ライフサイエンスコーパス: sialylate

1 retained the ability to bind fH when LOS was sialylated.

2 f polylactosamine alpha chains that could be sialylated.

3 s lipooligosaccharides (LOS) that are highly sialylated.

4 K(v)4.2, and K(v)4.3 were O-glycosylated and sialylated.

5 omplex, biantennary Fc glycan preferentially sialylated.

6 pooligosaccharide (LOS) molecule that can be sialylated.

7 l (RBC) surface receptors, many of which are sialylated.

8 anation for these findings is that levels of sialylated airway ligands for Siglec-F might be diminish

9 unotherapy in allergic patients also induced sialylated allergen-specific IgGs.

10 rmines that it binds to one or more alpha2,3-sialylated and alpha1,3-fucosylated glycan receptors tha

11 d glycine residues to interact with alpha2,3-sialylated and alpha1,3-fucosylated glycan receptors, in

12 on to and infection of neutrophils depend on sialylated and alpha1,3-fucosylated glycans.

13 Both sialylated and nonsialytated FetA bind to LPS, but only

14 ity to detect labile glycans such as heavily sialylated and polysialic acid N-glycans, which are diff

15 ine specificity of Siglec-8 toward different sialylated and sulfated carbohydrate ligands and determi

16 Purified mucin preparations carried sialylated and sulfated glycans, bound to eosinophils an

17 that are expected to carry high densities of sialylated and sulfated O-linked glycans.

18 We demonstrate that H-ficolin is sialylated and that removal of sialic acid abrogates IAV

19 We generated one highly sialylated and two distinct more galactosylated 6-19 IgG

20 ctive species of Panx3, likely glycosylated, sialylated, and phosphorylated, was highly expressed in

21 structural variants, including high mannose, sialylated, and terminal galactosylated species were stu

22 coprotein ligand-1 (PSGL-1) and the alpha2,3-sialylated- and alpha1,3-fucosylated-moiety sialyl-Lewis

23 Two strategies for installation of sialylated antennae are explored, and both approaches co

24 gen-specific: only T cells responsive to the sialylated antigen become tolerized.

25 Exposure of B cells to sialylated antigens results in the inhibition of key ste

26 The ability of sialylated antigens to inhibit BCR signaling through tra

27 onstrating that immune complexes composed of sialylated antihemagglutinin antibodies and seasonal ina

28 and desialylated A2HSG, and depleted in mono-sialylated ApoC-III (ApoC-III1).

29 ents were enriched in SAA, LBP, ApoC-III, di-sialylated ApoC-III (ApoC-III2) and desialylated A2HSG.

30 an also be engaged by two potentially lethal sialylated bacterial pathogens of newborns and infants,

31 y to unsialylated, as compared with alpha2-6-sialylated, beta1 integrins.

32 One group represents sialylated biantennary compounds with an N-glycan core t

33 with mass spectrometry and found to contain sialylated biantennary structures.

34 to 2,6-sialylated Fc compared with similarly sialylated, biantennary glycoproteins, thus suggesting t

35 typic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO).

36 taining fluorophore at the reducing end were sialylated by a one-pot three-enzyme system to generate

37 een the TGN and the plasma membrane, was not sialylated by a sialyltransferase at the TGN and that th

38 e may explain the increased pathogenicity of sialylated C. jejuni and may be key to the initiation of

39 s CD14, and the amplified response of DCs to sialylated C. jejuni LOS is CD14 dependent.

40 lpha and IFN-beta responses to i.v.-injected sialylated C. jejuni.

41 of Sn showed greatly reduced phagocytosis of sialylated C. jejuni.

42 cterial survival are also facilitated by GBS sialylated capsular polysaccharide interactions with Sig

43 The sialylated capsular polysaccharide of group B Streptococ

44 Many CTCs express sialylated carbohydrate ligands on their surfaces that a

45 e demonstrate that JCPyV can engage numerous sialylated carbohydrate receptors.

46 n of increased surface expression of several sialylated cell adhesion molecules, including the known

47 evealed that Siglec-8 is partially masked by sialylated cis ligands.

48 P1 of HPyV6 and HPyV7 does not interact with sialylated compounds in solution or on cultured human ce

49 tional analysis revealed that binding to all sialylated compounds was mediated by the C-terminal bind

50 s ST6Gal-I and ST6GalNAc-I, forming alpha2,6-sialylated compounds.

51 rm that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

52 e CHO cells is glycosylated with the typical sialylated core 1 structure.

