ライフサイエンスコーパス: shedding of

1 netic analysis of paired specimens confirmed shedding of 2 distinct HSV-2 strains collected at differ

2 RK1/2 through the metalloproteinase-mediated shedding of a factor activating the insulin-like growth

3 g of the mammalian Aurora B kinase, triggers shedding of a kinetochore protein, preventing microtubul

4 typic H5N1 virus was associated with reduced shedding of a pandemic H1N1 virus challenge, while vacci

5 In vitro, 200 nM D1(A12) inhibited shedding of ADAM17 substrates TNF-alpha, TNFR1-alpha, TG

6 ytes, resulting in significantly upregulated shedding of ADAM17 substrates, including EGF-family grow

7 d physicochemical modification of Ag NPs and shedding of Ag+, leading to an increased bioavailability

8 levels in all tissues and show virtually no shedding of all tested ADAM17 substrates, to clarify the

9 , and this regulation may be used to control shedding of amyloid precursor protein by enhancing alpha

10 on of ErbB receptors through the proteolytic shedding of an ErbB ligand.

11 r of ADAM9, these results indicate increased shedding of angiotensin-converting enzyme in the alveola

12 and ADAM cleavage assays to demonstrate that shedding of at least 12 of these proteins are potentiall

13 B. bronchiseptica or B. pertussis inhibited shedding of B. bronchiseptica.

14 hanism of immune escape involving tumor cell shedding of B7-H6, a ligand for the activating receptor

15 ated recognition by metalloprotease-mediated shedding of B7-H6.

16 in the feed showed a progressive decline in shedding of bacteria, significantly lower immune respons

17 e biochemistry of epithelial bonding and the shedding of binding proteins on the sperm head.

18 Ectodomain shedding of both human and mouse RAGE was dependent on A

19 Selective inhibition of ADAM17 prevented the shedding of both molecules.

20 llergen-induced miR-132-3p may contribute to shedding of bronchial epithelial cells.

21 2 antibody treatment reduced the nonspecific shedding of BST-2 and limited the encapsidation of BST-2

22 hanism studies showed that CgA inhibited the shedding of cancer cells in circulation from primary tum

23 Surgery induces increased shedding of cancer cells into the circulation, suppresse

24 dependent ATP release regulates this through shedding of CD21 and CD62L.

25 ein KIF2A, which subsequently alleviated the shedding of CD44 from DCs.

26 nd in vivo results point to a P2X7-dependent shedding of CD62L (with high levels in the serum), which

27 ctivity of CD39 and, therefore, abrogate the shedding of CD62L.

28 processes involving cleavage, processing, or shedding of cell adhesion molecules, growth factors, cyt

29 Studying the shedding of cell membrane-bound hTNF by Adam17, a known

30 Proteolytic shedding of cell surface proteins generates paracrine si

31 verting enzyme (TACE) is responsible for the shedding of cell surface TNF.

32 rize a novel viral strategy to influence the shedding of cell-surface molecules involved in immune re

33 This is due to decreased shedding of cell-surface N-cadherin by the ADAM family p

34 Respiratory symptoms and shedding of challenge virus were assessed.

35 In contrast, VEGFA induced shedding of charged GAGs.

36 t ADAM10 activity contributes to HDM-induced shedding of chemokines, including CCL20.

37 onensin, indicating that HDM induces surface shedding of chemokines.

38 asmic action of the retrograde IFT motor and shedding of ciliary ectosomes.

39 ributes and ADT-sensitivity, and reduces the shedding of circulating tumor cells in vivo with signifi

40 In support of our primary hypothesis, shedding of CMV DNA in semen was associated with increas

41 HIV DNA levels (p = 0.09) and more frequent shedding of CMV in seminal plasma (p = 0.002).

42 Increased PTC apoptosis allowed luminal shedding of cystine crystals and was partially compensat

43 ory signaling events by promoting ectodomain shedding of cytokine precursors and cytokine receptors.

44 y and signaling by inhibiting the ectodomain shedding of cytokines and their receptors.

45 Vaginal shedding of cytomegalovirus (CMV) DNA was determined lon

46 Since shedding of cytomegalovirus from mucosal surfaces is cri

47 binding induces ADAM10-dependent ectodomain shedding of DDR1.

48 cantly reduced the expression of heparanase, shedding of DeltaHS, and loss of occludin as detected by

49 ptor outer segments (POS) involves circadian shedding of distal rod POS tips and their subsequent pha

50 embrane metalloprotease mediating ectodomain shedding of diverse membrane proteins, was recently sugg

51 ferentiation, whereas TIMP3 may modulate the shedding of DLK1, a regulator of adipogenesis.

