ライフサイエンスコーパス: shield

1 ch enable them to penetrate the HIV-1 glycan shield.

2 a site-specific chemical polyethylene glycol shield.

3 nked glycans often referred to as the glycan shield.

4 tag from the massive trimer base and glycan shield.

5 protruding CDRH3 to penetrate the Env glycan shield.

6 wing parahydrogen bubbling within a magnetic shield.

7 ralization by penetrating the dense N-glycan shield.

8 = 50) or absence (n = 51) of bismuth breast shields.

9 the ability to image through electromagnetic shields.

10 nd most gamma rays are low energy and easily shielded.

11 be used to achieve the same level of steric shielding.

12 ic penetrating radiation and the ease of its shielding.

13 rug storage, the PEG realizes solubility and shielding.

14 ternum for ex vivo radiation with or without shielding.

15 d that this phenomenon was caused by epitope shielding.

16 MXenes and their polymer composites for EMI shielding.

17 and highlights the protective effect of leg shielding.

18 s trough caspase-3 activation compared to N2 shielding.

19 diation, half-body shielding (HBS), or 1-leg shielding (1LS)-and imaged repeatedly.

20 This is indicated by its highly shielded (29)Si NMR chemical shift (delta(29)Si = -155)

21 A 2,040-MBq self-shielded (68)Ge/(68)Ga generator provided metal-free (68

22 est, e.g., solubility, but the host can also shield a guest from the environment and protect it, e.g.

23 Likewise, CTCF sites shield a widely expressed gene from suppressive influenc

24 asma membrane provides an essential barrier, shielding a cell from the pressures of its external envi

25 VR1 adds complexity to HCV neutralization by shielding a diverse array of unexpectedly cross-genotype

26 trand in the blocked, or B, state, where Tpm shields actin from the binding of myosin heads.

27 The degree of shielding affected proliferation recovery, showing an in

28 est-a function that may serve as a defensive shield against conventional chemotherapeutic agents.

29 r response times, and having the information shielded against external magnetic field.

30 titive DNA sequences at chromosome ends, are shielded against the DNA damage response (DDR) by the sh

31 nts and found functions in the modulation of shielding against neutralizing antibodies, intracellular

32 throcytes to serve as reservoirs, protective shields (against proteases), and light-triggered launch

33 The sham shield allowed testing for shield-induced radiation beha

34 ensity corresponding to the solvent exposure/shielding alternation of the side chains.

35 membrane association and that FLAP may help shield an uncapped active site.

36 ed molecules or aspicules, where aspis means shield and cules refers to molecules, implying that they

37 ioning as a first point of contact antiviral shield and having additional later-phase roles in minimi

38 covery over 10 years is higher in the Guiana Shield and in the west (21 +/-3 Mg C ha-1) than in the s

39 The use of a pelvic lead shield and the cap reduced significantly the operator ra

40 st clouds, ballistic penetrators, spacecraft shielding and ductility in high-performance ceramics.

41 C passage of NTRcargo complexes, while cargo shielding and increased NTRcargo surface-ratios override

42 n assays we determined size-dependent steric shielding and multivalency effects.

43 owever, the similarity of these materials to shielding and the required radiation doses that may exce

44 avy ions and secondary radiation produced in shielding and tissues.

45 of polysaccharide on the surface (the glycan shield) and movement between spike domains that masks th

46 dic labeling module, and it is compact, self-shielded, and easy to operate using simple manual techni

47 mented insertional mutagenesis, carbohydrate shielding, and alanine scanning mutagenesis.

48 energy storage, electromagnetic interference shielding, and catalysis.

49 act system comprising dedicated electronics, shielding, and pumping unit controlled by custom firmwar

50 complexes regulates antigen accessibility by shielding antigen from B-cell receptor access.

51 It is a promising material for neutron shielding applications.

52 henalenyl species that do not require steric shielding are molecules of fundamental interest, but are

53 alyzing the variations in isotropic magnetic shielding around these molecules in each electronic stat

54 ogenic temperatures and showed that the cage shields around 75% of the HF dipole.

55 al structure provides significantly improved shielding as compared with a commercially available ferr

56 ers from clades A, B, and G, visualizing the shield at 3.4-3.7 A resolution.

