ライフサイエンスコーパス: shut

1 n and close while the nucleotide lid remains shut.

2 ion with a second photoreceptor protein Eyes Shut.

3 plex and SecA's polypeptide-binding clamp is shut.

4 that takes place while the channel is still shut.

5 C-linker, and twists the inner helical gate shut.

6 of alpha-kleisin from Smc3, thereby locking shut a "DNA exit gate." How Scc3 and Pds5, regulatory su

7 ) in PhuT H-bonds with a heme propionate, in ShuT a peptide loop partially takes up the space occupie

8 contribution to the stability of heme-loaded ShuT, albeit without directly interacting with the heme

9 block is very fast and that the channel can shut almost as fast as normal when the blocker was bound

10 eliciting the change of conformation between shut and open states of the channel.

11 ure of the heme pocket is quite different in ShuT and PhuT.

12 , were required for the release of heme from ShuT and translocation to ShuS.

13 aman, MCD, and UV-visible spectra of WT heme-ShuT are consistent with a five-coordinate high spin hem

14 assium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of

15 tors whose ligand-binding clefts were locked shut by disulfide bridges engineered across lobes.

16 il increased the occupancy of the long-lived shut conformations, thereby reducing the open probabilit

17 ism, and, along with the persistence of open-shut correlations in high agonist concentrations, sugges

18 they promptly inhibit neighbouring cells and shut down activity.

19 ripts from a gene before its activity can be shut down and its chromatin reset to an inactive state.

20 gonists and antiandrogens, cannot completely shut down AR signaling.

21 r ecosystem service of leguminous crops--was shut down at high nano-CeO(2) concentration.

22 Ethylene production is shut down at the level of 1-aminocyclopropane-1-carboxyl

23 ent-ionization (RESI) channel, are virtually shut down by mid-IR fields.

24 ar antigen and DNA, but the activity was not shut down by Pol delta in accord with rapid association/

25 ated in a system where cross-presentation is shut down by pretreatment with CpG.

26 pathogen, but then, the NKT cell response is shut down by two mechanisms; apoptotic contraction and m

27 ndfast sea ice produces enough resistance to shut down calving at the terminus.

28 rapy regimens, these xenograft breast tumors shut down classic estrogen signaling and activate altern

29 attenuates the TGFbeta signaling pathway to shut down clusterin expression, thereby stimulating angi

30 ed significant inhibition, and nitrification shut down completely with TBP addition.

31 isplatin activates ATR, CHK1 and WEE1, which shut down DNA replication and attenuate cisplatin induce

32 CME is shut down during early mitosis, but the mechanism of thi

33 s continuously in non-dividing cells, but is shut down during mitosis, when clathrin concentrates at

34 Thus, L. pneumophila can shut down ER-mitochondria communication through cleavage

35 both on the non-recombining Y chromosome, to shut down expression of maladapted genes [3], and on the

36 t documents, but by 1967, it was effectively shut down following the refusal of journals to accept ar

37 methylation alone might not be sufficient to shut down gene expression.

38 Human adenoviruses (HAdVs) shut down host cellular cap-dependent mRNA translation w

39 ly, IL-10-producing neutrophils specifically shut down IL-17A production by Th17 CD4 cells, but not I

40 These Treg shut down IL10, gain potential to express IL17, and swit

41 echanism by which activated transcription is shut down in human cells.

42 Retrograde transport was effectively shut down in this membrane-bound state, allowing for eff

43 subjected to degradation during apoptosis to shut down its signaling.

44 ovides a basis for eukaryotes to effectively shut down mature mRNA transport and thereby tailor prote

45 ling tubercle bacilli to restrict growth and shut down metabolism in a coordinated fashion.

46 translation in response to diverse stresses shut down most protein translation to conserve energy an

47 tion, glucose starvation not only signals to shut down mTOR, but also results in the transient phosph

48 in dendritic cells serving to simultaneously shut down multiple pathways of inflammation.

49 alone in p53 negative tumors resulted in the shut down of angiogenesis and led to sustained tumor reg

50 of the tumor microenvironment including the shut down of angiogenesis and the induction of cellular

51 the p53-dependent induction of TSP-1 and the shut down of angiogenesis.

