ライフサイエンスコーパス: siderophore

1 imide formation influence its function as a siderophore.

2 xes with enterobactin, the conserved E. coli siderophore.

3 ovides access to structural analogues of the siderophore.

4 acid, a compound that resembles a bacterial siderophore.

5 used as a phosphate storage compound or as a siderophore.

6 unlikely that that MC-LR is an extracellular siderophore.

7 ing step in the biogenesis of the eukaryotic siderophore.

8 bolites, including folates, menaquinone, and siderophores.

9 rations (1-2 pM) of hydrophilic ferrioxamine siderophores.

10 or its ability to use dozens of heterologous siderophores.

11 defenses distinguishes it from other E. coli siderophores.

12 ter they have lost the ability to synthesize siderophores.

13 st because Mtb cannot use iron salts without siderophores.

14 at bacteria use both mammalian and bacterial siderophores.

15 o metal charge transfer and/or reaction with siderophores.

16 yi may produce amphiphilic enterobactin-like siderophores.

17 f and also can be stimulated by Lcn2-evasive siderophores.

18 s capable of binding iron via catechol-based siderophores.

19 ample is the production of metal-detoxifying siderophores.

20 eric human pathogens that do not produce any siderophores.

21 ration of salicylic acid into the mycobactin siderophores.

22 ron using strain-specific chelators known as siderophores.

23 oire of iron-chelating moieties in microbial siderophores.

24 ) were screened for their ability to produce siderophores.

25 Anchoring a simple siderophore 2,3-dihydroxybenzoylglycine (H3L), which bea

26 ting step in the biogenesis of the mammalian siderophore 2,5-dihydroxybenzoic acid (2,5-DHBA).

27 -delivered iron was used, but the deferrated siderophores accumulated intracellularly, indicating a b

28 Toxic siderophore accumulation is prevented by a drug that inh

29 cess to iron and causing toxic intracellular siderophore accumulation.

30 e regions are enriched for genes involved in siderophore acquisition, and are widely distributed in c

31 mutant had a milder defect in extracellular siderophore activity and induction of epithelial cell da

32 nd concentration, protein binding of the apo-siderophore acts to dramatically enhance the iron exchan

33 The siderophore aerobactin is the dominant siderophore produ

34 These siderophores affect iron bioavailability and thus may be

35 tes E. coli biosynthesis of the enterobactin siderophore, allowing E. coli growth and biofilm formati

36 ting amount of siderophores than iron-loaded siderophores alone.

37 Siderophores also have the ability to activate plant imm

38 igned and synthesized conjugates of a native siderophore and the immunogenic carrier protein cholera

39 gh-affinity Fe(III) binding ligands known as siderophores and a cell-associated metalloreductase that

40 lead to altered concentrations of mycobactin siderophores and acylated sulfoglycolipids.

41 at VirR directly regulated the production of siderophores and controlled swimming motility.

42 simple gallium salts as well as more complex siderophores and hemes are potential carriers to deliver

43 ere stimulated with combinations of purified siderophores and Lcn2 and analyzed by gene expression mi

44 une response that targeted bacterial stealth siderophores and protected against UTI.

45 n the presence of common microbial exudates, siderophores and small organic acids.

46 ate immunity protein that binds to bacterial siderophores and starves them for iron, thus representin

47 These siderophores and synthetic analogs exhibit robust adhesi

48 small molecules as biomarkers: 2 mycobactin siderophores and tuberculosinyladenosine.

49 obed in the total synthesis of salmochelins (siderophores) and commercial anti-diabetic drugs (gliflo

50 n, inner membrane LbtB aids in export of the siderophore, and outer membrane LbtU and inner membrane

51 Modifications to the monocarbam linker, siderophore, and oxime portion of the molecules were exa

52 The MST enzymes (menaquinone, siderophore, and tryptophan biosynthetic enzymes) are st

53 Listeria does not secrete siderophores, and additionally, the siderophore secreted

54 that inhibits bacterial uptake of iron-laden siderophores, and by suppressing the ferritin iron pool.

55 on by heavy metals - a detoxifying effect of siderophores, and exploitation of this detoxifying effec

56 sition by bacteria that use catecholate-type siderophores, and lipocalin 2(-/-) mice are highly susce

57 the CTB-siderophore conjugate developed anti-siderophore antibodies in the gut mucosa, and when mice

58 lectively, our results demonstrate that anti-siderophore antibodies inhibit Salmonella colonization.

59 iron may be removed upon import of the holo-siderophore are presented.