53 Furthermore, for the generation of sialylated core 1 structures constructs encoding human p

54 anA, is required for S. pneumoniae to cleave sialylated core-1 O-linked glycans.

55 ted with gonococcal Por1B was similar to the sialylated counterpart only in the presence of higher (2

56 ts of eukaryotic plasma membranes, and their sialylated derivatives, gangliosides, are the major clas

57 rvation of an effective survival factor, the sialylated exopolysaccharide capsule.

58 This alpha2,6-sialylated Fc (sFc) has been reported to bind to the car

59 onstrate that it preferentially binds to 2,6-sialylated Fc compared with similarly sialylated, biante

60 ed the anti-inflammatory activity of IVIG or sialylated Fc fragments.

61 G subclass and Fc glycans, with abundance of sialylated Fc glycans (sFc) predicting quality of vaccin

62 eering of the IVIG's Fc glycans into a fully sialylated Fc glycoform, which may possess significantly

63 unctional P1 promoter, was unable to produce sialylated Fc in the systemic circulation, despite the p

64 parison of the structures of asialylated Fc, sialylated Fc, and F241A Fc, a mutant that displays incr

65 s identify an antibody receptor specific for sialylated Fc, and present the initial step that is trig

66 We now demonstrate that these sialylated Fcs require a specific C-type lectin, SIGN-R1

67 inflammatory status, pretreatment levels of sialylated FetA in the blood are indicative of the likel

68 y reveals that high levels of O-glycosylated sialylated FetA isoforms are found in patients exhibitin

69 Sialylated forms of the Fc fragment of immunoglobulin G,

70 odies made by p individuals recognize x2 and sialylated forms of x2, whereas x2 is lacking on P-defic

71 portion of antiproliferative factor (APF), a sialylated frizzled-8 related glycopeptide that inhibits

72 A lectin panel, distinguishing normally sialylated from hyposialylated glycans, used WGA, SNA, P

73 ecies, identifying CE peaks corresponding to sialylated (G1 + NANA, G2 + NANA), afucosylated (G0-GlcN

74 in which preferentially recognizes alpha-2,6 sialylated galactosides showed strong binding reactivity

75 on from Lewis(x)-type structures in mESCs to sialylated Galbeta1,3GalNAc-type glycans on differentiat

76 ialic acid precursor analogs to modulate the sialylated ganglioside-dependent interaction of MLV part

77 alylated PrP(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane ra

78 ins mediate attachment of bacterial cells to sialylated gangliosides on the platelet cell surface.

79 PyV can both engage LSTc as well as multiple sialylated gangliosides.

80 mutation on HA resulted in a mixed alpha2-3 sialylated glycan (alpha2-3)/alpha2-6 binding virus (NY1

81 lutinin (HA) to long (chain length) alpha2-6 sialylated glycan (alpha2-6) receptors on the human uppe

82 Composed of a sialylated glycan attached to a ceramide lipid, the same

83 O) structure, we show ABH antigens stabilize sialylated glycan clusters on erythrocyte membranes uniq

84 ies on sialic acid recognition using a novel sialylated glycan microarray containing modified sialic

85 Our results demonstrate the utility of this sialylated glycan microarray to investigate the biologic

86 f its B subunit, PltB, with specific lumenal sialylated glycan packaging receptors.

87 Crystal structures of EV-D68 in complex with sialylated glycan receptor analogues show that they bind

88 pecificity of the viral hemagglutinin to the sialylated glycan receptors (in the human host) by use o

89 on surfaces, obstructing a groove that binds sialylated glycan receptors in many other polyomaviruses

90 stability and ionization bias experienced by sialylated glycan species.

91 Campylobacter jejuni expressing a GD1a-like, sialylated glycan.

92 itative binding affinity of HA to alpha2-->6 sialylated glycans (human receptors) is one of the impor

93 inding, with Gal-8N recognizing sulfated and sialylated glycans and Gal-8C recognizing blood group an

94 --enables specific binding of HA to alpha2-6 sialylated glycans and that recognition of this topology

95 Sialylated glycans are found at elevated levels in many

96 Single-cell binding studies indicate that sialylated glycans are likely not required for initial a

97 Sialylated glycans are synthesized in mammals by a singl

98 glec) family that recognizes alpha2-6-linked sialylated glycans as ligands.

99 tissues and highlight a functional role for sialylated glycans as reovirus coreceptors in the CNS.

