ライフサイエンスコーパス: short-chain dehydrogenase

1 nd has structural features characteristic of short chain dehydrogenases.

2 lso illustrate the multifunctional nature of short-chain dehydrogenases and provide a potential mecha

3 etinal generated in transfected cells by the short-chain dehydrogenases CRAD1, CRAD3, or RDH1, to rec

4 and characterize an evolutionarily conserved short chain dehydrogenase, DHS-16, as a novel 3-hydroxys

5 g WWOX transcripts lack part, or all, of the short chain dehydrogenase domain and the putative mitoch

6 nhibitors of this and related enzymes of the short chain dehydrogenase enzyme class.

7 aratose synthase, a likely new member of the short-chain dehydrogenase family, represents the first d

8 pecificity observed for other members of the short chain dehydrogenase reductase family of enzymes of

9 This study on GFS, a unique member of the short chain dehydrogenase reductase family, coupled with

10 Like FabI and FabL, FabV is a member of the short chain dehydrogenase reductase superfamily, althoug

11 re NAD(+)-dependent enzymes belonging to the short chain dehydrogenase/reductase (SDR) family of enzy

12 trate binding loops for other members of the short chain dehydrogenase/reductase (SDR) family, which

13 eaction confirm PTR1's membership within the short chain dehydrogenase/reductase (SDR) family.

14 ses (PKSs) based on homology modeling to the short chain dehydrogenase/reductase (SDR) superfamily of

15 critical Ser-Tyr-Lys catalytic triad of the short chain dehydrogenase/reductase (SDR) superfamily.

16 hloroplast endoribonuclease belonging to the short chain dehydrogenase/reductase (SDR) superfamily.

17 UDP-glycosyltransferase (UGT), as well as a short chain dehydrogenase/reductase and a cytochrome P45

18 the identification of missense mutations in short chain dehydrogenase/reductase family 9C, member 7

19 17beta-HSD6 is a member of the short chain dehydrogenase/reductase family and shares 65

20 the identification of a novel member of the short chain dehydrogenase/reductase family, photorecepto

21 is highly homologous to other members of the short chain dehydrogenase/reductase family.

22 uctural themes found in other members of the short chain dehydrogenase/reductase family.

23 multiple retinol dehydrogenases (Rdh) of the short chain dehydrogenase/reductase gene family and reti

24 Tsc10p is a member of the short chain dehydrogenase/reductase protein family.

25 om the redox reactions normally catalyzed by short chain dehydrogenase/reductase superfamily enzymes.

26 The enzyme is a member of the short chain dehydrogenase/reductase superfamily in which

27 RDH1 represents a new member of the short chain dehydrogenase/reductase superfamily that dif

28 Here, we report that a novel member of the short chain dehydrogenase/reductase superfamily, frog sd

29 es which are well established members of the short chain dehydrogenase/reductase superfamily.

30 catalytic properties of a new member of the short chain dehydrogenase/reductase superfamily.

31 rt characterization of a novel member of the short chain dehydrogenase/reductase superfamily.

32 and characterized a sterol/retinol-oxidizing short chain dehydrogenase/reductase that prefers NAD+ an

33 yl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate

34 he retinoid substrate specificity of a novel short-chain dehydrogenase/reductase (SDR) encoded by Ral

35 of either the alcohol dehydrogenase (ADH) or short-chain dehydrogenase/reductase (SDR) enzyme familie

36 SQD1 is a member of the short-chain dehydrogenase/reductase (SDR) family of enzy

37 and IV demonstrates that they belong to the short-chain dehydrogenase/reductase (SDR) family of enzy

38 CDP nucleotide utilizing dehydratase of the short-chain dehydrogenase/reductase (SDR) family to be d

39 genes that encode proteins belonging to the short-chain dehydrogenase/reductase (SDR) family, wbmF,

40 carboxylase domain with other members of the short-chain dehydrogenase/reductase (SDR) family, we pro

41 NmrA shows an unexpected similarity to the short-chain dehydrogenase/reductase (SDR) family, with t

42 ture confirms that the enzyme belongs to the short-chain dehydrogenase/reductase (SDR) family.

43 ry DNA (cDNA) encoding a novel member of the short-chain dehydrogenase/reductase (SDR) gene family th

44 , expressed and identified as members of the short-chain dehydrogenase/reductase (SDR) gene family.

