ライフサイエンスコーパス: shedding

1 osis and glycoprotein Ib alpha chain (CD42b) shedding.

2 L) to differentiate pneumonia from pulmonary shedding.

3 in different degrees of pathology and viral shedding.

4 free energy of condensate promotes the self-shedding.

5 nimal even when drought led to complete leaf shedding.

6 o differentiate CMV pneumonia from pulmonary shedding.

7 om adaptive immunity, virus persistence, and shedding.

8 plasminogen activator, failed to cause LRP1 shedding.

9 tease to the cell surface and its subsequent shedding.

10 Seventeen of 44 patients had prolonged shedding.

11 ted by alternative splice variants and/or by shedding.

12 ignificantly associated with seminal HIV RNA shedding.

13 85% with blood VL > 5 log10 IU/mL had rectal shedding.

14 and NL63 starting 1 month following onset of shedding.

15 fragments (Nrxn-CTF) generated by ectodomain shedding.

16 causes recurrent lesions and frequent viral shedding.

17 of transmission proportional to the level of shedding.

18 n different degrees of lung damage and viral shedding.

19 pread beyond the respiratory tract and fecal shedding.

20 al tissue titers and enhanced reovirus fecal shedding.

21 conditioning were associated with prolonged shedding.

22 .6% of visits with detectable VL had genital shedding.

23 Of the 16 viruses studied for fecal shedding, 11 were detected in fecal samples.

24 Of the 236 women with data on HSV-2 shedding, 151 took ART during the study period.

25 sate and the solid surface triggers the self-shedding; (2) the release of the surface free energy of

26 Poliovirus shedding 7 days after challenge was less prevalent in ar

27 refore couples ROS sensing to p53 responses, shedding a new light on the role of PML in senescence or

28 re independent predictors of genital HIV RNA shedding after adjusting for plasma HIV RNA and longitud

29 ons was used to assess predictors of genital shedding among women with undetectable plasma viral load

30 roup exhibit evidence of MARV replication or shedding and all bats develop virus-specific secondary i

31 ent to promote inflammation, which increased shedding and allowed for intralitter transmission.

32 earance of megakaryocytes following platelet shedding and constrains platelet lifespan in the circula

33 However, little is known about eDNA shedding and decay in aquatic environments.

34 The eDNA shedding and decay rates reported within are the first f

35 Investigation of risk factors for prolonged shedding and intrahost genome evolution may provide crit

36 30 microg and 100 microg reduced genital HSV shedding and lesion rates.

37 ells (IECs) serve as the reservoir for fecal shedding and persistence.

38 ct infections may decrease the risk of HIV-1 shedding and potential transmission.

39 m prolonged placental or transplacental ZIKV shedding and potential utility of maternal antibody tite

40 m mouse to human and used parameters for PSA shedding and prostate cancer.

41 tion of VEGFR2 protects the receptor against shedding and provides evidence for an unprecedented mech

42 d with a significant reduction in both virus shedding and recurrent corneal herpetic disease.

43 a major factor in the level of pneumococcal shedding and required expression of capsule.

44 Menstruation is characterised by synchronous shedding and restoration of tissue integrity.

45 Epithelial shedding and scarring of fallopian tube mucosa are the m

46 ectable and the interactions between chronic shedding and seasonal drivers needed to explain persiste

47 e virus appear to correlate with urinary JCV shedding and serostatus.

48 a metalloproteinase inhibitor inhibited LRP1 shedding and significantly attenuated RAP-induced cytoki

49 tramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavage by gamma-

50 amics of condensate that the continuous self-shedding and sweeping effectively remove the droplets fr

51 rhydrophobic surface for enhancement by self-shedding and sweeping of condensate.

52 k on the condensing surface through the self-shedding and sweeping.

53 so demonstrate that apoptosis precedes CD42b shedding and that apoptosis inhibition enriches the FV(+

54 ta characterize mediators involved in PrP(c) shedding and the effect of this sPrP(c) on monocyte chem

55 uggest that targeting endothelial-derived MP shedding and their bioactivity may be a promising therap

56 y infected with BoHV-1, culminating in virus shedding and transmission.

