ライフサイエンスコーパス: sharply

1 h and nutrition goals and spending increased sharply.

2 idth of the size distribution also decreases sharply.

3 superconductor-graphene interface decreases sharply.

4 ing along the riverbed where the river bends sharply.

5 eks of August 17 and 24 and has since fallen sharply.

6 er which the likelihood of exoneration drops sharply.

7 d in the quasispecies and viral load dropped sharply.

8 petite-promoting hormone, acyl-ghrelin, rise sharply.

9 olution is smooth as well as when it changes sharply.

10 These phenotypes were sharply abrogated after castration but restored with exo

11 alization, we found that railway plants have sharply abrogated vernalization responsiveness and high

12 at the tuning of perceptual attention can be sharply accelerated after 20 min of noninvasive brain st

13 read ice retreat during the 20th century has sharply accelerated since 2004.

14 owly increasing before January 2015 but then sharply accelerated thereafter.

15 oncentration around secreting cells decaying sharply across only a few cell diameters.

16 also interferometry demonstrates that these sharply acute features provide extremely effective nucle

17 ey normalized transiently but then increased sharply after DAA therapy.

18 We demonstrate miR-29b increases sharply after embyoid body (EB) formation, which causes

19 defined maternal factors presumably decline sharply after fertilization, as the cytoplasm of pronucl

20 tion with MyFitnessPal, but logins decreased sharply after the first month.

21 e group expanded rapidly in early 2009, fell sharply after two tOPV rounds in mid-2009, and gradually

22 PAD prevalence and incidence are both sharply age-related, rising >10% among patients in their

23 ing day, but their control during apnoea was sharply altered: astronauts increased their burst freque

24 The accident death rate fell sharply among currently deployed soldiers, remained cons

25 esponse to natural productivity declines can sharply amplify the magnitude of naturally occurring pop

26 r the drift pathway, predicted GMs decreased sharply and nonlinearly, with GMs 64% lower in homes 250

27 riggers a nebular phase once accretion drops sharply and the ejecta become optically thin.

28 o the mother fell; income per head increased sharply and the poverty rate fell; and the education lev

29 text] the equilibrium genetic variance drops sharply and then declines gradually to that maintained u

30 This population increased sharply and transiently during acute infection, but was

31 In the long term, waste flows will increase sharply and will meet a substantial part of the total de

32 Rates then declined sharply, and remained significantly low until the end of

33 Medicare spending growth slowed sharply, and, more remarkable, hospitals posted record p

34 In the alpha chain nuFeHis dropped sharply at 20 mus, the final step in the R-T transition.

35 on from the fast to the slow regime occurred sharply at a threshold fraction of active motors.

36 ntrations in South China sediments increased sharply at the extinction, probably as a consequence of

37 Whereas the D2O intensities decrease sharply at the n = 9 position in the lipid bilayers, a m

38 dly at ca. 1300 AD, whereas intensities drop sharply, at a rate greater than modern field changes in

39 ng postsynaptic LFP signals were found to be sharply attenuated.

40 these MGII because MGII abundance decreased sharply below it.

41 Furthermore, the anisotropy drops sharply below the charge order transition, again similar

42 ng, and crystal structures suggest that they sharply bend DNA in the process.

43 al pentamers of ATP-associated AAA+ domains, sharply bending the duplex into a 180 degrees U-turn.

44 findings shed new light on the energetics of sharply bent dsDNA.

45 The polymorphic forms spanning canonical to sharply bent structures, like hairpins and loops, arise

46 In the IC, the DNA is sharply bent, as seen in crystal structures of hTDG lesi

47 h nectar alkaloid concentration and declined sharply between 200 and 380 ppm.

48 gh Specificity, and was able to discriminate sharply between complementary target miRNA, single-, thr

49 ne concentrations in manufacturers increased sharply between pre- and post-shift measurements on Mond

50 ull reactivation program, arguing for a less sharply bimodal definition of latency.

51 d an unexpectedly complex spatial pattern of sharply bounded regulatory states, organized orthogonall

52 IHF binding bends the DNA sharply, bringing an upstream recognition motif into con

53 retracted scientific publications has risen sharply, but it is unclear whether this reflects an incr

54 reased slightly until 2007 (35-33%) and then sharply by 2012 (18%) (linear P-trend < 0.0001).

