ライフサイエンスコーパス: short-term plasticity

1 de insight as to the mechanisms underpinning short term plasticity.

2 ion, as well as for modeling the dynamics of short-term plasticity.

3 naptic conductance waveform and postsynaptic short-term plasticity.

4 e to maintain a fixed EPSC-IPSC ratio during short-term plasticity.

5 differentially poised for exocytosis shapes short-term plasticity.

6 c facilitation, and protracted maturation in short-term plasticity.

7 gs at CA3/CA1 synapses revealed a deficit in short-term plasticity.

8 hout altering basal synaptic transmission or short-term plasticity.

9 ograde way, resulting in altered presynaptic short-term plasticity.

10 r contributing significantly to this form of short-term plasticity.

11 in more detail and identifies its impact on short-term plasticity.

12 (iii) cbl-b null mice show an enhancement in short-term plasticity.

13 r collateral axons have target-cell specific short-term plasticity.

14 T1 at distinct synaptic sites with different short-term plasticity.

15 for determining basal synaptic strength and short-term plasticity.

16 recruitment determines basal SV priming and short-term plasticity.

17 n mean amplitude, failure rate, kinetics and short-term plasticity.

18 ion of EPSP slope, a measure of pre-synaptic short-term plasticity.

19 us trains, varying 2-fold or more because of short-term plasticity.

20 cycle, modulating synaptic transmission and short-term plasticity.

21 scharged them after induction of presynaptic short-term plasticity.

22 ng-term synaptic plasticity without altering short-term plasticity.

23 ential-evoked release probability and alters short-term plasticity.

24 c, continuously changing because of synaptic short-term plasticity.

25 hips between initial release probability and short-term plasticity.

26 nsmitter release, synaptic transmission, and short-term plasticity.

27 e into functional circuits and show enhanced short-term plasticity.

28 pletion of synaptic vesicles determined this short-term plasticity.

29 TD without a change in basal transmission or short-term plasticity.

30 lly contributes to both the excitability and short-term plasticity alterations that we observed.

31 n and suggest that, in addition to effecting short-term plasticity, AMPA receptors regulate genes inv

32 Furthermore, short-term plasticity and calcium sensitivity of neurotr

33 tion to identify the quantal determinants of short-term plasticity and combine these with a short-ter

34 In the current paper it is proposed that short-term plasticity and dynamic changes in the balance

35 Whereas both inhibitory short-term plasticity and miniature IPSC frequency and a

36 nnels by CaS proteins is required for normal short-term plasticity and normal encoding of information

37 tsynaptic inactivation of presenilins alters short-term plasticity and synaptic facilitation.

38 for the first time how the interplay between short-term plasticity and temporal summation mediates th

39 Nxph1 plays an instructive role in synaptic short-term plasticity and the configuration with GABA re

40 naptic and ectopic sites in the magnitude of short-term plasticity and the proportions of Ca2+ channe

41 nc13-2-mediate opposite forms of presynaptic short-term plasticity and thus differentially affect neu

42 Rapid cold hardening (short-term plasticity) and developmental acclimation (lo

43 able to residual calcium (Ca(res))-dependent short-term plasticities, and the actions of neuromodulat

44 readily releasable pool of vesicles, alters short-term plasticity, and changes the properties of evo

45 e showed normal basal synaptic transmission, short-term plasticity, and decremental long-term potenti

46 ase probability, Ca2+ dependence of release, short-term plasticity, and fusion pore kinetics.

47 ces in some but not all forms of presynaptic short-term plasticity, and heterogeneity in the short te

48 Thus, basal synaptic strength, short-term plasticity, and homeostasis are determined in

49 synapses with appropriate receptor kinetics, short-term plasticity, and long-term dendritic spike-tim

50 ngstanding debate about a widespread form of short-term plasticity, and will enable future studies th

51 Here we show that, although a variety of short-term plasticities are normal, LTP at mossy fibre s

52 Several forms of short-term plasticity are caused largely by changes in t

53 in presynaptic release probability (Pr ) and short-term plasticity are intriguing features of cortica

54 est that alterations in presynaptic forms of short-term plasticity are linked to alterations in prepu

55 ngs suggest that basal synaptic strength and short-term plasticity are regulated at the level of rele

56 investigated whether specific mechanisms of short-term plasticity are regulated in a target-dependen

57 Our results identify altered short-term plasticity as a neural substrate underlying t

58 surable change in basal synaptic strength or short-term plasticity as analyzed in cultured cortical n

59 evoked release, they differentially affected short-term plasticity as assessed by the paired-pulse ra

60 nstrating the dominant role of timing in the short-term plasticity as well as the immediate response

61 pocampus are distinctive for their prominent short-term plasticity, as studied in slices.