100 IL-6 secretion were enriched in ApoC-III, di-sialylated glycans at multiple A1AT glycosylation sites

101 Two sialylated glycans bearing N-acetylneuraminic acid were

102 ot only result in accurate identification of sialylated glycans but also improve the characterization

103 ows for linkage specific characterization of sialylated glycans directly from the precursor mass but

104 Hemagglutinin (HA) binds to sialylated glycans exposed on the host cell surface in t

105 irus (IBV), require specific alpha2,3-linked sialylated glycans for attachment and entry.

106 Surprisingly, Gal6S is undetectable in sialylated glycans from eosinophils and BAL fluid analyz

107 me, fluorescence and radionuclide imaging of sialylated glycans in a murine tumor model in vivo.

108 ring 3F-NeuAc to mice dramatically decreases sialylated glycans in cells of all tissues tested, inclu

109 NAc), were incorporated into fucosylated and sialylated glycans in several cancer cell lines, allowin

110 MS analysis of sialylated glycans is challenging due to their low ioniz

111 The analysis of sialylated glycans is critical for understanding the rol

112 icity depends on toxin binding to terminally sialylated glycans on surface glycoproteins.

113 lutinin, and Sambucus nigra agglutinin) with sialylated glycans on the same cell surface.

114 Sialylated glycans on the surface of mammalian cells act

115 Binding of sialylated glycans or other ligands triggers signals tha

116 In vertebrates, sialylated glycans participate in a wide range of biolog

117 s in ionization efficiency among neutral and sialylated glycans prevent direct quantitative compariso

118 dulated by HopZ, including hopP, which binds sialylated glycans produced by GEPs in vivo.

119 in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans

120 array approach to analyze the repertoire of sialylated glycans recognized by viruses from the same c

121 ed from the aqueous phase, while neutral and sialylated glycans remained in the DCM phase.

122 Sialylated glycans serve as cell surface attachment fact

123 DRAG), to quantitatively compare neutral and sialylated glycans simultaneously by MALDI-MS.

124 binding to sialyl Lewis x (sLe(x)) and other sialylated glycans that decorate P selectin glycoprotein

125 tested preferentially utilize NeuAcalpha2-6-sialylated glycans to infect SRECs.

126 However, quantification of sialylated glycans using MS is not as reliable because o

127 tiates viral entry by engaging host receptor sialylated glycans via its receptor-binding site (RBS).

128 and alkaline BGE systems, the mobilities of sialylated glycans were shifted relative to nonsialylate

129 ly, we used a nonmetabolic approach to label sialylated glycans with an independent chemistry, enabli

130 viruses, specifically bind to long alpha2-6 sialylated glycans with this topology.

131 for simultaneous profiling both neutral and sialylated glycans without derivatization or labeling.

132 sialylated glycans) to human-like (alpha2-6 sialylated glycans) receptors is believed to be associat

133 hemagglutinin (HA) from avian-like (alpha2-3 sialylated glycans) to human-like (alpha2-6 sialylated g

134 ereas Gal-1 bound alpha2-3- but not alpha2-6-sialylated glycans, and Gal-3 bound to some glycans term

135 high-mannose glycans, fucolsylated glycans, sialylated glycans, and hybrid structures were studied.

136 2)v showed a predominant binding to alpha2-6-sialylated glycans, similar to human-adapted influenza A

137 which bound almost exclusively to alpha-2,6 sialylated glycans, the seal H3 bound preferentially to

138 -R1 has not previously been shown to bind to sialylated glycans, we demonstrate that it preferentiall

139 hibited significantly reduced binding to all sialylated glycans, whereas Gal-1 bound alpha2-3- but no

140 the ionization responses for all neutral and sialylated glycans.

141 mproved desorption of both large and heavily sialylated glycans.

142 protein exhibiting no detectable binding to sialylated glycans.

143 generally not microbial cell surfaces, have sialylated glycans.

144 hat lack coding nucleic acids but do possess sialylated glycans.

145 he seal H3 bound preferentially to alpha-2,3 sialylated glycans.

146 teroids, phospholipids, phosphopeptides, and sialylated glycans.

147 MCs depends on alpha1,3-fucosylated, but not sialylated, glycans.

148 -adapted pathogen that encounters terminally sialylated glycoconjugates and free sialic acid (Sia) in

149 Sialylated glycoconjugates on the surfaces of mammalian

150 genic tetrazine, allowing for the imaging of sialylated glycoconjugates within live zebrafish embryos

151 yze the removal of sialic acid residues from sialylated glycoconjugates.