55 up, mean macular thickness (+/-SD) increased sharply by 56 mum from 273 +/- 24 mum at baseline to 329

56 Rates of adolescent onset disorder dropped sharply by the late 20s (0.57, 0.45-0.73), suggesting a

57 land plant lineage, the similarity dropping sharply compared with orthologous charophyte sequences.

58 through the Ediacaran and Cambrian periods, sharply constraining the magnitude of the end-Proterozoi

59 onsisted of very brief (1-3 seconds) runs of sharply contoured theta activity without obvious evoluti

60 eproducible maps of individual digits in S1, sharply contrasted by a striking degree of intersubject

61 Two crustaceans producing sharply contrasting bioturbation--the copepod Amphiascus

62 In this review, we highlight the sharply contrasting disease phenotypes using ICAM-1 isof

63 Sharply contrasting protamine, we show that UHRA does no

64 fferences of 10 +/- 2 K between H2O and D2O, sharply contrasting with other hydrogen-bonded liquids f

65 ation traits existed in the ancestral state, sharply contrasting with the ubiquity of derived alleles

66 The free-molecule structure sharply contrasts with the furanose form observed in bio

67 IL-1beta and IL-10 cytokine responses, which sharply contrasts with the immune responses induced by w

68 ection-free time delays when detoured around sharply-curved paths, thus offering a unique paradigm fo

69 The termination rate sharply declined after 6 months.

70 However, the cell number sharply declined before a rapid increase of macrophages

71 ncreasing, alpha firstly kept constant, then sharply declined, and finally reduced very slowly.

72 Scleral buckling sharply declined, and preference for retinal detachment

73 spinal motor neuron progenitor domain (pMN) sharply declines at 48 hours post-fertilisation (hpf).

74 Our study demonstrates that X4-tropic HIV sharply declines in most patients during successful ther

75 pecies utilized for neuroscience research is sharply declining, as the field converges on a few selec

76 and show that the levels of these substances sharply decrease at the margins of a freshly inflicted w

77 depolarization ratio and the optical depth, sharply decrease from cloudy regions to clear-sky region

78 ncal catchment in Chile, runoff is likely to sharply decrease in the future and the runoff seasonalit

79 Presence of surfactants could sharply decreased alpha, and SDS was more effective to f

80 pression was induced in the acidic core, but sharply decreased at peripheral/upper microcolony region

81 Hematopoietic batf3 deficiency sharply decreased CD8alpha(+) DC numbers in spleen and l

82 de, blood glucose, and hemoglobin A1c levels sharply decreased during the first 2 years after bariatr

83 Sharply decreased effector KLRG1(+) CD8 response was obs

84 PABP1 relocalization was sharply decreased in cells infected with a strain of RVF

85 n of apoptosis and necroptosis effectors was sharply decreased in the absence of caspase-1 and -11.

86 addition of predation at a second life stage sharply decreased the ability to detect the effect of ea

87 Furthermore, FIBEROX intake sharply decreased the lithocholic/deoxycholic bile acid

88 in most of the samples, but their abundance sharply decreased when working under special clean air c

89 es in patients with LRBA or CTLA4 deficiency sharply decreased with CTLA4-Ig therapy in parallel with

90 easing amounts of nitric oxide (NO) but then sharply decreases for input concentrations above 50 ppbv

91 Increasing charge segregation from WT RAM sharply decreases transcriptional activation for all per

92 eases in the order MoF0 < MoF3 < MoF6 before sharply decreasing for MoF9, with a similar effect for t

93 t patterns in Abeta concentrations were more sharply defined by the precise mass spectrometry method

94 Morphogen gradients induce sharply defined domains of gene expression in a concentr

95 ion and show that mobile small RNAs generate sharply defined domains of target gene expression throug

96 repressed exons and flanking introns with no sharply defined peaks.

97 h's polar regions, called discrete for their sharply defined spatial configurations, are generated by

98 genetic testing at this scale, but has also sharply defined the limits of prior gene-panel focused t

99 many-body system, potentially allowing for a sharply defined topological phase even in a highly excit

100 e borders between areas are generally rather sharply defined.

