ライフサイエンスコーパス: sharpen

1 d when OS of their spiking responses becomes sharpened.

2 ed, and its spatial tuning profile gradually sharpened.

3 te were enhanced and spatial selectivity was sharpened.

4 sion 1.2 the description of the elements was sharpened.

5 s also provide a practical guide for optimal sharpening.

6 hreshold, the singular structure at its apex sharpens abruptly.

7 show a gain-of-function for BK channels that sharpens action potentials and supports higher firing ra

8 ynamic maps had a reduced surface area (were sharpened) after CSD.

9 can be implemented by a straightforward data-sharpening algorithm that is based on local sample means

10 tation with an intrinsic frequency acting to sharpen and adjust the location of the resonant peak.

11 ck mechanisms in T lymphocytes that together sharpen and amplify initial signaling differences relate

12 This study helps to sharpen and define a mechanistic understanding of patter

13 excitation, enabling sensory features to be sharpened and represented by sparse codes.

14 Several IR bands of bound nucleotide were sharpened and/or shifted relative to those in aqueous so

15 ed that perceptual learning is due to either sharpening and amplification of tuning curves in early v

16 shed from free ligand by the binding-induced sharpening and downshifting of vibrational bands.

17 t al.'s arguments in the target article need sharpening and rethinking at both mechanistic and evolut

18 ant current hypotheses of cochlear frequency sharpening and sensitization that are not based on negat

19 In this case, our model predicted reduced sharpening and strength of inverted disparity tuning.

20 This alternation between sharpening and transition occurs repeatedly within indiv

21 domain 4 peptide, the M632 resonance of UvrB sharpens and shifts to a position consistent with a UvrB

22 The wave sharpens and slows as it advances and may never reach st

23 e severe impairment of normal, developmental sharpening, and refinement of receptive fields and tonot

24 dition to amplification, vM1 activation also sharpened angular tuning of vS1 neurons in all cortical

25 The resultant gain and frequency sharpening are necessary for speech discrimination, part

26 This selectivity itself seems to sharpen as a sentence unfolds.

27 dditionally, hybridization activity profiles sharpen as the spacing between probes increases, indicat

28 ast between the W-rich layer and the bulk MP sharpens as the latter becomes more organic, while the W

29 es in energy (3.54 eV, 3.26 eV, 3.04 eV) and sharpens as the size of the QD increases (fwhm = 207 meV

30 er from paramagnetism to ferromagnetic order sharpens as the system is scaled up, prefacing the expec

31 s of the Drosophila larva and show that they sharpen at lower odor doses.

32 and calyces (postnatal days (P)1-P4), tuning sharpened at each stage.

33 inuously growing at the forming end and self-sharpening at the mature grinding tip.

34 et highly selective neuron subtypes, thereby sharpening attainable links between neuron type, behavio

35 ted by sealing the tips of electrochemically sharpened Au and Pt microwires into glass membranes at t

36 At such OT sites, AGF microstimulation also sharpened auditory receptive fields and shifted them tow

37 a FFAd, human form perception is transiently sharpened because "blur" signals are mitigated.

38 Importantly, spatial tuning was not sharpened between A1 and CL in aged monkeys as it is in

39 ith the flanking meso-aryl groups leads to a sharpened, blue-shifted wavelength lambdamax band, bucki

40 ressly pragmatic and tentative: he sought to sharpen boundaries for didactic reasons and to develop d

41 gion that is being reconstructed, and it can sharpen boundaries.

42 ck, the gradients involved would be strongly sharpened by the complementary countercurrent distributi

43 ingent on attentional engagement and in fact sharpened by top-down expectation.

44 RNA polymerase III, we illustrate how local sharpening can increase interpretability of density maps

45 aturation fusion method often applied for EM-sharpening can result in serious image artifacts, especi

46 recise specification of muscle cell types by sharpening cellular responses to Hedgehog.

47 te the physical barrier of the cell membrane sharpens chemical gradients across the cell.

48 Self-sharpening concentration fronts penetrating into the par

49 ntly to advance resilience research, both by sharpening concepts and theories and by conducting empir

50 h integration best explains the experimental sharpening data.