57 A dense glycan shield at the apex of pre-fusion hMPV F suggests that an

58 ge of engineering applications, from seismic shielding at low frequency to ultrasonic cloaking at hig

59 rom ex vivo radiation of blood samples under shields at breast-tissue level (unadjusted regression: b

60 brain is an immunologically privileged site shielded behind the blood-brain barrier, studies in the

61 It may act by shielding brainstem and spinal locomotor centers from ab

62 from neutralizing antibodies to HVR1 and by shielding broadly neutralizing antibodies from their epi

63 veloped a strategy to replace the natural FX shield by a site-specific chemical polyethylene glycol s

64 OIP to bacterial surfaces that are no longer shielded by host membranes and are already displaying ub

65 es an attractive target for such mAbs but is shielded by multiple mechanisms, including physical sequ

66 Nanosized aggregations of metal ions shielded by organic ligands possessing both exquisite st

67 crease in RN7SL1, an endogenous RNA normally shielded by RNA binding proteins SRP9/14.

68 backbone cleavages for those regions either shielded by the ligand or involved in new intramolecular

69 a destabilizing electrostatic effect that is shielded by the polar environments.

70 the mechanism of TA protein recognition and shielding by Get3 and suggest general principles of hydr

71 opes are correct, we predict that reduced UV shielding by O3 should further limit pCH4 to very low le

72 interaction of Trp(21) with the active site shielding C-terminal arm, suggesting that the RAMD metho

73 the latent proenzyme's interface between the shielding C-terminal domain and the main core provides i

74 The fibrin shield can be marked with R-specific antibodies, which t

75 e is considerable evidence that this "glycan shield" can help protect the virus from antibody-mediate

76 able to offer significantly greater protein shielding capacity than its linear or Y-shaped counterpa

77 the threats of peripheral infection; perhaps shielding cells that are less resilient from the degener

78 the tomato pathogen Cladosporium fulvum, to shield chitin from host-derived chitinases during infect

79 The coprimary outcomes for the lead shield comparison were (1) operator dose (microSv) and (

80 y removing cleavable N- and C-termini and by shielding components from metabolic enzymes.

81 gnificant functions of thermal metamaterials-shield, concentrator, diffuser, and rotator-in both simu

82 ibutions of this N-linked carbohydrate is to shield conserved peptide sequences from recognition by h

83 As N-linked glycans are thought to shield conserved regions of the EBOV GP receptor-binding

84 This extensive glycosylation not only shields conserved regions of the protein from the immune

85 t relatively low radiation exposures, breast shielding contributed to an increase in image noise and

86 the conformational properties of the glycan shield covering the surface of the HIV gp120/gp41 envelo

87 The extent of isotropic shielding delocalization in the contour plots in planes

88 It is shown that the profoundly different shielding distributions in the S0 states of C6H6 and C4H

89 Here we show that the Ku complex shields DNA ends from exonucleolytic digestion but facil

90 e material properties characteristic of this shielded domain of polyionic chemical phenomena.

91 We show that WRN regulates alt-NHEJ and shields DSBs from MRE11/CtIP-mediated resection to preve

92 e measured the impact of the shifting glycan shield during HIV infection on the abundance of oligoman

93 -rich groups is caused by ineffective charge shielding during ion pairing.

94 local muscle tissue radioprotection by lead shielding during irradiation preserves normal macrophage

95 his device requires no additional support or shielding during puncture events through protective tiss

96 The shielding effect of a methyl group incorporated in the c

97 However, the shielding effect of polyethylene glycol (PEG) is usually

98 reduction was primarily caused by the light-shielding effect of the captured bacteria.

99 The chemical shielding effect resulting from the amphiphobicity of th

100 tennas, as typical building materials have a shielding effectiveness (SE) of 80 dB to 100 dB.

101 -micrometer-thick Ti3C2Tx film exhibited EMI shielding effectiveness of 92 decibels (>50 decibels for

102 , and the hybrid foam exhibits excellent EMI shielding effectiveness which exceeds 38.4 or 47.5 dB in

103 < 0.001), indicating that stronger building shielding effects are valuable in areas with higher air

104 Our study suggests that mass transport and shielding effects can substantially extend the atmospher

105 The through-space shielding effects of the phenyl ring, as a function of s

106 ay of chemical reaction, mass transport, and shielding effects.