101 t led to aggregation of these particles into sharply delimited "puncta" positioned upon raised membra

102 at fidelity, soft tissue traces visible as a sharply delineated carbon film around the bones and marg

103 In the acute stage, ICG-A revealed sharply delineated dense hypofluorescent lesions, which

104 hat dementia is not a suddenly occurring and sharply delineated state, but rather a gradual change in

105 Autofluorescence showed sharply demarcated areas of RPE loss that coincided with

106 raphic atrophy is defined by the presence of sharply demarcated atrophic lesions of the outer retina,

107 s, areas of category 1 showed a relative and sharply demarcated reduction of scotopic threshold value

108 e intraretinal photocoagulation lesions were sharply demarcated, whereas RPE changes were rather subt

109 here the 6-month malaria and dry seasons are sharply demarcated.

110 usion-driven transformation and find that it sharply demarcates tumor initiation and maintenance.

111 becomes independent of filament lifetime and sharply dependent on crosslink dynamics.

112 The response to DNA damage was sharply different in these two phases; in the first phas

113 at the manner of CD40 ligation can determine sharply different outcomes for CD40 signaling and sugges

114 o reduction of plastoquinone in the dark was sharply diminished in maize homozygous mutant compared t

115 Conversely, forced production of ALDH2 sharply diminished the N(2)-ethylidene-2'-deoxyguanosine

116 rst areas and frequencies during apnoea were sharply diminished.

117 s that denote nocturnal urine overproduction sharply discriminate the risk of nocturia severity and s

118 The results reveal two sharply distinct classes of microbial genes, one of whic

119 RAS and BRAF sharply distinguished between PDTCs defined by the Turin

120 shared with a simple carbapenem, the pathway sharply diverges to the more structurally complex member

121 appeared to inhibit this induction: Dkk4 was sharply downregulated in beta-catenin-ablated mice, indi

122 led by distinct nRT activity, and nRT firing sharply dropped before the termination of all spindles.

123 -2.5% to 2.4%], P = .93), but each increased sharply during 1990-2008 (for prevalence, 4.5% [95% CI,

124 nfluenza A(H5N1) virus in Cambodia increased sharply during 2013.

125 Securin protein levels change sharply during cell cycle progression, enabling its time

126 ition, the large ion concentration increased sharply during particle growth, suggesting that during n

127 Our results indicate that OB size increases sharply during seed maturation, in part by OB fusion, an

128 ell divisions in early stages but then falls sharply during T-cell lineage commitment.

129 Linalool levels dropped sharply during the full-flowering and post-flowering sta

130 The number of suicides rose sharply during the late teens with 79 deaths by suicide

131 cycling in the paleotropical oceans changed sharply during the latest Katian time, with consequent c

132 of suicide attempts in the US Army increased sharply during the wars in Afghanistan and Iraq.

133 DNA breaks sharply elevate PARP-1 catalytic activity to mount a cel

134 mRNA abundance, which we show resulted from sharply elevated stability.

135 te infiltration into regenerated islets, and sharply elevated the expression of the beta cell markers

136 ionectomy," and "trisectionectomy" increased sharply especially in between 2006 and 2009.

137 rates peak near starts of genes and fall off sharply, exhibiting polarity.

138 ersely, reduction of PP2A or B55alpha levels sharply extends S phase even in low N/C extracts.

139 nt, whereas formic and oxalic acids decrease sharply for both two fungi.

140 nt prevalence of asymptomatic infection rose sharply from 3% to 48% from the low to high R0 settings.

141 Postpartum progesterone and CRP declined sharply from 90.85 +/- 42.51 ng/mL and 3.73 +/- 4.01 mg/

142 r of IPD cases due to 12F serotype increased sharply from about 3-4 cases per year (6% of IPD cases)

143 (1) The PC transcriptome diverges sharply from other cardiomyocytes; (2) Islet-1 is a posi

144 nctuated by CpG islands (CGIs), which differ sharply from the bulk genome by being rich in G + C and

145 Tase domain presents a new fold that differs sharply from the canonical Rossmann fold.

146 ampling can cause choice behavior to deviate sharply from the predictions of reinforcement learning.

147 levels for biofilm-infected tissue declined sharply from the surface, with no measurable oxygen dete

148 kingly, CA1 spine turnover dynamics differed sharply from those seen previously in the neocortex.

