ライフサイエンスコーパス: sialidase

1 hed endothelial cell (EC) expression of NEU1 sialidase.

2 ar calcium, activating P38MAPK and then Neu3 sialidase.

3 o and in vivo), despite the presence of Neu3 sialidase.

4 es and might contribute to research on viral sialidase.

5 treatment with an alpha2,3-linkage-specific sialidase.

6 fringens strains produce NanI as their major sialidase.

7 ains and several other proteins, including a sialidase.

8 HI and NanH, with the latter being the major sialidase.

9 n hypothesized to be regulated by endogenous sialidase.

10 lent adducts with virus, bacteria, and human sialidases.

11 lyl moiety modifies tyrosine residues of the sialidases.

12 ed target-specific irreversible inhibitor of sialidases.

13 by storage in the presence of inhibitors of sialidases.

14 ght express one or more catalytically active sialidases.

15 y sialylated upon addition of parasite trans-sialidases.

16 N-propionylneuraminic acid are sensitive to sialidases.

17 ase repeats that are a signature of nonviral sialidases.

18 equential actions of bacterial esterases and sialidases.

19 a, and Escherichia coli) that do not produce sialidases.

20 tion of glycoconjugates, and upregulation of sialidases.

21 of MMP-8 (94 ng/muL), elastase (33 ng/muL), sialidase (23 ng/muL), and levels of P. gingivalis (0.23

22 oglycan N-linked glycosidase F(PNGaseF)- and sialidase A-treated human erythrocyte glycoproteins (hEG

23 NEU3 sialidase, a key enzyme in ganglioside metabolism, is ac

24 ite contains certain conserved features of a sialidase: a nucleophilic tyrosine with its associated g

25 eas overexpression of Neu1 or treatment with sialidase abrogated LPS-induced tolerance, as defined by

26 Neu3 sialidase activation in DRGs is initiated by an influx o

27 ia a separate binding site distinct from the sialidase active site.

28 ractions in subsite 2 of the influenza virus sialidase active site.

29 ne of the three arginines usually found in a sialidase active site.

30 n the ranked hemagglutination and endogenous sialidase activities of these strains (Spearman's r = 0.

31 F. alocis showed nongingipain protease and sialidase activities.

32 tion in a pattern correlated with endogenous sialidase activity (r = 0.91, P < 0.001), although not c

33 Variation in sialidase activity and cytadherence among isolates was t

34 was then determined that culture supernatant sialidase activity and expression of exosialidase genes,

35 to the classic sialidase fold, but it has no sialidase activity and fulfills a purely non-enzymatic f

36 e the dynamic relationship between commensal sialidase activity and liberation of mucosal sialic acid

37 high glucose levels repressed F4969 culture sialidase activity and nanI expression even in the prese

38 trations repressed F4969 culture supernatant sialidase activity and nanI transcription levels.

39 NanH deficiency resulted in a total loss of sialidase activity associated with the outer-membrane an

40 NA displays sialidase activity by cleaving off the terminal N-acetyl

41 ed, FP and Db strains had little supernatant sialidase activity compared to other type A or C human i

42 knockdown of NEU1 and NEU3 each decreased EC sialidase activity for 4-MU-NANA by >65 and >17%, respec

43 crovascular EC lysates contained heat-labile sialidase activity for a fluorogenic substrate, 2'-(4-me

44 The EC lysates also contained sialidase activity for a ganglioside mixture.

45 s used for in situ imaging of the changes of sialidase activity in live cells.

46 tochemical imaging assay for influenza virus sialidase activity in living cells by using a new fluore

47 RSV infection increased endogenous sialidase activity in lung mononuclear cells.

48 Sialidase activity in P. gingivalis FLL401 was reduced b

49 no significant differences in the levels of sialidase activity in the outer membrane or secreted fra

50 Sialidase activity in vaginal fluids is diagnostic of BV

51 Inhibiting sialidase activity interferes with sperm binding to the

52 Sialidase activity is activated by caspase-dependent mec

53 Sialidase activity is most predictive of BV status and c

54 these results suggest that the P. gingivalis sialidase activity may be involved in regulating gingipa

55 The role of sialidase activity of mKL acting inside is supported by

56 or mouse polyomavirus and that inhibition of sialidase activity promotes virion binding in the absenc

57 orted by findings that mutations of putative sialidase activity sites in sKL and mKL abrogated the re