107 rfaces of any shape while providing high EMI shielding efficiency.

108 ctive behavior can be potentially useful for shielding electromagnetic sources that may also generate

109 are considered in applications including EMI shielding, electrostatic discharge protection, and elect

110 This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "S

111 gnal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei).

112 ety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei).

113 Glycans partially shield Env from recognition by the host immune system an

114 ssembly, but once assembled, collagen fibres shield Fn fibres from being stretched by cellular tracti

115 a first-of-its-kind distributed genomic food shield for characterizing and tracing foodborne outbreak

116 ination to internal organs, thus providing a shield for the developing adaptive immunity that clears

117 rsubunit clefts, facilitating proper solvent shielding for the catalyzed reaction.

118 uperconductivity with a Tc ~ 3 K and a large shielding fraction.

119 differentiate spontaneously if they are not shielded from external stimuli.

120 The insoluble aggregate-bound plasmin is shielded from inhibition by alpha2-antiplasmin and degra

121 reduced temperatures and light and are often shielded from localized anthropogenic stressors such as

122 brain and the peripheral nervous system are shielded from plasma proteins by the blood-brain barrier

123 t a model wherein the active site of LCAT is shielded from soluble substrates by a dynamic lid until

124 the ER membrane, the nascent polypeptide was shielded from the cytosol as it emerged from the ribosom

125 orm an enclosed aqueous pore that is largely shielded from the membrane.

126 conjugation demonstrated the most effective shielding from antibody recognition.

127 uently, highly sensitive cameras, sufficient shielding from background light, and long acquisition ti

128 m (ES) cells are locked into self-renewal by shielding from inductive cues.

129 hat platelets expressing factor VIII (FVIII) shield FVIII from immune detection.

130 r, revealing 8ANC195 insertion into a glycan shield gap to contact gp120 and gp41 glycans and protein

131 2, and MAPK) in response to different plasma shielding gas compositions.

132 ore, PEX9 may inhibit gelatin degradation by shielding gelatin and specifically preventing its bindin

133 idence interval [CI], 2.00-4.71 microSv lead shield group versus 12.57; 95% CI, 8.14-19.40 microSv co

134 es triggered during the inception, submarine shield growth, and final subaerial emergence of the Cana

135 ho underwent coronary CT angiography, breast shielding had no effect on DNA double-strand-break level

136 Results Breast shielding had no effect on DNA double-strand-break level

137 igher resolution understanding of the glycan shield has also emerged, enabling a more complete repres

138 on schemes-whole-body irradiation, half-body shielding (HBS), or 1-leg shielding (1LS)-and imaged rep

139 By working in a lead-shielded hot-cell system,(68)Ga(3+) of the generator elu

140 strong ionic interactions and strong solvent-shielded hydrogen bonds.

141 ing pocket and assist in the breaking of the shielded hydrogen bonds.

142 antibody 4G8, suggesting that the chaperone shields hydrophobic residues exposed on the oligomeric a

143 t completely consistent, with the 'oxidative shielding' hypothesis.

144 dienamine conformation provides an effective shielding if large electrophiles are used.

145 41 envelope (Env) trimer, and how the glycan shield impacts the accessibility of the underlying prote

146 y DNA-bound transcription factors, in effect shielding important DNA elements from UV damage.

147 hydrophobic cap in the crystal structure are shielded in aqueous solution by adopting a random coil c

148 These proteins are instead shielded in the cytosol by calmodulin.

149 thway have electrostatic repulsions that are shielded in the high ionic strength buffer and therefore

150 s that the epitopes of these mAbs may become shielded in the ligand-occupied state.

151 ame operators but this time wearing leg lead shielding in addition to upper body protection and compa

152 iable contribution of carbonyl sulfide (OCS) shielding in an evolving volcanic plume.

153 nd forms allow dehydrins to act as molecular shields in their unbound state and as membrane protectan

154 The sham shield allowed testing for shield-induced radiation behavior.

155 This glycan shield is a target for many of the recently isolated ant

156 This so-called glycan shield is considered to be a major protective mechanism

157 se to the host immune system, the HIV glycan shield is constantly evolving through mutations affectin

158 Glycan shielding is a mechanism by which HCV masks such epitope

159 N-glycan shielding is one mechanism by which immune evasion can b

160 ly close to the charge center, unless steric shielding is present.