52 Pretransplant urinary BKV shedding of donor and recipient is a risk for posttransp

53 Pretransplant urinary BKV shedding of donor or recipient was a significant risk fa

54 Inhibiting ectodomain shedding of Dsg2 with the matrix metalloproteinase inhib

55 erved P4-ATPase TAT-5 causes the large-scale shedding of ECVs and disrupts cell adhesion and morphoge

56 hysiological effects of meprinalpha-mediated shedding of EGF and TGFalpha were investigated with huma

57 functional relevance of iRhom2 in regulating shedding of EGF receptor (EGFR) ligands is established b

58 ) has anti-ADAM17 activity in vivo, inhibits shedding of EGFR ligands and has potential for use in EG

59 gulates oligodendrogenesis by modulating the shedding of EGFR ligands TGFalpha and HB-EGF and, conseq

60 rowth factor receptor (EGFR) activity and on shedding of EGFR ligands; exposure to 12% CO2 without ad

61 tion of PI(4,5)P2, a reaction needed for the shedding of endocytic factors from their membranes.

62 ase inhibitor studies show that constitutive shedding of endogenous DDR1 in breast cancer HCC1806 cel

63 Shedding of endogenous Tim-3 was found in primary human

64 ion of the endothelium leads to an increased shedding of endothelial cell microparticles (MP).

65 Cell adhesion was reversed by shedding of endothelial E-selectin, P-selectin, and alph

66 further induces activation of Rho kinase and shedding of endothelial microparticles carrying miR-503,

67 UA-induced shedding of endothelial TM may represent a novel mechani

68 The shedding of epithelial cell layers is usually effective

69 Programmed death and shedding of epithelial cells is a powerful defense mecha

70 The reduced shedding of essential postsynaptic cell adhesion protein

71 uction in oxygen coincides with an increased shedding of eukaryotic viruses in the oxycline, and a sh

72 rse astrophysical phenomena, for example the shedding of excess angular momentum from protostars by t

73 We demonstrate that flow-induced shedding of extracellular matrix from surface-attached b

74 The generation and shedding of extracellular vesicles (EVs), including exos

75 ith PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific sub

76 The shedding of FcgammaRIIIA/CD16A was at least partially AD

77 Finally, the shedding of FcgammaRIIIA/CD16A was restricted to activat

78 Moreover, the shedding of FcgammaRIIIA/CD16A was strongly correlated w

79 the glycosylation, proteolytic cleavage, and shedding of fibrocystin.

80 in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling

81 fferentially regulate synthesis, charge, and shedding of GAGs in GEnCs.

82 One such mechanism is the shedding of gangliosides into the local tumor microenvir

83 ors involves the synthesis and extracellular shedding of gangliosides, a class of biologically active

84 Importantly, no recurrent vaginal shedding of gE2-del DNA was detected in immunized guinea

85 Ectodomain shedding of glycoprotein (GP) Ibalpha is thought to medi

86 Ligand-induced ectodomain shedding of glycoprotein VI (GPVI) is a metalloproteinas

87 and ADAM17 can produce sgp130 by ectodomain shedding of gp130, even though this mechanism only accou

88 of GPIbbeta is critical for ADAM17-dependent shedding of GPIbalpha induced by the calmodulin inhibito

89 r was associated with macrothrombocytopenia, shedding of GPIbalpha, impaired platelet adhesion to von

90 In this study, shedding of GPIbalpha, the ligand-binding subunit of the

91 tion of either of the ITAM receptors induces shedding of GPVI and proteolysis of the ITAM domain in F

92 Shedding of GPVI continued after transient exposure to s

93 egation but minimally affected shear-induced shedding of GPVI.

94 nce of GPVI ligand, was sufficient to induce shedding of GPVI.

95 Prolonged, high-level IHS (ie, shedding of >5000 RNA copies/mL) was observed in 1 iART

96 nation is achieved is poorly understood, but shedding of guidance cues by metalloproteinases is emerg

97 a showed decreased expression and ectodomain shedding of HB-EGF and reduced incidence of cancer devel

98 oned medium on the expression and ectodomain shedding of HB-EGF by TNFalpha-converting enzyme/a disin

99 conditioning were associated with prolonged shedding of HCoV in HCT recipients.