52 Stable shut down of miR-21, p47(phox) or STAT3 and overexpressi

53 tes that a fraction of tumour cells survives shut down of oncogenic signalling.

54 physiological changes occur that lead to the shut down of photosynthesis and a cessation of growth.

55 he Drosophila model of aggression, the acute shut down of the entire serotonergic system yields flies

56 ly due to the across-the-board, non-specific shut down of transcription in a condition of growth arre

57 at later times postinfection, likely due to shut down of transgene expression, and indicating that t

58 s are driven toward the MS, and the field is shut down once the ions reach the vicinity of the MS inl

59 remain metabolically active, whereas others shut down or rely on anaerobic metabolism.

60 re activated intracellularly (PrfA 'ON') but shut down outside the host (PrfA 'OFF').

61 elay, while pyrylium-like ether terminations shut down proton exchange.

62 For example, it can be used to shut down radical pathways and to give access to aryl ca

63 Point mutations that disrupt the Y-Y dyad shut down radical transport.

64 w the replication of the virus to be quickly shut down should adverse effects be detected.

65 Surprisingly, Aire could be shut down soon thereafter and remain off for long period

66 Many will shut down sooner.

67 expressed on activated T cells and serves to shut down T-cell activation, culminating in T-cell death

68 embly during DNA replication and the need to shut down the activating system under replication-stress

69 While AG is known to shut down the expression of the stem cell maintenance ge

70 Here we show that SA can directly shut down the expression of the vir regulon.

71 This process may completely shut down the gated injection.

72 d with impurities and other methods that can shut down the hydrogenation reactions are highlighted in

73 The objective of HSCT is to immediately shut down the immune response and allow the transplanted

74 sor or valve during infection to temporarily shut down the lymph node to further antigenic challenge.

75 the N-RPS19 interaction is a novel target to shut down the N-mediated translation strategy and hence

76 ssion and glycolysis, and IFN-gamma addition shut down the oxidative metabolism in SYL-infected mphis

77 ker studies demonstrated the ability of 3 to shut down the PI3K/Akt pathway and induce apoptosis in c

78 of Gravin, paraxial mesodermal cells fail to shut down the protrusive activity mediated by the Rho/RO

79 ed task-related signals, but also completely shut down the spontaneous activity within the IO, which

80 ntegrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.

81 ectural elements to effectively condense and shut down the Xi.

82 Activation of PLC can shut down their activity if it depletes the PIP(2) pool

83 ly directed cell migration, but they fail to shut down their protrusive behavior and undergo the norm

84 rine bone marrow-derived M2 macrophages also shut down their TIMP-1 expression and produced proMMP-9

85 g infection, HSV-1 has evolved mechanisms to shut down these responses to evade the proinflammatory c

86 hotochemical azide activation pathway can be shut down through coordination of the terminal azide lig

87 caused by an indirect mechanism: these cells shut down transcription in response to DNA damage, effec

88 er growth-limiting conditions, budding yeast shut down transcription of genes of the translation appa

89 immune responses, the egress process can be shut down transiently.

90 tant Ndel1 lacking key phosphorylation sites shut down transport completely, as did a dominant-negati

91 How caspase activity is restrained and shut down under such nonapoptotic conditions remains unk

92 aureus colonization by producing a signal to shut down virulence.

93 This exchange process is completely shut down when [Cp2TiCH2CH(CD3)(SiMe3)](+) is used, sugg

94 e conditions until the decarbonation factory shut down with the collision of Greater India with Asia

95 ectopic expression patterns and hence were "shut down" by the model.

96 stituent (R=tBu), this catalytic reaction is shut down, but the complex becomes active for aqueous el

97 Under these conditions, where motility is shut down, microarray experiments showed an increased RN

98 Once star formation has been shut down, perhaps during the quasar phase of rapid accr

99 d that during mitosis, when transcription is shut down, Runx2 selectively occupies target gene promot

100 that the Compound I (peroxidase) pathway is shut down, so that instead the reaction intermediate div

101 when the plant was operating to when it was shut down, the plant was found to contribute a large per

102 ellular stress, cap-dependent translation is shut down.

103 from chromatin rapidly once transcription is shut down.