57 rovirus (MNoV) infection and regulates fecal shedding and viral titers in tissue.

58 ely only the presence of a sustained cloacal shedding (and not oropharyngeal shedding) was critical f

59 inued protection against infection, no viral shedding, and boosting of the immune response.

60 on against corneal neovascularization, HSV-1 shedding, and latency through passive immunization.

61 culation with HSV-1 had reduced eye disease, shedding, and latent infection.

62 to moderate diarrhea, lower titers of viral shedding, and no mortality, whereas the icPC22A virus ca

63 creased the duration of RV infections, viral shedding, and the risk of RV illnesses.

64 ence, we fit models with and without chronic shedding, and with different seasonal drivers, to determ

65 dynamics of viral infection, replication and shedding are poorly understood.

66 LPS also stimulated LRP1 shedding, as did the heat-shock protein and LRP1 ligand,

67 reated HEV-infected pigs cleared fecal viral shedding at 8 wk postinfection.

68 s versus children, with HIV-positive mothers shedding at a higher rate than HIV-negative mothers.

69 tment showed a significant decrease in viral shedding at day 3 relative to monotherapy, this differen

70 infection and are transmitted primarily via shedding at mucosal surfaces.

71 greater likelihood of detectable penile HIV shedding at the subsequent visit, compared to men with <

72 We compared the patterns of influenza viral shedding between these groups.

73 ated HEV-infected pigs continued fecal virus shedding beyond the acute phase of infection, whereas th

74 such as GPCR ligands induce ADAM17-mediated shedding, but do not alter the cell-surface abundance of

75 d vs. 12.4 d; P = 0.03) and reduced peak RV shedding by 0.4 log units (95% confidence interval, -0.7

76 L2 and that a subset of them is resistant to shedding by cell surface metalloproteases.

77 TAM expression and shedding by tubular epithelial cells were investigated b

78 We show that the consequence of this shedding can be the production of inflammatory mediators

79 nital human immunodeficiency virus (HIV) RNA shedding can continue despite HIV being undetectable in

80 Chronic shedding can enable persistence of L. interrogans within

81 s under purifying selection and with similar shedding capacity.

82 TACE; ADAM17, CD156b), the metalloproteinase shedding CD62L, was increased at diagnosis and significa

83 significantly increased rates of seminal HHV shedding compared with HIV-uninfected controls.

84 We propose that MT3-MMP activity and NgR1 shedding could stimulate circuitry remodeling in the adu

85 anding of this specialized enzyme family and shedding critical light onto the biosynthesis of bioacti

86 infection and validated them using clinical shedding data.

87 The proportion of visits with genital shedding decreased with time since ART initiation but th

88 -GPVI-induced platelet accumulation nor GPVI shedding, demonstrating that the other major FcgammaRIIB

89 Escape into the cytosol and outer-layer shedding depend on interaction of a hydrophobic surface

90 ansient thrombocytopenia and GPVI ectodomain shedding depend on the Fc portion of the anti-GPVI antib

91 romised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves.

92 Prevalence of shedding did not vary by time since ART initiation when

93 Capsule shedding drastically increases invasion of epithelial ce

94 Shedding duration was defined as time between first posi

95 63, 19% were HKU1, and 13% were 229E; median shedding duration was similar between strains (P = .79).

96 om respiratory samples, variability in viral shedding duration, lack of effective therapy, and high m

97 We characterized kinetics of oral shedding during primary and chronic infection for each v

98 abs and the frequency of genital lesions and shedding episodes.

99 ly detected self-limited, low-level oral CMV shedding events, which we termed transient CMV infection

100 t infections comprised 76 to 88% of oral CMV shedding events.

101 on the distribution of high-risk contact and shedding events.

102 ists as the embryo continues its growth post-shedding, eventually breaking through the surrounding ti

103 nization by C. rodentium, prolonged pathogen shedding, exaggerated cytokine responses, and greater ti

104 itudinal IFN-gamma, ELISA-antibody and fecal shedding experimental sensitivity scores for MAP infecti

105 e patients stimulated ADAM17-dependant CD163 shedding from healthy donor-derived monocytes.