62 We show how the differential recruitment of short-term plasticity at breathing versus sniffing frequ

63 ed a method of quantitatively characterizing short-term plasticity at cortical synapses that permits

64 t ultrastructural abnormalities and impaired short-term plasticity at dentate gyrus-CA3 excitatory sy

65 ere a progressive derailment of both LTD and short-term plasticity at perirhinal synapses.

66 d a novel mechanism for target cell-specific short-term plasticity at Schaffer collateral synapses in

67 This property presumably reflects the ample short-term plasticity at the corticogeniculate synapse.

68 targeting and are accompanied by changes in short-term plasticity at the mossy fiber/CA3 circuit.

69 Here, we studied short-term plasticity at the reciprocal synapse between

70 els can account for the Ca(2+) dependence of short-term plasticity at these synapses.

71 ere, we report that these receptors regulate short-term plasticity at two loci in the corticothalamic

72 reduced paired-pulse facilitation, a form of short term plasticity attributed to presynaptic mechanis

73 The model predicts that the differences in short-term plasticity between synapses onto CA1 pyramida

74 ein receptor (SNARE) proteins play a role in short-term plasticity, Botulinum toxins A, E, and F, wer

75 a stimulus train and does not contribute to short-term plasticity, but induces a steady-state, async

76 Cortical synapses exhibit several forms of short-term plasticity, but the contribution of this plas

77 excitatory synaptic transmission and effect short-term plasticity, but they do not directly regulate

78 gest that NCS-1 acts as a calcium sensor for short-term plasticity by facilitating neurotransmitter o

79 Hyperpolarization may effect a form of short-term plasticity by promoting recovery from sodium

80 lease of 0, 1 or multiple vesicles), P(RRV), short-term plasticity, calcium transients and the requis

81 hat interactions between multiple sources of short-term plasticity can account for the complex kineti

82 However, short-term plasticity causes synapses to act as temporal

83 supply to variable demand and thus influence short-term plasticity characteristics and synaptic funct

84 display unique time- and frequency-dependent short-term plasticity characteristics in response to spi

85 synaptic kainate receptors contribute to the short-term plasticity characteristics of mossy fiber syn

86 ned this hypothesis by investigating whether short-term plasticity contributes to the temporal filter

87 The observed short-term plasticity could enable mitral cells to overc

88 locker CNQX, and displayed multiple forms of short-term plasticity (depression in approximately 70% t

89 Short-term plasticity differentially alters responses fr

90 Here we compared the short-term plasticity displayed by a neocortical and a h

91 cilitation, suggesting that any differential short-term plasticity does not reflect differences in th

92 At most synapses in the brain, short-term plasticity dynamically modulates synaptic str

93 Short-term plasticity endows synapses with nonlinear tra

94 itation and temporal summation, two forms of short-term plasticity essential for working memory.

95 Synaptic depression is a form of short-term plasticity exhibited by many synapses.

96 All forms of short-term plasticity failed to significantly affect ong

97 Together, they determine short-term plasticity features that are superficially si

98 may thus be useful tools for characterizing short-term plasticity from multi-electrode spike recordi

99 proaches for estimating synaptic weights and short-term plasticity from pre- and postsynaptic spike o

100 on rapid timescales, but no suitable form of short-term plasticity has been identified that is both a

101 Although it is presynaptic, short-term plasticity has been shown at some synapses to

102 Thus short-term plasticity has real, important functional con

103 Target cell-specific differences in short-term plasticity have been attributed to difference

104 e smaller global Ca(2+) increases to produce short-term plasticity have remained elusive.

105 of both normal channel protein turnover and short-term plasticity, how is the balance of membrane co

106 riven by one instruction for learning causes short-term plasticity in a Purkinje cell's mossy fiber/p

107 of presynaptic terminals that can influence short-term plasticity in a stimulus-dependent manner.

108 in weaker synapses that are less capable of short-term plasticity in aged individuals, and therefore

109 Previous studies of short-term plasticity in central nervous systems synapse

110 abbits is divided into two opposing forms of short-term plasticity in different cell classes.