104 omes stable at induced HSP70 genes that have shut down.

105 , for the first time, that RTS-based control shuts down a dangerous short-circuit event 3 times earli

106 during embryonic development, but it usually shuts down after birth.

107 zation of azobenzene switching, while Cu(II) shuts down azobenzene isomerization.

108 ctivated during mitochondrial inhibition and shuts down biosynthetic processes to help conserve cellu

109 ular ischemia model in mice that selectively shuts down blood supply to the ipsilateral hippocampal f

110 f the enzyme and induces a loop closure that shuts down catalysis at the active site.

111 tion of a long-chain phospholipid completely shuts down electron transfer.

112 OP1 provides a regulatory feedback loop that shuts down excessive inflammatory responses and thereby

113 an erythrocyte, the developing erythroblast shuts down expression of most of its genes but preserves

114 S. Typhi of TviA, a regulatory protein that shuts down flagellin (FliC) expression when bacteria tra

115 This process shuts down general protein synthesis to conserve amino a

116 . aeruginosa secreting ExoS, upon infection, shuts down host cell survival signal pathways by inhibit

117 iation of a "switched" Th1 population, which shuts down IFN-gamma secretion and upregulates IL-10 and

118 ain (CTD), we find that oocyte transcription shuts down independently of maturation.

119 findings will help explain how L. heterotoma shuts down its hosts' immunity and shed light on the mol

120 tions become unfavorable in early autumn, it shuts down its reproductive axis, increases its body wei

121 Galphas promotes maturation of endosomes and shuts down mitogenic MAPK-ERK1/2 signals from endosomes.

122 of the IDH mutation on intrinsic apoptosis, shuts down oxidative phosphorylation and reduces ATP lev

123 Thus, upon abrupt glucose depletion, yeast shuts down pathways consuming large amounts of energy, i

124 d stress response pathways in bacteria, RelE shuts down protein synthesis by cleaving mRNA within the

125 motes NRP internalization, which effectively shuts down receptor-mediated signaling by a second ligan

126 Knock-down of either pathway shuts down SA biosynthesis and abrogates pathogen resist

127 NeuAc), added to the media of cultured cells shuts down sialylation by a mechanism involving its intr

128 d isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of th

129 The use of base shuts down the isomerization pathway and allows for the

130 m the environmental occurrence of P3N, which shuts down the Krebs cycle by inactivating succinate deh

131 R (PKR), a versatile antiviral host factor, shuts down the translation machinery upon activation in

132 tiation of human dendritic cells effectively shuts down their immunogenic pathways and implicates tra

133 in eukaryotic mRNA decay that simultaneously shuts down translation initiation and activates mRNA deg

134 r 31 was used, the electron-transfer pathway shuts down.

135 e autoregulation (RPAR) loop is critical for shutting down ATP-consuming active potassium uptake to c

136 romoting adipogenesis and lipogenesis and by shutting down catabolic processes such as lipolysis and

137 mediated cleavage of complement C3b, thereby shutting down complement activation.

138 The likely contaminant responsible for shutting down cross-presentation is peptidoglycan (PGN).

139 aining NuRD complex plays a critical role in shutting down expression of specific synaptogenesis-rela

140 ic (D/DMga4) is completely inactive in vivo, shutting down expression of the Mga regulon.

141 of the mutant phenotypes can be recovered by shutting down FAF1 expression through the administration

142 Our study also reveals a novel mechanism of shutting down gp96 post-translationally in regulating it

143 sport networks of small safe conduits and/or shutting down hydraulic function by dropping leaves duri

144 orylation at S344 of MtCCaMK is adequate for shutting down its activity, and is epistatic over previo

145 on through depleting client oncoproteins and shutting down multiple oncogenic pathways.

146 ion (EHT) is a dynamic process involving the shutting down of endothelial gene expression and switchi

147 ation genes, but rather is important for the shutting down of the pluripotency network in differentia

148 these organisms, equalization is achieved by shutting down one of the two X chromosomes in the somati

149 and rapidly moved to restore Pak1 levels by shutting down Pak1 shRNA expression through a methylatio

150 duced starvation response can be reverted by shutting down polyP synthesis genetically or pharmacolog

151 ere, we demonstrate that RFS-1/RIP-1 acts by shutting down RAD-51 dissociation from ssDNA.

