ライフサイエンスコーパス: sibling

1 volving parents, affected children and their siblings).

2 nd fathers of TD/CTD probands (compared with siblings).

3 ously forging alliances between opposite-sex siblings.

4 sis vaccine response was detected in group B siblings.

5 ly background characteristics shared between siblings.

6 ld income, cohabiting parents, and number of siblings.

7 ings and 16.7% (95% CI, 15.2%-18.4%) of male siblings.

8 e sex-specific recurrence rates of ASD among siblings.

9 n all patients and in age-matched unaffected siblings.

10 L3 in 1 patient and a variant in CREBBP in 2 siblings.

11 tion (c.589C>T; p.Gln197*), in both affected siblings.

12 st, and the loss was comparable to wild-type siblings.

13 nd resilience between the patients and their siblings.

14 etween children with HeFH and the unaffected siblings.

15 quences to each other than to their non-twin siblings.

16 children with HeFH than untreated unaffected siblings.

17 by comparing exposed children with unexposed siblings.

18 ings and 12.9% (95% CI, 12.2%-13.6%) of male siblings.

19 n the positions of complex centromeres among siblings.

20 by measured and unmeasured factors shared by siblings.

21 greater at baseline compared with unaffected siblings.

22 parental characteristics that are shared by siblings.

23 of sibling MR with MR in Gen 2/Gen 3/Swedish siblings.

24 n patients and benign variants in unaffected siblings.

25 en with HeFH compared with the 65 unaffected siblings (0.397+/-0.049 and 0.377+/-0.045 mm, respective

26 isions for their parent (47%), spouse (28%), sibling (13%), child (3%), or other relation (8%).

27 and a child in 67% of cases and less often 2 siblings (29%).

28 (ASD: 37, unaffected parents: 36, unaffected siblings: 33) and 100 unaffected Lebanese controls.

29 trols (28 of 39 [71.8%]; mean [SD] number of siblings, 4.29 [1.41]; P = .001).

30 8.4 times more likely to be frail than their siblings (95% CI, 2.0-34.5; P = .003).

31 erval = 1.42-1.49) and their unaffected full siblings (adjusted hazard ratio = 1.47; 95% confidence i

32 MT between children with HeFH and unaffected siblings after 2 years was no longer significant (0.408+

33 freshwater hatchery with that of their full-siblings after seawater acclimatisation (SW) by a 16S rR

34 ed 12-23 years), 103 mothers and fathers, 31 siblings (aged 12-26 years), and 42 friends (aged 12-24

35 bases, we used a corelative design with full siblings alongside a general Swedish population sample.

36 A third sibling also died of a similar presentation, but DNA was

37 The siblings also had the pathogenic variant p.Ala13Thr vari

38 Two siblings also showed polymicrogyria.

39 positively associated with presence of older siblings among carriers of known asthma risk alleles at

40 Sibling analyses demonstrated that higher GWG was indepe

41 In contrast, epidemiological sibling analyses revealed that the siblings of female in

42 (HR, 1.32; 95% CI, 1.13-1.54) and in matched-sibling analysis (HR, 1.61; 95% CI, 1.02-2.56).

43 In matched-sibling analysis, no association was observed between ma

44 ng pregnancy and offspring depression in the sibling analysis.

45 spring depression and performed a discordant sibling analysis.

46 ed hematopoietic cell transplantation (HCT), sibling and unrelated donors (UDs) are biologically diff

47 gnosed in 4.2% (95% CI, 3.8%-4.7%) of female siblings and 12.9% (95% CI, 12.2%-13.6%) of male sibling

48 gnosed in 7.6% (95% CI, 6.5%-8.9%) of female siblings and 16.7% (95% CI, 15.2%-18.4%) of male sibling

49 interferon-stimulated genes we identify two siblings and a singleton variably demonstrating severe n

50 Subgroup analyses were carried out among siblings and also after adjustment for maternal anthropo

51 ctions occurred much more frequently between siblings and between fathers and offspring than between

52 cial conditions that reduce conflict between siblings and between males and offspring will be fundame

53 asured at age 16 and FCA-assessed from SA in siblings and cousins, and educational attainment in pare

54 uctivity was observed in soil conditioned by siblings and genetically diverse groups.

