ライフサイエンスコーパス: sib

1 Genotyping data were available for 106 sib pairs (43 CA, 63 AA) from 27 CA (44% male probands)

2 combined analysis of MN cohorts 1 and 2 (187 sib-pair families) showed that markers in 6p11-p21 (D6S4

3 tin-1 and EFEMP1, in subsamples (145 and 189 sib pairs, respectively) of the data.

4 e genes including nicotinic receptors in 200 sib pairs selected from the Mid-South Tobacco Family pop

5 To date, we have collected 212 sib pairs from 46 CA and 50 AA families.

6 a subset of families (102 families; n = 224 sib pairs) from the Beaver Dam Eye Study and performed a

7 n two sets of data: (1) 325 individuals (225 sib pairs) from the Beaver Dam Eye Study (BDES), and (2)

8 629 women from 311 extended families (1,242 sib pairs) in the Framingham Heart Study Offspring cohor

9 The panel contains 350 siblings and 245 sib-pairs.

10 ains >10,000 relative pairs (including 1,249 sib pairs) that are useful for linkage analyses, we perf

11 autosomal markers in 325 individuals (N=263 sib pairs) from 102 pedigrees.

12 e Study (BDES), and (2) 297 individuals (346 sib pairs) from the Family Age Related Maculopathy Study

13 n 34 extended families (297 individuals, 349 sib pairs) ascertained through index cases with neovascu

14 itional previous population of 66 BMI >or=35 sib-pairs led to a significant LOD score of 3.8 at the 1

15 ymorphisms (SNPs) and 50K transcripts in 400 sib pairs from the MRCA family panel, has been widely us

16 ising of 278 families, 634 siblings, and 470 sib-pairs.

17 l from 267 multiplex families, including 472 sib-pairs affected with type 2 diabetes.

18 reported a two-stage genomewide screen of 48 sib pairs affected with intracranial aneurysms (IAs) tha

19 e-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage

20 analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive diso

21 cus in an extended sample (380 families, 520 sib-pairs, maximum LOD score 4.3).

22 lled between 1997 and 1999, 12 of 327 (3.7%) sibs and 11 of 161 (6.8%) parents reported a history of

23 ans without diabetes (from 162 families, 750 sib-pairs).

24 ive-compulsive disorder) was conducted on 77 sib pairs collected by the Tourette Syndrome Association

25 ning 48 cM across chromosome 18q12-q22 in 81 sib pairs affected with autoimmune thyroid disease (AITD

26 We similarly classified our data set of 82 sib pairs with AutD, identifying 45 families with AutD a

27 cally (total siblings 582, 182 families, 860 sib-pairs: LOD = 3.5).

28 hundred fifteen nuclear families yielded 870 sib pairs for linkage, with significant logarithm of odd

29 A sib-pair method has been used to examine the familiality

30 ion of Neur can induce both cells to adopt a sib fate similar to gain of function Notch.

31 hanges into GMC-1 and generates an RP2 and a sib without affecting the expression of key genes at the

32 ion of Notch in a cell committed to become a sib.

33 ring two alleles IBD at a putative QTL for a sib-pair.

34 of complexity is involved in implementing a sib pair study and interpreting the results.

35 d volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation o

36 h that associated with random selection of a sib for genotyping.

37 Numb, which prevents Notch from specifying a sib identity.

38 We are now adding sib pairs and increasing marker density on chromosome 10

39 Affected sib pair (ASP) analysis has become common ever since it

40 Affected sib-pair analysis yielded multipoint maximum LOD scores

41 atoconus sib pair families with 110 affected sib pairs of white or Hispanic origin.

42 with a sample size expanded to 139 affected sib pairs, along with 83 other affected relative pairs (

43 Of 166 affected sib pairs, 30 (12 MZ, 17 DZ, and 1 of unknown zygosity)

44 d no evidence of linkage, among 201 affected sib pairs, in the region of chromosome 2 that contains t

45 The study cohort comprised 2076 affected sib-pairs and 66 affected half-sib-pairs of the British

46 5 ARM families comprising up to 212 affected sib pairs was genotyped for 386 markers.

47 267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families.