161 As isotropic shielding isosurfaces and contour plots show very clearl

162 he accuracy of subsequent predictions and to shield it from further weakening.SIGNIFICANCE STATEMENT

163 e, full-length RasGAP favors Akt activity by shielding it from deactivating phosphatases.

164 strate in a highly reactive conformation and shields it from the aqueous environment, thereby mimicki

165 common to metazoans, regulates Smoothened by shielding its heptahelical domain from cholesterol, or b

166 al immune response because of its ability to shield itself and replicate and evolve rapidly.

167 re one of the most promising lightweight EMI shielding materials, owing to their unique nanostructure

168 advanced high temperature sensing, radiation shielding, mechanical strengthening, electron emission a

169 acral lentiginous melanoma (ALM), a rare sun-shielded melanoma subtype associated with worse survival

170 0(7)) mechanical modes in a phononic-bandgap shielded membrane resonator.

171 ect a cell, the bacterial membrane partially shields microbial structures from the immune system, pre

172 This standard steric shielding model has recently been challenged by the disc

173 refers to molecules, implying that they are "shielded molecules".

174 , it is unknown how effective PAs will be in shielding native species from invasions under projected

175 involves multiple KRAB zinc finger proteins, shields neuronal genomes from excess CTCF binding and is

176 envelope (Env) trimer is covered by a glycan shield of approximately 90 N-linked oligosaccharides, wh

177 posed PD-1 function by acting as a molecular shield of key tyrosine residues that are targets for the

178 Blue Cross Blue Shield of Michigan and Blue Care Network, as part of the

179 te coronary syndrome) in The Blue Cross Blue Shield of Michigan Cardiovascular Consortium database be

180 Blue Cross Blue Shield of Michigan Foundation, Department of Veterans Af

181 dies have been isolated that bind the glycan shield of the HIV-1 envelope spike.

182 e of soluble Env trimers and that the glycan shield of well-formed HIV Env trimers is virtually impen

183 Thus, site-specific shielding of Ad5 vectors with polyethylene glycol render

184 promoted catalytic effect can be assigned to shielding of electrostatic repulsion between monomers on

185 tion via dynamic and specific intramolecular shielding of histone interaction sites.

186 Shielding of ICL1 and ICL2, but not the C terminus, beca

187 ty of envelope proteins E1 and E2 of HCV and shielding of important epitopes by hypervariable region

188 ubsystems and large electrophiles provides a shielding of one face and causes different reactivities

189 Because of the steric shielding of one of the BHP hemispheres, the products we

190 pressed for biphenyl-type ligands due to the shielding of Pd(II) by sterically demanding JackiePhos,

191 f the apparent activation constant of PKA or shielding of PKA from bulk cytosolic cAMP via localizati

192 sitizing TGCTs to cisplatin, consistent with shielding of platinum-DNA adducts from excision repair.

193 of the C18 ring through the progressive NMR shielding of the (1)H nuclei from ca. 4.70 to 1.25 ppm g

194 We propose that shielding of the cavity ensures that the transporter is

195 Moreover, the shielding of the hydrophobic core by the charged exterio

196 issue dynamics, including notably the cells' shielding of the matrix plasticity.

197 ee values are reported despite insufficient shielding of the second double bond.

198 lated water molecule, indicating the partial shielding of the water dipole by the encapsulating cage.

199 of complexes 3a-c increased with the steric shielding of their leaving chloride ligand, and complex

200 ules that cause the electrostatic screening (shielding) of hydrogen bonds in bulk water as the critic

201 important role of capsule polysaccharide in shielding OmpA and thereby inhibiting anti-OmpA MAb bind

202 Purpose To examine the effect of breast shielding on blood lymphocyte deoxyribonucleic acid (DNA

203 reast-tissue level, and the effect of breast shielding on image quality.