55 of 48 affected children and their unaffected siblings and identified in total 241 variants (single nu

56 ificant differences were found in unaffected siblings and parents versus controls (primary and perman

57 atched birth and school records from Florida siblings and twins born in 1994-2002 to provide the larg

58 SNPs) were then genotyped in the co-affected siblings and unrelated probands.

59 mined willingness to cooccupy the tube, with siblings and/or cagemates of both sexes exhibiting highe

60 il conditioned by groups of closely related (siblings) and diverse genotypes of Deschampsia cespitosa

61 (siblings, mothers, fathers), second- (half siblings) and third-degree (cousins) relatives, compared

62 atients with bipolar disorder, 64 unaffected siblings, and 41 healthy volunteers.

63 at both deliveries, in cord blood from both siblings, and in infants before and after they received

64 ioeconomic characteristics of their parents, siblings, and male partners.

65 2 years, the factors urban living, number of siblings, and male sex lost their importance.

66 identified the need for support of parents, siblings, and racial and ethnic minority groups.

67 rental income, parental education, number of siblings, and rural/urban status.

68 evels of pertussis antibodies in all group B siblings at birth were significantly higher than those i

69 ere significantly higher than those in their siblings at birth, even as the interval since maternal v

70 2 cohort participants and all adult Swedish siblings born after 1932 identified in 1997 and followed

71 nts (group A; 86 mother-infant pairs) and in siblings born after the women received Tdap vaccine (gro

72 l uptake between ASD cases and their control siblings, but only during discrete developmental periods

73 ge with the child of a parent's opposite-sex sibling-but it is unclear who benefits from these exchan

74 c bone marrow transplant from an HLA-matched sibling can halt disease progression but is limited by d

75 Both index persons have an affected sibling carrying the same mutations.

76 We report a pair of siblings carrying a homozygous missense mutation p.P333L

77 We observed both phenotypes in 2 siblings carrying the same compound heterozygous variant

78 homozygous missense mutation in WDR1 in two siblings causing periodic fevers with immunodeficiency a

79 BS+/-, a model for hyperhomocysteinemia, and sibling CBS+/+ control mice revealed that deficiency of

80 d self-renewal arise as opposing outcomes of sibling CD4(+) T cells.

81 g a TCF1-silenced daughter cell as well as a sibling cell maintaining TCF1 expression.

82 velopmental potentials, can be manifested in sibling cell size asymmetry.

83 fundamental process responsible for creating sibling cell size asymmetry; however, how the cortex cau

84 f asymmetric cell division that can generate sibling cell size differences.

85 rm cells develop as a cyst of interconnected sibling cells in a broad range of organisms in both sexe

86 ls in male fruit flies divide to produce two sibling cells that are equal in size.

87 Asymmetric cell division, creating sibling cells with distinct developmental potentials, ca

88 R, 1.27; 95% CI, 1.09-2.79), and having >/=5 siblings/children in the household (HR, 2.24; 95% CI, 1.

89 synaptic networks in the tadpole larva of a sibling chordate, the ascidian, Ciona intestinalis.

90 s by estimating dynamic effects on surviving siblings' cognitive and socioemotional outcomes, as well

91 oblems were compared between survivors and a sibling cohort.

92 ample of survivors of childhood cancer and a sibling comparison group who were enrolled in the Childh

93 e) among survivors of childhood cancer and a sibling comparison group.

94 Estimates from the commonly-used sibling comparison method were driven primarily by a pat

95 s no longer statistically significant in the sibling comparison models or after the exclusion of como

96 In the fully adjusted sibling comparison models, patients had higher risks of

97 In sibling comparisons with within-family covariates, assoc

98 maternal and paternal covariates, as well as sibling comparisons, timing of exposure comparisons, and

99 , with different timings of exposure, and in sibling comparisons.

100 tions were consistent with findings from the sibling comparisons.

101 ormalities in autism lymphoblastoid cells: a sibling control study.