48 to 364 ARM families with up to 329 affected sib pairs, the linkage signal on chromosome 9 vanished,

49 type model (DSM-IV OCD definite; 41 affected sib pairs) and a broad phenotype model (DSM-IV OCD defin

50 391 families, containing up to 452 affected sib pairs, we found linkage evidence in four regions: 1q

51 SM-IV OCD definite and probable; 50 affected sib pairs).

52 For samples of 500 affected sib pairs, the tests are powerful in detection of genoty

53 ographical regions containing 2,658 affected sib-pairs (ASPs).

54 porating 530 families and up to 736 affected sib pairs.

55 number of affected twin pairs among affected sib pairs to expected values in two separate samples of

56 we model locus heterogeneity among affected sib pairs with prostate cancer by including covariates i

57 hen 50% of families consisted of an affected sib pair and one parent genotyped under an additive gene

58 We performed exome sequencing on an affected sib-pair with normal ultrastructure in more than 85% of

59 use three approaches: pedigree and affected sib-pair linkage studies and association studies of popu

60 are available for unrelated cases, affected sib pairs (ASPs), or only one sibling per Asp. We constr

61 methods (e.g., variance components, affected sib pair, extremely discordant sib pairs, etc.) that tru

62 in 187 and 356 families containing affected sib pairs (ASPs) yielded apparently conflicting results,

63 or smaller pedigrees especially for affected sib pair kindreds.

64 utation frequencies were greater in affected sib pairs than in sporadic CD cases but actually decreas

65 dy of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the e

66 s not inflate type I error rates of affected sib pair (ASP) statistics in the whole parameter space,

67 oint model-free linkage analysis of affected sib pair data.

68 families recruited on the basis of affected sib pairs for asthma reveal significant association for

69 l on the trait data for a sample of affected sib pairs, with disease penetrances and disease-SNP hapl

70 nger affected sib than in the older affected sib (P < 0.02).

71 3.93 on chromosome 18, a two-point affected sib pair (ASP) LOD score of 3.11 on chromosome 16, sever

72 We find that, by choosing the affected sib who shows the most evidence for pairwise allele shar

73 We focus on the affected sib-pair study design and develop test statistics that a

74 (APP) region is strongly linked to affected sib pairs of the oldest current age (i.e., age either at

75 int linkage methods were applied to affected sib-pairs with inflammatory bowel disease, and significa

76 A genome-wide scan (GWS) using affected sib pair linkage analysis was performed on 218 sibling p

77 Two-point linkage analysis using affected sib pairs yielded LOD scores of 3.15 at D12S1623 and 1.4

78 A genome-wide affected sib-pair linkage study with 221 Japanese families with c

79 in an additional 140 families with affected sib pairs.

80 tely 13 times higher in the younger affected sib than in the older affected sib (P < 0.02).

81 to increased allele sharing between affected sibs.

82 Clinical severity of mildly affected sibs with the same PMM2 mutations did not correlate with

83 in the families with three or more affected sibs compared with sib pairs.

84 ased in families with three or more affected sibs, raising the possibility of genetic heterogeneity.

85 le of 105 families with two or more affected sibs.

86 specific high-risk HLA genotypes or affected sibs' ages at disease onset, provided evidence of linkag

87 rwise allele sharing with the other affected sibs in families, the test statistic is increased by >20

88 e of whom has autism; the remaining affected sibs carry diagnoses of either Asperger syndrome or perv

89 ecessive disease: one allele in the affected sibs and multiple alleles in unaffected sibs and parents

90 family composed by a father and two affected sibs with Adams Oliver syndrome (AOS) (OMIM 100300).

91 lected because each had exactly two affected sibs, we observed a remarkably high proportion of affect

92 ort, we have used a covariate-based affected-sib-pair linkage method to analyze the chromosome 21 cli

93 imum LOD scores (MLS) obtained from affected-sib-pair analysis of all 345 families yielded suggestive

94 Similarly, in affected-sib-pair analysis of our schizophrenia dataset (241 sibl

95 e high proportion of twins found in affected-sib-pair studies can be adequately explained by the high

96 archers are increasingly relying on affected-sib-pair (ASP) data.

