ライフサイエンスコーパス: short-chain fatty acid

1 d products that may be used by the host (eg, short-chain fatty acids).

2 is a G protein-coupled receptor activated by short chain fatty acids.

3 imuli including tastants, mechanic force and short chain fatty acids.

4 vation of fatty acid receptors for long- and short-chain fatty acids.

5 tors, two pathways that could be affected by short-chain fatty acids.

6 s, including 5-azacytidine, hydroxyurea, and short-chain fatty acids.

7 in these membrane vesicles is inhibitable by short-chain fatty acids.

8 of SLC5A8 as a Na(+)-coupled transporter for short-chain fatty acids.

9 enhanced promoter activity induced by other short-chain fatty acids.

10 most important for allowing growth on these short-chain fatty acids.

11 inization of gut contents, and absorption of short-chain fatty acids.

12 high-fiber diet and supplementation with the short-chain fatty acid acetate on the gut microbiota and

13 main metabolites of the gut microbiota, the short-chain fatty acid acetate.

14 Levels of the fecal short-chain fatty acids acetate and caproate were reduce

15 The short-chain fatty acids acetate, propionate and butyrate

16 41), are each predominantly activated by the short-chain fatty acids acetate, propionate, and butyrat

17 Short-chain fatty acids affect immune responses and epit

18 Short-chain fatty acids also reduced NF-kappaB activity

19 d long-chain fatty acids exacerbate, whereas short-chain fatty acids ameliorate, autoimmunity in the

20 Also, caecal pH was monitored and short chain fatty acids analysed by gas-liquid chromatog

21 tyrate and demonstrate the interplay between short chain fatty acids and cellular proteasome activity

22 bserved in media containing a combination of short chain fatty acids and glucose and surprisingly, in

23 G protein-coupled receptor that responds to short chain fatty acids and has generated interest as a

24 or 2 in which Gi-mediated signalling by both short chain fatty acids and synthetic agonists was maint

25 gical and biochemical properties, whole-cell short-chain fatty acid and mycolic acid analyses, DNA-DN

26 on of various fermentation products, such as short-chain fatty acids and alcohol.

27 ch diverse environmental cues (e.g., certain short-chain fatty acids and bile acids) inhibit SPI-1 ex

28 ceramides, and an increased incorporation of short-chain fatty acids and dihydroxylated bases into in

29 identity as a Na(+)-coupled transporter for short-chain fatty acids and lactate.

30 host features that are affected by microbial short-chain fatty acids and other metabolites.

31 nd redox potential through the production of short-chain fatty acids and that the bacteria adjacent t

32 In cells transfected with HNF-4alpha, short-chain fatty acids and trichostatin A, an inhibitor

33 lant cell wall biomass to microbial protein, short chain fatty acids, and gases.

34 nts of the digestion of lipids consisting of short chain fatty acids are higher than those of lipids

35 Short-chain fatty acids are a major product of prebiotic

36 e is expressed abundantly in the colon where short-chain fatty acids are generated by bacterial ferme

37 el that the ST polyketide synthase uses this short-chain fatty acid as a starter unit.

38 under low- or high-fat feeding, particularly short-chain fatty acids, but not hydrogen sulfide, direc

39 ipase showed the highest specificity towards short-chain fatty acids butanoic and hexanoic acids, the

40 transformed colonic epithelial cells to the short chain fatty acid butyrate, a physiological regulat

41 f tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate and an approved food add

42 phenylbutyrate (PBA) is a derivative of the short-chain fatty acid butyrate and is approved for trea

43 The short-chain fatty acid butyrate has been shown to elevat

44 r 95% of the acetyl-CoA was derived from the short-chain fatty acid butyrate, irrespective of the pre

45 The short-chain fatty acid butyrate, produced by microbial f

46 ost epithelium through the production of the short-chain fatty acid butyrate.

47 ut neither AcAc nor the structurally related short-chain fatty acids butyrate and acetate, suppresses

48 riptional initiation of c-myc induced by the short-chain fatty acid, butyrate, consistent with elevat

49 was associated with apoptosis induced by the short-chain fatty acid, butyrate.

50 Interestingly, short chain fatty acids (butyric acid), the product of l

51 lasm ratio) of medium and long chain but not short chain fatty acids by 2-3.6-fold.

52 erium in the human skin microbiome, produces short-chain fatty acids by glycerol fermentation that ca

53 acid (VPA), which, like NaB, belongs to the short-chain fatty acid class of HDAC inhibitors, fails t

54 ated amino acids and nicotinate and depleted short chain fatty acids compared to crude fecal control

55 Regarding short-chain fatty acid concentrations, prebiotic adminis

56 re observed in stool frequency or form or in short-chain fatty acid concentrations.