102 to better understand how dynamic networks of sibling cyclases and effector proteins result in sensibl

103 When we combined parental and sibling data in FHS pedigrees, heritability of MR was es

104 Recent work has shown that experiencing a sibling death is common and long-term effects are large.

105 MRI of both siblings demonstrated polymicrogyria but did not show oc

106 In the sibling design, the heritability of perinatal depression

107 Using a split half-sibling design, we exposed embryos of 10 families from e

108 ly high-risk families that had three or more siblings diagnosed with T1D at early ages.

109 red overall cohort findings (n = 1,108) with sibling differences (n = 246 sibling sets).

110 In contrast to wild type siblings, disc1 mutant larvae show altered crh levels, f

111 Here, we identify QIL1 null alleles in two siblings displaying multiple clinical symptoms of early-

112 ltiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates than strangers,

113 costs when they, their parents, or same-sex siblings do.

114 marry relatives but not when their same-sex siblings do.

115 tients who received conventional HLA-matched sibling donor (SIB) and HLA-matched unrelated donor (MUD

116 ) is the other therapeutic option: a matched sibling donor remains the best choice.

117 -host disease, are greater without a matched sibling donor.

118 ismatched unrelated donors (n = 37), matched sibling donors (n = 14), matched family donors (n = 12),

119 t fails to mobilize 33% of normal allogeneic sibling donors in 1 apheresis.

120 2 efficacy trial was conducted in allogeneic sibling donors.

121 found for concordant causes of death (i.e., siblings dying from the same causes) but not for discord

122 i) parents have more grandchildren; and (iv) siblings, especially brothers, benefit when their opposi

123 One male and full-sibling female African black-footed cat developed vision

124 enced the death of a mother, a father, and a sibling from childhood through midlife.

125 ed affected than to the unrelated unaffected sibling from the CDS and then, sum over such individuals

126 (hazard ratio, 32.84) but were uncommon (34 siblings from 11 sibships).

127 ed a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asi

128 We then studied differentially exposed full siblings from 947 942 families; of these, 3563 families

129 (p.Arg209Trp) was inherited by two affected siblings from their healthy mother, who is mosaic.

130 he default mode network was increased in the sibling group compared with both the patient group and t

131 ts that characteristics of roots produced by sibling groups slow down N cycling but moderate the expe

132 f seedlings compared with litter produced by sibling groups.

133 ordance for height (reference was the taller sibling): >/=10 cm difference between brothers hazard ra

134 The siblings had a severe course, whereas the mother had a m

135 Moreover, both twins and their siblings had more vocal sequence similarity with each ot

136 Impairments in siblings had no progressive increase and were unrelated

137 For both GABA+ measures, unaffected siblings had significantly lower levels compared with co

138 tients with ASD and 2417 healthy parents and siblings) had been previously recruited in the United St

139 ough overall risk of recurrence of ASD among siblings has been estimated to be between 6.1% and 24.7%

140 Siblings have been shown to reduce the risk of childhood

141 line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations.

142 of the LPR in the maculae or one of the two sibling HCs in neuromasts.

143 erformed across HLA-DP disparities absent in sibling HCT.

144 udy from Brazil (N = 2,626), and the Swedish Sibling Health Cohort (N = 258 sibling pairs), we compar

145 ogressive changes in size, doubling time, or sibling health.

146 A total of 4.8% of AS cases had a sibling history of AS.

147 A sibling history of clinically diagnosed AS was associate

148 Furthermore, a sibling history of hypertension in pregnancy may be a no

149 A sibling history of hypertension in pregnancy was also as

150 Two full-sibling Hungarian Vizsla puppies from a litter of nine p

151 re pronounced for those who lost a noninfant sibling (i.e., >1 year of age) (hazard ratio = 1.53, 95%

152 ated behaviours of their parents, two eldest siblings (if eligible), and first husbands or long-term

153 e interval: 1.18, 1.95) and those who lost a sibling in adolescence (i.e., between the ages of 12 and

154 evidence of an association between loss of a sibling in adulthood and subsequent mortality, there hav

155 igators have examined whether the death of a sibling in childhood is associated with adult mortality

156 we tested the effect of living with stressed siblings in a gull species where, as in many vertebrates

157 Two affected siblings in the third family were compound heterozygous

158 xposed children were compared with unexposed siblings (incidence of autism spectrum disorder was 3.40

159 lly rescued plants grew as well as wild-type siblings, indicating that mitotic progression delays alo

160 nce similarity with each other than with non-sibling infants.

