ライフサイエンスコーパス: side chain

1 n proximal ADP-ribose and a given amino acid side chain.

2 5 because of the inherent flexibility of its side chain.

3 d, and a Yamaguchi esterification to set the side chain.

4 motif depend on the nature of the amino acid side chain.

5 es a reactive azide moiety in its amino acid side chain.

6 s exchanged between the polymer backbone and side chain.

7 a-carboxyl-linkages to the growing glutamate side chain.

8 a sterically hindered alpha-chiral aliphatic side chain.

9 tion with 3-deoxy-glucosone at the guanidine side-chain.

10 interaction generated by the six cyclohexyl side chains.

11 table scaffold with optimized alkyl ammonium side chains.

12 a a set of hydrogen bonds between disordered side chains.

13 altered solvent accessibility of amino acid side chains.

14 itatively equivalent to that between dynamic side chains.

15 strong steric hindrance of bulky ethylhexyl side chains.

16 aves ubiquitin moieties that have free Lys48 side chains.

17 row tunnel, which excludes larger amino acid side chains.

18 cessible surface area (<SASA>) of amino acid side chains.

19 toids containing only alpha-chiral aliphatic side chains.

20 re of the electronic transitions of aromatic side chains.

21 n rate constants favors randomly distributed side chains.

22 ic lipids with defined head groups and lipid side chains.

23 ion, number, and nature of their hydrophobic side chains.

24 ride can specifically interact with aromatic side chains.

25 he steric bulk of both N(alpha)- or C(alpha)-side chains.

26 llowing the accommodation of bulky inhibitor side chains.

27 onments to tune the reactivity of amino acid side chains.

28 are possible for all the aromatic amino acid side-chains.

29 terminal 1,2-fucosyl residues to xyloglucan side chains - a key step in the biosynthesis of fucosyla

30 Unlike other macrolides, which carry several side chains, a single desosamine sugar is attached to th

31 ersible light-switching of single amino acid side-chains, adding a dynamic dimension to protein site-

32 at pHs of 4.5-6 reveal the repositioning of side chains along one side of the FeMo-cofactor, and the

33 The orientation of the glutamine side chains also tend to be "buried" inside, explaining

34 ially because of hydrogen bond networks from side chain amides forming extended Asn/Gln ladders.

35 sentially investigated with peptoid aromatic side chains, among which the chiral 1-naphthylethyl (1np

36 ants of TP2 with shorter and longer arginine side-chain analogs translocate slower than TP2.

37 critical interactions between the inhibitor side chain and amino acids of the active site of DNA top

38 acids [beta-Caa(l)] with a d-lyxo furanoside side chain and beta-hGly in 1:1 alternation.

39 g to withaferin A class with a beta-oriented side chain and demonstrated that the 17-BHW scaffold can

40 (CCP) family that metabolizes polyglutamate side chain and its loss results in neurodegeneration and

41 distinct interactions at 4.7 A between Phe1 side chain and perfluoroaryl electrophile moiety are obs

42 cyclodehydration between a Cys, Ser, or Thr side chain and the backbone carbonyl carbon to form a th

43 uctural analyses showed an increase in polar side chains and a decrease in hydrophobic side chains li

44 The deconstruction of rhamnogalacturonan-II side chains and backbone are coordinated to overcome ste

45 stituents were introduced ortho to the upper side chains and compared to a control to test our hypoth

46 analysis unveiled the exact position of the side chains and explains their extensive contribution to

47 ckbone with greatly reduced alpha1-2-mannose side chains and no arabinose caps.

48 opy dynamics of the corresponding tryptophan side chains and observed two distinct relaxations from t

49 ficance of the observed patch of carboxylate side chains and resulting metallocluster for biominerali

50 e modified with chondroitin/dermatan sulfate side chains and tends to oligomerize to form higher aggr

51 end on steric constraints on nascent peptide side chains and that confined movements of cramped side

52 tides, including their chemical diversity of side chains and their ability to form secondary structur

53 er other amino acids containing nucleophilic side chains and was applicable to the conjugation of a v

54 reactivity toward Lys and, particularly, Tyr side chains, and can be used to target nonenzymes (e.g.,

55 on on molecular engineering (e.g., backbone, side chains, and substituents), then the discussion move

56 oss), and its reactivity with epsilon-lysine side chains ( approximately 40.77% loss).