152 rylation, VEGF, or VEGFR2 are ineffective in shutting down signaling to ERK1/2.

153 e homolog as a repair template is regulated, shutting down simultaneously for both CO and noncrossove

154 flammatory cytokines and trophic factors, by shutting down STAT1/STAT5 signaling that mediate essenti

155 rations, favoring fast nutrient utilization, shutting down stress responses, and boosting growth.

156 ressing the formation of H3+ and effectively shutting down that mode of cooling.

157 ng RNAs (siRNAs) and evaluated the effect of shutting down the expression of these proteins on rotavi

158 It is generally believed that shutting down the kinase activity of BCR-ABL by imatinib

159 t contribute to decreasing DC activation and shutting down the production of pathogenic IL-23.

160 for achieving an effective HTP, is twofold: shutting down the radically induced chain-growth additio

161 These results suggest that shutting down the residual activity of the limbic-arousa

162 onally thought as a consequence of the brain shutting down to external inputs, it is now acknowledged

163 phenotype than Lis1 RNAi alone, essentially shutting down transport.

164 ming of the cold-induced FLC transcriptional shut-down and upregulation of FLC antisense transcripts,

165 eceptor promotes M2-polarization in order to shut-down deleterious immune responses and limit bystand

166 lcyclopropane and ethephon revealed that the shut-down mechanism in ethylene biosynthesis is developm

167 ould form a positive feedback loop for rapid shut-down of ceramide channels.

168 even under the harsh conditions of start-up, shut-down, and/or hydrogen starvation.

169 the active ES, correlated with transcription shut-down.

170 e, open probability (P(OPEN)), and mean open/shut duration.

171 on even when an observer's eyes remain 'wide shut' during learning.

172 desensitized state in which the ion channel shuts even though the neurotransmitter molecules remain

173 rst crystal structures of two such proteins, ShuT from Shigella dysenteriae and PhuT from Pseudomonas

174 re readings taken after the Macondo well was shut in for the well integrity test.

175 After the well was successfully capped and shut in on July 15, 2010, a variety of monitoring activi

176 that the Macondo Well was not leaking after shut in, and therefore, it could remain safely shut unti

177 ociated with the flow rate of the well, well shut in, killing the well, and determination of the loca

178 grity Team evaluated the geologic hazards of shutting in the Macondo Well at the seafloor and determi

179 irically from pressures measured during well shut-in and from pressures and flow rates measured the p

180 t plume depths for over six weeks after well shut-in and were likely caused by common marine heterotr

181 To investigate reactions during the shut-in period of hydraulic fracturing, experiments were

182 possibility that, under the anticipated high shut-in pressures, oil could leak out of the well casing

183 allation of the capping stack and subsequent shut-in.

184 xponential components, and the four shortest shut intervals of each distribution were considered to o

185 and closing, the location and nature of the shut ion channel gate, the transitions between the close

186 ision based on the processed information and shuts itself down.

187 mic binding proteins, demonstrates that PhuT/ShuT more closely resembles BtuF, which reflects the clo

188 totic fusion pores that can flicker open and shut multiple times.

189 Site-directed ShuT mutants of the absolutely conserved Tyr residues, T

190 When V. philippinarum were wired shut, octopuses switched techniques.

191 to active, phosphorylated GPCRs and thereby shut off 'classical' signalling to G proteins, trigger i

192 uption to enhance NMJ stability, and is then shut off allowing NMJ disassembly during persistent cyto

193 econd, signalling activities display a rapid shut off and a slower adaptation during which responsive

194 ation and rapidly declining when the origins shut off and neighboring promoters turn on.

195 activated cells, host DNA synthesis is then shut off and replaced with virus DNA synthesis.

196 nic protein, and the subsequent inability to shut off angiogenesis.

197 eraction and subvert the immune response are shut off at intermediate levels of CodY activity, while

198 While normal B cells promptly shut off BCL6 when they exit the GC, many GC-derived B-c

199 l of GRK1 accelerated the dim flash response shut off but had no effect on the saturated response shu

200 es, and previous data suggest that SOCS3 may shut off cytokine activation at the early stages of live

201 shed the acceleration of saturated responses shut off during light adaptation.