106 ollectively, these results suggest that LRP1 shedding from microglia may amplify and sustain neuroinf

107 the role of the Asp358Ala variant in sIL-6R shedding from neutrophils and its pro-inflammatory effec

108 and will evaluate the effect of 4b on viral shedding from sanctuary sites in EBOV survivors.

109 e demonstrate the prognostic impact of CD62L shedding from T cells and increased sCD62L plasma levels

110 tomers were occupied by the CD4mc, and gp120 shedding from the Env trimer was increased in the presen

111 ated microglia was its ability to cause LRP1 shedding from the plasma membrane.

112 We quantified Nectin-4 shedding from the surface of ovarian cancer cells after

113 omarker kinetics that accounts for biomarker shedding from tumor and healthy cells, biomarker entry i

114 Importantly, the CARS signals from cellular sheddings from MCAs with LPA treatment are consistent wi

115 se to its targets where it then executes its shedding function.

116 cent of infant mountain gorillas were orally shedding GbbLCV-1, suggesting primary infection during t

117 After seed shedding, germination can be prevented by a property kno

118 in asthma and is characterized by epithelial shedding, goblet cell hyperplasia, basement membrane thi

119 performed to evaluate factors for prolonged shedding (>/=21 days).

120 Prolonged viral shedding has been reported in semen, suggesting the pres

121 As determined by vaginal shedding, HLA-DR4 mice were more susceptible to a transc

122 We found rectal HCV shedding in 20 (47%) of 43 men, only one (2%) of whom ha

123 allowed us to study the propensity of fiber shedding in a mechanistic way.

124 ed the effects of valganciclovir on oral EBV shedding in a randomized, double-blind, placebo-controll

125 The mean levels of influenza viral RNA shedding in asymptomatic and paucisymptomatic cases were

126 stsynaptic Nlgn1 or inhibition of ectodomain shedding in axonal Nrxn1-beta increases presynaptic rele

127 n crucial to understanding the role of prion shedding in disease transmission and for diagnosis.

128 tablish chronic infections with active viral shedding in healthy humans but whether persistence is as

129 nical relevance of this ADAM17-mediated ACE2 shedding in hypertensive patients and further identify t

130 edding vs. intensity and duration of chronic shedding in individuals.

131 nized pups required high levels of bacterial shedding in nasal secretions and was temporally correlat

132 s to reduce PV replication to diminish viral shedding in OPV recipients.

133 solution of viremia and termination of virus shedding in oropharynges and feces.

134 Understanding the function of Nectin-4 shedding in ovarian cancer progression is critical to fa

135 The presence of influenza viral shedding in patients with influenza who have very few or

136 Cytomegalovirus (CMV) urinary shedding in pregnant women infected with human immunodef

137 sulted in 2.77 times the likelihood of prion shedding in saliva compared to that from inoculation wit

138 infect deer affects the likelihood of prion shedding in saliva; oral inoculation of deer with CWD-po

139 The primary outcome was poliovirus shedding in stool 7 days after bivalent OPV challenge at

140 -1 reactivation from TG and subsequent virus shedding in tears that trigger recurrent corneal herpeti

141 ype 1 receptors promote ADAM17-mediated ACE2 shedding in the brain of hypertensive patients, leading

142 to better understand the mechanisms of fiber shedding in the context of microplastic fiber release in

143 s in both epithelial cells (explaining virus shedding in the gastrointestinal tract) and lymphoid/mon

144 s in both epithelial cells (explaining virus shedding in the gastrointestinal tract) and lymphoid/mon

145 inal tissue viral titers and increased viral shedding in the stool.

146 ts have describe high-level persistent viral shedding in the urine of infected patients, but the asso

147 w analyses of a fossil fish demonstrate that shedding involved tooth resorption, a primitive feature

148 When this shedding is blocked, excessive ICOS internalization occu

149 determine the time-scale over which chronic shedding is detectable and the interactions between chro

150 MARV shedding is detected in oral, rectal and urine specimens

151 we demonstrated that the level of bacterial shedding is highest in pups infected intranasally at age

152 novel Col13a1tm/tm mice in which ectodomain shedding is impaired.