45 Subsequent conversion by the short-chain dehydrogenase/reductase (SDR) MdpC into the

46 recognized as substrate by human microsomal short-chain dehydrogenase/reductase (SDR) RoDH-4 with th

47 Although the short-chain dehydrogenase/reductase (SDR) superfamily co

48 that vestitone reductase is a member of the short-chain dehydrogenase/reductase (SDR) superfamily de

49 sent evidence that the structurally distinct short-chain dehydrogenase/reductase (SDR) superfamily ma

50 In humans, four different members of the short-chain dehydrogenase/reductase (SDR) superfamily of

51 e enzymes are closely related members of the short-chain dehydrogenase/reductase (SDR) superfamily.

52 nd with NAD(+) and UDP reveals a homodimeric short-chain dehydrogenase/reductase (SDR), belonging to

53 We report a mouse short-chain dehydrogenase/reductase (SDR), retinol dehyd

54 T2 (ABA2) which encodes a unique Arabidopsis short-chain dehydrogenase/reductase (SDR1) that function

55 novel gene that we have designated prostate short-chain dehydrogenase/reductase 1 (PSDR1), that exhi

56 mily that we have designated murine prostate short-chain dehydrogenase/reductase 1 (Psdr1).

57 at has been designated variously as prostate short-chain dehydrogenase/reductase 1, retinal reductase

58 We have previously identified a short-chain dehydrogenase/reductase 3 (dhrs3), which sho

59 his expression pattern and the presence of a short-chain dehydrogenase/reductase domain and specific

60 ains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain.

61 Members of the alcohol dehydrogenase and short-chain dehydrogenase/reductase enzyme families cata

62 ide-diphosphosugar modifying subclass of the short-chain dehydrogenase/reductase enzyme family, havin

63 SalM is a short-chain dehydrogenase/reductase enzyme from the mari

64 ve protein exhibit homology to the family of short-chain dehydrogenase/reductase enzymes and thus ide

65 Although short-chain dehydrogenase/reductase enzymes are widely r

66 ts reveals that IBR1 encodes a member of the short-chain dehydrogenase/reductase family and that IBR1

67 nases (R-HPCDH and S-HPCDH) belonging to the short-chain dehydrogenase/reductase family catalyze the

68 de reductase was identified by searching the short-chain dehydrogenase/reductase family for proteins

69 dehydrogenase 5, and dehydrogenase/reductase short-chain dehydrogenase/reductase family member 9, whi

70 nt example of the recruitment of a canonical short-chain dehydrogenase/reductase family member as an

71 This protein, a member of the short-chain dehydrogenase/reductase family of enzymes, h

72 , whose predicted product is a member of the short-chain dehydrogenase/reductase family of enzymes, w

73 oupled to a region with high homology to the short-chain dehydrogenase/reductase family of enzymes.

74 ng information, and predict inclusion in the short-chain dehydrogenase/reductase family of enzymes.

75 other tropane alkaloids, no proteins of the short-chain dehydrogenase/reductase family were found th

76 zation of a previously unknown member of the short-chain dehydrogenase/reductase family, CRAD3 (cis-r

77 n is known to be catalyzed by enzymes of the short-chain dehydrogenase/reductase family.

78 us of WAX2 is most similar to members of the short-chain dehydrogenase/reductase family.

79 on by retinol dehydrogenases, members of the short-chain dehydrogenase/reductase family.

80 ecific gene Jingwei (jgw) is a newly evolved short-chain dehydrogenase/reductase in Drosophila.

81 2 represents the fifth isozyme in a group of short-chain dehydrogenase/reductase isozymes (retinol de

82 folM encodes an unusual short-chain dehydrogenase/reductase known to have dihydr

83 d that dhrs3a, which encodes a member of the short-chain dehydrogenase/reductase protein family, is b

84 for identifying candidate substrates for 27 short-chain dehydrogenase/reductase proteins of known ca

85 UDP-galactose 4-epimerase are members of the short-chain dehydrogenase/reductase SDR family.

86 ol/carveol dehydrogenases are members of the short-chain dehydrogenase/reductase superfamily and are

87 dehydrogenase, retSDR1, that belongs to the short-chain dehydrogenase/reductase superfamily and loca

88 rates that tyvelose epimerase belongs to the short-chain dehydrogenase/reductase superfamily of enzym

89 rogenase 12 (RDH12) is a novel member of the short-chain dehydrogenase/reductase superfamily of prote

90 CF244 and HCF173 are members of the atypical short-chain dehydrogenase/reductase superfamily, a modif

91 Thus, unlike other members of the short-chain dehydrogenase/reductase superfamily, FabG un

92 al characterization of a novel member of the short-chain dehydrogenase/reductase superfamily, retinal

93 id biosynthesis, which instead belong to the short-chain dehydrogenase/reductase superfamily.