152 nflammation, depends on a specific alpha-2,6-sialylated glycoform of IgG Fc to induce Interleukin 4 (

153 Gangliosides (sialylated glycolipids) play an essential role in the CN

154 Herein, we report a total of 45 sialylated glycopeptides and an increase of sialylation

155 ive proteomics strategy in which we enriched sialylated glycopeptides by SNA, labeled them at the N-t

156 Fucosylated and sialylated glycopeptides from human lactoferrin served a

157 in the presence of m-NBA the charge state of sialylated glycopeptides increased and the chromatograph

158 can quantitatively and qualitatively enrich sialylated glycopeptides more than the commercially avai

159 aracteristic fragmentation of differentially sialylated glycopeptides.

160 A sialylated glycoprotein called serum amyloid P (SAP) inh

161 n-destructed mutants, transgenic plants that sialylate glycoproteins in alpha2,6- or alpha2,3-linkage

162 processes; however, it is laborious to study sialylated glycoproteins due to the labile nature of sia

163 22 ligands, the receptor is known to bind to sialylated glycoproteins on the cell surface.

164 ral pH to label the majority of cell-surface sialylated glycoproteins while maintaining high cell via

165 Therefore, OmpA interacts with sialylated glycoproteins.

166 e to incorporate sialic acid precursors into sialylated glycoproteins.

167 We report here that sialylated glycosphingolipids with 5 N-acetyllactosamine

168 Quantitatively minor terminally sialylated glycosphingolipids with 5 to 6 LacNAc repeats

169 roles have been attributed to this family of sialylated glycosphingolipids, e.g. in modulation of ion

170 Gangliosides, sialylated glycosphingolipids, found on all vertebrate c

171 ionally modified with N-linked glycans and a sialylated glycosylphosphatidylinositol (GPI) anchor.

172 e generated their degalactosylated or highly sialylated glycovariants and compared their pathogenic e

173 n FcgammaR-independent mechanism by which Fc-sialylated glycovariants might limit proinflammatory IgG

174 retions that can result in desialylation of (sialylated) gonococcal LOS.

175 ly at amino acid 1203 (N1203R) also bound to sialylated gonococci and restored killing.

176 ctional importance of Arg-1203 by incubating sialylated gonococci with normal human serum, in the pre

177 define amino acids important for binding to sialylated gonococci.

178 ain 20 of HufH contains the binding site for sialylated gonococci.

179 are consistent with the hypothesis that the sialylated GPI anchor attached to PrP(C) acts as a synap

180 tition studies showed that pretreatment with sialylated GPIs prevented the targeting of PrP(C) to syn

181 The total neutral and sialylated HMGs were derivatized with a bifunctional flu

182 atic activity to be confined to specific non-sialylated HMOs and synergistic with a number of convent

183 in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those

184 allowed the generation of SM6 decorated with sialylated human-type oligosaccharides, comparable to pl

185 heir capacity to produce inhibitory IgG4 and sialylated IgG able to mediate anti-inflammatory mechani

186 Transfer of low amounts of antigen-specific sialylated IgG Abs was sufficient to inhibit B cell acti

187 Sialylated IgG Abs, which are immunosuppressive, and Tre

188 ry from murine studies, which states that Fc-sialylated IgG alters the balance between activating and

189 ghlighting the anti-inflammatory activity of sialylated IgG antibodies.

190 Sialylated IgG Fc (sFc) increases the activation thresho

191 Sialylated IgG Fc domains have antiinflammatory properti

192 lly recombinant preparation of appropriately sialylated IgG Fc fragments.

193 nvolving basophils and the binding of highly sialylated IgG Fc to DC-SIGN-expressing myeloid cells.

194 on of IVIg, but unexpectedly, recombinant Fc-sialylated IgG or sialic acid-enriched IVIg were equally

195 Protective antibodies, including IgG4, Fc sialylated IgG, and IgA, have the capacity to modulate t

196 ment, and thus generate a fully recombinant, sialylated IgG1 Fc with greatly enhanced potency.

197 through the generation of immunosuppressive sialylated IgGs and may provide insight on the role of T

198 Here we propose that these Fc-sialylated IgGs engage a unique receptor on macrophages

199 tory mechanism mediated by anti-inflammatory sialylated IgGs that are formed on TD tolerance inductio

200 se expression and secreted immunosuppressive sialylated IgGs that were sufficient to block antigen-sp

201 that TI immune responses induced suppressive sialylated IgGs, in contrast to TD proinflammatory Th1 a

202 alizing antibodies through immunization with sialylated immune complexes.