149 increasing length-tension relationship, with sharply higher tension at longer lengths, is needed to d

150 of higher order organisms in the future for sharply improved control over MS instruments in a projec

151 emitters over 6 meV, and material processing sharply improves the single photon purity.

152 % in aerated pH 9 buffer solution that drops sharply in deaerated solution.

153 surgery followed by radiotherapy has fallen sharply in many countries, and is influenced by patient

154 For example, sensitivity declines sharply in peripheral (vs. foveal) vision and is typical

155 ropenis, and ambiguous genitalia, have risen sharply in recent decades, but the causes of these malfo

156 showed that population growth rates declined sharply in response to male skews and declines for inbre

157 tressed DNA is close to 10(-5), it increases sharply in small DNA circles reaching 1 open bp per circ

158 dritic spontaneous EPSP amplitudes increased sharply in the dendrite with distance from the soma (len

159 supplies are restricted and farm prices rise sharply in the face of inelastic food demands.

160 ps before the warning, but started declining sharply in the intervention group only after the warning

161 imbs during gestation but sometimes declines sharply in the months following delivery.

162 placement therapy (RRT) are expected to rise sharply in the next decade.

163 at the use of LCMs in such studies increased sharply in the past decade, notably in the domain of inf

164 y and cardiomyocyte telomere length decrease sharply in wild-type mouse hearts after birth, resulting

165 rval: 0.36, 0.81), and PD incidence declined sharply (incidence rate ratio = 0.39, 95% confidence int

166 ch the nucleation propensity and growth rate sharply increase.

167 MP2 from NG(21) in hMSC encapsulating matrix sharply increased bFGF expression in the patterned const

168 HFMD outbreaks and reported cases have sharply increased in China since 2008.

169 Mef2c expression was sharply increased in compensating phase of RVH tissues b

170 ne-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethality.

171 The research interest on the subject is sharply increased since the beginning of 21st century pr

172 l we estimate that the transmission distance sharply increased to 5.3 km (10 km when excluding infect

173 of NPA during physiologic conditions, which sharply increased with ALI.

174 choices of high-cost/high-reward options are sharply increased.

175 interferes with protein translation, to ATRA sharply increases APL cell killing to the extent that cu

176 ment of dendritic cells (DCs) and monocytes, sharply increases at the monocyte-DC progenitor (MDP) st

177 which we also find that pulldown efficiency sharply increases for DNA fragments with four or more mC

178 ds 9 atomic %, the faradaic efficiency of O2 sharply increases from approximately 30% to 90%, suggest

179 perconducting critical temperature TC of MnP sharply increases near the critical pressure PC approxim

180 fness of both linear and nonlinear materials sharply increases once the thickness is reduced below 5

181 h resembles the role of the lipid rafts that sharply increases the reaction rate of biomolecules by g

182 ugh fusion, after which phenotypic diversity sharply increases.

183 search into their behavior and fate has been sharply increasing in recent years.

184 decreasing the contribution of Liangshan, or sharply increasing the Qinling contribution while decrea

185 The transcriptional cofactor ANKRD1 is sharply induced during wound repair, and its overexpress

186 enic effects on mammalian cardiomyocytes, is sharply induced in perivascular cells after injury to th

187 elated orphan receptor (Ror)alpha/gamma were sharply induced in Shp(-/-) liver.

188 when the increase of the density of floaters sharply influences (step-function-like) the territories.

189 ity between individual human beta-cells were sharply inhibited at all glucose concentrations tested,

190 od, IgE antibodies to all aeroallergens rose sharply into adolescence.

191 This leads to a sharply kinked DNA molecule that may fray the DNA four b

192 that decrease PIP2 or enhance ubiquitination sharply limit access of the gamma-ENaC extracellular dom

193 e, plastic flow of metallic glasses (MGs) is sharply localized in shear bands, which are a key featur

194 After 6h OGD, rtPA sharply lowered cell viability; pyruvate dampened this e

195 c table from Li(+) to Cs(+), PFL-AE activity sharply maximizes at K(+), with NH4(+) closely matching

196 3 depletion induced cell differentiation and sharply mitigated tumor formation.

197 its thermal expansion coefficient, increase sharply on cooling below the equilibrium freezing point.