57 myeloperoxidase while decreasing total fecal short-chain fatty acid concentrations.

58 ography-mass spectroscopy was used to assess short-chain fatty acid concentrations.

59 cronutrient intake, stool diaries, and fecal short-chain fatty acid concentrations.Patients were rand

60 Furthermore, KGM increased cecal short-chain fatty acid contents, and both KGM and inulin

61 Most importantly, short chain fatty acids control proliferation and differ

62 he gut microbiota ferment carbohydrates into short-chain fatty acids, convert dietary and endogenous

63 A novel gamma-globin-inducing short-chain fatty acid derivative (SCFAD), RB7, which wa

64 Recently, selected short-chain fatty acid derivatives (SCFADs) were identif

65 Selected short-chain fatty acid derivatives (SCFADs) were recentl

66 -28 are required for the biosynthesis of the short-chain fatty acid-derived side chains of the dauer

67 tion pathways for corresponding alcohols and short-chain fatty acids, dissimilatory sulfur oxidation,

68 nic transport of lactate/pyruvate as well as short-chain fatty acids (e.g. acetate, propionate, and b

69 es of histone deacetylase (HDAC) inhibitors, short-chain fatty acids exhibit the least potency, with

70 We have previously shown that butyrate, a short-chain fatty acid fiber fermentation product, induc

71 We examined the role of butyric acid, a short-chain fatty acid formed by fermentation in the lar

72 uman acyl-ACP substrate and readily releases short chain fatty acids from full-length FASN during tur

73 tion of endogenous bowel flora in generating short-chain fatty acids from diet-derived fiber and othe

74 disaccharides partially restored total fecal short-chain fatty acids from the level significantly rep

75 transit rate, and reduced harvest of energy (short-chain fatty acids) from the diet.

76 at a group of metabolic by-products, namely, short-chain fatty acids, from bacteria that cause period

77 d established that metabolism of butyrate, a short-chain fatty acid generated during the fermentation

78 Short-chain fatty acids generated from microbial ferment

79 Short-chain fatty acids, generated in colon by bacterial

80 We determined that short-chain fatty acids, gut microbiota-derived bacteria

81 Butyrate, a four-carbon short-chain fatty acid, has received increased attention

82 uorobenzyl bromide derivatives of these very short chain fatty acids have high sensitivity of isotopo

83 icrobial and anti-inflammatory activities of short-chain fatty acids have been previously well charac

84 ation-inducing agents, such as retinoids and short-chain fatty acids, have an inhibitory effect on tu

85 when cultured with butyric acid, a principal short-chain fatty acid in the fermentation metabolites o

86 R43 as essential for the biologic effects of short-chain fatty acids in colon.

87 s microbiota-liberated sugars, hormones, and short-chain fatty acids in regulating pathogenicity.

88 Short chain fatty acids, including propionate, are gener

89 volved in the metabolism of carbohydrates to short-chain fatty acids, increases in colonic short-chai

90 uited to the Glc-6-Pase gene promoter during short-chain fatty acid-induced transcription from this p

91 Short-chain fatty acids known to induce unique ileal mot

92 Uptake of short-chain fatty acids (lactate, pyruvate, acetate, pro

93 e abundance of Bacteroidetes, elevated fecal short chain fatty acid levels, enrichment of genes assoc

94 Y-FL-pentanoic-acid staining revealed higher short chain fatty acids levels in the intestine of treat

95 hort-chain fatty acids, increases in colonic short-chain fatty acid levels, and alterations in the re

96 Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-

97 crobial organophosphate degradation produces short chain fatty acids like acetic acid, which induces

98 mary effect of HDAC inhibition by endogenous short-chain fatty acids like lactate is to promote gene

99 that supplementation of germ-free mice with short-chain fatty acids, major products of gut bacterial

100 tions included involvement of amino acid and short-chain fatty acid metabolism pathways.

101 Here, we demonstrate that the short-chain fatty acid n-butyrate, which is secreted in

102 The short chain fatty acid octanoic acid and all-trans-retin

103 The short-chain fatty acid octanoic acid failed to reproduce

104 A short-chain fatty acid olfactory receptor Olfr78, recent

105 hain fatty acids, eicosanoids, and bacterial short chain fatty acids on control of germination.

106 Here we investigated the effects of short-chain fatty acids on the expression of this gene i

107 Short-chain fatty acids or certain chemotherapeutics hav

108 acid metabolism in subjects with medium- and short-chain fatty acid oxidation defects.