204 suggesting an active top-down mechanism for shielding ongoing internal processes from potentially di

205 quantum covalency can overcome the powerful "shielding" opposition of long-range electrostatic forces

206 Shielding or reduction of the surface charge or impositi

207 ed regression: beta = .08; P = .43 versus no shielding), or in vivo radiation of circulating lymphocy

208 roadly neutralizing antibody epitopes, while shielding other sites that might otherwise be immunogeni

209 offer miniaturized waveguides, antennas and shielding patterns are on anvil.

210 ultrahigh electromagnetic-interference (EMI)-shielding performance are highly desirable in fields of

211 We investigate the shielding performance of a metabarrier in a scaled exper

212 in foams, leading to a greatly improved EMI shielding performance.

213 the peroxisomal membrane protein Pex3, which shields Pex15 from Msp1-dependent turnover.

214 he two other arms carry identical sterically shielded phenanthroline stations.

215 e RADPAD is a sterile, disposable, lead-free shield placed on the patient with the aim to minimize op

216 e was correlated to reactive species: oxygen-shielding plasma induces a cell response more efficientl

217 f rotatable bonds, provides the potential to shield polar surface area and reinforces binding through

218 rmine if facial features or a protective eye shield prevents sleep position-induced limbal strains du

219 effect markedly differs from the more common shielding protection of threaded functions by the macroc

220 O2 shielding provided stronger apoptotic effects trough cas

221 ed in a 1:1:1 ratio to a radiation absorbing shield (RADPAD), standard treatment (NOPAD), or a sham s

222 imetric characteristics of an isocentrically shielded RapidArc (IS-RA) technique for treatment of loc

223 ake from the environment in trypanosomes and shields receptors from exposure to the host.

224 ce, the standard use of the RADPAD radiation shield reduced operator radiation exposure compared with

225 ys that culture organizes experience: (a) It shields reflexive processing by making everyday life fee

226 This was done by comparing "shielded" remote-loaded with "exposed" surface labeled v

227 The coax cores and outer shields serve as integrated working and counter electrod

228 DPAD), standard treatment (NOPAD), or a sham shield (SHAMPAD).

229 hus, light chain accommodation of the glycan shield should be taken into account in vaccine design ta

230 Furthermore, we design a structure to shield simultaneously at the fundamental and first harmo

231 -acetylation appears not to affect cell wall shielding, since serotypes 33A and 33F exhibit comparabl

232 Shade works by physically shielding skin from direct harmful UV rays; however, ski

233 only practical approach for uncovering well-shielded special nuclear materials is by use of active i

234 lypyrimidine tract binding protein 1 (PTBP1) shields specific retroviral and cellular transcripts fro

235 n (hpf, 2-cell) to 2 hpf (64-cell) or 6 hpf (shield stage) leads to impacts on the early embryonic DN

236 Computational analysis based on isochemical shielding surface and trigger bond dissociation enthalpy

237 y MXenes and their composites enable them to shield surfaces of any shape while providing high EMI sh

238 urrent (induced) density (ACID), isochemical shielding surfaces (ICSSzz), harmonic oscillator model o

239 r, we found that removal of the heavy glycan shield surrounding conserved regions of the glycoprotein

240 tching back to metabolic quiescence may help shield T cells from RICD as they transition into the mem

241 binding domain of Cdc13 is less effective at shielding telomeres.

242 , in particular the sigmayy component of the shielding tensor of [Se(NHC)] model compounds, respectiv

243 ral chemical shift analysis of this chemical shielding tensor shows that sigmayy probes the pi-accept

244 tive orientations between bonds and chemical shielding tensors, respectively, regardless of separatio

245 ccal surface, generating a protective fibrin shield that inhibits phagocytosis.

246 ree V5 loops are unusual holes in the glycan shield that may have been necessary for initiating this

247 The head of the host, which is covered by a shield that projects anteriorly, bears a long stout unir

248 Together, they form a flexible perinuclear shield that protects myonuclei from intrinsic or extrins

249 S)/spinal cord (SC) and the jaws were set to shield the BS/SC while ensuring the target coverage duri

250 ments show that Ccp lacks enough activity to shield the cytoplasm from exogenous H2O2 However, it rec

251 can transport heme in trematodes and thereby shield the parasite from the harmful effects of heme.