203 ibits unique regioselectivity and is able to sialylate internal galactose residues in poly-LacNAc ext

204 able process for generating a well-qualified sialylated IVIg drug candidate with maximum Fc sialylati

205 tion, with several isomers, corresponding to sialylated lacto-N-tetraose.

206 ted during HMO fermentation and is active on sialylated lacto-N-tetraose.

207 sion of the fucosylated epitopes Lewis X and sialylated Lewis X in CHO cells, indicating competition

208 immune encephalomyelitis, Sn interacted with sialylated ligands expressed selectively on CD4(+)Foxp3(

209 e (Mphi)-restricted receptor that recognizes sialylated ligands on host cells and pathogens.

210 Sialylated lipids serve as cellular receptors for polyom

211 eltafHbp DeltaNspA Deltalst mutant unable to sialylate lipooligosaccharide or bind human fH via the k

212 essing gonococcal PorB.1B in the presence of sialylated lipooligosaccharide bound more fH, more effec

213 trate for the first time that in addition to sialylated LOS, the biofilm formed by NTHI in vivo conta

214 Highly sialylated LPS was ineffective in depleting bactericidal

215 ans, 3-sialyl globo unit of glycolipids, and sialylated macromolecules to 5'-CMP.

216 counterpart of factor H binding showed that sialylated meningococcal mutants that possessed gonococc

217 ce of extracellular DNA, and the presence of sialylated moieties on or between bacteria.

218 tran show that the endosomal accumulation of sialylated molecules can be largely attributed to impair

219 nfluenza infection increases sialic acid and sialylated mucin availability and enhances desialylation

220 via multiple interactions involving terminal sialylated mucin glycans.

221 sequences of trans interactions by employing sialylated multivalent antigens that can engage both CD2

222 icient and consist mostly of core 1 alpha2,6 sialylated N-acetylgalactosamine, a configuration suspec

223 nked glycans, characterized by a terminal or sialylated N-acetylgalactosamine.

224 The LC method is capable of separating sialylated N-glycan isomers differing in alpha2-3 and al

225 first total synthesis of triantennary, fully sialylated N-glycan of complex type is described.

226 ering approach led to secreted A1AT carrying sialylated N-glycan structures largely resembling its se

227 attributed to a decrease in neutral and mono-sialylated N-glycans and an increase in di-sialylated N-

228 NeuAcalpha2-6-terminated polylactosamine and sialylated N-glycans are important determinants for infl

229 eceptors for binding to HA in the absence of sialylated N-glycans at the cell surface.

230 l viruses tested interacted with one or more sialylated N-glycans but not O-glycans or glycolipid-der

231 inhibitory activities, showing a key role of sialylated N-glycans in inducing the IgM-mediated immune

232 the syntheses of bi- and triantennary fully sialylated N-glycans is described.

233 n heterogeneity was identified of the highly sialylated N-glycans of rHuEPO by extensive acetylation,

234 Sialylated N-glycans play crucial roles in physiological

235 The key step to identify the sialylated N-glycans was to quantitatively neutralize th

236 ry appeared to be affected by the absence of sialylated N-glycans, dynamin-dependent entry was not af

237 uded the detection of a new class of heavily sialylated N-glycans, including polysialylated N-glycans

238 o-sialylated N-glycans and an increase in di-sialylated N-glycans.

239 ng binding to sialylated polylactosamine and sialylated N-glycans.

240 PrP(C) has two sialylated N-linked carbohydrates.

241 Sialylated N-linked glycans have been reported to be ess

242 r knowledge, we show for the first time that sialylated N-linked glycans induce the internalization o

243 C1INH sialylated-N- and -O-glycans were not only essential for

244 Highly sialylated negatively charged glycans also exhibit high

245 linear (maltooligosaccharides) and branched (sialylated, neutral and core fucosylated biantennary IgG

246 ts and immunological responses to whole-cell sialylated NTHi were measured.

247 Using bovine fetuin (because it contains the sialylated O-glycans most commonly found on biopharmaceu

248 We find that sialylated O-glycans on these novel PILRalpha ligands, a

249 ritic cartilage and has reduced affinity for sialylated O-glycans, a glycophenotype associated with i

250 er cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST).