57 ved performance of EFCs containing the short side chain Aquivion ionomers relative to Nafion is trace

58 A set of recently available short side chain Aquivion ionomers spanning a range of equival

59 a 3-fluoro-2-(phosphonomethoxy)propyl (FPMP) side chain are known to be moderately potent antihuman i

60 revealed that 17-BHWs with a alpha-oriented side chain are superior to known TRAIL-sensitizing witha

61 However, in reality, side chains are attached to the peptide backbone and sur

62 Furthermore, as the side chains are constructed chemically, many unnatural m

63 nificant variety of biologically relevant AA side chains are tolerated including those for alanine, v

64 Complex sterols with modified side chains are unique to eukaryotes, although simpler s

65 olines with dibenzylmethylamine (dibemethin) side chains, are efficacious.

66 h a nonpolar domain formed by six cyclohexyl side chains arranged along one side of the 14-helix.

67 due that has been proposed to flip its amide side chain as a critical step in the propagation of conf

68 The frequent observation of side chains associated with turn motifs at CDR3 position

69 em from strong interference with hydrophobic side-chain association, regardless of the residues' loca

70 variant allele (C382R) alters an amino acid side chain at a principal interface between the intramem

71 ic motif represented by a lipophilic n-octyl side chain at position 1 and a positively charged azepan

72 Mutation of the conserved small side chain at position 4.53 within packing cluster 2 is

73 g Ala(1) or His(1) and a variety of aromatic side chains at the aza-amino acid residue in the 4-posit

74 Thiol, hydroxyl, and aliphatic-based side chains at the i-1 position had higher N-glycosylati

75 vealed a more compact packing of helices and side chains at the intermonomer interface, compared to t

76 identified a band of glutamate and aspartate side chains at the lower end of the pore that enables pr

77 acetamide model compounds containing various side chains both on the N(alpha)- and C(alpha)-atoms in

78 hain electronic interactions (n --> pi*) and side chains bulkiness in promoting cis-amides was essent

79 ecreased in an E310A mutant having a shorter side chain, but the overall rates of metabolism were ret

80 operties were associated with strongly basic side chains, but the greatest in vivo antitumor activity

81 s swift modification of the phytosphingosine side chain by amidation of an advanced methyl ester prec

82 nts by dictating the mechanisms by which the side chain can reach a more favorable environment and th

83 rings (a simple model of aromatic amino acid side chains) can switch inherent dynamical tendencies fo

84 ding Zta residues Ala185 and Ser186 (via its side chain carbon Cbeta atom).

85 se activation step corresponds to subsequent side chain carbonylation, likely at Lys72/73.

86 ge system is reliable for residues that lack side chain charge.

87 structure of AMPs was distorted owing to the side-chain charge interaction.

88 spectroscopy was performed for backbone and side-chain chemical-shift assignments of monomeric pEAbe

89 We report the first direct side-chain chlorination of 3-methylbenzoate affording me

90 ituent group (electronic effect) without the side-chain conformation being affected by a stereoelectr

91 , hydrogen bonding, and dipole interactions; side-chain conformational entropy; and solvation energy

92 the pY residues cluster into three distinct side chain conformations.

93 b-states characterized by different aromatic side-chain conformations at the RNA-binding surface allo

94 urrence revealed a positively charged lysine side chain, conserved in other flavin mediated oxidoredu

95 elf-assembly triples the extent of non-polar side chain contacts.

96 thyl amine)), semi-fluorinated monomers with side chains containing between three and 21 fluorine ato

97 Homology modeling suggested that the Glu-221 side chain could sterically hinder insertion of the N te

98 Minute differences in the side chains could be distinguished, and affinities up to

99 more, it may be speculated that this pair of side chains could promote oligomerization of kalata B1 t

100 Teixobactin is a head to side chain cyclodepsipeptide that contains two positive

101 ng of the delta1 methyl groups of isoleucine side chains demonstrates that, in solution, NS5BDelta21

102 ds incorporate 13 different amine-containing side chains designed to bind in the minor groove of DNA

103 Bisbenzimidazoles with alkynyl side chains display excellent E. coli DNA topoisomerase

104 regimes with controlled grafting density and side chain distribution, molecular attributes that dicta

105 trol the backbone sequence and therefore the side chain distribution.