51 nd inhibition is a neural mechanism that can sharpen desired movement by inhibiting unwanted movement

52 , and their underlying neural circuits, will sharpen diagnostic precision and understanding of risk f

53 synchronized cultures and voxel analysis of sharpened DIC z stacks, we present the first quantitativ

54 results in broadened orientation tuning and sharpened direction tuning in a stimulus-selective subpo

55 Our results indicate that, rather than sharpening directional selectivity per se, these circuit

56 dent extraction of orientation and direction sharpens directional tuning through surround inhibition

57 Eph receptors and ephrins can sharpen domains within developing tissues by mediating r

58 The voltammetric response sharpens dramatically as the temperature increases, beco

59 e frequency tuning of neuronal ensembles was sharpened due to both increased gain at the preferential

60 of visual cortical neurons is progressively sharpened during development.

61 disparity tuning of cortical cells generally sharpened during the time course of response.

62 or inhibitory connections that promotes this sharpening effect by adjusting these connections to main

63 pon completion of analyte focusing, the self-sharpening effect greatly restricts analyte diffusion an

64 citatory connections is required to obtain a sharpening effect.

65 This "blur-sharpening" effect allows selectivity conveyed by excita

66 chophoresis (cITP) systems that exhibit self-sharpening effects can be complex, especially when the b

67 This sharpening enhances the processing of transients and may

68 ely, BMP gain-of-function experiments caused sharpened expression boundaries of extra-embryonic targe

69 ndividual differences in cognitive aging has sharpened focus on identifying biological factors underl

70 ly, during the last decade, there has been a sharpened focus on the convergence of metabolism and imm

71 The sharpening focus on global health and the growing recogn

72 In the present paper, the concept is first sharpened for representative models of uncharged fermion

73 how that adaptation to stimulus dynamics can sharpen form perception.

74 passive mechanics within the organ of Corti sharpen frequency selectivity by defining which OHCs enh

75 cochlear amplification does not appreciably sharpen frequency tuning for cochlear regions that respo

76 that increase the amplitude of vibration and sharpen frequency tuning, the data have typically been l

77 ad frequency range and did not substantially sharpen frequency tuning.

78 weaknesses, which synergize when combined to sharpen gene expression boundaries.

79 We demonstrate greatly sharpened global and gene-specific differential expressi

80 sited in the Protein Data Bank and show that sharpening improves the electron density map in many cas

81 r (L)2/3, but not L4, excitatory neurons was sharpened in the presence of sound or optogenetic activa

82 ections, results in the apparently normal OS sharpening in excitatory neurons.

83 place in two distinct stages: representation sharpening in the early visual areas and competitive int

84 tivity could recapitulate in cis the kinetic sharpening (increased onset and deactivation rates) and

85 graph-based semi-supervised learning, graph sharpening integration, composite association network, B

86 natal choline supplementation systematically sharpened interval timing functions by reducing the asso

87 in of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak.

88 To sharpen intuition about possible mechanisms underlying t

89 Sharpening is a powerful method to restore the details f

90 Sharpening is evident for both trained and untrained sti

91 l and imaging studies are included when they sharpen issues or reveal underlying mechanisms.

92 that GABAB modulation of synaptic input can sharpen ITD selectivity.

93 Furthermore, increasing the intensity sharpens lemniscal receptive field profile as adaptation

94 that a routine practice of electron density sharpening may have a broad impact on the outcomes of st

95 to help overcome viscous forces and thereby sharpen mechanical tuning of the sensory cells.

96 This vibrating probe is an insulated, sharpened metal wire with a small platinum-black tip (10

97 otinic activation within glomerular circuits sharpens mitral cell chemoreceptive fields, even in the

98 at nicotinic cholinergic receptor activation sharpens mitral cell chemoreceptive fields, likely via i

99 In addition, the sharpening models generate complicated codes that rely e

100 ropose a country-led, data-driven process to sharpen national health plans, seize opportunities to ad

101 xperiences may interact over time to sustain sharpened neural processing in central auditory nuclei w

102 l. (2016) demonstrate that presence of sound sharpens neural tuning in the primary visual cortex via

103 Attention elevates neural responses and sharpens neural tuning to the attended feature, as shown

104 identification of orthogonal orientations by sharpening neuronal selectivity.