58 luid-generated NanI fragments possessed more sialidase activity than did full-length rNanI, further s

59 LPS-activated microglia exhibited a sialidase activity that desialylated PC12 cells and coul

60 Sialidase activity varies widely among strains and tends

61 The recombinant enzyme does not show any sialidase activity with the standard fluorogenic sialic-

62 GBS wild-type and DeltanonA strains lack sialidase activity, but forced expression of pneumococca

63 concentrations increased culture supernatant sialidase activity, largely by stimulating nanI transcri

64 hat DAS181 (Fludase), an antiviral drug with sialidase activity, potently inhibited replication of wi

65 -derived glycoproteins or from surface-borne sialidase activity, respectively.

66 ence its function and is dictated in part by sialidase activity, we asked whether airway epithelia ex

67 ted hBMEC invasion depends only partially on sialidase activity, whereas the N-terminal lectinlike do

68 lted in only a slight reduction in the total sialidase activity, with no significant differences in t

69 Both effects involve putative Klotho sialidase activity.

70 in levels, and NEU1 accounted for >70% of EC sialidase activity.

71 ed from capacitated sperm and measured sperm sialidase activity.

72 ved in apoptosis-related increase of surface sialidase activity.

73 the plasma membrane by inhibiting host cell sialidase activity.

74 on the latter is actually independent of its sialidase activity.

75 ases GM1 expression and increases endogenous sialidase activity.

76 least two genes, nanA and nanB, that express sialidase activity.

77 acid (Neu5Ac), which are the end products of sialidase activity.

78 sma membrane, where it greatly increases the sialidase activity.

79 ellular receptor while retaining substantial sialidase activity.

80 ne region, a stalk, and a globular head with sialidase activity.

81 lence factor, NanA, which has neuraminidase (sialidase) activity and promotes blood-brain barrier pen

82 nd epididymal epithelial cells by endogenous sialidases after a premature acrosome reaction during ac

83 ine to an alanine converts the enzyme into a sialidase, albeit a poor one, which we confirm by kineti

84 We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conver

85 TrkC is activated by T. cruzi surface trans-sialidase, also known as parasite-derived neurotrophic f

86 presses a membrane-bound neuraminidase/trans-sialidase, also known as parasite-derived neurotrophic f

87 We report that treatment with sialidase, an enzyme that cleaves one class of axonal re

88 n some neurons is reversed by treatment with sialidase, an enzyme that hydrolyzes sialic acids and el

89 ented by glycosidase assisted analysis using sialidase and endoglycosidase F2/F3, respectively, to im

90 the feedback loop, cause a downregulation of sialidase and TGF-beta1 accumulation.

91 sialic acids help resist the action of many sialidases and are present at high levels in the mammali

92 s differed most notably by its complement of sialidases and other genes of the N-acetylneuraminate sc

93 lications associated with BV, the role(s) of sialidases and the participation of individual bacterial

94 ong with the T. cruzi Tc24 antigen and trans-sialidase antigen 1 (TSA1), induced significant numbers

95 rrhea of CPE-associated AAD and SD, but this sialidase appears to be dispensable for the acute pathog

96 Sialidases are important bacterial virulence factors.

97 d Neu5Gc showed that mammalian and bacterial sialidases are much less able to hydrolyze alpha2-8-link

98 date sialoglycans as therapeutic targets and sialidase as a candidate therapy for spinal cord injury.

99 s in P. gingivalis showed the characteristic sialidase Asp signature motif (SXDXGXTW) and other uniqu

100 The parent compound inhibits influenza virus sialidase at a sub-muM level; the introduction of small

101 ary small airway and A549 ECs expressed NEU1 sialidase at the mRNA and protein levels, and NEU1 accou

102 SAP) inhibits fibrocyte differentiation, and sialidases attenuate SAP function.

103 Consistent with NanI sialidase being the major C. perfringens sialidase when

104 ion in CNS axons and in PNS axons after Neu3 sialidase blockade.

105 investigated the roles of the SiaHI and NanH sialidases by generating and characterizing specific del

106 Bacterial sialidases can play roles in pathogenesis by cleaving si

107 Neuraminidases (sialidases) catalyse the removal of terminal sialic acid

108 Neuraminidases (sialidases) catalyze the removal of sialic acid residues

109 lation transition states for Vibrio cholerae sialidase-catalyzed hydrolysis reactions.