111 riments that elucidate how facilitation, and short-term plasticity in general, contributes to circuit

112 osensitivity, the discovery of long-term and short-term plasticity in hypoxic ventilatory regulation,

113 described "augmenting responses," a form of short-term plasticity in some thalamocortical pathways t

114 wo interconnected neurons exhibited enhanced short-term plasticity in terms of paired pulse ratio (PP

115 on itself exhibited a trend toward enhanced short-term plasticity in terms of PPR and Pr.

116 and altered basal synaptic transmission and short-term plasticity in the CA1 region of the hippocamp

117 Here we looked for the signature of short-term plasticity in the fine-timescale spiking rela

118 therefore play a critical role in regulating short-term plasticity in the olfactory system.

119 putative monosynaptic interactions reflected short-term plasticity in their dynamic and predictable m

120 ) regulate glutamate release probability and short-term plasticity in various areas of the brain.

121 MKII promoter led to deficits in presynaptic short-term plasticity including paired-pulse facilitatio

122 rst discharge >14 Hz and showed considerable short-term plasticity, including paired-pulse depression

123 nt species and is considered to be a form of short-term plasticity inherent to the processing of sens

124 eedback pathway, the different components of short-term plasticity interacted to increase EPSC amplit

125 Synaptic short-term plasticity is a key regulator of neuronal com

126 Short-term plasticity is a pervasive feature of synapses

127 ar and tufted neurons, and that this form of short-term plasticity is attributable to a reduction of

128 Although short-term plasticity is believed to play a fundamental

129 ven the polarity, of that activity-dependent short-term plasticity is changed.

130 tion of synaptic vesicle fusion kinetics and short-term plasticity is critical for rapid encoding and

131 , indicating that the uniquely robust mf-CA3 short-term plasticity is KAR independent.

132 short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanist

133 transmit a range of frequencies in spite of short-term plasticity is poorly understood.

134 owever, paired-pulse facilitation, a form of short-term plasticity, is significantly decreased in BDN

135 the normal maturation of synaptic inhibitory short-term plasticity (iSTP) in the auditory cortex, and

136 entiation (PTP) is a widely observed form of short-term plasticity lasting for tens of seconds after

137 Short-term plasticity may contribute, therefore, to temp

138 ibition (DSI) is an endocannabinoid-mediated short-term plasticity mechanism that couples postsynapti

139 Such short-term plasticity might also contribute to spatio-te

140 ort-term plasticity and combine these with a short-term plasticity model and cumulative excitatory po

141 The molecular mechanisms of short-term plasticity observed during synaptic transmiss

142 rt-term plasticity, and heterogeneity in the short term plasticity of synapses onto interneurones.

143 ed-pulse and tetanic depression, whereas the short-term plasticity of asynchronous release has not be

144 the properties and underlying mechanisms of short-term plasticity of asynchronous release.

145 We investigated the short-term plasticity of both the mitral-to-granule exci

146 These results suggest that short-term plasticity of cortical synapses could shape t

147 hus demonstrating spiking activity-dependent short-term plasticity of electrical synapses.

148 atory and inhibitory neuron and incorporated short-term plasticity of EPSPs and IPSPs and slow IPSPs.

149 Short-term plasticity of EPSPs with increasing frequency

150 We show that, in vivo, short-term plasticity of excitatory inputs to CA3 pyrami

151 (KO) of Rab3B does not alter the strength or short-term plasticity of excitatory or inhibitory synaps

152 GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result n

153 stimulation, we isolated and quantified the short-term plasticity of GABAergic lateral IPSCs (L-IPSC

154 Therefore, this short-term plasticity of GABAergic synaptic inputs is li

155 pyramidal cells and interneurones including short-term plasticity of inhibitory and excitatory synap

156 Short-term plasticity of L-IPSCs may thus influence the

157 amplitude, kinetics, voltage dependence and short-term plasticity of mossy fibre-mediated EPSCs.

158 Short-term plasticity of On- and Off-EPSPs, and its pote

159 rtex (V1) show pronounced adaptation-induced short-term plasticity of orientation tuning primarily at

160 he synchronization, temporal patterning, and short-term plasticity of spiking in projection neurons,

161 Surprisingly, the time course and short-term plasticity of synaptic signaling were nearly

162 Thus, short-term plasticity of the intracortical circuit can m

163 thermore, domain specific differences in the short-term plasticity of the postsynaptic response indic

164 ores the contributions to different forms of short-term plasticity of the readily releasable vesicle

165 , demonstrating that they are concerned with short-term plasticity of the synapse.

166 th differences in intrinsic excitability and short-term plasticity of their inputs.