153 We reveal that the mechanism for self-shedding is two-fold: (1) that the external force on con

154 HuNoV shedding lasted for 16 days in wild type pigs, compared

155 stability or interactions with its partners, shedding light into potential molecular mechanisms givin

156 ion progress kinetic analysis was performed, shedding light on a possible mechanism for this catalyti

157 ir and mutation mechanisms in cells, thereby shedding light on evolution, genomic disorders, cancer,

158 the distinct anomeric fragment ions, in turn shedding light on gas-phase dissociation mechanisms of g

159 esent the earliest definitive termitophiles, shedding light on host associations in the early evoluti

160 n the sociology of education and inequality, shedding light on how schools can-at once-be egalitarian

161 ch slower off rate than the IL-36R agonists, shedding light on IL-36 pathway inhibition.

162 veals PNA's intrinsic structural properties, shedding light on its reported sequence selectivity or i

163 poral couplings in focusing has been gained, shedding light on previously unexplored parameters of th

164 n regulating responses to rewarding stimuli, shedding light on the broader neurobiology of emotions a

165 ome sequencing has reinvigorated this field, shedding light on the contemporary history of this patho

166 Shedding light on the crosstalk between allergic respons

167 ers an interpretation of feature importance, shedding light on the driving forces of the underlying b

168 l effect in southwest China, and the results shedding light on the higher level of species richness i

169 Furthermore, we argue that shedding light on the interplay between number and conti

170 he 100S complexes in Gram-positive bacteria, shedding light on the mechanism of translation suppressi

171 ed specifically to repair alkylation damage, shedding light on the molecular mechanism of X-linked tr

172 the cuprate electronic structure potentially shedding light on the origin of superconductivity in the

173 position and microstructure of the pigments, shedding light on the preparation recipes and pigment ch

174 ill debated, this complicated association is shedding light on the role of lysosomes in neurodegenera

175 time in the assembled peptide network, thus shedding light on the role of water in a self-assembly p

176 influences the observed enantioselectivity, shedding light on the success of this emerging ligand cl

177 ith retinoic acid transcriptional signaling, shedding light on the well documented association betwee

178 ong-term potentiation at mossy cell outputs, shedding light on their mysterious function.

179 In addition to shedding light on this critical process, these findings

180 properties of the C2 domain-bearing protein, shedding light to understand the fine-tuning control of

181 edicts for poor prognosis of esophageal SCC, shedding light upon the tumor promoting oncogenic aspect

182 incident with a suppression of vaginal HSV-2 shedding, low lesion scores, and a reduction in latent H

183 ed between PIVs and persistent low-level AdV shedding may account for the higher method discordance o

184 Vaginal CMV shedding may provide a route for sexual and possibly per

185 ons of these organs behave under stress, and shedding more light into the potential cellular and mole

186 inoids, displayed distinct kinetic profiles, shedding more light on their mechanism of action and the

187 g attention by changing choice bias, thereby shedding new light on how the brain mediates attention.

188 onkeys, cows, and, most recently, catsharks, shedding new light on the genetic diversity and host ran

189 ermi liquid description of the normal phase, shedding new light on the nature of the strongly attract

190 Transcriptomics is shedding new light on the relationship between photosynt

191 fic regulation of inflammation mediators and shedding new light on the role of fibroblasts in chronic

192 oire of oxidative stress genes in S. mutans, shedding new light on the role of Spx regulation.

193 ERalpha-AFs in breast cancer proliferation, shedding new light on the therapeutic potential of selec

194 omes from additional members of this family, shedding new light on their unusual biology.

195 netic analysis of paired specimens confirmed shedding of 2 distinct HSV-2 strains collected at differ

196 llergen-induced miR-132-3p may contribute to shedding of bronchial epithelial cells.

197 Surgery induces increased shedding of cancer cells into the circulation, suppresse

198 ctivity of CD39 and, therefore, abrogate the shedding of CD62L.

199 Studying the shedding of cell membrane-bound hTNF by Adam17, a known

200 Pretransplant urinary BKV shedding of donor and recipient is a risk for posttransp

201 Inhibiting ectodomain shedding of Dsg2 with the matrix metalloproteinase inhib

202 tion of PI(4,5)P2, a reaction needed for the shedding of endocytic factors from their membranes.