202 LF delayed the time taken for these genes to shut off during recovery from heat shock.

203 Failure to shut off histone expression disrupts centromeric chromat

204 d 3C(pro), to process their polyproteins and shut off host cell activities detrimental to virus repli

205 We also show that the viruses fail to shut off host cell polypeptide production.

206 had no effect on the ability of the virus to shut off host cell protein synthesis but did affect viru

207 han MP-12 did in Vero E6 cells and failed to shut off host protein synthesis in Vero cells.

208 rods and the acceleration of their response shut off in background light.

209 ve cytokines, although IL-17A production was shut off in the course of the infection.

210 levels of OTUD1 inhibit cancer stemness and shut off metastasis.

211 ld is predicted to decrease with time and to shut off naturally when the Moon recedes far enough from

212 it can compensate for radiative cooling and shut off precipitation.

213 tion; however, the mechanisms of PAR1 signal shut off still remain unclear.

214 The liver, skin, and tail fibroblasts shut off tadpole genes and activate frog genes in the sa

215 lizes kinetochore-microtubule attachments to shut off the spindle checkpoint, suggesting that cells r

216 tly induced upon viral infection and rapidly shut off thereafter.

217 olved mechanisms to rapidly and specifically shut off these beneficial inflammatory activities before

218 impaired the cell's ability to appropriately shut off transcription of the induced ARG1 gene, indicat

219 cellular compartments where it is unable to shut off translation and repress viral replication.

220 ed these processes but subsequently acted to shut off viral gene expression and replication after the

221 age of a temperature-sensitive polymerase to shut off viral transcription, and we demonstrate that SI

222 expression had been induced and subsequently shut off were able to persist in vivo and reinitiate leu

223 ermits NO signalling, and this signalling is shut off when Hb alpha is reduced to the Fe(2+) state by

224 receptors bind ethylene, their signaling is shut off, activating responses.

225 During mitosis, transcription is shut off, chromatin condenses, and most transcription fa

226 but had no effect on the saturated response shut off.

227 ng infection, when host protein synthesis is shut off.

228 in no longer is required and the gene can be shut off.

229 rgo ringdown decays when the cavity input is shut off.

230 entual promoter eviction and transcriptional shut off.

231 ntraction coupling, and ideally this release shuts off completely between heartbeats.

232 s of a hormone-coupled molecular switch that shuts off earlier developmental programs to allow for la

233 Influenza A virus (IAV) infection shuts off host cell gene expression at transcriptional a

234 protein of encephalomyocarditis virus (EMCV) shuts off host cell nucleocytoplasmic trafficking (NCT)

235 mediated conformational switch of HK853 that shuts off its phosphatase activity under acidic conditio

236 This defect shuts off miR-198 expression in favor of sustained FSTL1

237 transport of Li ions, while the Li-based SEI shuts off Na-ion transport.

238 EPEC barely elicits cytokine production and shuts off nuclear translocation of NF-kappaB p65.

239 cking general-base capability in this pocket shuts off rescue.

240 AML1-ETO quickly shuts off scl expression, and restoration of scl express

241 The cold upper atmosphere shuts off the anticipated enhanced-Jeans, hydrodynamic-l

242 d a cell autonomous program that temporarily shuts off the insulin gene.

243 the AAA ATPases in the 19 S regulatory cap, shuts off the proteasome through the inhibition of ATPas

244 A key switch in the hypothalamus shuts off this arousal system during sleep.

245 ontrol loop model that is proposed to aid in shutting off ABA signal transduction, to counteract leak

246 In addition to its role in shutting off cap-dependent host mRNA translation, L(pro)

247 ter anomaly was carried to the Labrador Sea, shutting off deep convection.

248 ne" diseases was the realization that merely shutting off expression of a disease-encoding transgene

249 n of type I IFNs and IFN-stimulated genes by shutting off host cell macromolecular synthesis, which i

250 tical to control the differentiation program shutting off the c-Myc gene in large pre-B cells.