198 Here we show that interest in sex peaks sharply online during major cultural and religious celeb

199 lesions; there were multiple, disseminated, sharply outlined, contrast-enhancing, oval foci with per

200 The LFP signature is observed to decay sharply outside the cortical region receiving the thalam

201 y seen in (18)F-FDG PET images has increased sharply over recent years.

202 Urban air pollution concentrations vary sharply over short distances (<<1 km) owing to unevenly

203 enturies and is very likely to increase more sharply over the 21st century.

204 driver of pathogen dispersal, has increased sharply over the past century, along with the availabili

205 xtraction-derived wastewaters have increased sharply over the past decade, but the ultimate fate of t

206 rthern Hemisphere sea ice has been declining sharply over the past decades and 2012 exhibited the low

207 cost of developing a new drug has increased sharply over the past years.

208 fraction from protein crystals includes both sharply peaked Bragg reflections and diffuse intensity b

209 This emission is more sharply peaked towards the Galactic Centre than is the s

210 eroid, e.g., a giant basin at the big end, a sharply perpendicular silhouette near the neck region, a

211 low, slender, conical papillae with multiple sharply pointed, strongly divergent, apical branches tha

212 ty, the slope of the linear relationship was sharply reduced by KLF15, consistent with incoherent FFL

213 ); however, the survival of young neurons is sharply reduced by postinjury inflammation.

214 s expressed in the embryonic brain that show sharply reduced expression shortly after birth.

215 r 3 (IRF3) to IFN-beta or ISGs promoters and sharply reduced gene activation.

216 -replicating cells with DAA and anti-miR-122 sharply reduced HCV RNA amounts.

217 ETH signaling deficits lead to sharply reduced JH levels and consequent reductions of o

218 , a gene within the 20q CDR, is expressed at sharply reduced levels in CD34+ cells from most MDS case

219 These defects correlated with the sharply reduced levels of CD1d-presented glycolipid anti

220 gh plasma BChE after gene transfer exhibited sharply reduced plasma ghrelin.

221 a-a process that was closely associated with sharply reduced ribosomal RNA expression.

222 nce of more than 50 TN was associated with a sharply reduced risk of thick melanoma (odds ratio, 0.32

223 Activation of hM4D signaling sharply reduced synaptic release probability and synapti

224 ice, dietary intervention with omega-3 PUFAs sharply reduced the incidence of T1D, modulated the diff

225 opposed excitatory presynaptic terminals was sharply reduced upon postsynaptic knockout of OGT.

226 d strength of electrical coupling in TRN was sharply reduced, but not abolished, in KO mice.

227 pogenesis from glucose and viral growth were sharply reduced.

228 ed with control mice, and Ag-specific IgG is sharply reduced.

229 Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenoc

230 YAP depletion sharply reduces CSCs and tumorigenicity of osteosarcomas

231 ed IL-33 content of the ptges(-/-) lungs and sharply reduces pulmonary eosinophilia and basal secreti

232 Verdant sharply reduces the time required for analysis of assemb

233 atistical power to detect associations while sharply reducing cost, effort, and experimental variabil

234 B cells in Emu-myc mice are tumorigenic and sharply regress in the periphery between 41 and 65 days

235 e promoter -10 element, ensures that pnrf is sharply repressed.

236 of EfOM and humic acid (HA), moderately and sharply, respectively, suggesting electrostatic and also

237 nd anisotropy vanish whereas the resistivity sharply rises.

238 in the United States, such as Oklahoma, face sharply rising numbers of earthquakes.

239 DAMA reveals an abrupt linguistic transition sharply separating all post-Reagan from all pre-Reagan s

240 adian molecular profiles which often exhibit sharply-shaped, cuspidate waveforms.

241 of stalk and fusion pore (FP) formation in a sharply sigmoidal fashion.

242 rcial Hg use peaked in 1970 and has declined sharply since.

243 The study microsite (0.04 km(2)) is sharply subdivided geologically, edaphically, and ecolog

244 Variability decreased sharply, suggesting that the network is stabilized by in

245 hydrogenase kinase inhibitor dichloroacetate sharply suppressed B cell proliferation and Ab secretion

246 The carrier transport sharply switches from n-type to p-type when the sputteri

247 In contrast, sharply synchronous firing has rarely been seen and has

248 dian number of injections required increased sharply to 6 injections (mean, 7 injections).