106 here the peptoid group enabled us to explore side-chain diversity well beyond that of natural amino a

107 phosphate synthases), the large, hydrophobic side chain does not occupy a central hydrophobic tunnel.

108 While the variation of the side chains does not alter the photoconductive propertie

109 the use of a new 2D IR probe to measure the side chain dynamics in a protein and also illustrates th

110 without conformational changes, where distal side-chain dynamics is modulated on ligand binding and t

111 gnificantly, two highly conserved asparagine side chains, each one located between two tryptophan res

112 The prominent role of backbone to side chain electronic interactions (n --> pi*) and side

113 shape and functionality of the noncanonical side chain enabled the active site to be remodeled to en

114 E310D and E310Q substitutions having longer side chains exhibit lower overall rates, likely due to h

115 Random oxidative modification of cryptic side chains exposed by mechanical unfolding can be slowe

116 and that a conformational switch of aromatic side-chains fine-tunes sequence specific binding affinit

117 lations while changing the nature of the Xaa side chain finely tuned the conformers ratio.

118 leads to an unanticipated increase in methyl side-chain flexibility and thus stabilizes the complex e

119 fects tune non-covalent interactions between side-chain fluorinated benzyl esters and main-chain term

120 ory shows that, among others, degradation of side-chain fluorinated polymers in the environment and l

121 folded conformation defined by the isoprenyl side-chain folding back over the napthoquinone in a U-sh

122 in the peptide changes a highly unfavorable side chain for the p9 pocket to an optimal one that is d

123 eneric platform to target other redox-active side chains for native conjugation.

124 ydrophobic interface is stabilized by apolar side chains from adjacent sheets, whereas the hydrated p

125 f which were in steric zipper segments where side chains from amino acids tightly interdigitate in a

126 de of the helix was dominated by three polar side chains, from beta(3)-homolysine (K) and/or beta(3)-

127 te binding, correct juxtaposition of protein side chain functional groups, and transition-state stabi

128 , producing polysulfonates with a variety of side chain functionalities in >99 % conversion within 10

129 ynthesis of unnatural amino acids with small side-chain functionalities usable for further transforma

130 Directed chemical design via side-chain functionalization with polar groups allows ma

131 ics, d-arabinopyranose (d-Arap) caps the LPG side-chain galactose residues, blocking interaction with

132 ncrease the average distance between grafted side chains, generating polymers with variable grafting

133 en reported for rapidly exchangeable peptide side-chain groups in bulk measurements using stopped-flo

134 ydrogen bonding with the amide groups in the side chains has to be contrasted with the hydration inte

135 ges, is primarily accomplished by tuning the side-chain hydrophobic or ionic interactions.

136 Zta Ser186 (a unique residue for Zta) whose side chain hydroxyl oxygen atom interacts with the two h

137 rty describing the energetics of an isolated side chain in the bilayer.

138 tional transitions of a conserved tryptophan side chain in the LBD that trigger reorganization of the

139 erminal carboxylate of ubiquitin to a lysine side chain in the protein substrate.

140 y despite the presence of only 50% of chiral side chain in the sequence.

141 nts suggest interactions between hydrophobic side chains in a pi-clamp mutant and the perfluoroaryl p

142 pY conformation which places two adjacent pY side chains in a specific relative orientation.

143 se (Hyp-beta1,4Araf-beta1,2Araf-beta1,2Araf) side chains in an alpha-linkage, to yield Hyp-Araf4 whic

144 n supporting the importance of these charged side chains in fibril formation of betaS.

145 bations to measure coupling energies between side chains in molecular switches that mediate shear dur

146 ei procyclic forms have truncated GPI anchor side chains in TbRFT1 null parasites when compared with

147 the peptide backbone and surrounded by other side chains in the protein scaffold in biology, which ma

148 ity of TRPV6 arises from a ring of aspartate side chains in the selectivity filter that binds Ca(2+)

149 Here, we delineate side chains in the telomerase active-site cavity importa

150 estimate the surface exposure of amino-acid side-chains in the variable region directly from the ant

151 n also be directly introduced as part of the side chain, including isotope reporters (19F, 13C) that

152 In the N139L mutant, the bulky L139 side chain inhibits timely reprotonation of E286 through

153 to enable intersheet association mediated by side chain interactions, which is characteristic of the

154 this internal redistribution and rewiring of side-chain interactions led to large cancellations resul

155 ealed a binding mode involving side-chain-to-side-chain interactions that reduced the distance the an

156 embrane proteins fold involves the burial of side chains into lipid bilayers.