110 The antibody-sialidase conjugate desialylated tumor cells in a HER2-d

111 Here, we report the development of antibody-sialidase conjugates that enhance tumor cell susceptibil

112 Sialidase conjugation to trastuzumab enhanced ADCC again

113 The Vibrio cholerae sialidase contains two CBMs, one of which is designated

114 Externally applied sialidase converted GD1a ganglioside to GM1 and rescued

115 Analysis of sialidase-deficient bacterial mutants confirms the key c

116 Colonization of gnotobiotic mice with a sialidase-deficient mutant of Bacteroides thetaiotaomicr

117 In vitro foraging studies demonstrated that sialidase-dependent E. coli growth on mucin is enabled b

118 inct subfamilies that share a characteristic sialidase domain at their amino termini.

119 is C-terminal to a classical beta-propeller sialidase domain.

120 hes with disrupted microbiomes had increased sialidase enzyme and cytadherence activity, traits assoc

121 Neuraminidase (NA) is a sialidase expressed on the surface of influenza A viruse

122 few immunodominant peptides encoded in trans-sialidase family genes.

123 opes from the large and highly diverse trans-sialidase family of surface proteins.

124 ler structure with similarity to the classic sialidase fold, but it has no sialidase activity and ful

125 ype D animal disease strain CN3718 uses NanI sialidase for adhering to enterocyte-like Caco-2 cells.

126 lycosidase digestion studies, treatment with sialidase from Arthrobacter ureafaciens--which hydrolyze

127 yses indicate the GBS NanA ortholog has lost sialidase function - and for this distinction we designa

128 NanA in GBS, potential costs of maintaining sialidase function.

129 Ganglioside conversion by Neu3 sialidase further activates the ERK pathway.

130 DAS181 (Fludase) is a sialidase fusion protein in clinical development as a br

131 DAS181 (Fludase), a novel sialidase fusion protein that enzymatically removes sial

132 TLV) and subdominant TSKB74 (VNYDFTLV) trans-sialidase gene (TS)-encoded epitopes with up to 40% of a

133 frequency were calculated for codons in the sialidase gene of 16 strains of M. synoviae and for its

134 y drives sequence diversity in the passenger sialidase gene of M. synoviae.

135 T cells recognizing the immunodominant trans-sialidase gene-encoded peptide TSKB20 (ANYKFTLV) account

136 nscript levels of the known vaginolysin, and sialidase genes.

137 NEU3 sialidase has been shown to be a key player in many phys

138 KdoH1 (related to sialidases) has a single predicted N-terminal transmembr

139 Treatment of platelets with sialidases having different linkage specificities showed

140 popolysaccharide, toxin coregulated pilus A, sialidase, hemolysin A, flagellins (FlaB, FlaC, and FlaD

141 ast two decades, human neuraminidases (human sialidases, hNEUs) have been found to be involved in num

142 model in which 1) G. vaginalis extracellular sialidase hydrolyzes mucosal sialoglycans, 2) liberated

143 NanA has been shown to be a promiscuous sialidase, hydrolyzing the removal of Neu5Ac from a vari

144 s and intranasal instillation of recombinant sialidase in murine airways enhanced transduction effici

145 hesis of a physiological role played by NEU3 sialidase in protecting cells from hypoxic stress and ma

146 data indicate a novel role for an endogenous sialidase in regulating T cell GM1 expression and antivi

147 NanC is an unusual sialidase in that its primary reaction product is 2-deox

148 is-associated cytokine TGF-beta1 upregulates sialidases in human airway epithelium cells, lung fibrob

149 Evidence of IT-sialidases in human metagenomes indicates that this enzy

150 U1 and NEU3 identified a lack of one or both sialidases in sperm of some male idiopathic infertility

151 rix metalloproteinase [MMP]-8, elastase, and sialidase) in GCF and subgingival plaque levels of Porph

152 erfringens can produce up to three different sialidases, including NanI, its major exosialidase.

153 platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and

154 Intravenous administration of recombinant sialidase increased tissue levels of terminally galactos

155 In PNS axons, axotomy activates Neu3 sialidase, increasing the ratio of GM1/GD1a and GM1/GT1b

156 y pretreatment of the platelets or PMNs with sialidase, indicating that there was bacterial recogniti

157 lence and supports the clinical potential of sialidase inhibition for dampening inflammation caused b

158 id from SIgA, but not in the presence of the sialidase inhibitor dehydro-deoxy-sialic acid.