249 1 pN) until approximately 70% and then rises sharply to approximately 23 pN at high filling, which is

250 s at or near ceiling until 48 Hz and dropped sharply to chance level at 60 Hz and above.

251 at intermediate speeds are poised to respond sharply to changes in mechanical context-at low force or

252 ric pressure gradient receiver that responds sharply to high-frequency sound arriving from an azimuth

253 They respond sharply to small shifts in temperature and form dense mi

254 dC revealed that all three proteins localize sharply to the division site.

255 e text] the outcrossed equilibrium collapses sharply to the purged equilibrium genetic variance.

256 lack of suitable drug carriers that respond sharply to visible light stimuli at clinically relevant

257 PNIPAAM, micelle solutions (at >/=2.5 wt %) sharply transitioned into stable, hydrated gels.

258 ectorial membrane and reticular lamina, were sharply tuned in the radial direction.

259 ation can evoke both fast broadband and slow sharply tuned responses of the reticular lamina, but onl

260 For small stimuli, electrical resonances sharply tuned the hair-cell membrane in the frequency ra

261 Receptors sharply tuned to 2 kHz are completely unaffected by the

262 al-to-noise ratios of -21 dB, since they are sharply tuned to 2 kHz.

263 neurons unresponsive to CI stimulation were sharply tuned to frequency and sound level.

264 Altogether, although face identification is sharply tuned to horizontal angles, both inversion and o

265 SINs showed a weaker modulated (F1) response sharply tuned to orientation and/or direction.

266 f primary auditory cortex, many of which are sharply tuned to sound frequency, could help solve this

267 Grid cells were more sharply tuned to time and distance than non-grid cells.

268 ally 10-30 dB and was broad-band rather than sharply tuned.

269 s, the number of detected features increased sharply up to 60k in both positive and negative mode.

270 Survival statistics deteriorated sharply when ECMO was required for >3 days.

271 ation on copper (Cu) nanoparticles increases sharply when the catalyst is illuminated with visible li

272 Firmicutes increased sharply, whereas Proteobacteria, Actinobacteria, Cyanoba

273 the resulting bifunctional enzyme can switch sharply while remaining coherent.

274 with theoretical expectations but contrasts sharply with alternative numerical methods.

275 undances of both Crocosphaera types declined sharply with depth between 45 and 75 m in both sites.

276 indirect-acting mutagenicity did not decline sharply with distance from mining areas.

277 t cost for both sectors is found to increase sharply with every year of delay beyond 2020.

278 ion was an excellent CoP, with VE increasing sharply with fold rise: VE was estimated at 0% for the s

279 ose at the trailing range edge-could decline sharply with global climate change.

280 maintained, but virion production decreased sharply with high levels of Gag-Pol.

281 loss factor of the almond kernels decreased sharply with increasing frequency over the RF range (10-

282 ), even though their efficiency can decrease sharply with increasing phylogenetic distance.

283 The probability of prescribing statins rose sharply with increasing plaque burden under the GACR com

284 This stimulatory effect of LIS1 contrasts sharply with its documented ability to inhibit the activ

285 or horizontally filtered images and declined sharply with oblique and vertically filtered images.

286 This contrasts sharply with oxidative heterocyclization reactions catal

287 immediate online post-test scores contrasted sharply with poor end-rotation scores on an in-house tes

288 he probability of diving behaviour increases sharply with prey abundance at relatively low levels of

289 cyclization efficiency (j factor) increases sharply with temperature and depends strongly on the str

290 This behavior contrasts sharply with that exhibited by nonswitching proteins, wh

291 This contrasts sharply with the adaptationist approach to human behavio

292 These findings contrast sharply with the disorganized vasculature elicited by in

293 duration of F-actin attachment, which varies sharply with the ensemble size, motor duty ratio, and ex

294 ere not employed full-time, which contrasted sharply with the experiences of women.

295 ielded non-saturating patterns that contrast sharply with the results of experimental studies, where

296 We find that correlation increases sharply with the swarm's density, indicating that the in

297 dorant representation found in PCX contrasts sharply with the topographical representation seen in ot

298 The findings contrast sharply with those of a recent systematic review and met

299 ried by less than +/- 1 mM, and it increased sharply with tumor progression.

300 MgSO4 droplets, water diffusivity decreases sharply with water activity and is consistent with predi