157 ycin analog lacking the hydroxymethyl ring I side chain is considerably less active than the parent.

158 At pH 10.5, where the K side chain is largely uncharged, we measured hydrophobic

159 with four or eight pendant 1,2,3-triazolium side chains is described.

160 uences, through which a subset of the native side chains is displayed on an unnatural building block

161 ither oligodimethylsiloxane (oDMSi) or alkyl side chains is unraveled by combining experimental and t

162 Throughout, the impact of PFSA chemistry and side-chain is also discussed to present a broader perspe

163 yl, can be formed by rotation of an arginine side chain, leaving the intermolecular interface otherwi

164 ecificity of KMTs is highly sensitive to the side chain length of the residue to be methylated.

165 es show similar variation dependent upon the side chain length.

166 hitectural parameters-network strand length, side-chain length and grafting density.

167 ase in rate constants with increasing carbon side-chain length.

168 e properties near the catalytic copper, i.e. side chains likely to be involved in substrate positioni

169 ar side chains and a decrease in hydrophobic side chains lining the vestibule, and this was reflected

170 n the plasma membrane that govern amino acid side-chain-lipid interactions.

171 he forward reaction and how metals or enzyme side chains may interact with the network to modulate th

172 ns caused by chiral inversions of amino acid side-chains may be especially valuable in elucidating th

173 Aromatic amino acid side chains mediate most coat-internal scaffolding prote

174 , a conformational change of the carboxylate side chain metal ligand to allow for hydrogen bonding wi

175 We discovered that the placement of a single side chain methyl group at specific positions in a trapt

176 We conclude that these clamping side chains minimize the Gibbs free energy for substrate

177 heir monomers were examined as a function of side-chain modification and pi-extension.

178 so glycosylphosphatidylinositol (GPI) anchor side-chain modification.

179 n backbone-modifying activity, rather than a side-chain-modifying one.

180 n DeltaDeltaGsc(o) for more than half of the side chains, most of which are polar residues.

181 tative relationship between measures of fast side-chain motion and the underlying conformational entr

182 From the picosecond side chain motions to aggregates that form over the cour

183 orylation was found to block some nanosecond side-chain motions while increasing the flexibility of o

184 Protein side-chain mutation is fundamental both to natural evolu

185 ermodynamic effects of, for example, protein side-chain mutations.

186 The grafting density (number of side chains/number of norbornene backbone repeats) could

187 This is coupled with a flip of the side chain of Arg48 which ties down the key catalytic dy

188 sidues (I170 and L230), over the carboxylate side chain of E165.

189 mono-l-glutamine is covalently linked to the side chain of glutamate 45 in eEF1A.

190 loop" required for AMP binding releases the side chain of His23 from the dimer-dimer interface.

191 The side chain of histidine-123 in the MIO domain dictated t

192 ggests that oxidation by Mical reorients the side chain of M44 and induces a new intermolecular inter

193 The induction effect of the side chain of N-terminal Asp reduces the basicity of the

194 nity analog ML418, suggesting that the polar side chain of T153 creates a barrier to low-affinity lig

195 es establish that modification of the lactam side chain of the 7-azaindenoisoquinolines can modulate

196 -heterocycle interaction between the Lys-155 side chain of the double substitution, R155K/D168A, and

197 is modification is to lock the hydroxymethyl side chain of the neomycin or paromomycin ring I, as par

198 lectivity filter is lined by the carboxylate side chains of a functionally important glutamate and th

199 the Trp243 residue positions the amino acid side chains of Arg161 and Glu127 in specific orientation

200 a1,4-d-glucuronic acid linkage that caps the side chains of complex AGPs.

201 were extensively bound to GlcNAc through the side chains of cysteine residues in human cells, and the

202 00 of NhaA to amino acid residues containing side chains of different polarity and length (i.e. Ala,

203 mid-chain mechanism that targets the acidic side chains of E46 and E83.