94 It is composed of putative short-chain dehydrogenase/reductase Ycf39, encoded by th

95 whereas microsomal retinol dehydrogenase (a short-chain dehydrogenase/reductase) catalyzes the reduc

96 We determined the orientation of the SDR (short-chain dehydrogenase/reductase) rat RoDH1 (retinol

97 r of the subclass 'intermediate' of the SDR (short-chain dehydrogenase/reductase) superfamily with th

98 rex phenotype is caused by a mutation in the short-chain dehydrogenase/reductase, RDH10.

99 e report cloning a cDNA that encodes a novel short-chain dehydrogenase/reductase, SDR-O, conserved in

100 Human and mouse liver express SDR-O (short-chain dehydrogenase/reductase-orphan) mRNA intense

101 the NCBI data bank that encodes a peroxisome short-chain dehydrogenase/reductase.

102 Although they belong to the superfamily of short chain dehydrogenase-reductases, the epimerase-acti

103 Two short chain dehydrogenase/reductases mediate naphthol re

104 rogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases whose distinctive p

105 ultifunctional catalytic nature, as do other short chain dehydrogenase/reductases.

106 lar carbonyl reductase (PTCR) belongs to the short chain dehydrogenases/reductases (SDR) superfamily

107 Interestingly, mycobacterial short chain dehydrogenases/reductases (SDRs) within fami

108 be significant in the sequentially analogous short chain dehydrogenases/reductases, where a serine is

109 Short-chain dehydrogenase/reductases catalyse the metabo

110 Three genes coding for the NAD(+)-dependent short-chain dehydrogenases/reductases (SDRs) NV10127, NV

111 ave significant sequence homology with other short-chain dehydrogenases/reductases (SDRs).

112 d insight into the multifunctional nature of short-chain dehydrogenases/reductases and into the enzym

113 protein has sequence similarity to bacterial short-chain dehydrogenases/reductases and might represen

114 e superfamily and are related to other plant short-chain dehydrogenases/reductases involved in second

115 Human short-chain dehydrogenases/reductases with dual retinol/

116 and demonstrate that Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share simil

117 cture is similar to that of NAD(H)-dependent short-chain dehydrogenases/reductases, with a conserved

118 ily with remarkable substrate diversity, the short-chain dehydrogenases/reductases.

119 mbrane protein that belongs to the family of short-chain dehydrogenases/reductases.

120 acid similarity with other retinoid/steroid short-chain dehydrogenases/reductases: CRAD1, CRAD2, and

121 The short-chain dehydrogenase-related protein Ayr1 forms an

122 Thus, the new short chain dehydrogenase represents a novel type of mic

123 tyrate dehydrogenase (BDH2), a member of the short-chain dehydrogenase (SDR) family of reductases, ca

124 245-amino acid protein presents the typical short-chain dehydrogenase (SDR) Rossmann-fold motif for

125 The enzyme, which is a member of the short chain dehydrogenase superfamily, uses NAD+ as a co

126 ructure reveals that 3HNR is a member of the short-chain dehydrogenase superfamily of enzymes.

127 RDH1 is the most efficient known mouse short-chain dehydrogenase that catalyzes dehydrogenation

128 e a mouse cDNA that encodes a 316-amino acid short-chain dehydrogenase that prefers NAD+ as its cofac

129 t a mouse cDNA that encodes a 317-amino acid short-chain dehydrogenase which recognizes as substrates

130 codes retinol dehydrogenase type 1 (RDH1), a short-chain dehydrogenase, which recognizes as substrate

131 oid/androgen dehydrogenase type 1 (CRAD1), a short-chain dehydrogenase, which recognizes as substrate

132 tion: a zinc-dependent alkyltransferase, two short-chain dehydrogenases with specificities for the ch