97 th the conditional analysis and the affected-sib-pair two-locus analysis provided further evidence fo

98 -dimensional, linear Ising model to affected-sib-pair (ASP) analysis in genetics.

99 By expanding the traditional affected-sib-pair design to include unaffected and discordant sib

100 tative trait in the analysis, using affected-sib-pair data.

101 5 years, overall survival (OS) was 44% after sib alloHSCT, 36% after MUD alloHSCT, and 19% after chem

102 All sib pairs were concordant for a diagnosis of Gilles de l

103 Not all sib pairs in the sample were concordant for hoarding.

104 results indicate that, in African Americans, sibs and parents of sarcoidosis cases have about a 2.5-f

105 009), SimWalk2 Statistic A (P = 0.0002), and sib-pair analyses (maximum likelihood score = 6.07) all

106 gnifies sex biases and promotes helping; and sib-mating, promiscuity, and reproductive autonomy also

107 without parental genotypes), sib trios, and sib quads.

108 a was also found for male family members and sibs born later in the birth order.

109 dispositions of children toward parents and sibs are expected to be sensitive to cues of marital sta

110 a multivariate model fit to the parents and sibs data, the familial relative risk adjusted for age,

111 ves of MSGB differences between probands and sibs (area under the receiver operator curves, 0.57 [95%

112 kage Analysis Testing), that can perform any sib pair statistical test currently in use, as well as a

113 advocate the ASP/DSP design with appropriate sib-pair statistics that test the difference in allele s

114 multipoint identity by descent (IBD) between sib pairs and false-positive evidence for multipoint mod

115 , the intraclass correlations (ICCs) between sib-pairs (pairs of unaffected siblings and schizophreni

116 ned by the overall trait correlation between sibs in a population.

117 nt antibiotic stress than their IOP-burdened sibs.

118 of the linkage evidence derives from the CA sib pairs.

119 undertook a genomewide scan in 158 Canadian sib-pair families and identified three regions of sugges

120 er and type 1 diabetes in 364 U.S. Caucasian sib-pair families (P < 0.006).

121 Both the H-cell and the glutamatergic H-cell sib are the asymmetric progeny of the MP3 midline precur

122 H-cell sib cell fate is dependent on Notch signaling, whereas H

123 ons (EC)) and the other forcing it (circular sib mating (CM)).

124 We detected sib-pair linkage of 5q34 GABA(A) receptor genes to alcoh

125 A candidate gene search of diabetic sibs discordantly affected, concordantly affected and co

126 and hence on type I error rates of different sib-pair linkage approaches that assume LE.

127 design to include unaffected and discordant sib pairs, analytical power and robustness to type I err

128 ter space, and that, in any case, discordant sib pairs (DSPs) can be used to control for marker-marke

129 ntitative traits, such as extreme discordant sib pairs.

130 nts, affected sib pair, extremely discordant sib pairs, etc.) that truncate all "negative evidence ag

131 f association in family triads or discordant sib pairs but are not theoretically valid in multiplex f

132 ly applicable to case-control and discordant-sib-pair studies.

133 o 19-amino-acid proteins (Ibs) opposite each sib gene.

134 ngly suggests that one should incorporate EC sib pairs along with ED sib pairs, in both design and an

135 d4;) by genotyping extremely concordant (EC) sib pairs and including them along with ED sib pairs in

136 ) sib pairs and including them along with ED sib pairs in the statistical analysis.

137 hould incorporate EC sib pairs along with ED sib pairs, in both design and analysis.

138 Elliptical sib pair analysis showed significant associations of the

139 ngs (study participants), forming an exposed sib-pair.

140 Each exposed sib-pair was matched up to 5 unexposed sib-pairs from th

141 ata, we identified in a sample of 961 female sib-pairs, three genome-wide significant QTLs for apolip

142 an average resolution of 8 cM in 719 Finnish sib pairs with type 2 diabetes.

143 ed, and no phenotype was observed for a five-sib deletion strain.

144 s by use of genotype data were developed for sib and half-sib pairs.

145 nt marker densities and heterozygosities for sib pairs (with and without parental genotypes), sib tri

146 Our simulation study shows that, for sib-pair data, even when the coverage probability of the

147 of ancestral, sexually dimorphic traits for sib-rearing.