204 arbohydrate-binding interface comprising the side chains of four tryptophan residues in a co-planar l

205 amino or hydroxyl groups mimicking the bound side chains of neomycin and paromomycin, respectively, s

206 readily form Schiff-base conjugates with Lys side chains of nuclear proteins in vitro and in vivo.

207 gosaccharides related to the arabinogalactan side chains of pectin as novel biochemical tools to dete

208 In molecular dynamics simulations, the side chains of residues coordinating the zinc rearrange

209 nucleophilic functional groups, such as the side chains of serine and cysteine, using electrophilic

210 The side chains of several amino acids can be oxidized to re

211 ion, we demonstrate that Wnts bind to the HS side chains of syndecan-1 and that this binding contribu

212 gar and the protein are intact, although the side chains of the binding-site residues were not restra

213 ha-(1'-fluoro)vinyl amino acids, bearing the side chains of the cognate amino acids.

214 bility of beta-linked d-Galp residues in the side chains of the molecules.

215 aryotic ubiquitin-like protein Pup to lysine side chains of the target protein via an isopeptide bond

216 Orientations of aromatic side chains of these complexes are distinctive, suggesti

217 an adhesive patch formed by stacking of the side chains of two arginine residues and by salt bridges

218 formational change, which helps position the side chains of two key hydrophobic residues (I170 and L2

219 on binding to K2hPg sterically optimizes the side chains of VKK38 for maximal binding to K2hPg and mi

220 and emphasizes the key role of the C(alpha)-side chain on the conformational preference of the foldi

221 ive and specific modification of sialic acid side chains on erythrocyte surfaces with mild sodium met

222 en-bonded network and salt bridges involving side chains on ligand binding.

223 ns while increasing the flexibility of other side chains on the faster timescale.

224 the effects from different cross-conjugated side-chains on the physical and electronic properties of

225 imple adamantyl core structure with acrylate side chains optimized for cellular antagonist activity.

226 often a hydrolysis reaction - in the polymer side chain or backbone.

227 o the nitrogen atom (N-linked) of asparagine side chains or to the oxygen atom (O-linked) of serine a

228 on the question of how changes in amino acid side-chain orientation, and the resultant alterations in

229 comes from kinase group and family specific side chain orientations.

230 all-atom statistical potential derived from side-chain packing, named OPUS-DOSP, for protein structu

231 along the long axis of the crystal with the side chains perpendicular to the long axis.

232 We report ncAAs with aryl carbamate side chains (PheK and FPheK) that can react with proxima

233 Notably, a phenylalanyl side chain pointing toward the metal may hinder such a f

234 Some compounds with side chain polar groups had particularly high affinities

235 ntribution of charge at a conserved arginine side chain previously suggested to form a salt bridge wi

236 Here, we use side-chain proton NMR relaxation dispersion measurements

237 on donor) and glycine acetamide of the lower side chain (proton acceptor).

238 ied between the NH amide proton of the upper side chain (proton donor) and glycine acetamide of the l

239 tion for the complete homologous series with side chains ranging from 3 to 33 carbons.

240 bility and potency, whereas more hydrophilic side chains reduced VL activity.

241 etween interresidue contacts and accompanied side-chain reorientations that drive the major redistrib

242 Mutant receptors with a variety of side-chain replacements still accessed both the ON and O

243 ygen atom (O-linked) of serine and threonine side chains represent the two major protein glycosylatio

244 epts a hydrogen-bonding interaction from the side chain residue of Asn315.

245 e of a lack of negatively charged amino acid side-chain residues that would enable efficient ionizati

246 This is the first known example of a side chain self-assembled chromophore formed due to prot

247 e groups, when incorporated onto polypeptide side-chains, serve as both H-bond donors and acceptors a

248 Doped with NOBF4, PQTS12 (with sulfur in side chains) shows a conductivity of 350 S cm(-1), the h

249 tamine's side chains with significantly more side chain-side chain H-bonds than regular proteins in t

250 rsions are subtle in that they do not change side-chain size, flexibility, hydropathy, charge, or pol

251 itro barrel assembly, because they exhibit a side chain-specific energetic contribution determined by

252 Combined screening for m/z 130.1 along with side chain-specific J1 [M - 173](+) and J2 [M - 291](+)

253 work, we studied the effect of inverting the side chain stereochemistry of individual Thr or Ile resi