251 etylesterase acting on glycosidically linked sialylate-O-acetylesterase substrates, particularly at n

252 However, some gut bacteria, in turn, produce sialylate-O-acetylesterases to remove them.

253 Sialylated oligosaccharide epitopes found on a variety o

254 alpha1-acid glycoprotein (AGP) as well as of sialylated oligosaccharide reference standards and found

255 -resolution insights into the recognition of sialylated oligosaccharides by a parasite surface protei

256 allowing the observation of both neutral and sialylated oligosaccharides in a single negative ion mod

257 dies of various complexes between TgMIC1 and sialylated oligosaccharides provide high-resolution insi

258 nce standards and found that for more highly sialylated oligosaccharides the loss is greater than the

259 ed in situ is utilized by the same enzyme to sialylate other O-glycans and by other sialyltransferase

260 ferences in interactions with strains of the sialylated pathogen, group B Streptococcus, and with sia

261 strate that Sn plays a key role in capturing sialylated pathogens and promoting rapid proinflammatory

262 aining NeuAcalpha2-6, with strong binding to sialylated polylactosamine and sialylated N-glycans.

263 r is similar to that reported previously for sialylated Por1B gonococci.

264 Upon incubation with human serum, Por1A and sialylated Por1B strains bound full-length human fH (Huf

265 Both sialylated PorB.1B- and (unsialylated) PorB.1A-bearing g

266 gG3 mAb are poorly galactosylated and hardly sialylated, possibly contributing to the pathogenic pote

267 red by the difficulty of generating suitable sialylated products for clinical use.

268 Airway epithelia express sialylated receptors that recognize exogenous danger sig

269 t unfavorable to bind any negatively charged sialylated receptors, consistent with the recombinant H1

270 sting that EV-D68 can use multiple redundant sialylated receptors.

271 ed homogeneous glycoforms, including a fully sialylated (S2G2F) glycoform that may gain anti-inflamma

272 atic, scalable process to produce a tetra-Fc-sialylated (s4-IVIg) IVIg drug candidate and its qualifi

273 ic eosinophilic airway inflammation and less sialylated Siglec-F ligands in their airways.

274 use of in-source and metastable decay of the sialylated species.

275 Factor H binding to the sialylated strain remained unchanged over this factor H

276 enables the controlled in vivo synthesis of sialylated structures with different interlinkages and d

277 ycans from tissues and serum have mature and sialylated structures.

278 odified with hybrid, highly fucosylated, and sialylated sugars.

279 Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, bu

280 rapid identification of various fucosylated, sialylated, sulfated glycotopes and definitive determina

281 both the sialyl Lewis-X (sLe(X)) and the di-sialylated T-antigen (NeuAcalpha2,3Galbeta1,3(NeuAcalpha

282 counts for the accommodation of the alpha2,6-sialylated terminus of a biantennary N-glycan by viscumi

283 Three mono- and di-sialylated tetra-antennary N-glycans and one mono-sialyl

284 nnary structures, as well as the increase in sialylated tetraantennary and FA3G3S[3,3,3]3 structures.

285 As a result, spleen-derived PrP(Sc) is more sialylated than brain-derived PrP(Sc).

286 ets can also supply the sialic acid donor to sialylate the synthetic acceptor, Gal(beta1,4)GlcNAcalph

287 have demonstrated that Neisseria gonorrhoeae sialylates the terminal N-acetyllactosamine present on i

288 on SP cells is hypoglycosylated and heavily sialylated; the characteristics of the tumor-specific fo

289 an enzyme up-regulated in numerous cancers, sialylates TNFR1 and thereby protects tumor cells from T

290 lated tetra-antennary N-glycans and one mono-sialylated tri-antennary N-glycan of rHuEPO are reported

291 eover, we observed a progressive increase of sialylated triantennary and tetraantennary structures tw

292 and 2-6 sialyllactose as well as 2-3 and 2-6 sialylated triantennary glycan.

293 The 2,6-sialylated tridecasaccharide 1 associated with the Fc fr

294 The recognition of FITC-APBA to sialylated TRITC-AF leads to the FRET signal that is ana

295 d terminal Galp residues that become readily sialylated upon addition of parasite trans-sialidases.

296 The highly sialylated vascular endothelial surface undergoes change

297 was significantly more immunogenic than the sialylated version when administered in two different ad

298 et endothelial cell adhesion molecule-1, was sialylated via alpha2,6-linkages, as shown by Sambucus n

299 ction potential waveforms and gating of less sialylated voltage-gated Na+ channels were altered consi

300 t strains when lipooligosaccharide (LOS) was sialylated, whereas PorB molecules of lptA null mutants

301 Glycans at Asn-168 were predominantly sialylated with bi- to tetra-antennary branches, and Asn