148 For sibs and parents combined, lambda was 2.49 (95% confiden

149 24 (95% confidence interval: 1.16, 3.92) for sibs and 2.82 (95% confidence interval: 1.41, 5.05) for

150 d, one or more individuals from each of four sib groups displayed a genotype that was identical to th

151 s screened with heterologous liver cDNA from sib-pairs of contrasting HDL-C phenotypes on two differe

152 As large full sib family sizes can be obtained in fish, the practical

153 ilies composed of mother, father, and 2 full sibs delivered between 38 and 41 weeks' gestation within

154 dicted to be particularly evident among full sibs.

155 dairy cattle breeding schemes but from full sibs it contributes considerably to accuracy within fami

156 to state birth certificates to identify full sibs and half-sibs and to obtain information on birth or

157 ly discordant pairs that are ostensibly full sibs may be half sibs.

158 loci (QTL) scan was performed within 10 full-sib families that had received a natural seawater IPN ch

159 ge map was generated from a set of 1976 full-sib progeny, with the positioning of 8793 expressed gene

160 201 AFLP and SSR markers scored on 228 full-sib individuals of autotetraploid potato is used to illu

161 3 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one indiv

162 an was performed on the offspring of 50 full-sib families, for traits related to fitness (length, wei

163 A full-sib design was set up in which families of Culex pipiens

164 ity loci in outbred populations using a full-sib family as an example.

165 mapping in autotetraploid species for a full-sib family derived by crossing two parents.

166 on patterns from molecular markers in a full-sib family derived from an arbitrary polyploid combining

167 h-resolution genetic linkage map from a full-sib family of 124 individuals and their parents using th

168 ge analysis of polymorphic markers in a full-sib family of autotetraploids.

169 ation rate per site per generation in a full-sib family of Drosophila melanogaster recently sampled f

170 ) linkage maps were constructed using a full-sib population of 238 plants and SSR and STS markers to

171 set of SSR and AFLP markers scored in a full-sib population of tetraploid potato.

172 variation in the drought response of a full-sib second generation (F(2)) mapping population from a c

173 additional diallel cross was done among full-sib progeny from a cross of a self-sterile and a self-fe

174 tionships, such as unrelated, half- and full-sib, or parent-offspring, little attention has been paid

175 ci (QTL) using the double haploid (DH), full-sib (FS) and hierarchical (HI) designs implemented in ou

176 ages of growth using a three generation full-sib design population which originated from a cross betw

177 ossing populations, hybrid generations, full-sib families and selfing lines) have recently received m

178 ion of a large sample of individuals in full-sib families of the same small size, the same large size

179 partition individuals in a sample into full-sib and half-sib families using genetic marker data with

180 lated population consisting of multiple full-sib families.

181 in most traits due to one generation of full-sib mating.

182 ment is by either self-fertilization or full-sib mating.

183 ver generations is described for self-, full-sib-, and half-sib-generated RILs with no dominance in t

184 k tolerant and two heat shock sensitive full-sib oyster families.

185 elf-medication behaviour across several full-sib families to evaluate the plasticity of diet choice a

186 crosses: the first included many small full-sib families and the second was derived from five genera

187 maturity was performed on a tetraploid full-sib family of potato comprising 227 clones from a cross

188 markers scored on two parents and their full-sib progeny.

189 gregation ratios was assembled for this full-sib family, and a total of 409 SNP markers were mapped o

190 ) obtained from mesocarp tissues of two full-sib progeny contrasting for CI, about 48 and 13% of whic

191 method is evaluated in simulations with full-sib families.

192 as evaluated in the F(1) progeny of 169 full-sibs of the cross.

193 x P. elliottii pseudo-backcross of 345 full-sibs (BC1).

194 The full-sibs segregated into four compatibility classes, suggest

195 pairs (with and without parental genotypes), sib trios, and sib quads.

196 ethod, was asymptotically greatest with half sibbing, less with sibbing, and least with selfing.

197 rs that are ostensibly full sibs may be half sibs.

198 Cosegregation information from half sibs contributes little to accuracy of GEBVs in current

199 ing the importance of identification of half sibs.