203 Ectodomain shedding of glycoprotein (GP) Ibalpha is thought to medi

204 conditioning were associated with prolonged shedding of HCoV in HCT recipients.

205 Intermittent shedding of human immunodeficiency virus type 1 (HIV) in

206 tion of ICOS/ICOSL results in ADAM10-induced shedding of ICOSL on B cells and moderate ICOS internali

207 Furthermore, IL-1beta induced shedding of IL-1R2 in vivo.

208 tes, and that NMDAR activity is required for shedding of its ectodomain by metalloproteinases.

209 phils showing signs of increased reactivity: shedding of l-selectin, CD11b upregulation, increased ox

210 We use chronic shedding of Leptospira interrogans serovar Pomona in Cal

211 creases soluble RANKL by reducing ectodomain shedding of membrane RANKL through downregulation of met

212 SEM images show distinct shedding of microvilli-like features upon treatment with

213 indings support a role for MT3-MMP-dependent shedding of NgR1 in regulating excitatory synapse develo

214 This approach enabled us to discriminate the shedding of prions in saliva and the detection of prions

215 nt to CWD biology from our analyses: (i) the shedding of prions in saliva increases with time postino

216 genicity through tissue factor upregulation, shedding of procoagulant MPs, endothelial nitric oxide s

217 to P4, and was associated with a progressive shedding of procoagulant MPs.

218 We propose that shedding of PrP(c) could be a potential target for thera

219 in the CNS of HIV-infected people, increase shedding of PrP(c) from human astrocytes by increasing t

220 Here we observed that ectodomain shedding of RAGE is critical for its role in regulating

221 onuclear cells exposed to RhCMV antigens and shedding of RhCMV in saliva.

222 did not receive mOPV2, as assessed by faecal shedding of Sabin 2 by reverse transcriptase quantitativ

223 However, faecal shedding of Sabin 2 in household contacts was increased

224 Faecal shedding of Sabin 2 in infants who did not receive the m

225 Shedding of sEphrin-B2 promotes fibroblast chemotaxis an

226 samples from 37 participants, we found that shedding of sIL-6R from neutrophils was greater in carri

227 ALL, TRC105 alone was ineffective due to the shedding of soluble CD105.

228 gulation of Tyro3 and Mer mRNA and increased shedding of sTyro3 and sMer.

229 However, secreted MMP-7 participated in the shedding of Syndecan-4 from the surface of B-lymphocytes

230 of MMP-7 which in turn is important for the shedding of Syndecan-4 in response to infectious stimuli

231 lux of chemokines through the regulation and shedding of syndecans.

232 Despite shedding of the bacteria, the remnant matrix remains int

233 Many vertebrates replace teeth through shedding of the functional tooth.

234 ated platelets and endothelial cells induces shedding of the P-selectin ectodomain into the circulati

235 s undesired premature drug release until the shedding of the shell, which accelerates the cleavage of

236 or Rab5, increases dramatically the cleavage/shedding of VEGFR2.

237 cal signs and did not develop viremia, virus shedding or antibodies against FMDV nonstructural protei

238 to demonstrate sustained depression of viral shedding or protection from recurrences.

239 o and in vitro, including reduced l-selectin shedding, oxidative burst, chemotaxis, neutrophil extrac

240 Immunogenicity, viraemia, and shedding post-vaccination were evaluated as secondary ob

241 t the preclinical phase of disease; (ii) the shedding propensity is influenced neither by sex nor by

242 same subcellular distribution and ectodomain shedding properties.

243 TACE is a major shedding protease, responsible for the liberation of the

244 PS exposure is tightly coupled to substrate shedding provoked by diverse ADAM17 activators.

245 EBV shedding rate and quantity decreased less dramatically i

246 CMV shedding rate and viral load were higher in children wit

247 HHV-6 shedding rate and viral load were similar between childr

248 Compared with baseline, genital HSV-2 shedding rates immediately after dosing were reduced wit

249 ; and factors influencing concentrations and shedding rates of pathogens originating from animal fece

250 mothers with chronic HSV infection had lower shedding rates than children with primary infection.