100 y high glucose was associated with increased shedding of heparan sulfate (DeltaHS) and the tight junc

101 confirmed the superfusion results and caused shedding of heparan sulfate, pointing to disruption of t

102 wnstream ERK activation depends on increased shedding of heparin-binding EGF.

103 Here, we describe extracellular shedding of HEPCAM at two alpha-sites through a disinteg

104 To investigate the role of genital shedding of herpesviruses in human immunodeficiency viru

105 Shedding of HHV in saliva was prospectively studied in p

106 The PCR assay demonstrated shedding of HHV-7, EBV, HHV-6, and CMV, listed by order

107 symptomatic STIs, is associated with seminal shedding of HIV in men receiving ART, conferring a poten

108 However, isolated shedding of HIV type 1 (HIV-1) in semen (IHS) can occur

109 es a potential mechanism for acquisition and shedding of HIV via chronic leukocyte recruitment to the

110 TV has been shown to increase vaginal shedding of HIV, which may influence HIV sexual and peri

111 M through a mechanism involving cell surface shedding of HS.

112 cantly reduced the number of days of vaginal shedding of HSV-2 DNA compared with that for mock-immuni

113 nglia in mice and reducing recurrent vaginal shedding of HSV-2 DNA in guinea pigs.

114 7 for prevention of genital disease, vaginal shedding of HSV-2 DNA, and latent infection of dorsal ro

115 imals had little effect on recurrent vaginal shedding of HSV-2 DNA, despite significantly reducing ge

116 r, 5/8 animals in each group had subclinical shedding of HSV-2 DNA, on 15/168 days for the gC2/gD2 gr

117 inate recurrent lesions or recurrent vaginal shedding of HSV-2 DNA.

118 rrent genital lesions, and recurrent vaginal shedding of HSV-2 DNA; however, protection was incomplet

119 Pharmacological treatments revealed that shedding of hTfR1 by PC7 requires endocytosis into acidi

120 Here, ectodomain shedding of human and murine IL-23R was identified as an

121 Intermittent shedding of human immunodeficiency virus type 1 (HIV) in

122 ng parameters but did associate with greater shedding of hyaluronan in blood.

123 tion of ICOS/ICOSL results in ADAM10-induced shedding of ICOSL on B cells and moderate ICOS internali

124 pport a role for metalloproteinase-dependent shedding of IgLON family members in regulating neurite o

125 Inflammasome activation and platelet shedding of IL-1beta-rich microparticles correlated with

126 Furthermore, IL-1beta induced shedding of IL-1R2 in vivo.

127 Shedding of IL-23R was induced by stimulation with the p

128 ion in this model, it is not ADAM17-mediated shedding of IL-6R within the pouch that orchestrates thi

129 We report that during cystitis, shedding of infected bladder epithelial cells (BECs) was

130 spiratory viruses revealed that NS2 promotes shedding of infected epithelial cells, resulting in two

131 ds with an influx of innate immune cells and shedding of infected epithelial cells.

132 Shedding of infectious prions in saliva and urine is tho

133 ve and inducible metalloproteinase-dependent shedding of integrin beta2 from mouse macrophages are de

134 es the ability of metalloproteinase-mediated shedding of integrin beta2 to promote macrophage efflux

135 tes, and that NMDAR activity is required for shedding of its ectodomain by metalloproteinases.

136 The shedding of its ectodomain from the cell surface is phys

137 ge of MerTK at an unidentified site leads to shedding of its soluble ectodomain (soluble MER; sMER),

138 Rapid shedding of Juno from the oolemma after fertilization su

139 toxicity and was able to selectively inhibit shedding of known ADAM10 substrates in several cell-base

140 In agreement with this, activation-induced shedding of L-selectin also mediated decreased lubricin

141 domain of L-selectin to regulate ectodomain shedding of L-selectin on the other side of the plasma m

142 phils showing signs of increased reactivity: shedding of l-selectin, CD11b upregulation, increased ox

143 cell to modulate the function and ectodomain shedding of l-selectin.

144 We use chronic shedding of Leptospira interrogans serovar Pomona in Cal

145 Proteolytic shedding of ligands for the NK group 2D (NKG2D) receptor

146 Finally, we addressed how shedding of ligands is regulated by EGFR.

147 h) is solubilized by proteolytic processing (shedding) of lipidated peptide termini in vitro.

148 l tract, which resulted in a delayed vaginal shedding of live organisms, accelerated the chlamydial s

149 naling within B cells is blunted through the shedding of LMP1 via exosomes.