161 Among 5132 FHS Gen 2/Gen 3 participants with sibling information, 1062 had MR.

162 aking unmeasured factors shared between full siblings into account.

163 environmental and genetic factors shared by siblings, labor induction was no longer associated with

164 were used to analyze the association between sibling loss during childhood and death in young adultho

165 ly brothers, benefit when their opposite-sex siblings marry relatives but not when their same-sex sib

166 benefit when their children or opposite-sex siblings marry relatives but suffer costs when they, the

167 Sibling-matched cohort study conducted between May 2009

168 parents and offspring, interactions between siblings may play an equally important role.

169 D, individuals with TD/CTD and their first- (siblings, mothers, fathers), second- (half siblings) and

170 had MR compared with 17% (562/3335) without sibling MR (multivariable-adjusted odds ratio, 1.20; 95%

171 In Sweden, sibling MR was associated with a hazard ratio of 3.57 (9

172 We estimated the association of sibling MR with MR in Gen 2/Gen 3/Swedish siblings.

173 Of siblings with sibling MR, 28% (500/1797) had MR compared with 17% (562

174 Donors were HLA-matched sibling (n = 1), HLA-matched unrelated (n = 9), HLA-mism

175 ed unrelated (n = 3), and HLA haploidentical sibling (n = 1).

176 Among siblings (n = 2,388), very preterm women were 23 mm shor

177 Siblings (n = 4,023) established the baseline population

178 14-SNP GRS could distinguish the co-affected siblings (n = 90) of the earliest probands from those (n

179 ctural units of macrocircuitry formed by the sibling neurons of single progenitors called neuroblasts

180 ression analyses, adjusting for maternal and sibling obesity, maternal diabetes, mode of delivery, so

181 CI=0.39, 0.62) and substantially stronger in siblings (odds ratio=0.35, 95% CI=0.24, 0.51) discordant

182 defined as the diagnosis of ASD in a younger sibling of an older sibling with an ASD diagnosis.

183 re at higher familial risk for ADHD than the siblings of affected male individuals (odds ratio [confi

184 differences were found in the SA and IQs of siblings of BPI vs matched control probands.

185 and divide by binary fission, generating two siblings of equal morphology.

186 iological sibling analyses revealed that the siblings of female individuals with ADHD are at higher f

187 ubjects undergoing colonoscopy in Hong Kong, siblings of individuals with at least 1 advanced adenoma

188 to investigate intrafamilial spread among 4 siblings of infection due to a hypervirulent GAS strain

189 h the general population and unaffected full siblings of OCD individuals.

190 ADs was very similar in mothers, fathers and siblings of OCD probands, whereas it tended to be higher

191 Studies of infant siblings of older autistic probands, who are at elevated

192 lness or delayed illness onset in unaffected siblings of patients with bipolar disorder.

193 atric and neurodevelopmental disorders among siblings of persons with ASD.

194 Siblings of POAG cases have a ten-fold increased risk of

195 lant patients that are unrelated or that are siblings of the donors, using a hidden Markov model (HMM

196 schizophrenia was verified using co-affected siblings of the GWAS probands and trend effect across un

197 ontemporary information on 6 117 263 Swedish siblings, of which 13 442 had a clinical diagnosis of AS

198 s the effects of experiencing the death of a sibling on children's developmental outcomes.

199 given transplantation from an HLA-identical sibling or a 10/10 allelic-matched unrelated donor in th

200 ADA-deficient SCID and no available matched sibling or family donor were enrolled between 2009 and 2

201 tomycorrhizal fungi, soil microbes, and full-sibling or nonsibling neighbouring seedlings.

202 [CI, 1.41-7.47]; P=0.01), particularly their siblings (OR, 1.92 [CI, 1.06-3.51]; P=0.03), extended fa

203 amily history of retinoblastoma in a parent, sibling, or first- or second-degree relative.