109 to higher ileal and faecal concentrations of short-chain fatty acids (P<0.05).

110 eta cell-expressed GPCR that is activated by short chain fatty acids, particularly acetate.

111 imethylamine/trimethylamine N-oxide pathway, short-chain fatty acids pathway, and primary and seconda

112 that the major role of FabH is production of short-chain fatty acid primers.

113 responds to dietary changes, and butyrate, a short chain fatty acid produced by normal intestinal flo

114 Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the l

115 onic epithelial cells as it is the principal short-chain fatty acid produced by bacterial fermentatio

116 Because butyric acid (BA) is the major short-chain fatty acid produced by fermentation of dieta

117 idium-histolyticum groups, and increased the short-chain fatty acids produced compared to the negativ

118 ring diarrhea are considered to be important short-chain fatty acid producers and may be important fo

119 Butyrate, a four-carbon short-chain fatty acid product of fiber fermentation wit

120 o differences in gut microbiota diversity or short chain fatty acid production across time or with di

121 Short chain fatty acid production during in vitro fermen

122 This could contribute to reduced short chain fatty acid production in IBD.

123 tients with massive loss of small intestine, short chain fatty acid production supports survival by r

124 The colon provides important functions of short chain fatty acid production, sodium and water abso

125 compensatory protective responses, including short chain fatty acid production.

126 Bifidobacterium animalis potentiates colonic short chain fatty acids production and decreases abundan

127 the therapeutic effects of metformin through short-chain fatty acid production, as well as for potent

128 The short-chain fatty acid profile contributed by dominant g

129 A decrease in cecal pH and alterations in short chain fatty acid profiles occurred with consumptio

130 lactate, a slightly acidic pH, and specific short-chain fatty acid profiles, which are high in aceta

131 o parallel pathways for the breakdown of the short chain fatty acid propionate in Caenorhabditis eleg

132 ng the activity of the endogenously produced short chain fatty acid propionate in Gi-mediated pathway

133 lycylsarcosine), lipid (oleoylethanolamine), short chain fatty acid (propionate) and major rat bile a

134 ylmethionine (SAM) cycle and breaks down the short-chain fatty acid propionic acid, preventing its to

135 colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal pro

136 The short chain fatty acid receptor FFA2 is able to stimulat

137 Analysis of the roles of the short chain fatty acid receptor, free fatty acid 3 recep

138 Short-chain fatty acids reproducibly initiated giant mig

139 The concentrations of short-chain fatty acids required to stimulate leptin pro

140 elineate a molecular mechanism through which short chain fatty acid's, their related drug-congeners (

141 d the intestinal habitat, allowing increased short chain fatty acid (SCFA) production.

142 Butyrate is a short chain fatty acid (SCFA) that bypasses the LCFA tra

143 sociated with an increase in the levels of a short chain fatty acid (SCFA), butyrate.

144 n LAD) with [2-(13)C] butyrate (4 mmol/L), a short chain fatty acid (SCFA), plus [2-(13)C] glucose (1

145 breadth of cellular responses engendered by short chain fatty acid (SCFA)-hexosamine hybrid molecule

146 Short chain fatty acids (SCFA) are metabolites of intest

147 was significantly reduced in the presence of short chain fatty acids (SCFA), acetate, propionate and

148 , plasma and muscle biochemistry, intestinal short chain fatty acids (SCFA), and liver glycogen of tr

149 Fermentation end products, in particular the short-chain fatty acid (SCFA) acetate, are believed to b

150 aturing Gradient Gel Electrophoresis (DGGE), short-chain fatty acid (SCFA) and ammonium analyses were

151 iched diet on gut microbiota composition and short-chain fatty acid (SCFA) concentrations in parallel

152 in cell culture by sodium butyrate (NaB), a short-chain fatty acid (SCFA) histone deacetylase (HDAC)

153 ng studies in U4 cells treated in vitro with short-chain fatty acid (SCFA) mixtures that mimic the di

154 P < 0.0001), stool frequency (P = 0.02), and short-chain fatty acid (SCFA) producer Lachnospira [fals

155 nockout mice studies implicate the mammalian short-chain fatty acid (SCFA) receptors, FFAR2 and FFAR3

156 Sodium butyrate (NaBu), a form of short-chain fatty acid (SCFA), acts classically as a pot

157 We found that in mice a short-chain fatty acid (SCFA), butyrate, produced by com

158 f carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other meta

159 Short-chain fatty acids (SCFA) are the major anion in st

160 his study evaluated the properties of faecal short-chain fatty acids (SCFA) as diagnostic biomarkers

161 Short-chain fatty acids (SCFA) were measured by HPLC.

162 Short-chain fatty acids (SCFA), formed by microbial ferm

163 We determined that short-chain fatty acids (SCFA), microbiota-derived bacte

164 Two other short-chain fatty acids (SCFA), propionate and butyrate,

165 ts dietary non-digestible carbohydrates into short-chain fatty acids (SCFA).