150 significantly slowed down after 10 h due to shedding of LRP-1 from the cell surface and formation of

151 17) is a membrane-bound enzyme that mediates shedding of many membrane-bound molecules, thereby regul

152 metalloprotease 10 (ADAM10) is required for shedding of membrane proteins such as EGF, betacellulin,

153 creases soluble RANKL by reducing ectodomain shedding of membrane RANKL through downregulation of met

154 y amyloid fibrils is caused by the molecular shedding of membrane-active oligomers in a process that

155 ible step in many signalling pathways is the shedding of membrane-anchored proteins.

156 active ADAMs are responsible for ectodomain shedding of membrane-associated proteins.

157 rm of CD154 (sCD154), which results from the shedding of membrane-bound CD154, plays a key role in th

158 ugh inhibition of invadopodia maturation and shedding of membrane-derived microvesicles, the two key

159 ey to this process is the protease-mediated "shedding" of membrane-tethered ligands, which then activ

160 ntify the proteolytic enzyme responsible for shedding of meprin A, we generated stable HEK cell lines

161 istate 13-acetate-, and ionomycin-stimulated shedding of meprin beta and meprin A in the medium of bo

162 ponsible for the constitutive and stimulated shedding of meprin beta and meprin A.

163 -acetate and ionomycin stimulated ectodomain shedding of meprin beta and meprin A.

164 verexpression of ADAM10 resulted in enhanced shedding of meprin beta from both transfectants.

165 This induces ectodomain shedding of metalloprotease-sensitive cell surface prote

166 ubicin and melphalan) selectively affect the shedding of MIC molecules that are sensitive to proteoly

167 SEM images show distinct shedding of microvilli-like features upon treatment with

168 Patients with sepsis also displayed reduced shedding of monocyte tumor necrosis factor receptors upo

169 thin the lipid bilayer, an event preceded by shedding of most of the substrate's ectodomain by alpha-

170 indings support a role for MT3-MMP-dependent shedding of NgR1 in regulating excitatory synapse develo

171 ses is attenuated, and they have an enhanced shedding of noninfectious particles and are incapable of

172 an catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Notch.

173 (human Y422) is shown to be associated with shedding of NUP62 from the nuclear pore complex (NPC) an

174 enhance the duration and magnitude of fecal shedding of O157 in cattle or have any significant impac

175 n presentation, modulation of apoptosis, and shedding of obsolete protein.

176 to <6% on days 3-7 after challenge), reduced shedding of organisms (by 25% on days 1 and 3 after chal

177 Stimulated shedding of other ADAM17 substrates, such as TGFalpha, i

178 c strains from adhesion to NETs involved the shedding of outer membrane vesicles (OMVs) that outcompe

179 alloproteinase is responsible for ectodomain shedding of pathologically significant substrates includ

180 oplatelet strings in the bloodstream and the shedding of platelets into the circulation.

181 Any fecal shedding of poliovirus type 1 was 8.8, 9.1, and 13.5% in

182 We examined the frequency of urinary shedding of polyomaviruses BKV and JCV and their relatio

183 o BM sinusoids and triggering the subsequent shedding of PPs into the blood.

184 This approach enabled us to discriminate the shedding of prions in saliva and the detection of prions

185 nt to CWD biology from our analyses: (i) the shedding of prions in saliva increases with time postino

186 he role of damage to the nasal mucosa in the shedding of prions into nasal samples as a pathway for p

187 st that enteroglial cells may facilitate the shedding of prions via the intestinal tract.

188 genicity through tissue factor upregulation, shedding of procoagulant MPs, endothelial nitric oxide s

189 to P4, and was associated with a progressive shedding of procoagulant MPs.

190 RECENT FINDINGS: The shedding of prostate cancer cells by the primary tumor i

191 We propose that shedding of PrP(c) could be a potential target for thera

192 in the CNS of HIV-infected people, increase shedding of PrP(c) from human astrocytes by increasing t

193 Here we observed that ectodomain shedding of RAGE is critical for its role in regulating

194 ution to the bedding reservoir compared with shedding of resistant bacteria in faeces.

195 Circadian shedding of retinal photoreceptor cell discs with subseq

196 was evaluated for the ability to reduce oral shedding of RhCMV following subcutaneous challenge.

197 Vaccinees exhibited significantly reduced shedding of RhCMV in saliva and urine following RhCMV ch

198 onuclear cells exposed to RhCMV antigens and shedding of RhCMV in saliva.

