersized annuloplasty ver

245 Renal IRI or sham surgery was induced in C57BL/6 mice, and SCr level

246 Sham surgery was performed as an infarction control (n =

247 IT or sham surgery was performed on 4-month-old male UCD-T2DM

248 Sham surgery was performed on the contralateral artery,

249 eline and following small bowel resection or sham surgery was performed.

250 TAC and sham surgeries were performed after baseline imaging.

251 Construct injections or sham surgeries were performed in 28 eyes; 11 were inject

252 sham surgeries were performed in a control group of mice

253 Adult male prairie voles received a sham surgery, were gonadectomized, or were gonadectomize

254 aputaminal AAV2-neurturin is not superior to sham surgery when assessed using the UPDRS motor score a

255 sibility rats were adrenalectomized or given sham surgery, with half of the adrenalectomized rats rec