204 dren, and those without a partner, children, siblings, or parents.

205 icts between parents and offspring and among siblings over optimal mating strategies.

206 .001); cumulative incidence was only 1% for siblings ( P < .001 v low-risk survivors).

207 , has a tendency to transmit to offspring or siblings (P = 0.010) and is associated with forced expir

208 dence interval, 0.0095-0.0192) in unaffected siblings (P=0.002).

209 55 [19%] of 752 survivors vs 88 [14%] of 610 siblings, p=0.010), inattention-hyperactivity (15 [19%]

210 associated Wiedemann-Steiner syndrome in one sibling pair and their mother.

211 A sibling pair had unilateral high myopia in their right e

212 In the other sibling pair, targeted testing of the known disease gene

213 ationship between BW/GA and BP in cohort and sibling-pair analyses, but the clinical or public health

214 In the sibling-pair subgroup, associations were slightly strong

215 a method of analysis [affected to discordant sibling pairs (A2DS)] that tests if shared variants cont

216 als are compared with a cohort of discordant sibling pairs (CDS) to derive a comparative similarity s

217 ability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated individuals and expl

218 43 years; 47% male), including 114 same-sex sibling pairs deliberately sampled to be discordant on s

219 -Generation Register, we identified all full-sibling pairs discordant for height.

220 Full-sibling pairs exhibited significantly greater (13) C tra

221 estry and homozygous c.322-10G>A in affected sibling pairs from two unrelated families of Puerto Rica

222 Subsequent targeted NGS in 24 discordant sibling pairs identified 17 nonsynonymous coding variant

223 The use of sibling pairs reduces the likelihood that familial confo

224 Differences in mean IQ scores between sibling pairs were: full scale = -0.2 (95% CI, -2.6 to 2

225 Here, we report two sibling pairs with syndromic primary immunodeficiencies

226 The study cohort included sibling pairs within 36 months in age and currently 8 to

227 d the Swedish Sibling Health Cohort (N = 258 sibling pairs), we compared associations of maternal smo

228 solates were either from the same patient or siblings pairs.

229 n that transmissions were identified between sibling patients shows that WGS is an effective tool for

230 nical, cellular, and molecular features in 2 siblings presenting with progressive bone marrow failure

231 d in controls, suggesting a role for PHEX in SIBLING protein degradation.

232 Results were robust in sibling random effects models that account for family ba

233 parallel using fresh-frozen lung tissue from sibling rats of the same cages.

234 nses nearly three-fold greater than those of siblings reared in streams.

235 In HLA-genotypically matched sibling recipients, the average recipient mismatching of

236 hed unrelated recipients than in HLA-matched sibling recipients.

237 nct genetic architectures underlying the low sibling recurrence risk in S-CHD and NS-CHD.

238 The method, referred to as "half-sibling regression," is inspired by recent work in causa

239 ial variation in risk of gallbladder cancer (sibling relative risk 3.15 [95% CI 1.80-5.49]).

240 longitudinal neuroimaging study of high-risk siblings revealed a specific pattern of brain developmen

241 VUR is familial, with transmission rate and sibling risk both approaching 50%, and appears highly ge

242 The sibling's father also carried the p.Ala13Thr variant, in

243 ncrease and were unrelated to their affected sibling's time of illness onset (time trend: social acti

244 After adjustment for religion and sibling's vaccination status, the VE decreased to 71% (-

245 n = 1,108) with sibling differences (n = 246 sibling sets).