105 rons in the mouse primary visual cortex (V1) sharpens neuronal feature selectivity and improves perce

106 This coupling results in a sharpened NMR line width relative to a GaCu analogue, in

107 rization, our method sharpens signal without sharpening noise and can remarkably increase both the dy

108 Spatial sharpening occurred on a scale of tens of seconds and co

109 ared with idle conditions, with the greatest sharpening occurring during the location-relevant task.

110 synaptic processes that could be involved in sharpening odorant signals.

111 of category membership, compatible with the sharpening of a representation coding for physical appea

112 impairment in the functional and structural sharpening of an inhibitory tonotopic map, as evidenced

113 , we introduce a general procedure for local sharpening of cryo-EM density maps based on prior knowle

114 uning was not required for the developmental sharpening of excitatory tuning but did precede binocula

115 about the cortical processes underlying the sharpening of feature selectivity.

116 heir initial inputs, resulting in a two-fold sharpening of functional topography.

117 ncy increased, reflecting increased temporal sharpening of inputs by the olfactory bulb.

118 tation at high intensities and a significant sharpening of intensity tuning.

119 This change in threshold may account for the sharpening of ITD selectivity during the stimulus.

120 ions, we provide a mechanistic model for the sharpening of MC receptive fields by nAChRs, which could

121 et al. show that category training leads to sharpening of neural responses in high-level visual cort

122 (20 mM) attenuated the neostigmine-dependent sharpening of ORFs.

123 he input dynamic range and caused additional sharpening of output responses beyond unselectively supp

124 hyperphosphorylation and endocytosis) allow sharpening of PCP signaling locally on the tips of the f

125 perature to 50 degrees C leads to a dramatic sharpening of peaks in the 15N-1H HSQC spectrum of human

126 ing facilitated perceptual processing or the sharpening of perceptual representations.

127 nal responses accompanied by contraction and sharpening of receptive fields, and contraction and weak

128 optimized spectroscopy sequence resulted in sharpening of resonances but also losses of signal inten

129 gions resulted in both the amplification and sharpening of responses at attended time points, in esse

130 Increasing noise disrupts sharpening of rhombomere boundaries and proper patternin

131 t emerge in the primary visual cortex V1 are sharpening of selectivity for spatial frequency and for

132 as shorter and faster, reflecting a temporal sharpening of sensory inputs.

133 nsistent with a slow-speed prior) and scale (sharpening of similar features).

134 cending auditory pathway as a consequence of sharpening of spatial sensitivity and increasing forward

135 from these studies was a new way to achieve sharpening of specific peaks in the CE separations of pe

136 al changes remain an untapped source for the sharpening of such warning signals.

137 This sharpening of taste selectivity was specifically attribu

138 t: increases in spike rate (rate coding) and sharpening of the coincidence of spiking in active neuro

139 The latter phase is accompanied by a sharpening of the excitatory but not inhibitory frequenc

140 (30-50%) in the magnitude and a significant sharpening of the force distribution indicating reduced

141 ed frequencies of the cell and a significant sharpening of the frequency tuning of membrane responses

142 Sharpening of the GEAn(+*) transient absorption and a sh

143 ned with excitation, and leads only to minor sharpening of the spectral response properties.

144 width decreases, leading to the notion that sharpening of tuning curves improves population codes.

145 ge fusion through several applications: (i) 'sharpening' of IMS images, which uses microscopy measure

146 mitral cell firing rates and hence does not sharpen olfactory representations under a rate metric.

147 notation, imposes a logical discipline that sharpens one's understanding of the structure and functi

148 There are four types of modulations: sharpening or broadening of duration tuning, and lengthe

149 [2-5], and feedback has been demonstrated to sharpen orientation tuning of neurons in the primary vis

150 creased spiking of PV+ interneurons markedly sharpened orientation tuning and enhanced direction sele

151 Learning improved neural discriminability, sharpened orientation tuning, and led to higher contrast

152 itory tuning is critical for maintaining and sharpening OS at high contrast.