167 Induction of LTP or LTD altered the short-term plasticity of transmission onto both pyramida

168 synthesis is required for long-term, but not short-term, plasticity of GABA release from type 1 canna

169 ptual framework for analyzing the effects of short-term plasticity on the I/E balance in disease mode

170 ges in the size of evoked synaptic currents, short-term plasticity, or apparent calcium dependence of

171 ad no effect on basal synaptic transmission, short-term plasticity, or LTP induced by several trains

172 tracellular Ca(2+) requirement for a form of short-term plasticity, post-tetanic potentiation (PTP) a

173 NMDAR) activation can trigger both long- and short-term plasticity, promote cell survival, and initia

174 ate of inhibitory inputs combined with their short-term plasticity properties, regardless of the actu

175 the reciprocal impact of different forms of short-term plasticity (reactivations) on a persistent fo

176 ic facilitation (SF) is a ubiquitous form of short-term plasticity, regulating synaptic dynamics on f

177 dependent manner, but the mechanisms of such short-term plasticity remain unknown.

178 nprimary auditory cortices, attention-driven short-term plasticity retunes neurons to segregate relev

179 In short-term plasticity, RIM1 accelerates the priming of s

180 ggest new mechanisms by which inhibition and short term plasticity shape neural responses.

181 significant role in three important forms of short-term plasticity: short-term depression, facilitati

182 adapting neurons connected by synapses with short-term plasticity, showing that the observed linear

183 ation that interacts with activity-dependent short-term plasticity so that the magnitude, and sometim

184 Short Term Plasticity (STP) has been shown to exist exte

185 ose-dependently (0.5-2 mg/kg, i.p.) impaired short-term plasticity (STP) and long-term potentiation (

186 Presynaptic short-term plasticity (STP) dynamically modulates synapt

187 Studies of short-term plasticity (STP) in the hippocampus, performe

188 examine how long-term potentiation (LTP) and short-term plasticity (STP) interact in two different ce

189 This short-term plasticity (STP) is a key determinant of neur

190 y of the postsynaptic interneuron, while the short-term plasticity (STP) of inhibitory-to-excitatory

191 Short-term plasticity (STP) represents a key neuronal me

192 ptic processes give rise to several forms of short-term plasticity (STP), which is believed to contro

193 napses show large variations in strength and short-term plasticity (STP).

194 this synapse reflects its functional role in short-term plasticity (STP).

195 in high-frequency synaptic transmission and short-term plasticity (synaptic depression and potentiat

196 were modeled by incorporating mechanisms of short-term plasticity that are known to be driven by res

197 Here, we examine the mechanisms of short-term plasticity that can influence transmission at

198 nd the ready releasable pool-key elements of short-term plasticity that define the ability of synapse

199 urs in aging, negatively regulated a form of short-term plasticity that enhances synaptic throughput.

200 Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmissio

201 inner plexiform layer of the retina undergo short-term plasticity that may mediate different forms o

202 d here may represent a basic form of in vivo short-term plasticity that modifies neuronal function.

203 Facilitation is an important form of short-term plasticity that occurs in most synapses.

204 from incorporating nonlinear terms, such as short term plasticity, that provide theoretical advances

205 rachidonoylglycerol (2-AG)-dependent form of short-term plasticity, that is, depolarization-induced s

206 xhibit normal fast synaptic transmission and short term plasticity, they are severely impaired in in-

207 r control and an altered endocytosis affects short-term plasticity through quantal size changes.

208 n/secretion coupling, vesicle recycling, and short-term plasticity throughout the CNS.

209 modulate vagal brainstem circuits undergoes short-term plasticity via alterations in cAMP levels sub

210 Furthermore, short-term plasticity was disrupted in AC8-/- mice but n

211 In contrast, this form of short-term plasticity was not further enhanced in RIM1al

212 Short-term plasticity was unchanged at CF-PC synapses, s

213 possible mechanisms for these differences in short-term plasticity, we developed a mechanistic mathem

214 lus protocols that invoke different forms of short-term plasticity, we find differences in some but n

215 he experimental basis for a general model of short-term plasticity, we studied three synapses in rat

216 presynaptic proteins, and impaired synaptic short term plasticity were observed in hippocampal neuro

217 nother cell type tend to show characteristic short-term plasticity, which varies from facilitating to

218 These results demonstrate the presence of short-term plasticity within spinal inhibitory circuits.

219 Short-term plasticity would allow rapid re-weighting tha