199 Shedding of RotaTeq vaccine strains in 7 of 13 infants w

200 lture, and asymptomatic bacteremia and stool shedding of S. Typhi was also observed.

201 did not receive mOPV2, as assessed by faecal shedding of Sabin 2 by reverse transcriptase quantitativ

202 However, faecal shedding of Sabin 2 in household contacts was increased

203 Faecal shedding of Sabin 2 in infants who did not receive the m

204 of ERM by siRNA blocked the P2X7R-dependent shedding of sAPPalpha.

205 TNF-alpha-induced MMP9-mediated shedding of SDC4 is likely to contribute to the endothel

206 herapeutic anti-EGFR antibodies also inhibit shedding of sEGFR, thus implicating the cell surface pre

207 Shedding of sEphrin-B2 promotes fibroblast chemotaxis an

208 d yet ADAM17 is unable to support stimulated shedding of several of its substrates, including heparin

209 e we show that activity-dependent ectodomain shedding of signal regulatory protein-alpha (SIRPalpha)

210 samples from 37 participants, we found that shedding of sIL-6R from neutrophils was greater in carri

211 Thus, ectodomain shedding of SIRPalpha is an activity-dependent trans-syn

212 In addition, shedding of SNAP-Tac into the medium was greatly influen

213 ALL, TRC105 alone was ineffective due to the shedding of soluble CD105.

214 Shedding of soluble DLK1 (sDLK1) by pre-adipocytes was i

215 critical role in phagocytosis), resulting in shedding of soluble-Mer (sMER) and loss of MERTK functio

216 , is crucial for the rapid activation of the shedding of some, but not all substrates of ADAM17.

217 gulation of Tyro3 and Mer mRNA and increased shedding of sTyro3 and sMer.

218 the FGF7/FGFR2b signalling axis to stimulate shedding of substrates of ADAM17, including ligands of t

219 ain proteases responsible for the ectodomain shedding of surface proteins.

220 Heparanase enhances shedding of syndecan-1 (CD138), and high levels of hepar

221 Enhanced shedding of syndecan-1 following loss of heparan sulfate

222 However, secreted MMP-7 participated in the shedding of Syndecan-4 from the surface of B-lymphocytes

223 of MMP-7 which in turn is important for the shedding of Syndecan-4 in response to infectious stimuli

224 lux of chemokines through the regulation and shedding of syndecans.

225 Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta responsiveness

226 ction is also critically dependent on normal shedding of terminally differentiated keratinocytes, a p

227 mic domain of ADAM17 show reduced stimulated shedding of the ADAM10 substrate betacellulin, whereas t

228 s also depends on EGFR/ERK1/2 signalling and shedding of the ADAM17 substrate HB-EGF.

229 levated CO2 also inhibited stretch-activated shedding of the ADAM17 substrate TNFR1 from airway epith

230 tacellulin, whereas the ionomycin-stimulated shedding of the ADAM17 substrates CD62-L and TGFalpha is

231 human HaCaT keratinocytes, melittin induced shedding of the adhesion molecule E-cadherin and release

232 regulating extracellular matrix turnover and shedding of the adipogenic regulator DLK1, but that in a

233 s concomitantly with disease progression and shedding of the bacteria in feces.

234 Despite shedding of the bacteria, the remnant matrix remains int

235 Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC1

236 brane, which in turn results in cleavage and shedding of the damaged part of the cell membrane.

237 Regulated shedding of the ectodomain of cell membrane proteins by

238 Imatinib stimulated shedding of the EGFR ligand heparin-binding EGF-like gro

239 poietic cells, supported TACE maturation and shedding of the EGFR ligand TGF-alpha in Rhbdf2-deficien

240 nt, as well as v-Src enhance ADAM17-mediated shedding of the EGFR ligand TGFalpha.

241 evidence of a mechanism involving ectodomain shedding of the EGFR ligands amphiregulin (AREG) and TGF

242 dent manner, leading to increased ectodomain shedding of the epidermal growth factor (EGF) receptor (

243 We show that shedding of the extracellular domain of activated leukoc

244 Shedding of the extracellular domain of cytokine recepto

245 likely increases the maternal sFlt-1 through shedding of the extracellular domain of Flt-1 receptor.

246 Many vertebrates replace teeth through shedding of the functional tooth.

247 We hypothesized that marked shedding of the glycocalyx core protein, syndecan-1, occ

248 The MMP-2-mediated shedding of the I-like domain from beta1 integrins resul

249 naceous substrates provided by mucus and the shedding of the intestinal epithelium.