166 ed ligand selectivity and sensitivity to the short chain fatty acids (SCFAs) acetate and propionate.

167 (rutin) to identify phenolic metabolites and short chain fatty acids (SCFAs) and compare relative ant

168 Short chain fatty acids (SCFAs) are produced in the gut

169 the induction of T regulatory cells, and the short chain fatty acids (SCFAs) butyrate, propionate and

170 nd lactobacilli, resulting in high levels of short chain fatty acids (SCFAs) in the cecal material an

171 ticle, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression o

172 g bacteria, which ferment dietary fiber into short chain fatty acids (SCFAs) known to be important fo

173 lacking intestinal commensals, which supply short chain fatty acids (SCFAs) such as acetate, also ex

174 Among the potential mechanisms, short chain fatty acids (SCFAs), the byproducts of micro

175 eceptor expressed in the kidney, responds to short chain fatty acids (SCFAs).

176 3, GPR41) and 2 (FFA2, GPR43), for which the short-chain fatty acids (SCFAs) acetate and propionate a

177 tions in gastrointestinal microbiota-derived short-chain fatty acids (SCFAs) after allogeneic bone ma

178 Short-chain fatty acids (SCFAs) and dimethyl sulfoxide (

179 Microbiota-generated fiber-derived short-chain fatty acids (SCFAs) and free fatty acid rece

180 Because short-chain fatty acids (SCFAs) and heat shock proteins

181 The short-chain fatty acids (SCFAs) are bacterial metabolite

182 KEY POINTS: The short-chain fatty acids (SCFAs) are bacterial metabolite

183 Short-chain fatty acids (SCFAs) are fermentation end pro

184 Short-chain fatty acids (SCFAs) are major products of gu

185 Short-chain fatty acids (SCFAs) are physiological regula

186 Short-chain fatty acids (SCFAs) are the main products of

187 sobacterium nucleatum produce five different short-chain fatty acids (SCFAs) as metabolic by-products

188 okines (n = 29), fecal calprotectin, and the short-chain fatty acids (SCFAs) butyrate and propionate

189 n the concentrations of fecal microbiota and short-chain fatty acids (SCFAs) in patients starting 14-

190 The effects of luminal short-chain fatty acids (SCFAs) in the foregut are unkno

191 Luminal short-chain fatty acids (SCFAs) influence gut physiologi

192 se inhibitors (HDACi) in the form of various short-chain fatty acids (SCFAs) known to be endogenously

193 Short-chain fatty acids (SCFAs) of 2 to 6 carbons in len

194 red the microbiota and the concentrations of short-chain fatty acids (SCFAs) present in the ileum and

195 Short-chain fatty acids (SCFAs) promoted TPH1 transcript

196 Short-chain fatty acids (SCFAs) stimulate colonic Na+ ab

197 metabolic product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from ferment

198 GPR43) has been identified as a receptor for short-chain fatty acids (SCFAs) that include acetate and

199 In the gut, anaerobes produce short-chain fatty acids (SCFAs) that modulate immune and

200 icroArray screen, we demonstrate that excess short-chain fatty acids (SCFAs) trigger replicative cell

201 insulin and leptin were determined by ELISA; short-chain fatty acids (SCFAs) were measured in stool s

202 n be fermented by colon microbiota producing short-chain fatty acids (SCFAs) with the ability to prev

203 ABSTRACT: The short-chain fatty acids (SCFAs), acetate, propionate and

204 The short-chain fatty acids (SCFAs), acetate, propionate and

205 absorption, bifidobacteria, total bacteria, short-chain fatty acids (SCFAs), and fecal pH in women w

206 y GPR43, a receptor for bacterially produced short-chain fatty acids (SCFAs), as a modulator of micro

207 rescribed anticonvulsant valproic acid, both short-chain fatty acids (SCFAs), dramatically increase c

208 naerobic metabolism, like butyrate and other short-chain fatty acids (SCFAs), induce regulatory T cel