153 g of the inhibitory tuning is sufficient for sharpening OS.

154 nhibition may improve spatial resolution and sharpen other forms of selectivity in rodent lateral gen

155 To help sharpen our ability to discriminate patients with hippoc

156 s, our research and clinical agenda needs to sharpen our lens on the fundamental importance of our pa

157 eart disease, and review techniques that can sharpen our understanding of cardiovascular biology.

158 and cell types in different conditions will sharpen our understanding of how and why cells regulate

159 The current findings sharpen our understanding of sirtuins as potential pharm

160 e sequencing (scWES) has deeply expanded and sharpened our knowledge of cancer evolution and subclona

161 Sharpening our focus on deliberate decision making offer

162 Practice sharpens our perceptual judgments, a process known as pe

163 single location, the representation of which sharpens over the course of several milliseconds, as the

164 The mechanisms that establish and sharpen pattern across epithelia are poorly understood.

165 e first demonstrate that the contents of LTM sharpen perceptual sensitivity for targets presented at

166 polycrystalline diamond on electrochemically sharpened platinum wires (76-, 25-, and 10-microm diamet

167 Additionally, attention could sharpen position tuning at the neural population level,

168 ual mechanism involving both signal gain and sharpened position tuning would be highly efficient at i

169 onal sputter erosion, field-directed sputter sharpened probes have smaller radii and produce lithogra

170 ces a mobility shift that acts to enrich and sharpen protein fronts as proteins enter the microchanne

171 remained unchanged, resulting in an overall sharpening rather than a weakening of OS.

172 r stimuli, complex stimuli revealed markedly sharpened receptive fields, largely as a result of adapt

173 eractions among neuronal subtypes ultimately sharpen recurrent excitation, producing specific and rel

174 ynaptic circuit mechanisms underlying the OS sharpening remain unclear.

175 The ability to sharpen representation of repeating elements is crucial

176 rcement learning signals in the striatum and sharpen representations of associative values in prefron

177 hat representations in A1 change not only to sharpen representations of task-relevant stimuli but als

178 porating these factors (plus inequality) can sharpen researchers' predictions.

179 ls as opposed to increasing response gain or sharpening response spectra.

180 stood about the mechanisms whereby attention sharpens responses to unattended sounds.

181 Sharpening resulted primarily from increased suppression

182 hese results suggest that dLGN maintains and sharpens retinal direction selectivity and integrates op

183 pally subtract from excitatory responses and sharpen selectivity.

184 aphy in human observers (men and women) that sharpened selectivity for a particular color arises from

185 We conclude that attention sharpens selectivity over time by attenuating the respon

186 ces associated with a rhythmic motor routine sharpen sensory representations, enacting auditory 'acti

187 ly simulated by a Prediction Error and not a Sharpened Signal model.

188 ugh wavelet-basis regularization, our method sharpens signal without sharpening noise and can remarka

189 Computational simulations of Sharpened Signals and Prediction Errors during speech pe

190 uish representations of Prediction Error and Sharpened Signals in other perceptual domains.

191 ced or sharpened via interactive activation (Sharpened Signals).

192 mulated through virtual ears of adults, SRFs sharpened significantly and the amount of transmitted in

193 from tuned simple inhibitory neurons acts to sharpen spatial frequency tuning, lower responses to low

194 he units recorded in A1 showed substantially sharpened spatial tuning during the behavioral tasks as

195 nd we did not find evidence that Ntsr1 cells sharpen spatiotemporal filtering.

196 dynamic catch-and-release mechanism used to sharpen spatiotemporal signals mediated by diverse senso

197 might contribute to memory consolidation by sharpening specificity of subsequent synaptic input and

198 ances the fidelity of spike transmission and sharpens spike timing.

199 M-off areas may form a flip-flop switch that sharpens state transitions and makes them vulnerable to

200 h-sealing and experimentally challenging tip-sharpening steps used in conventional fabrication protoc

201 t, suppression was not tuned and appeared to sharpen stimulus selectivity.