159 Conversely, sialidase inhibitor Neu5Gc2en prevented TLR4 ligand-indu

160 topoietic cells or systematic treatment with sialidase inhibitor Neu5Gc2en protected mice against end

161 Exposure of AMs in the presence of a sialidase inhibitor or anti-IAV antibody resulted in vir

162 but that the extracellular application of a sialidase inhibitor prevented the regulation of TRPV5 by

163 ose-dependently inhibited by the competitive sialidase inhibitor, 2,3-dehydro-2-deoxy-N-acetylneurami

164 permatozoa was effectively counteracted by a sialidase inhibitor.

165 lso known as DANA), a nonspecific hydrolytic sialidase inhibitor.

166 ld be inhibited by Tamiflu, a neuraminidase (sialidase) inhibitor.

167 Importantly, sialidase inhibitors ameliorate anti-GPIbalpha-mediated

168 dases potentiates fibrosis, and suggest that sialidase inhibitors could be useful for the treatment o

169 Injections of the sialidase inhibitors DANA and oseltamivir (Tamiflu) star

170 Sialidase inhibitors protect mice against sepsis by a me

171 ing a role for NanI in host cell attachment, sialidase inhibitors reduced F4969 adhesion to Caco-2 ce

172 human RVs and the majority of animal RVs are sialidase insensitive.

173 ns with terminal sialic acid (Sia), whereas 'sialidase-insensitive' human rotavirus strains bind to g

174 We delivered recombinant sialidase intrathecally to rats following a spinal cord

175 trans-Sialidase is an essential enzyme for Trypanosoma cruzi,

176 port showed that when the gene encoding this sialidase is knocked out, this led to a reduction in bio

177 . perfringens to enterocyte-like cells, NanI sialidase is now emerging as a potential auxiliary virul

178 ance of alpha2-8-linked Neu5Gc to vertebrate sialidases is the detrimental effect requiring the relat

179 DAS181, an inhaled sialidase, is undergoing clinical development for the tr

180 9149 strain produces an intramolecular trans-sialidase (IT-sialidase) that cleaves off terminal alpha

181 es and up-regulation of genes encoding trans-sialidase-like and ribosomal proteins.

182 e T. cruzi gp83 ligand, a cell surface trans-sialidase-like molecule that the parasite uses to attach

183 repression of TLR function by Siglecs and a sialidase-mediated de-repression that allows positive fe

184 is dependent on the N-glycan of TRPV5 and a sialidase-mediated stimulation that is lipid raft-depend

185 Thus, our study suggests that NanH sialidase might play roles in bacterial colonization by

186 Sialidase mimicked this stimulatory action.

187 In addition, sialidase modified the N-glycan of transferrin, a model

188 es of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>13

189 erium has been shown to express two distinct sialidases, namely, SiaHI and NanH, with the latter bein

190 Upon scavenging by the bacterial sialidase NanA, Sias serve as carbon sources for the bac

191 S. pneumoniae encodes up to three sialidases, NanA, NanB, and NanC, that have been implica

192 There are three pneumococcal sialidases: NanA, NanB, and NanC.

193 his preference and show that, like the leech sialidase, NanB acts as an intramolecular trans-sialidas

194 uring infection, Salmonella used its two GHs sialidase nanH and amylase malS for internalization by t

195 Cleavage of sialidase Neu1 by caspase 3 was shown to be directly inv

196 ere we show that deficiency of the lysosomal sialidase NEU1 leads to the spontaneous occurrence of an

197 e active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sia

198 y of human sperm samples for the presence of sialidases NEU1 and NEU3 identified a lack of one or bot

199 to detect mRNAs for the four known mammalian sialidases, NEU1, -2, -3, and -4, NEU1 mRNA was expresse

200 The human plasma membrane sialidase NEU3 is a key enzyme in the catabolism of memb

201 In the same cells, stable overexpression of sialidase NEU3 significantly enhances cell resistance to

202 ead NEU1 mutant, NEU1-G68V, or another human sialidase, NEU3, did not.