250 ndothelial cell protein C receptor-dependent shedding of the Kunitz 1 domain from membrane-associated

251 a disintegrin and metalloproteinase-mediated shedding of the L1 ectodomain that has been shown to reg

252 Chemically induced shedding of the lectin-like domain of TBM resulted in si

253 in and metalloprotease 17 (ADAM17)-dependent shedding of the ligand neuregulin-1 (NRG-1).

254 Antibody-induced shedding of the major surface protein circumsporozoite p

255 t analysis demonstrated that heparin induced shedding of the N-terminus of Flt-1 both in vivo and in

256 of manganese or zinc, but not copper, causes shedding of the N1 fragment of PrP(C) and of the ectodom

257 this article, we describe that an increased shedding of the NKG2D ligand MICA is observed postinfect

258 in and metalloproteinase) protease-dependent shedding of the Notch ligand Delta-like 1 (Dll1), leadin

259 her by increasing ADAM17-mediated ectodomain shedding of the Notch receptor or by modification of spe

260 The shedding of the old exoskeleton that occurs in insects a

261 ated platelets and endothelial cells induces shedding of the P-selectin ectodomain into the circulati

262 tment of neutrophils to the nasal cavity, or shedding of the pathogen.

263 e I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in

264 s present on syndecan core proteins suppress shedding of the proteoglycan.

265 es in an "inside-out" fashion the ectodomain shedding of the receptor.

266 on of BlaR1 is still observed, including the shedding of the sensor domain, an observation that leads

267 s undesired premature drug release until the shedding of the shell, which accelerates the cleavage of

268 NMDA receptor activation rapidly triggers shedding of the signalling-competent NRG2 extracellular

269 soluble TNF-alpha (sTNF-alpha) promotes the shedding of the TNF-alpha receptor 1 ectodomain via incr

270 atosis characterized by lifelong, continuous shedding of the upper epidermis.

271 aluate the persistence, biodistribution, and shedding of the vector following subretinal delivery.

272 proteases of the ADAM family, leading to the shedding of their ectodomains.

273 ion as cell surface receptors, or mainly via shedding of their secreted ectodomains, such as neurotro

274 eased hyaluronidase activity, suggesting the shedding of these components.

275 Shedding of these micelles into the aqueous solution res

276 The shedding of these proteins by membrane vesicles into the

277 After shedding of this ectodomain, CTF-eta is further processe

278 susceptibility gene for ccRCC and ectodomain shedding of this molecule may be a predictive biomarker

279 PMA-induced shedding of Tim-3 was abrogated by deletion of amino aci

280 idue within the intracellular domain rescues shedding of Tim-3.

281 protection of hepatocytes involves the rapid shedding of TNF receptor 1 to limit TNFalpha signaling.

282 ng TNF-converting enzyme-mediated ectodomain shedding of TNF type I receptor (TNFR1), the membrane-bo

283 TNF-alpha convertase (TACE), which controls shedding of TNF-alpha and its biological activity in viv

284 complexes, stimulated iRHOM2/TACE-dependent shedding of TNF-alpha in mouse and human cells.

285 Ectodomain shedding of transmembrane precursor proteins generates n

286 that anionic lipids may modulate ectodomain shedding of transmembrane receptors.

287 he effects of therapies interfering with the shedding of tumor cells or fragments, circulating (stem)

288 Ectodomain shedding of tumor necrosis factor receptor 1 (TNFR1) pro

289 altered by sepsis and may result in reduced shedding of tumor necrosis factor receptors.

290 ng ALCAM in tumor-bearing mice revealed that shedding of tumor, but not host-derived ALCAM is elevate

291 Of importance, shedding of VEGF-165 from the cell surface together with

292 Increased shedding of VEGFR2 (via inhibition of constitutive endoc

293 Shedding of VEGFR2 produces an N-terminal soluble fragme

294 or Rab5, increases dramatically the cleavage/shedding of VEGFR2.

295 t the utility of analyzing sewage to monitor shedding of viral pathogens and the high viral diversity

296 (RhCMV-WT), particularly in relation to the shedding of virus into bodily fluids and the potential f

297 emination or replication and does not induce shedding of virus with stool.

298 and mouse plasma, indicating that ectodomain shedding of VLDLR occurs endogenously.

299 Shedding of VPAC2 from the ciliary surface results in te

300 morbidity and mortality but did not prevent shedding of West African challenge viruses.

301 They experienced 238 episodes of viral shedding, of which 23 (10%) were not accompanied by symp