251 accelerating turnover of Mre11 at DNA ends, shutting off the DNA damage checkpoint and allowing cell

252 ding, NADP(+) bends and interacts with D317, shutting off the entrance to create a protected micro-en

253 e and high quality printing while completely shutting off the nonilluminated counterparts.

254 intrinsic instability of Sda contributes to shutting off the pathway.

255 cell division and the processes involved in shutting off YneA activity.

256 to neuronal cell death, indicating that the shut-off aerobic glycolysis is essential for neuronal su

257 of chromosomal intertwines, transcriptional shut-off and complete segregation of chromosomes.

258 roarray analysis revealed host transcription shut-off and identified three temporal classes of phage

259 hosphate-responsive element-binding protein) shut-off and nuclear accumulation of class IIa histone d

260 Fah does not execute host transcription shut-off and relies on host RNA polymerase (RNAP) sigma(

261 n accumulation can be cleared after promoter shut-off by a combination of autophagy and vacuolar prot

262 ha-P dephosphorylation, assessed by a kinase shut-off experiment, progressed normally in Sephin1-trea

263 To prevent toxic accumulation, rapid shut-off mechanisms are required.

264 ation factor (eIF)-2 complex, resulting in a shut-off of general translation, induction of apoptosis,

265 deficient states, resulting in translational shut-off of global hepatic protein synthesis, including

266 Coliphage N4 infection leads to shut-off of host DNA replication without inhibition of h

267 due to their inability to prevent host-cell shut-off of protein synthesis caused by hyperphosphoryla

268 ing that inhibition of NMD induces premature shut-off of TCR-beta rearrangement.

269 eformed replicase, thereby resulting in slow shut-off of viral RNA synthesis.

270 nct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) s

271 Of 177 selected conditional shut-off strains tested, the virulence of 102 was blocke

272 nts via interaction with RecA and competence shut-off via interaction with ComE, avoiding physiologic

273 prA interaction with ComE altered competence shut-off.

274 l a specific stimulus commands a coordinated shut-off.

275 thogen and a paradigm for virus-induced host shut-off.

276 We found that after 1 or 3 weeks of shutting-off hAPP expression, the glomerular circuit was

277 cooperate with host immunity in an effort to shut out pathogens.

278 On the basis of sequence identity, the ShuT protein is most closely related to the class of PBP

279 the glycine receptor-and find that the open-shut reaction is similar for both full and partial agoni

280 Site-directed mutagenesis of ShuT residues proposed to be required for stabilization

281 echanisms with three binding sites and extra shut states could describe the observations.

282 that contain more than the minimum number of shut states, either as desensitized distal states (Jones

283 ngs show only whether the channel is open or shut: states of equal conductance are aggregated, so tra

284 ption of this short-helix crippled PDLIM2 in shutting Tax to the nuclear matrix for ubiquitination-me

285 A new study indicates that repressors can 'shut the door' to newly initiating polymerases, allowing

286 ormal range of extracellular pH, pH 7.4-7.3, shut the pore by a conformational transition referred as

287 vigilante groups, and hackers, who sometimes shut them down with cybernetic attacks.

288 ifenprodil selectively affected the area of shut time constants, but not the time constants themselv

289 it will usually be missed (together with the shut time that follows it), so the true burst length is

290 cts with fair accuracy the apparent open and shut-time distributions in different concentrations of a

291 NR1/NR2A(S670G) shut-time distributions were best described by a mixture

292 ime constant describing the intra-activation shut-time histogram and modestly reduce channel open tim

293 UBP684 produced a dramatic reduction in long shut times and a robust increase in mean open time.

294 Correlations between shut times and adjacent open times were observed in all

295 ly longer (~160-800-fold, respectively), and shut times are shorter (~8-fold) when activated by 4BP-T

296 s of agonists, correlations between open and shut times, and both the rising and falling phases of th

297 f heme from the periplasmic binding protein, ShuT, to the cytoplasmic binding protein, ShuS, are coup

298 ut in, and therefore, it could remain safely shut until reservoir pressures were suppressed (killed)

299 Nucleocytoplasmic shutting was determined by heterokaryon analyses.

300 A comparison of PhuT/ShuT with the vitamin B(12)-binding protein BtuF and the