203 induces Fc-independent platelet activation, sialidase neuraminidase-1 translocation and desialylatio

204 possess a gene encoding the surface-anchored sialidase (neuraminidase) NanA, which cleaves sialic aci

205 ose, and 6'-sialyllactose), linkage-specific sialidases (neuraminidase and sialidase S), lectins (Maa

206 plore the mechanisms through which the human sialidase, neuraminidase-1 (NEU1), promotes the interact

207 Treatment of RSV-infected mice with the sialidase/neuraminidase inhibitor oseltamivir decreased

208 We report the presence of two sialidases (neuraminidases Neu1 and Neu3) on mammalian s

209 the sialidase of M. synoviae, but not on the sialidase of M. gallisepticum or the sialidases or other

210 s of sequence evolution showed that only the sialidase of M. synoviae was under significant (P < 0.00

211 Diversifying selection acting on the sialidase of M. synoviae, but not on the sialidase of M.

212 Trans-sialidases of parasites transfer alpha2,3-linked sialic

213 ved in an UPEC epididymitis mouse model, and sialidases on the sperm surface are considered to be act

214 Combining either PI-PLC and sialidase or NEP1-40 and P4 was additive.

215 mpal neuron outgrowth was mostly reversed by sialidase or P4 and only modestly reversed by PI-PLC or

216 e L858R/T790M EGFR mutant, when treated with sialidase or sialyltransferase inhibitor, showed an incr

217 Pretreatment of host cells with sialidase or trypsin reduces or nearly eliminates, respe

218 on the sialidase of M. gallisepticum or the sialidases or other enzymes essential for sialic acid sc

219 es an enzyme (PA2794) that is annotated as a sialidase (or neuraminidase), as it possesses three bact

220 Sialidase (or saline solution) was infused to the injury

221 coccus pneumoniae genomes encode up to three sialidases (or neuraminidases), NanA, NanB and NanC, whi

222 n and competition assays show that the trans-sialidase/parasite-derived neurotrophic factor (PDNF), p

223 We recently identified two T. cruzi trans-sialidase peptides that are targets of approximately 30%

224 what appears to be a sialidase - TGF-beta1 - sialidase positive feedback loop.

225 All three pneumoccocal sialidases possess a carbohydrate-binding domain that is

226 also activate fibroblasts, and we found that sialidases potentiate fibrocyte differentiation.

227 gest that a positive feedback loop involving sialidases potentiates fibrosis, and suggest that sialid

228 en with gonococcal infections have levels of sialidases present in cervicovaginal secretions that can

229 ted an adhesive response to galectin-3 after sialidase pretreatment.

230 NeuAc/NeuGc abundances) and linkage-specific sialidases prior to infection indicated that the influen

231 Sialidases produced by some members of the colonic micro

232 NanB is an intramolecular trans-sialidase producing 2,7-anhydro-Neu5Ac selectively from

233 DAS181, a recombinant sialidase protein containing the catalytic domain of Act

234 Resistance of Neu5Gc-containing polySia to sialidases provides a potential explanation for the rari

235 me extent that erythrocyte pretreatment with sialidase purified from Clostridium perfringens did (P <

236 These features facilitate a novel sialidase reaction in which the final step of product fo

237 The three sialidase-related proteins in P. gingivalis showed the c

238 lidase, NanB acts as an intramolecular trans-sialidase releasing Neu2,7-anhydro5Ac.

239 the catalytic domain of Actinomyces viscosus sialidase, removes cell surface sialic acid, and we prop

240 Bacteroidetes sialate-O-acetylesterases and sialidases, respectively, and subsequent utilization of

241 allow virus internalization and the NA is a sialidase responsible for cleaving sialic acid to aid vi

242 The principle sialidases responsible for this desialylation appear to

243 ucins is mediated by an intramolecular trans-sialidase (RgNanH).

244 nkage-specific sialidases (neuraminidase and sialidase S), lectins (Maakia amurensislectin andSambucu

245 irway epithelia express catalytically active sialidase(s).

246 imal RVs (of P[1], P[2], P[3], and P[7]) are sialidase sensitive, human RVs and the majority of anima

247 hesion of S. gordonii DL1 cells to gp340 was sialidase sensitive, verifying that Hsa has a major role

248 205 colon carcinoma cells bind selectins via sialidase-sensitive O-linked glycans presented on CD44v,

249 The existing paradigm is that 'sialidase-sensitive' animal rotavirus strains bind to gl

250 cells expressing MUC1, that this binding is sialidase-sensitive, and that MAG physically associates

251 ed 16 new putative T2S substrates, including sialidase, several proteins participating in chitin util

252 We propose that the three pneumococcal sialidases share a common catalytic mechanism up to the

253 Overall, the pneumococcal sialidases show remarkable mechanistic diversity while m

254 g site and unusual kinetic properties of the sialidase site which promote receptor binding via this s

255 ue to unusual kinetic characteristics of the sialidase site which specifically enhance binding to hum

256 ch is discrete from the enzymatically active sialidase site.