209 Short-chain fatty acids (SCFAs), metabolites produced th

210 We report that short-chain fatty acids (SCFAs), produced by gut microbi

211 plementation of antibiotic-treated mice with short-chain fatty acids (SCFAs), products of microbial m

212 and commensal microbes, such as vitamins and short-chain fatty acids (SCFAs), regulate Treg generatio

213 Microbiota-produced short-chain fatty acids (SCFAs), substrates in the colon

214 Short-chain fatty acids (SCFAs), such as butyrate, produ

215 Short-chain fatty acids (SCFAs), the most abundant micro

216 beneficial bacteria in the colon to produce short-chain fatty acids (SCFAs), which are proposed to h

217 fermentation of "indigestible" prebiotics to short-chain fatty acids (SCFAs), which in turn modulate

218 s stimulated by transepithelial gradients of short-chain fatty acids (SCFAs).

219 high concentrations of microbially-produced short-chain fatty acids (SCFAs).

220 ural properties, and capability of producing short-chain fatty acids (SCFAs).

221 LP-1) and peptide YY (PYY) when activated by short-chain fatty acids (SCFAs).

222 Short-chain fatty acids (SCFAs; butyrate and propionate)

223 We show that short-chain fatty acids selectively increase the number

224 sodium glucose tranporter-1 (SGLT-1) or the short chain fatty acid sensing receptor FFAR2 (GPR43), f

225 1) is a G-protein coupled receptor for which short-chain fatty acids serve as endogenous ligands.

226 lly and structurally related to the class of short-chain fatty acid signaling molecules such as diffu

227 viously showed that the structurally related short chain fatty acid sodium butyrate (SB) induces TH t

228 Our study included short-chain fatty acids (sodium butyrate and valproic ac

229 Unlike acetate, short chain fatty acids such as butyrate and propionate

230 nd 65 mug/g, respectively, which, along with short chain fatty acids such as butyric acid (13 mg/g) e

231 D, soluble fiber is the best way to generate short-chain fatty acids such as butyrate, which has anti

232 Exposure to short-chain fatty acids, such as acetate, proprionate, a

233 Short-chain fatty acids, such as butyrate, induce EBV-TK

234 ious types of lipids, including fish oil and short chain fatty acids, suggest that fats play an impor

235 rein, we demonstrate that butyrate and other short chain fatty acids supplemented to model human inte

236 hain length acyl thioesters generating novel short-chain fatty acid synthases.

237 driven with proteins, carbohydrates or other short-chain fatty acids, systems fed with acetic acid re

238 llulosic plant polysaccharides and releasing short chain fatty acids that are then metabolized by the

239 ducts of polysaccharide fermentation include short-chain fatty acids that are ligands for Gpr41, a G

240 l class of Zn(2+)-chelating, motif-tethered, short-chain fatty acids that exhibited varying degrees o

241 es significant amounts of butyrate and other short chain fatty acids, these data provide a functional

242 estingly, all three GDSL enzymes transferred short chain fatty acids to sterols.

243 d, little is known about the contribution of short-chain fatty acids to the adipogenic differentiatio

244 e, consistent with the encoded protein-SMCT1-short-chain fatty acid transport function.

245 the small intestine, commensal bacteria, and short-chain fatty acid transport in the colon.

246 undertaken to determine whether the branched short chain fatty acid VPA could also regulate TH gene e

247 Certain monomeric phospholipids containing short chain fatty acids were antigenic whether oxidized

248 Butyrate and other short chain fatty acids were previously shown to increas

249 6 and C18:3n3) from soya bean oil emulsions; short chain fatty acids were released faster than long c

250 Concentrations of fecal short-chain fatty acids were determined by using gas chr

251 ns were higher in African Americans, whereas short-chain fatty acids were higher in native Africans.

252 Fecal short-chain fatty acids were measured by gas chromatogra

253 costerone, microbiota composition, and cecal short-chain fatty acids were measured.

254 polyunsaturated fatty acids and formation of short-chain fatty acids were recorded.

255 enic glutathione complexes, arsenosugars and short chain fatty acids) were also evaluated to assess t

256 d GPR43, is a G-protein coupled receptor for short chain fatty acids which is involved in the mediati

257 Supplementation of the diet with short-chain fatty acids, which do not require CD36-facil

258 tion of valproate (VPA), a widely prescribed short chain fatty acid with anticonvulsant and anticance

259 e deacetylase (HDAC) inhibitors by tethering short-chain fatty acids with Zn(2+)-chelating motifs, wh

260 enzymes preferentially hydrolyzed esters of short-chain fatty acids, yielding the highest activity w