ライフサイエンスコーパス: shared epitope

1 ultiple interactions and specificity for the shared epitope.

2 CTL line recognizes at least one additional shared epitope.

3 Q452 and Q453 to be able to contribute to a shared epitope.

4 Genomic DNA was analyzed for presence of the shared epitope.

5 ave implicated alleles of DRB1 that encode a shared epitope.

6 sive disease or both carried 2 copies of the shared epitope.

7 t ITP patients recognize a limited number of shared epitopes.

8 percent of the FDRs had > or =1 copy of the shared epitope, 20% had > or =1 copy of the PTPN22 polym

9 5H includes a highly homologous motif of the shared epitope, a sequence that is overrepresented in ba

10 A) has long been associated with an HLA-DRB1 shared epitope, a systematic search for other epitopes h

11 HLA-DRB1*1001 (DR1001) is a shared epitope allele associated with rheumatoid arthrit

12 onditioned TDTs revealed overtransmission of shared epitope alleles (P = 2.12 x 10(-5)) and an allele

13 t interaction for anti-CCP formation between shared epitope alleles and smoking in 3 North American R

14 The shared epitope alleles consistently correlated with anti

15 -environment interaction between smoking and shared epitope alleles for anti-CCP formation was found

16 Two non-shared epitope alleles were also strongly associated wit

17 Using multiple logistic regression analyses, shared epitope alleles were still the most significant r

18 confirm this interaction between smoking and shared epitope alleles, we performed a case-only analysi

19 citrullinated protein in carriers of HLA-DR shared epitope alleles.

20 toid factor status, and carriage of HLA-DRB1 shared epitope alleles.

21 r of validated RA risk loci beyond HLA-DRB1 'shared epitope' alleles to include additional major hist

22 hed new light on the conditions in which the shared epitope - alone or in combination with other gene

23 to the less conserved nature of the proposed shared epitope (amino acid sequence 9-18) in genotype 3a

24 of alpha(1)-antitrypsin form polymers with a shared epitope and so are likely to have a similar struc

25 in vitro at individual residues within this shared epitope and using peptide analogues with single a

26 ion between the human leukocyte antigen DRB1 shared epitope and worse radiographic outcomes in patien

27 To delineate the role of "shared epitope" and gene complementation between DR and

28 ive protein, rheumatoid factor, the HLA-DRB1 shared epitope, and cumulative glucocorticoid dose) to e

29 ANOVA of immune responses to "shared epitope" antigens in monozygotic twin couples sho

30 th HLA-DR alleles carrying the RA-associated shared epitope appeared to have more B cells with autoim

31 he third hypervariable region with DRB1*0401(shared epitope) are associated with a predisposition to

32 no acid sites shared by several HLA alleles (shared epitopes) are most likely better descriptors of t

33 To identify the HLA shared epitopes associated with diabetes, we analyzed hi

34 In RA, not all shared-epitope-bearing haplotypes had the same TNFab.

35 is clone may thus, define a hitherto unknown shared epitope between beta 2GP-1 and prothrombin.

36 To demonstrate a shared epitope between beta2GPI and a serine protease, 1

37 s the first example of a broad repertoire of shared epitopes between CD4(+) and CD8(+) T cells in the

38 that have similar peptide-binding sites, or shared epitopes, can be missed.

39 different characteristics with regard to HLA shared epitope, cigarette smoking, and inflammation (cyt

40 An interaction between smoking and shared epitope-coding non-*04 HLA-DRB1 alleles (particul

41 model indicated highest RA penetrance among shared-epitope compound heterozygotes.

42 levels of cross-protective immunity to past shared epitopes could confer protection.

43 be antigenic suggesting the possibility that shared epitope domains may exist.

44 TNFa2b1 was often on HLA haplotypes without shared-epitope DRB1 alleles.

45 (P < 0.01) of an association with a DRB1 JIA shared epitope (DRB1*JIASE) that includes well-character

46 ipate in hydrogen bond interactions with the shared epitope DRbeta residues Q70 and R71.

47 he expression of the same protein or whether shared epitopes elaborated by other proteins could accou

48 g71 is significant because it is part of the shared epitope expressed by DR alleles associated with R

49 There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the devel

50 To identify shared epitopes for melanoma-reactive CTL restricted by

51 ding epitopes representing unique as well as shared epitopes from both the N- and C-domains of the pr

52 uence the RA penetrance associated with DRB1 shared-epitope genotypes and that DRB1 effects on RA pro

53 The observation that not all shared-epitope genotypes confer the same risk suggests t

54 er, this did not simply reflect an excess of shared-epitope haplotypes bearing TNFa2b1.

55 no acids and used this program to assess the shared epitope hypothesis in RA.

56 antiate any of the 3 recent revisions of the shared epitope hypothesis in this large cohort of Caucas

57 In support of the latter possibility, the shared-epitope hypothesis has been postulated, stating t

58 1 data, the results were consistent with the shared-epitope hypothesis.

59 The "shared epitope" hypothesis predicts that similar motifs

60 uman leukocyte antigen (HLA)-DRB1 (HLA-DRB1) shared epitope in DNA by means of Luminex polymerase cha

61 The concurrence of C4B deficiency and the shared epitope in seropositive RA may have broad implica

62 on the role of the rheumatoid arthritis (RA)-shared epitope in the cause and pathogenesis of RA.

63 sting that C4B deficiency interacts with the shared epitope in the development of seropositive RA.