254 culate the free energy cost of inverting the side-chain stereochemistry of individual Thr or Ile resi

255 etic resonance (NMR) spectroscopy in protein side-chain structural studies offers unique advantages o

256 es available at that time, reported that the side chain structures of phosphorylated tyrosine (pY) ar

257 all-phenylene backbone and different alkoxy side chain substitution patterns were synthesized using

258 s requires the atomic-level orchestration of side chains, substrates and cofactors, and yet the abili

259 Relevant side chains such as trehalose, lactose, glucose, carboxy

260 electively a very stringent set of aliphatic side chains such as valine, leucine, and isoleucine of p

261 Because 4-aminoquinolines with modified side chains, such as AQ-13, are active against resistant

262 n-bond interactions with the ubiquitin Lys48 side chain, suggesting that USP7 preferentially interact

263 tabolites functionalized with cis-amide acyl-side chains, termed pepteridine A (1) and B (2).

264 ein scaffold affects the DeltaDeltaGsc(o) of side chains that are buried in unfavorable environments

265 kbone accommodate the introduction of lysine side chains that form stabilizing salt-bridge interactio

266 which contains heteroaromatic links between side chains that give it a rigid polycyclic globular str

267 noxylan backbone is decorated with arabinose side chains that may be substituted with ferulic acid, t

268 uxtaposition of pyroglutamate pE3 and the F4 side chain (the "pEF head") confers a pronounced bulky h

269 ar translocation, is replaced with a neutral side chain, the pH effect is abolished, and high-affinit

270 When bearing an orthogonal group on the side chain, the polysulfonates can be further functional

271 ables the programmed installation of protein side chains through the use of rapid, mild and operation

272 radentate siderophores using a His and a Tyr side chain to complete the Fe(III) coordination.

273 de and diallyl trisulfide can transfer allyl side chains to low molecular weight thiols.

274 ing the precise chemical contribution of Arg side chains to protein function and pharmacology has pro

275 Stapling of side chains to stabilize an alpha-helical structure has

276 olded V1V2 revealed a binding mode involving side-chain-to-side-chain interactions that reduced the d

277 embrane proteins depend on the magnitudes of side-chain transfer free energies (DeltaDeltaGsc(o)).

278 by altering the donor-acceptor properties of side-chain triazole units via protonation-deprotonation.

279 we explored alternatives to the acrylic acid side chain used in many antiestrogens.

280 time scale, specificity for protein residue side chains vs backbone as well as selectivity for diffe

281 irecting effect of the 1,2,3-triazolium-type side chain was studied on dimeric peptoid models with va

282 s a 2-acetylphenylboronic acid moiety as its side chain, was found to incorporate into several bacter

283 (K side chain) with a primary amide group (Q side chain) weakens the hydrophobic interaction generate

284 Quinolones containing the amine-based side chain were selected as the pharmacophore for furthe

285 Specifically, 13 different noncanonical side chains were incorporated at 12 different positions

286 bz-protected amino acids bearing hydrophobic side chains were prepared in good to excellent yield by

287 antoin core, with unique heterocycles on the side chains were synthesized as potential noncovalent in

288 hain hydrogen bonding with human CRM1 Lys568 side chain, which acts as a specificity filter that prev

289 ration of O-acetyl esters on the sialic acid side chain, which can occur at colonic pH, may serve as

290 6 position with a para-substituted phenethyl side chain, which could be exploited to obtain cRGD-base

291 in their structure of an extended alkyl-aryl side chain, which establishes idiosyncratic interactions

292 and electrostatic repulsions between acidic side chains, which collectively drive a sharp pH-trigger

293 e polymer, with N-acetylglucosamine (GlcNAc) side chains, which is an essential virulence determinant

294 ng aldoximes containing chemically different side chains, whose break-down products are involved in s

295 rsely, the protein interaction of the Tg O-2 side chain with SPCA1a appears comparable with that of S

296 e to the "glue-like" behavior of glutamine's side chains with significantly more side chain-side chai

297 ng suggests that replacing an amine group (K side chain) with a primary amide group (Q side chain) we

298 1473 occupies the position of a canonical pY side chain, with the combination of pT and Y mimicking a

299 s both with agonist and with a conserved Thr side chain within the receptor.

300 hains and that confined movements of cramped side chains within and through the tunnel fine-tune elon