60 Siderophores are high-affinity iron chelators produced b

61 Over 500 siderophores are known, but they utilize a small set of

62 Because siderophores are nonimmunogenic, we designed and synthes

63 Hydrophilic siderophores are predominantly found across regions of t

64 Siderophores are small iron-binding molecules secreted b

65 Siderophores are specific ferric iron chelators synthesi

66 In addition to Fe, A. vinelandii siderophores are used for the acquisition of the nitroge

67 Because their cognate siderophores are water soluble, we hypothesized that the

68 ithiocin, a natural product iron chelator (a siderophore), as a platform for structure-activity relat

69 Second, B. subtilis synthesizes its own siderophore bacillibactin (dhbACEBF) and turns on bacill

70 Certain siderophores-bacterial iron chelators-consist of paired

71 gens, blocking microbial iron acquisition by siderophore-based immunization or other siderophore-targ

72 This siderophore-based mechanism of microbial antagonism may

73 ntage is counter-regulated by lipocalin 2, a siderophore-binding host protein, which rescues MPO from

74 nd fecal concentrations of the antimicrobial siderophore-binding peptide Lipocalin-2 (Lcn2) are obser

75 Here we show that siderocalin, a mammalian siderophore-binding protein from the lipocalin family, s

76 r iron theft by Ent, neutrophils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug

77 Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iro

78 g ability of outer-membrane transporters and siderophore-binding proteins for Fe-siderophores has bee

79 e transporters and Gram-positive lipoprotein siderophore-binding proteins have been characterized, an

80 In response, the host secretes siderophore-binding proteins, such as lipocalin 24p3, wh

81 f ferribactin to pyoverdine is essential for siderophore biogenesis in fluorescent pseudomonads, such

82 siologically relevant mode of regulation for siderophore biosynthesis in vivo.

83 Siderophore biosynthesis is essential for the virulence

84 Addition of iron salts to an Mtb siderophore biosynthesis mutant stimulated more growth i

85 e enzymes are also regarded as essential for siderophore biosynthesis.

86 ulation is prevented by a drug that inhibits siderophore biosynthesis.

87 horismate and salicylate synthase enzymes of siderophore biosynthesis.

88 ms a separate clade with homologs from other siderophore biosynthetic gene clusters and is representa

89 tes iron-exchange from Fe-siderophore to apo-siderophore bound to the protein, the first Gram-positiv

90 ory functions dependent on being loaded with siderophore-bound iron (holo-form) or not (apo-form).

91 e was known to use reductive iron uptake and siderophore-bound iron transport to scavenge iron from t

92 inflammation, in addition to stabilizing the siderophore-bound labile iron pool.

93 Depletion of the mammalian siderophore by inhibiting expression of bdh2 results in

94 ample of such a scenario is the secretion of siderophores by bacteria into their environment to fetch

95 We confirmed the selective benefit of siderophores by showing that taxa producing large amount

96 that the production of fewer iron-scavenging siderophores by the pathogen reduces the fitness of the

97 The ferric-siderophore complex limits local access to iron because

98 nt for the uptake of structurally similar Fe-siderophore complexes like Fe-aerobactin.

99 llium nitrate, maltolate, and simple gallium siderophore complexes such as gallium citrate have shown

100 ation of a suite of eight amphi-enterobactin siderophores composed of the cyclic lactone of tris-2,3-

101 Siderophore concentrations in iron-deficient waters aver

102 Mice immunized with the CTB-siderophore conjugate developed anti-siderophore antibod

103 test this hypothesis, we immunized mice with siderophores conjugated to an immunogenic carrier protei

104 istant Pseudomonas aeruginosa, we focused on siderophore-conjugated monocarbams.

105 Siderophore conjugates are thus a promising strategy for

106 Our results suggest that siderophores could partly chelate Fe(III) in cloud water

107 aliana) plants after leaf treatment with the siderophore deferrioxamine (DFO).

108 isms secrete small molecule chelators called siderophores defined by their ability to bind extracellu

109 ores were taken up by the export mutant, and siderophore-delivered iron was used, but the deferrated

110 For a variety of organic acids and siderophores, delta(53)Cr values of dissolved Cr(III) ar

111 able, under mild aqueous conditions, using a siderophore derivative.

112 The presence of the siderophore desferrioxamine B (a strong Mn(III)-complexi

113 rom minerals by examining the effects of the siderophore desferrioxamine B (DFOB) on Fe removal from

114 YxeB binds ferrioxamine B (FO, Fe-siderophore)/desferrioxamine B (DFO, apo-siderophore) in

115 In the presence of a representative siderophore, desferrioxamine B (DFOB), iron (Fe) was rel

116 The two siderophores differ in structure only by a lipophilic al

117 o-hydroxyphenylacetic) acid, indicating that siderophores eliciting activities rely on their strong i

118 Ornibactin and malleobactin are hydroxamate siderophores employed by human pathogenic bacteria belon

119 of this idea, supplementation with mammalian siderophore enhances bacterial growth in vitro.

