ライフサイエンスコーパス: sibship

1 2.84) but were uncommon (34 siblings from 11 sibships).

2 0 diabetic siblings of control subjects (172 sibships).

3 ereas some are amenable to nuclear families (sibships).

4 ple for DNA collection (757 individuals, 297 sibships).

5 at estimated for the parents from the entire sibship.

6 the single-gene cause of proteinuria in this sibship.

7 ative-trait loci by use of sibling pairs and sibships.

8 , among sibships or among individuals within sibships.

9 onparametric" linkage analysis with affected sibships.

10 of linkage, using marker genotype data from sibships.

11 region in Alzheimer disease (AD) discordant sibships.

12 ings in genotyping, especially for multiplex sibships.

13 ent genetic variation, and unlimited size of sibships.

14 Mexican-American affected sib-pairs from 246 sibships.

15 tative-trait loci in randomly selected human sibships.

16 comprised of 709 affected sib-pairs from 472 sibships.

17 milies with parents and data from discordant sibships.

18 ng of a large sibship into two or more small sibships.

19 and paternal or maternal (but not both) half sibships.

20 individuals to infer parentage jointly with sibships.

21 incidence of recessive disease within these sibships.

22 nd are thus completely reliable in inferring sibships.

23 edigrees and similar power to the FEXAT with sibships.

24 on the basis of its high recurrence rate in sibships.

25 NOA) sibships (1381 African-Americans in 592 sibships, 1116 Caucasians in 503 sibships and 1378 Mexic

26 Epidemiology Network of Arteriopathy (GENOA) sibships (1381 African-Americans in 592 sibships, 1116 C

27 otyping Service) and 1,082 subjects from 256 sibships (243 markers, the Utah Molecular Genetics Labor

28 correlations between siblings (n=682, in 291 sibships, 517 pairs) and between spouse pairs (n=206 pai

29 w method can be used to infer full- and half-sibships accurately from marker data with a high error r

30 e syndrome were ascertained in nine separate sibships among the Old Order Amish.

31 information and of the power of a parentage/sibship analysis.

32 e largely independent of position within the sibship and national GNI per capita.

33 te a few methods have been proposed to infer sibship and parentage among individuals from their multi

34 The full-likelihood method assigns sibship and parentage relationships among all sampled in

35 t randomly a single affected child from each sibship and to apply the TDT to those data.

36 cans in 592 sibships, 1116 Caucasians in 503 sibships and 1378 Mexican-Americans in 416 sibships), fi

37 Here, we assessed 30 sibships and 89 parent/case trios of presumed ocular tox

38 We extend our method to larger sibships and apply it to an NIDDM1 data set.

39 ) (centenarians or near-centenarians) in 137 sibships and identified statistically significant linkag

40 lymorphisms in 257 multiplex prostate cancer sibships and in 355 race-matched healthy unrelated contr

41 ted females and unaffected parents in single sibships and in highly consanguineous families with mult

42 or only one sex is polygamous to infer full sibships and paternal or maternal (but not both) half si

43 oci (QTLs) has previously been restricted to sibships and small pedigrees.

44 is that age cohorts will tend to be paternal sibships and social groups will be genetically substruct

45 Hypertensive sibships and their offspring and/or parents in the Hyper

46 s, paternal half sibships, and maternal half sibships and to the case of a two-generation sample of i

47 to calculate correlation coefficients within sibships and within spouse pairs.

48 amples, we show that, by carefully selecting sibships and/or individuals on the basis of allele shari

49 tivariable Cox models adjusted for age, sex, sibship, and baseline stroke risk factors, we observed t

50 of two or more small sibships into a single sibship, and type II errors originate from the spurious

51 gamous to infer full sibships, paternal half sibships, and maternal half sibships and to the case of

52 prevents effectively the splitting of large sibships, and reduces type II errors greatly with little

53 Sibships are commonly used in genetic dissection of comp

54 accuracy of sibship assignments, except when sibships are expected to be uniformly small or marker in

55 ng conditional logistic regression, treating sibship as the matching factor.

56 equally affected males and females in single sibships, as well as the presence of consanguinity, supp

57 sing simulated data and exome chip data from sibships ascertained for hypertension collected as part

58 Sibships ascertained through a single proband are discus

59 than pairwise methods in both parentage and sibship assignments because of the more efficient use of

60 result, it improves the overall accuracy of sibship assignments, except when sibships are expected t

61 The model is based on the between-within-sibship association model presented in 1999 by Fulker an

62 In each sibship, both parents were found to be affected, opening

63 inical and genetic data obtained on affected sibships by the National Institute of Mental Health Alzh

64 ort study linking registry data on birth and sibship characteristics with a laboratory surveillance d

65 There was significant sibship clustering of the phenotype although in some fam

66 to reanalyze genome scan data from affected sibships collected by the Alzheimer Disease (AD) Genetic

67 f European ancestry, notable for their large sibships, communal lifestyle, and limited number of five

68 n effect of a locus into between- and within-sibship components, the method controls for spurious ass

69 als, interest in linkage and imprinting, and sibship composition.