202 To examine the role of the inhibition in sharpening stimulus selectivity, we have quantitatively

203 h a DUB prevents undesired ubiquitination to sharpen substrate specificity for an associated ubiquiti

204 dicted that this reduces spike latencies and sharpens suprathreshold responses in BCs, which we verif

205 These changes served to sharpen taste selectivity, mainly by reducing responses

206 a novel biased-probe field-directed sputter sharpening technique applicable to conductive materials,

207 of inhibitory interactions normally used to sharpen temporal processing of sensory inputs.

208 Thus, facilitation by homologous CT feedback sharpens thalamic receptive field focus, while suppressi

209 ic and mood-enhancing drug, is shown here to sharpen thalamocortical activity and to increase electri

210 ry actions impact health outcomes, we aim to sharpen the analytic distinctions between studies that d

211 both unliganded and hormone-bound GR and to sharpen the cellular response to hormone.

212 erplay of experiment and theory in ways that sharpen the conclusions of both and animate future studi

213 al inhibition between pain and itch may help sharpen the distinction between these sensations.

214 Instead, a primary function may be to sharpen the dynamic range of gene expression changes dur

215 als along monaural pathways, and bushy cells sharpen the encoding of fine structure and feed binaural

216 that in vertebrates; in vertebrates, miRNAs sharpen the first developmental transition, whereas in p

217 lear amplifier, serving to localize and thus sharpen the frequency region of amplification.

218 -in this highly columnar cortex-task demands sharpen the frequency tuning in superficial cortical lay

219 ensitivity and low selectivity can laterally sharpen the frequency tuning of neurons, ensuring their

220 pport a "switch-like" response that helps to sharpen the ind dorsal boundary.

221 These results sharpen the picture of the mechanical unfolding of membr

222 y engaging complementary neural resources to sharpen the precision of the task-relevant object in mem

223 into grid cell models, we show that they can sharpen the precision of the temporal code and enhance t

224 etabolic steps with stoichiometric models to sharpen the prediction of intervention strategies for im

225 ory signals to vS1 that serve to amplify and sharpen the response of neurons in the barrel cortex to

226 The findings sharpen the scientific question about how variation in t

227 est that the net effect of L4 activity is to sharpen the spatial representations of L5 neurons.

228 s interactions provides a novel mechanism to sharpen the specificity of cell-cell interactions.

229 y and inhibitory inputs respectively greatly sharpen the spike latency tuning and expand its dynamic

230 intain the interareal stimulus signaling and sharpen the stimulus representation by gamma-synchronize

231 arkedly reduce the discharge probability but sharpen the temporal precision of action potential gener

232 VgrG-like partners show that these proteins sharpen the tip of the T6SS spike complex.

233 1), so-called "sideband" inhibition helps to sharpen the tuning of local neuronal responses.

234 e 2014-2016 global coral bleaching event has sharpened the focus on such interventionist approaches.

235 anticholinesterase drug neostigmine (20 mM) sharpened the ORF responses of mitral cells.

236 The conductance-dependent suppression also sharpened the STDP curve, with reliable synaptic potenti

237 oved the quality of temporal predictions and sharpened the temporal selection of relevant auditory in

238 , but large clinical correlative studies are sharpening the focus of which markers can be used by the

239 istils, perhaps by degrading excess GABA and sharpening the gradient leading to the micropyle.

240 and lower gain at intermediate frequencies, sharpening the high-frequency resonance.

241 kinases and our own drug redesign geared at sharpening the inhibitory impact.

242 an important role in cerebellar function by sharpening the precision of Purkinje cell spike output.

243 i activity suppresses alternative responses, sharpening the response profile and encouraging exploita

244 Several factors are sharpening the tension between the supply and demand for

245 he C-lobe of CaM in the presence of Ng, thus sharpening the threshold for the C-domain to become Ca(2

246 VI in "matched" (homologous) barrel columns sharpens the angular tuning curves of single VPM neurons

247 envisaged to constitute a feedback loop that sharpens the border with the developing AVC and IC by de

248 nism: the presence of competitors shifts and sharpens the Ca2+ frequency-dependence of CaM binding pr

249 This work sharpens the conceptual rationale for therapeutic target

250 mbers effectively integrates information and sharpens the discrimination of fine differences.