251 at include viral infections with lower virus-shedding rates than IHNV or where higher viral titers ar

252 Longitudinal shedding rates were determined by Kaplan-Meier survival

253 Shedding rates were particularly high among men, which m

254 Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic

255 s, the subtle dynamical influence of chronic shedding relative to more obvious epidemic drivers, and

256 , but the mechanism and significance of uPAR shedding remain obscure.

257 me since ART initiation but the magnitude of shedding remained unchanged when plasma VL was undetecta

258 pare the magnitude and prevalence of genital shedding, respectively, by time since ART initiation.

259 Mass spectrometry on the cellular sheddings show that a large number of proteins, both mem

260 tectable (P = .195), though the magnitude of shedding significantly increased (P = .04).

261 F, and the CusBA complex have been resolved, shedding some light on the efflux mechanism underlying t

262 I IFN receptor had minimal effects on viral shedding, suggesting that endogenous type I IFN signalli

263 ent and temporal association with penile HIV shedding, suggesting that genital immune activation may

264 and quantitative techniques with the aim of shedding the light on f-MWNT's brain distribution follow

265 e receptor against plasma membrane cleavage (shedding), thereby preserving the functional state of th

266 Among children with RTI, the median HMPV shedding time by PCR was 13 days (range, 6-28 days), but

267 genotyped HMPV-positive samples and assessed shedding time in 32 HMPV-infected children.

268 brane molecule, it also undergoes ectodomain shedding to become a synaptic basal lamina component.

269 demonstrations of the importance of chronic shedding to pathogen persistence at the population-level

270 defined by substantial differences in viral shedding trajectories.

271 Studying chronic shedding using commonly collected disease data is hamper

272 rentiate between CMV pneumonia and pulmonary shedding, using current CMV pneumonia prevalence figures

273 ions, characterized by persistent high-level shedding, viremia, and seroconversion.

274 lence risk ratios (adjPRR) of detectable HIV shedding (VL > 40 copies/mL) were estimated by Poisson r

275 effects of population prevalence of chronic shedding vs. intensity and duration of chronic shedding

276 nt women not on antiretrovirals, urinary CMV shedding was a significant risk factor for CMV and HIV t

277 PMA-induced shedding was abrogated by an ADAM (A disintegrin and met

278 Detection of rectal HCV shedding was associated with blood VL > 5 log10 IU/mL (p

279 men with a detectable plasma VL, penile HIV shedding was detected at 136 visits (16.8%).

280 Viral shedding was detected in only six (6%) of 101 participan

281 Prevalence of HSV shedding was lower and mostly intermittent, but its asso

282 The rate of oral herpes simplex virus (HSV) shedding was lower overall, and children and mothers wit

283 Biomarker shedding was monitored by serial blood sampling, whereas

284 Persistent shedding was more common for CMV and EBV when compared t

285 With exception of HHV-7, HHV shedding was not significantly influenced by HIV RNA lev

286 However, the importance of chronic shedding was only apparent when surveillance data includ

287 The duration of viral RNA shedding was shorter and declined more rapidly in paucis

288 We determined that eDNA shedding was statistically similar across mussel densiti

289 In addition, sVLDLR-N shedding was suppressed under hypoxia.

290 ined cloacal shedding (and not oropharyngeal shedding) was critical for transmission.

291 s to protect HG MKs from apoptosis and CD42b shedding, we also demonstrate that apoptosis precedes CD

292 Predictors of viral shedding were determined using backwards selection in a

293 Predictors of genital shedding were HIV disease stage, antiretroviral regimen,

294 e gamma-glutamyl transferase and fecal virus shedding were significantly higher in immunocompromised

295 Each HHV has a distinct pattern of oral shedding which depends partially on the age and immune s

296 th ascites fluid significantly increased sN4 shedding, which could be blocked using a dual inhibitor

297 ompromised mice demonstrated prolonged virus shedding with modest induction of immune responses compa

298 Sustained virus shedding with transmission to contact-exposed birds, alo

299 used mild diarrhea and lower fecal viral RNA shedding, with no mortality, whereas PC21A caused severe

300 determined by severity and length of vaginal shedding, WT C57BL/6 and HLA-DR4 mice were significantly