64 I subtypes often permit the presentation of shared epitopes in conformationally identical formats bu

65 The results suggest that DS exposes shared epitopes in the cornea, conjunctiva, and LG that

66 thin flavivirus antibody assays, produced by shared epitopes in the envelope proteins, can complicate

67 e focused on a direct role for the HLA-DRB1 "shared epitope" in disease susceptibility.

68 These data suggest that the role of the "shared epitope" in RA predisposition may be through the

69 There is strong evidence that the shared epitope influences susceptibility, but inconclusi

70 obes could result in memory responses to the shared epitope leading to aggressive and severe heart fa

71 pes identified in preexisting memory subsets shared epitope length matches (8-12 amino acids) with hu

72 Nondominant shared epitopes may lead to the generation of low titers

73 el provided a good fit to the data, as did a shared-epitope model with RA most penetrant among indivi

74 Additional shared-epitope models that grouped DRB1 alleles into fiv

75 red peptide sequence (p135H-AA) carrying the shared epitope motif (QKRAA) was as effective as the nat

76 utero could contribute to RA development in shared epitope-negative women.

77 ed changes in expression of L-selectin and a shared epitope of CD11b/c on circulating neutrophils.

78 he expression of the CD34 protein and not to shared epitopes on unrelated proteins.

79 d position 13, located outside the classical shared epitope (Pomnibus = 6.9 x 10(-135)).

80 ive contributions and the interaction of the shared epitope, PTPN22 and smoking in conferring the ris

81 Although the mechanistic basis of shared epitope-RA association remains an enigma, observa

82 interaction of RA-associated alleles to the shared epitope region.

83 presence of 2 HLA-DRB1 alleles encoding the shared epitope (SE) (compared with 1 or 0 copies) was as

84 matory polyarthritis and the presence of any shared epitope (SE) allele; the strongest individual ris

85 Shared epitope (SE) alleles were significantly more comm

86 group of UK RA families carrying 2 copies of shared epitope (SE) alleles.

87 ciation of the co-occurrence of the HLA-DRB1 shared epitope (SE) and RANKL single-nucleotide polymorp

88 associated with HLA-DRB1 alleles encoding a shared epitope (SE) in positions 70-74 of the HLA-DRbeta

89 To determine whether the HLA-DRB1 shared epitope (SE) is associated with early mortality a

90 We have recently proposed that the shared epitope (SE) may contribute to rheumatoid arthrit

91 have a history of smoking and to be HLA-DRB1 shared epitope (SE) positive.

92 tients, 105 (74%) had at least 1 copy of the shared epitope (SE) sequence, compared with 29 (54%) of

93 In this study, we demonstrate that the shared epitope (SE), an HLA-DRB1-coded sequence motif th

94 The shared epitope (SE), carried by the vast majority of rhe

95 tis (RA), particularly in patients who carry shared epitope (SE)-coding HLA-DRB1 alleles.

96 Associations between shared epitope (SE)-encoding HLA-DRB1 alleles and rheuma

97 ncode similar HLA-DRB1 sequences, called the shared epitope (SE).

98 ns 70-74 of the HLA-DRbeta-chain, called the shared epitope (SE).

99 ty was strongly associated with the HLA-DRB1 shared epitope (SE).

100 ies to account for sex, RA severity, and the shared epitope (SE).

101 re a similar amino acid sequence, termed the shared epitope (SE).

102 1 alleles to identify those that contain the shared epitope (SE).

103 HLA-DRB1 alleles encoding the RA-associated shared epitope (SE).

104 (by chi-square test) was the presence of the shared epitope (SE).

105 Furthermore, HLA-DR molecules encoded by shared-epitope (SE) alleles were predicted to bind these

106 .4-2.6 for those who carried at least 1 DRB1 shared epitope [SE] allele), with slightly greater effec

107 e association of the HLA-DRB1 (including the shared epitope [SE]) and PTPN22 genes with the risk of d

108 antigen (HLA)-DRB1 gene (HLA-DRB1) encode a "shared epitope" (SE) associated with rheumatoid arthriti

109 The HLA-DRB1 "shared epitope" (SE) genotypes are associated with rheum

110 eles encoding the rheumatoid arthritis (RA) "shared epitope" (SE) were not predictive of erosive dama

111 status and/or the presence of the HLA-DRB1 "shared epitope" (SE).

112 MHC, in particular class II alleles with a 'shared epitope' (SE), and multiple non-MHC loci.

113 in (DnaJ) or HLA-DR4 allele (both having the shared epitope sequence with different flanking regions)

114 carried the rheumatoid arthritis-associated shared epitope sequence, compared with 45% of control su

115 is specific for DR4 molecules containing the shared epitope sequence.

116 elucidation of the relationship between the shared epitope, smoking and anticitrullinated protein/pe

117 The shared epitope TB10.3/10.4(20-28) is presented by H-2 K(

118 With the help of genotypic information, the shared epitope, the causal relationship between two biom

119 eta, from a human brain cDNA library and the shared epitope was located at the catalytic site of DMPK

120 The prevalence of 2 shared epitopes was also much higher for anti-CCP-positi

121 prime boosting increased T-cell responses to shared epitopes, while heterologous vector prime boostin

122 The association of the shared epitope with C4B deficiency was significantly gre

123 We found that the intraneuronal material shared epitopes with full-length APP but not free Abeta.