200 population included 599 clones from 17 half-sib families, which were successfully genotyped using 43

201 families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioi

202 Fgrm = 0.125, a value resulting from a half-sib mating, LBS declined by 72% for females and 95% for

203 2076 affected sib-pairs and 66 affected half-sib-pairs of the British Genetics of HyperTension study.

204 dividuals in a sample into full-sib and half-sib families using genetic marker data without parental

205 Full and half-sib groups of T. nubilale were obtained from a nested ma

206 enotype data were developed for sib and half-sib pairs.

207 is described for self-, full-sib-, and half-sib-generated RILs with no dominance in true crossovers.

208 e-based methods of QTL analysis such as half-sib regression interval mapping and a variance component

209 nvestigate the power of differentiating half-sib, avuncular and grandparent-grandoffspring relationsh

210 Breeding experiments employing half-sib designs were conducted on both collectively and indi

211 ating genetic variance components given half-sib covariances estimated by our experimental design.

212 e reconstructed multiple interconnected half-sib families in the Vinson population, with some genets

213 rent-child trios, and arbitrarily large half-sib pedigrees.

214 opportunities and rewards for producing half-sib clutches, and thereby its exposure to selection pres

215 A subsequent half-sib breeding design revealed an amount of additive genet

216 of heritability are available from the half-sib pedigree design: the sire, dam and genotypic estimat

217 d 489 Suffolk animals in five and three half-sib families, respectively, were genotyped for microsate

218 foliator Thaumetopoea pityocampa) using half-sib families drawn from a sample of the population of Pi

219 val mapping by linear regression within half-sib families and a variance components analysis of a six

220 certificates to identify full sibs and half-sibs and to obtain information on birth order and demogr

221 t account for the presence of full- and half-sibs commonly found in large clutches of many organisms.

222 s included 39,361 individuals (sibs and half-sibs).

223 e fit in terms of recruitment than were half-sibs sired by social mates.

224 ication of the disease status of the healthy sib, and the effect of nonpaternity were considered.

225 ssification of the disease status of healthy sibs, as well as the discarding of incomplete families,

226 duct--rather than the squared difference--in sib trait values, is, in general, less powerful than VC

227 classify the major sources of discretion in sib pair linkage analysis.

228 The minimum shared haplotype in sib pairs with similar trait values spans 4.9 cM and is

229 quares-based VC method for mapping of QTL in sib pairs (Elston et al.).

230 us expression of maternal genes to result in sib-care, the hallmark of highly evolved social life in

231 milial risk ratio (lambda) of sarcoidosis in sibs and parents of cases, the authors studied 179 Afric

232 aplodiploidy is developed which incorporates sib mating, deleterious mutations generated by mutation,

233 -Elston method was developed for independent sib pairs; its generalization to nonindependent sib pair

234 rkers in nuclear families and in independent sib pairs.

235 These families included 39,361 individuals (sibs and half-sibs).

236 both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of

237 Multiple genome-wide scans involving sib-pairs or limited pedigrees have been extensively use

238 was performed with data from 67 keratoconus sib pair families with 110 affected sib pairs of white o

239 x trait with a sibling relative risk (lambda(sibs)) between 18 and 36.

240 we assumed relative risk to siblings (lambda(sibs)) values of 1.15, 1.2, 1.3, or 1.4.

241 ed independently in a study of affected LOAD sib-pairs.

242 howing their differential expression in male sib pairs discordant for idiopathic ASD.

243 A polymerase chain reaction-mediated sib-selection technique was successfully adapted for the

244 re genotyped for 335 markers, and multipoint sib pair linkage analyses were conducted.

245 These processes include mutation, sib competition, and invisible fractions.

246 pairs; its generalization to nonindependent sib pairs is not straightforward.

247 nkage to chromosome 2q (D2S116 nonparametric sib-pair LOD score [MLS] 1.12 at 198 cM).

248 to simultaneously estimate, on the basis of sib-pair linkage data, both the position of a trait locu

249 ion to model the squared trait difference of sib pairs with the shared allele identical by descent (I

250 A new function of sib-pair phenotypes, the product of pair values correcte

251 ontinuing to survive after 20 generations of sib x sib mating.