70 Thus, when sibships contain multiple affected individuals, the TDS

71 ), with follow-up in 49 additional multiplex sibships, containing 50 ASPs.

72 Using the sibship data obtained from 32 low income Mexican America

73 ational burden for haplotype inference using sibship data when compared with using unrelated parental

74 from a normal likelihood based on multiplex sibship data, conditional on identical-by-descent sharin

75 For affected-sibship data, we describe three genotype-based weight va

76 hich is tailored for extensively accumulated sibship data.

77 ed by using 308 individuals belonging to 137 sibships demonstrating exceptional longevity.

78 The authors discuss how the sibship design can be used to detect and control for fam

79 et al. in this issue of the Journal uses the sibship design to capture the relation between birth wei

80 ssions and trait values with a family-based (sibships) design.

81 ily-based and included 436 subjects from 134 sibships discordant for AD that were analyzed using the

82 lt in an independently identified set of 217 sibships discordant for Alzheimer's disease (Consortium

83 From these, based on significance in the sibship disequilibrium test (P<0.05) or protein-altering

84 The sibship disequilibrium test (SDT) also revealed a signif

85 The sibship disequilibrium test (SDT) is designed to detect

86 scordant for AD that were analyzed using the sibship disequilibrium test (SDT, p = 0.68) and the sib

87 und that the test was more powerful than the sibship disequilibrium test of Horvath and Laird.

88 ical use and, if violated, can severely bias sibship estimates as shown by simulations in this articl

89 I also derive sibship exclusion probabilities, and investigate the pow

90 3 sibships and 1378 Mexican-Americans in 416 sibships), finding association with LDL-C level in ARIC

91 However, two sibships (four subjects) did not map to either locus, ra

92 We examined AO in 148 individuals in 57 sibships from the SCA2 founder population in Cuba.

93 clinic-based discordant sibships (N = 1,567 sibships) from the Colon Cancer Family Registry (Colon C

94 wever, as the number of affected sibs in the sibship grows, the relative efficiency of the TDS test v

95 In two exceptional sibships, however, children aged 10 and 13 years had FCD

96 ate cancer (CaP) who were from 230 multiplex sibships identified five regions with nominally positive

97 ies there were significant differences among sibships in larval growth and development rates, and in

98 e-wide linkage analysis was conducted in 211 sibships in which > or =2 siblings had diabetes and reti

99 There were 42 sibships in which at least 1 sibling had a stroke, and i

100 edish sample of male-male siblings, 436 full-sibships in which at least one member was reared by one

101 age 61 yr, 56% women, 75% hypertensive) from sibships in which two or more members had essential hype

102 icated these results in 2,341 male-male half-sibships, in which, controlling for clustering within fa

103 ed to partition the population into complete sibships, including, if known, prior knowledge of the di

104 , can reach the same power for parentage and sibship inferences as the highly informative marker simp

105 inate from the spurious splitting of a large sibship into two or more small sibships.

106 Subgroups were formed by dividing the sibships into a group with a positive family history (FH

107 rom the spurious fusion of two or more small sibships into a single sibship, and type II errors origi

108 fixed effects) analysis of variance in which sibship is the random factor, marker genotype is the fix

109 asymptotically equivalent when the number of sibships is large.

110 properties: it uses all the siblings in the sibship; it remains valid if there are misclassification

111 formation regarding linkage and exclusion in sibships larger than size 2 increased as approximately a

112 here was, however, a weak correlation at the sibship level between mean growth rate and microsatellit

113 In 207 sibships, more than 1 child had HbSS.

114 sing population- and clinic-based discordant sibships (N = 1,567 sibships) from the Colon Cancer Fami

115 maller distinct units, which will usually be sibships, nuclear families, or small pedigrees.

116 The effect of the sibship of primary reproductives on mate mortality and t

117 en a disease locus and a SNP, to accommodate sibships of arbitrary size and disease-phenotype configu

118 re variation that are applicable to affected sibships of arbitrary size and that do not require genot

119 The proposed test is naturally applicable to sibships of arbitrary size.

120 ive some suggestions regarding how to weight sibships of different sizes, in forming an overall stati

121 lic and multiallelic markers, as well as for sibships of different sizes.

122 comparisons, the authors selected the 1,721 sibships of full brothers that included at least 1 male

123 roximately all possible pairs n(n-1)/2 up to sibships of size 6.

124 We considered sibships of sizes two through five, 27 different genetic

125 We considered sibships of sizes two through four, four different exten

126 o choose statistics for studies that include sibships of various sizes.

127 ther both sexes are monogamous to infer full sibships only or only one sex is polygamous to infer ful

128 asing either the number of affected sibs per sibship or the number of unaffected control sibs.