252 a superhelical structure that could not only shield the poly(A) tail but also serve as a scaffold for

253 This mechanism is likely to shield the priming of antiviral responses against inhibi

254 ulators' in higher eukaryotes, these factors shield the proximal promoter from the action of more dis

255 and Thr(201), linking the BC and FG loops to shield the retinal-binding pocket in the interior from t

256 d by approximately 90N-linked glycans, which shield the underlying protein from immune surveillance.

257 n containing four N-linked glycans (IZN4) to shield the underlying protein surface.

258 ne nuclear spin-free ligand, which served to shield the vanadium centers against solvent nuclear spin

259 nteractions with incoming HIV-1 capsids help shield the virus from recognition by antiviral effector

260 lly or chemically with numerous polymers for shielding the Ad surface, accomplishing extended blood c

261 ction forces required to avoid disruption or shielding the critical nucleus formation.

262 o be targets for collectins are important in shielding the more vulnerable sites in the LPS core, rev

263 We hypothesize a role of this domain in shielding the polyisoprenyl-phosphate for transport to t

264 performing therapeutic NM procedures without shielding the radiation source in the 1980s (HR, 1.32; 9

265 tivity at positively controlled promoters by shielding the transcription factor in the DNA-bound stat

266 growing at the surface of tungsten oxide and shielding the wire surface from flowing electrolyte.

267 ns and consists of a protective layer, which shields the contacting solution from the metal, a protei

268 und HNO), it cannot form a hydride as the NO shields the Fe from protonation.

269 Zn(II) binding at this unique site shields the S100A9 C-terminal tail from proteolytic degr

270 nfigured catalyst, the tert-butyl group that shields the si face of the substrate plays the most ster

271 ch therefore serves as a natural buffer that shields the surrounding coasts from potentially more pow

272 This thin and dry outer phase therefore shields the systems from humidity variations.

273 n repressing lineage-inappropriate genes and shielding them from activation by transcription factors.

274 r binding the highly basic histone proteins, shielding them from non-specific interactions, facilitat

275 ed telomeres within its DNA binding channel, shielding them from other DNA repair machineries.

276 annels from the ER to the plasma membrane by shielding them from premature degradation.

277 end-binding protein Ku sequesters seDSBs and shields them from exonuclease activities.

278 e the antibody loop must traverse the glycan shield, thereby facilitating V1V2 binding via a non-prot

279 ne-bound parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of

280 These structures reveal the HIV-1-glycan shield to comprise a network of interlocking oligosaccha

281 uggest that CD47(hi) young RBC may provide a shield to the malaria parasite from clearance by the pha

282 eins compared to detergent micelles and less shielding to those protein residues that exist outside t

283 utralizing antibodies that target the glycan-shielded trimer.

284 ed in the patients were graft rejection (1), shield ulcers (2), graft infection (2), and interface va

285 sed on a shielding unit-donor-acceptor-donor-shielding unit (S-D-A-D-S) structure is reported.

286 y thiophene as the donor and fluorene as the shielding unit, the best performance fluorophores IR-FE

287 w (NIR-II) molecular fluorophores based on a shielding unit-donor-acceptor-donor-shielding unit (S-D-

288 The lead shield use resulted in a 76% reduction in operator dose

289 ecular and supported catalysts but with more shielded values for the supported complexes.

290 on by intravenously-injected Ad5 vectors and shields vector particles from neutralization by natural

291 ve strategies, assembly of protective fibrin shields via coagulases and protein A-mediated B cell sup

292 This shielding was abrogated by fragment N2.

293 overcome the barriers imposed by the glycan shield, we crystallized fully glycosylated Env trimers f

294 aled a conformationally heterogeneous glycan shield with a network of glycan-glycan interactions more

295 n provide electromagnetic interference (EMI) shielding with minimal thickness are highly desirable, e

296 Here, we present a shielded X-ray irradiation assay that allows us to follo

297 adiation exposures (median, 3.4 mSv), breast shielding yielded a 33% increase in image noise and 19%

298 -butyl ketone added less rapidly to the less shielded (Z)-1 [but never to (E)-1]; this singly diaster

299 We report on the development of Ni-shielded ZnO nanorod (NR) structures and the impact of t

300 MR signal of the methyl group located in the shielding zone of the ring.