252 e analysis was followed by identification of sib pairs with linkage and construction of core shared h

253 nflation as a function of the resemblance of sib pairs and the criteria for discordance used for sele

254 in 11 additional individuals (including one sib-pair).

255 Considering only sib pairs compared with unrelated persons, distance corr

256 ry number of prior generations of selfing or sib-mating.

257 individuals, as indicated by the sib-sib OR (sib-sib OR adjusted for known risk factors (95% CI): 4.2

258 ternity was high, indicating that outcrossed sibs within families were sired by the same father.

259 loci with locus-specific disease prevalence/sib-risk ratios (lambda(s)) <1.4.

260 f a recurrent depression locus in a previous sib-pair study.

261 st likely relationship of a pair of putative sibs.

262 io, lambdas, and sibling-sibling odds ratio (sib-sib OR), for the adverse pregnancy outcomes of prete

263 g errors at each locus in each reconstructed sib family.

264 More-robust sib-pair designs and appropriate methods for their analy

265 onal pairs in the Drosophila nerve cord, RP2/sib, has a complicated migratory route.

266 In the NB4-2 --> GMC-1 --> RP2/sib lineage, a well-studied neuronal lineage in the vent

267 In the typical GMC-1-->RP2/sib lineage, we found that loss of Neur activity causes

268 n, in a typical lineage, NB4-2-->GMC-1-->RP2/sib, suggest that at least part of the process operates

269 We have previously shown that RP2/sib, a well-studied neuronal pair in the Drosophila vent

270 In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down r

271 ng ruled out linkage at 14q21-23 (lambda(s) [sib recurrence risk or genotypic risk ratio] = 1.8).

272 he implicit assumption that randomly sampled sib pairs share half their alleles identical by descent

273 Studies of a second sib with severe liver disease and other living family me

274 Even though we select sibs on the basis of a nonparametric statistic, the addi

275 Sib-sib correlations were calculated with the SAGE 5.0 progr

276 utcome of assigning alloHSCT with a sibling (sib) or matched unrelated donor (MUD) to patients younge

277 Across arthropod societies, sib-rearing (e.g. nursing or nest defence) may be provid

278 entral nerve cord, Notch signaling specifies sib fate to one of the daughter cells of GMC-1.

279 The squared sib-pair phenotype difference (SQD) has been used as a d

280 The sib-sib correlation for DR severity was 0.1358 in the to

281 The sib-TDT analysis also showed significant association bet

282 disequilibrium test (SDT, p = 0.68) and the sib transmission/disequilibrium test (Sib-TDT, p = 0.81)

283 unaffected individuals, as indicated by the sib-sib OR (sib-sib OR adjusted for known risk factors (

284 n in the data, because it only considers the sib-pair trait-value difference.

285 compared to other proposed functions of the sib-pair phenotypes.

286 h the distribution of phenotypes amongst the sibs of the individual and this depends on the genotypes

287 ds and their parents is preferred, and three sibs will be required to have close power if parents are

288 In addition to sib-pair linkage and case-control association analyses,

289 to have greater power than does traditional sib-pair analysis.

290 ely to be ascertained than affected non-twin sib pairs (or 7 times more likely if "stoppage" plays a

291 ulation included 69 community-dwelling twin, sib-sib, or parent-offspring pairs (n = 138), comprising

292 common diseases, sampling affecteds and two sibs will generally be more efficient than trios.

293 amilies with one affected and one unaffected sib were analyzed.

294 based on affected, discordant, or unaffected sib pairs, as well as on pairs defined by threshold valu

295 cted sibs and multiple alleles in unaffected sibs and parents.

296 posed sib-pair was matched up to 5 unexposed sib-pairs from the Multi-Generation Registry by birth an

297 th three or more affected sibs compared with sib pairs.

298 ls, to the problem of predicting DeltaF with sib indices in discrete generations since previously pub

299 ng association, even for disease models with sib relative risk as low as lambda S=1.1, or when eviden

300 ically greatest with half sibbing, less with sibbing, and least with selfing.

301 ing to survive after 20 generations of sib x sib mating.