251 ing and an activator of the Wnt pathway that sharpens the distinction between opposing Wnt and Notch

252 s is consistent with the view that attention sharpens the neural responses that are elicited by the t

253 irectionality of channel gating considerably sharpens the neuronal frequency selectivity at the perip

254 omechanical filter process that considerably sharpens the neuronal response.

255 KZip(+) significantly sharpens the precision of neuronal genetic control avail

256 Feedforward inhibition sharpens the precision of neurons throughout ascending a

257 und suppression in a manner that effectively sharpens the priority map.

258 We conclude that long-term familiarization sharpens the response dynamics of neurons in both monkey

259 Scap/cholesterol/Insig interactions further sharpens the sensitive switch that exerts precise contro

260 alcium concentration close to the source but sharpens the spatial and temporal calcium gradients.

261 This dynamically sharpens the spatial focus of the receptive field and in

262 ral frequencies at the first retinal synapse sharpens the temporal resolution of the light response;

263 tion is a fundamental circuit operation that sharpens the tuning properties of cortical neurons.

264 nalyses suggest 1) that surround suppression sharpens the visual responses in V1 to a stationary scen

265 aller length scale while preserving, or even sharpening, the sharpest features.

266 y finding or consolidating partnerships, and sharpening their e-pencils, as they prepare for the next

267 naptic tuning as an additional mechanism for sharpening their frequency selectivity.

268 d interpreted separately; this approach will sharpen therapeutic approaches and could shed light on t

269 hibition transforms olfactory bulb output to sharpen these dynamics.

270 Further studies are warranted to further sharpen this instruments validitity and general clinical

271 of the vgat gene throughout the TMN further sharpened this phenotype.

272 However, boundaries can also sharpen through cellular plasticity, with cell fate chan

273 In some cases, domain boundaries sharpen through differential adhesion-mediated cell sort

274 of model: one in which the tuning curves are sharpened through cortical lateral interactions, and one

275 the corners and edges of the nanocubes were sharpened through the introduction of Br(-) as a regulat

276 We report that sharpening through lateral interactions does not improve

277 Under the sharpened tip of an AFM probe, nano-Newton impingement f

278 nization will be reshaped, repositioned, and sharpened to match the object's shape and scale.

279 ened beyond recognition at high field can be sharpened to narrow peaks in the low-field dimension.

280 include the ability to apply thermal factor sharpening to electron density maps.

281 g nor plasticity is sufficient on its own to sharpen transition regions between different rhombomeres

282 BDD films by chemical vapor deposition onto sharpened tungsten wires.

283 ir effects on vibration are small and do not sharpen tuning.

284 holds at the calyceal spike initiation stage sharpened tuning and advanced response phase.

285 We speculate that sharpened tuning of neuronal representations may cause r

286 ling a smaller range of best frequencies and sharpening tuning.

287 For example, we describe how inhibition sharpens tuning for spatial and temporal features of the

288 to obtain food rewards; the current findings sharpen understanding of the boundaries of cottontop tam

289 nt spread function at 2.2-mum wavelength was sharpened uniformly to 0.3'' over a field of at least 2'

290 domain, and this resonance then shifted and sharpened upon addition of a 5'-phosphate-terminated dow

291 lasticity, and their combination in boundary sharpening using multi-scale, stochastic models.

292 e N-oxide, possessing a slightly shifted and sharpened UV-vis spectrum (lambdamax = 737 nm).

293 ir orientation discrimination, mirroring the sharpened V1 orientation tuning.

294 features of the speech input are enhanced or sharpened via interactive activation (Sharpened Signals)

295 rget flanked by distractors, consistent with sharpened visuospatial perceptual representations.

296 re coevolution of human altruism and further sharpen what any theory of human cooperation needs to ex

297 t fundamental sensing limits are necessarily sharpened when the need to communicate information is ta

298 We tested the hypothesis that spatial tuning sharpens when an animal engages in an auditory task.

299 's stretch band moves to lower frequency and sharpens with freezing, and the bending band goes to hig

300 hile the timing of rhythmic excitatory drive sharpens within the pool as speed increases, there are s