257 lls >20 hr earlier than immunodominant trans-sialidase-specific T cells.

258 partic acid that acts as an acid/base in all sialidases studied to date.

259 y in living cells by using a new fluorescent sialidase substrate, 2-(benzothiazol-2-yl)-4-bromophenyl

260 ation model of sepsis to show that microbial sialidases target the sialic acid-based recognition of C

261 Trypanosoma cruzi trans-sialidase (TcTS) is a key target protein for Chagas dise

262 Therefore, T. cruzi trans-sialidase (TcTS) presents a potential and appealing ther

263 ular TGF-beta1, forming what appears to be a sialidase - TGF-beta1 - sialidase positive feedback loop

264 pneumococcal neuraminidase, NanA, which is a sialidase that catalyzes the cleavage of terminal sialic

265 ize MSO, B. longum subsp. infantis deploys a sialidase that cleaves alpha2-6 and alpha2-3 linkages.

266 Neuraminidase (NA) is a sialidase that is one of the major surface glycoproteins

267 epithelia express catalytically active NEU1 sialidase that regulates EGFR- and MUC1-dependent signal

268 oduces an intramolecular trans-sialidase (IT-sialidase) that cleaves off terminal alpha2-3-linked sia

269 In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solut

270 ociated bacterium Gardnerella vaginalis uses sialidase to break down and deplete sialic acid-containi

271 evidenced by partial reversal by addition of sialidase to cleave GD1a and GT1b or by P4, an inhibitor

272 hese studies show that G. vaginalis utilizes sialidase to support the degradation, foraging, and depl

273 We chemically fused a recombinant sialidase to the human epidermal growth factor receptor

274 Infusion of Clostridium perfringens sialidase to the injury site markedly increased the numb

275 Conversely, addition of sialidases to human peripheral blood mononuclear cells i

276 side receptors can restore susceptibility of sialidase-treated MDCK cells to infection by both recent

277 tative analysis of AAV9 binding to parental, sialidase-treated or sialic acid-deficient mutant CHO ce

278 rotein Misfolding Cyclic Amplification using sialidase-treated PrP(C) substrate and then restored to

279 ptor-bearing streptococci, agglutinated with sialidase-treated red blood cells, and formed monospecie

280 owed that the increased TRPV5 activity after sialidase treatment is caused by inhibition of lipid raf

281 Sialidase treatment of eosinophils revealed that Siglec-

282 e, this binding was substantially reduced by sialidase treatment of erythrocytes.

283 Sialidase treatment of fibrinogen reversed the suppressi

284 Sialidase treatment of PC12 cells enabled Gal-3 to bind

285 Sialidase treatment significantly enhanced hindlimb moto

286 rict hydrolase activity (Trypanosoma rangeli sialidase, TrSA) provides us a unique opportunity to und

287 uzi supergene family comprising active trans-sialidase (TS) and TS-like proteins.

288 immunizations with the unique T. cruzi trans-sialidase (TS) antigen protect against gastric and syste

289 targeting epitopes encoded by variant trans-sialidase (TS) genes.

290 The Trypanosoma cruzi trans-sialidase (TS) is a unique enzyme with neuraminidase and

291 Strong trans-sialidase TSKB18- and TSKB20-specific CD8+ T-cell respon

292 ed, suggesting a common mechanism with other sialidases up to the final step of product formation.

293 ucosal T. cruzi infection and T. cruzi trans-sialidase vaccination.

294 Secretion of reactive oxygen species and sialidase varied quantitatively (P < 0.01) among strains

295 alpha2-->3,6,8,9 sialidase was used to remove the sialic acid residues on

296 In CNS axons, P38MAPK and Neu3 sialidase were not activated by axotomy.

297 anI sialidase being the major C. perfringens sialidase when produced, FP and Db strains had little su

298 eatment of cultured hippocampal neurons with sialidase, which cleaves GT1b (and other sialoglycans),

299 e-active enzymes, including the mu-toxin and sialidases, whose catalytic properties are consistent wi

300 ite-derived neurotrophic factor (PDNF)/trans-sialidase with neurotrophic receptors TrkA and TrkC, as