129 measures either among all individuals, among sibships or among individuals within sibships.

130 nt linkages were found in an analysis of all sibships or in an analysis restricted to discordant sib

131 were randomly distributed among children in sibships (P =.0012).

132 eters well-provided that the total number of sibship pairs in the pedigree data is reasonably large,

133 of both sexes being polygamous to infer full sibships, paternal half sibships, and maternal half sibs

134 For example, within a sibship, presumed full sibs actually might be MZ twins,

135 In addition, sibship reconstruction allows the estimation of populati

136 Most current methods for sibship reconstruction from microsatellite data use stat

137 existing techniques indicate that the use of sibship reconstruction is superior to earlier methods, h

138 original and improved likelihood methods in sibship reconstruction of a large sample of individuals

139 In sibship reconstruction, type I errors come from the spur

140 of errors made by the likelihood methods in sibship reconstruction, using both analytical and simula

141 bjects and 634 white subjects in 215 and 265 sibships, respectively).

142 e and association analyses for simple random sibship samples, under the variance-components model pro

143 In affected sibship samples, we show that, by carefully selecting si

144 n expected by chance, among the members of a sibship segregating fragile X.

145 These global findings on sibship size and childhood asthma, rhinoconjunctivitis a

146 nd mutual adjustment for family composition (sibship size and/or birth order).

147 ositively associated (P < 0.0001) with total sibship size in both age groups.

148 ge of exposure to childhood infection, while sibship size may be a proxy for the probability of expos

149 (mean age, 72.4 +/- 7.4 years), the average sibship size was 2.7 per family.

150 Average AA and CA sibship size was 2.73.

151 ts by clinical and neuropathologic features, sibship size, and APOE genotype.

152 The authors examined whether birth order, sibship size, and childhood housing density affect risk

153 al heritability, recombination distance, and sibship size, using fixed-size sampling.

154 nal efficiency is not affected by increasing sibship size.

155 eness; exposure to parental psychopathology; sibship size; birth order; and gender.

156 ies with exceptional longevity, satisfactory sibship sizes and numbers of living siblings, and high a

157 sample size and power, allowing for varying sibship sizes, ascertainment criteria, and genetic model

158 , the same statistics performed well for all sibship sizes.

159 rovement on the likelihood methods to reduce sibship splitting, and thus type II errors by downscalin

160 also illustrates the potential complexity of sibship studies and the challenges they present for appr

161 lly and understanding their genetic risk via sibship studies will provide crucial insight into progre

162 dating allele frequencies with reconstructed sibships taken into account, by allowing for the use of

163 a minimal pedigree connecting those affected sibships that are in the database and determine the most

164 The fixed-effects regression analysis of the sibships that included both twins and singletons showed

165 In large sibships, the new method is slightly more powerful than

166 ratio (lambda*S) estimated by restriction of sibships to those ascertained through a proband who alre

167 nd linkage analysis of DNA samples from four sibships, we identified an approximately 2-cM interval o

168 studies of complex diseases sampled affected sibships, we propose a strategy for association testing

169 The parents of this sibship were recently included in an exome sequencing pr

170 These sibships were a subset of 322 sibships who had participa

171 A total of 501 sibships were included in the regression analysis.

172 hese techniques allow reconstruction of half sibships when some or all of the maternal genotypes are

173 del fitting was performed on 2658 unselected sibships, which provided evidence for a single common fa

174 These sibships were a subset of 322 sibships who had participated in a previous linkage stud

175 ens and Spielman extended the TDT for use in sibships with at least one affected and one unaffected i

176 equire parental data but requires discordant sibships with at least one affected and one unaffected s

177 This analysis included all sibships with at least one parous woman and at least one

178 There were 1,088 people from 488 sibships with at least two siblings who could contribute

179 clear factor 4-a (HNF-4alpha) in 64 affected sibships with evidence for high chromosomal sharing at i

180 Ordered subset analyses based on sibships with extreme mean values of diabetes-related qu

181 xamined the effects of various treatments of sibships with multiple affected individuals.

182 Designs including sibships with multiple affected sibs are typically the m

183 cted sibs and was based on DNA pooling), for sibships with one affected child.

184 Finally, we also demonstrate that for sibships with parents, only the parents require individu

185 These designs include sibships with parents, sibships without parents, and use

186 gnificantly different between singletons and sibships with stroke.

187 For example, for sibships with three affected, one-third fewer families a

188 ples were studied: (a) 1,184 subjects in 317 sibships, with 243 markers typed by the Utah Molecular G

189 e analysis in an initial set of 90 multiplex sibships, with parents, containing 97 independent affect

190 g application of the principle of the TDT to sibships without parental data.

191 These designs include sibships with parents, sibships without parents, and use of unrelated controls.

192 For sibships without parents, but with unaffected as well as

193 For sibships without parents, this test is analogous to the