246 cation in three patients (two families); two siblings shared the same homozygous frameshift mutation,

247 ssion, and households with a large number of siblings should receive additional counseling as childho

248 Genetic testing performed on both siblings showed a mutation in COL18A1, diagnostic of KS.

249 dence, fledglings that grew up with stressed siblings showed reduced body size, high levels of oxidat

250 Because unaffected siblings (Sibs) of individuals with ASD share some redox

251 licoverpa assulta, a pair of closely related sibling species differing mainly in their host range, by

252 ng cytoplasmic incompatibility (CI), and its sibling species E. gennaroi (EG), not infected by bacter

253 nt in the tropical Andes that gave rise to a sibling species, formerly considered the "wild ancestor"

254 s to conduct a systematic review of twin and sibling studies that examine the allergic phenotypes tha

255 ored specific evidence generated by twin and sibling studies to understand the aetiology of atopic ma

256 of 1,445 infants from representative infant-sibling studies) were predicted by worse stochastic patt

257 tion that transmission only occurred between siblings suggests that Staphylococcus aureus acquisition

258 ng 580 survivors of childhood cancer and 173 siblings, survivors of childhood cancer were more likely

259 Compared with siblings, survivors treated with chemotherapy only were

260 2 families; of these, 3563 families included siblings that were discordant for TD/CTD.

261 the level of aggressive interactions between siblings to that between parents and their offspring in

262 lyses of segregation patterns in parents and siblings, to shed new light on aetiology.

263 3 decades confirms the role of HLA-identical sibling transplantation for children and adults with SCD

264 s study are 1000 recipients of HLA-identical sibling transplants performed between 1986 and 2013 and

265 rd ratio for all-cause mortality in bereaved siblings versus nonbereaved siblings was 1.39 (95% confi

266 lity in bereaved siblings versus nonbereaved siblings was 1.39 (95% confidence interval: 1.14, 1.69).

267 eous patient from a family with two affected siblings, we identified a single homozygous missense mut

268 Comparing probands and unaffected siblings, we observe several DNM trends.

269 centiles between 1 and 4 years of age within siblings were also associated with higher adult BMI in t

270 Corticosterone-implanted chicks and their siblings were faster in responding to a potential predat

271 inke whale blubber, whereas their eight male siblings were fed a control diet containing pig fat as t

272 ention control group within 7 days of birth; siblings were randomized together as one randomization u

273 rrow aplasia from a family with two affected siblings, whereas none of the >60,000 subjects from the

274 comparisons were made with their unaffected siblings, which implies that the effects of TBI were con

275 However, in models that compared siblings while adjusting for pregnancy, maternal, and pa

276 perties were preserved in patients and their siblings while both groups showed reductions in the cohe

277 iages may escalate conflict between same-sex siblings who compete over mates, while simultaneously fo

278 The patient had three siblings who had the same condition, with one having die

279 We report a family with 2 siblings who have had recurrent mucocutaneous infections

280 Cousins and siblings who were discordant on smoking during pregnancy

281 When comparison was made within siblings whose births were discordant with respect to in

282 ced adenoma compared with subjects who had a sibling with a screening colonoscopy with no identified

283 osis of ASD in a younger sibling of an older sibling with an ASD diagnosis.

284 Individuals with >1 sibling with AS had an exceptionally high risk (hazard r

285 Having at least 1 sibling with AS was associated with a hazard ratio of 3.

286 ere at high risk for ASD because of an older sibling with ASD, and 122 were at low risk with no famil

287 60%]; 90.7% white non-Hispanic; 57.6% with a sibling with type 1 diabetes), 550 completed the trial i

288 e of CEP164, this is the first report of two siblings with a BBS-like syndrome with mutations in this

289 Seven percent of infants had siblings with a history of FPIES, and 5% reacted during

290 quencing analysis of DNA from three affected siblings with Grange syndrome identified compound hetero

291 ome sequencing of a family of three affected siblings with isolated cleft lip and palate, we discover

292 CASE PRESENTATIONS: We report on two siblings with KS.

293 s found by next-generation sequencing in two siblings with LQTS in a Spanish family of African ancest

294 single nucleotide polymorphism typing in two siblings with neonatal diabetes from a consanguineous pe

295 leading to susceptibility to infection in 3 siblings with severe G6PD deficiency.

296 Of siblings with sibling MR, 28% (500/1797) had MR compared

297 ation also in the cosibling design comparing siblings with varying degree of discordance for height (

298 fe, yet few life-course studies have data on siblings with which to control for family-level confound

299 weighed the same on average as nontransgenic siblings, with normal endosperm starch and total N conte

300 Siblings within a mother cell have similar numbers of or