120 bind the Fe(III) complex of the hexadentate siderophore enterobactin (Kd approximately 0.4 +/- 0.1 m

121 lC mutants synthesize but cannot secrete the siderophore enterobactin, which collects in the periplas

122 erric iron uptake or the ferric iron binding siderophores enterobactin and salmochelin are required f

123 recognition of its cognate ligand, the iron siderophore enterochelin, this protein can capture and t

124 These pathogen-associated stealth siderophores evade host immune defenses and enhance bact

125 ransporters MmpL4 and MmpL5 are required for siderophore export and virulence in Mtb.

126 This study indicates that targeting siderophore export/recycling would deliver a one-two pun

127 eport that enterobactin (Ent), a catecholate siderophore expressed by Escherichia coli, inhibited PMA

128 lic siderophore, which resembles a bacterial siderophore, facilitates mitochondrial iron import in eu

129 responsible for iron acquisition related to siderophores (fepA, fhuA, fecA, iroN, fyuA, iutA).

130 s a key role in transporting the catecholate siderophore ferric enterobactin from the outer to the in

131 respond to the presence of the heterologous siderophore ferrioxamine in the environment.

132 orter (TBDT) that actively imports the small siderophore ferripyoverdine (Fe-Pvd) by coupling to the

133 ns on bacillibactin (feuABC) and hydroxamate siderophore (fhuBCGD) uptake systems to scavenge iron fr

134 on towards taxa that produce relatively more siderophores following copper contamination.

135 zobium japonicum USDA110 does not synthesize siderophores for iron utilization in aerobic environment

136 er perturbed the iron-binding properties and siderophore function of SB as evidenced by experimental

137 ters and siderophore-binding proteins for Fe-siderophores has been determined.

138 ntents and even more strongly to hydroxamate siderophore (HS) concentrations.

139 One suggestion is that microcystins are siderophores (i.e., ligands with an extremely high affin

140 The roles of these siderophores in hvKP infection have not been optimally d

141 Fe-siderophore)/desferrioxamine B (DFO, apo-siderophore) in vitro.

142 t, pathogenic Gram-negative bacteria secrete siderophores, including enterobactin (Ent).

143 Modified or structurally distinct siderophores, including yersiniabactin (Ybt) and glycosy

144 Surprisingly, none of the siderophores increased growth in human urine.

145 id supplemented with exogenous siderophores, siderophores increased the growth of hvKP1DeltaiucA, wit

146 at under Fe-limitation the production of all siderophores increases, while under Mo-limitation only c

147 The biosynthetic pathways for both siderophores involve a nonribosomal peptide synthetase i

148 lated genes corresponded to the 3 recognized siderophore iron uptake clusters, reflecting the iron-re

149 a bacteriostatic factor, Lcn2 obstructs the siderophore iron-acquiring strategy of bacteria and thus

150 Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a

151 based on manipulating an endogenous protein:siderophore:iron clearance pathway.

152 reciprocal regulation of 24p3 and mammalian siderophore is a protective mechanism limiting microbial

153 a previously unreported cyclic dihydroxamate siderophore, is a chimera of two well-known siderophores

154 protein lipocalin 2, which counteracts some siderophores, is essential, given that S. Typhimurium is

155 ed to acquire this essential nutrient is the siderophore legiobactin.

156 e agent of Legionnaires' disease, secretes a siderophore (legiobactin) that promotes bacterial infect

157 over antibody based systems is the fact that siderophores like pyoverdine can be considered as "immut

158 Eukaryotes produce a siderophore-like molecule via a remarkably conserved bio

159 le of this is the deletion of the equibactin siderophore locus that is associated with iron acquisiti

160 cture to rhizoferrin, a polycarboxylate-type siderophore made by many fungi and several unrelated bac

161 that enable 'cross-feeding' on heterologous siderophores made by neighboring organisms, although lit

162 uorescent pseudomonads that are required for siderophore maturation and are capable of acting on larg

163 ding molecules and review how copper-binding siderophores may confer virulence-associated gains of fu

164 uggest that ecological selection will favour siderophore-mediated decontamination, with important con

165 search expands the existing understanding of siderophore-mediated Fe acquisition from minerals by exa

166 Because siderophore-mediated iron acquisition is a virulence tra

167 roteins, such as lipocalin 24p3, which limit siderophore-mediated iron import into bacteria.

168 pleiotropic functions mainly rely on NGAL's siderophore-mediated iron transport properties.

169 ucture: The ferric complex of a tetradentate siderophore mimic was synthesized and co-crystallized wi

170 A series of tetradentate siderophore mimics was synthesized in which the length o

171 This was attributed to the metabolization of siderophore-mobilized Fe from the nanotube structure.

172 Under conditions of iron limitation, these siderophore-modified antibiotics provide enhanced antiba

173 Wild-type (WT) P. mendocina and a siderophore(-) mutant were used to monitor siderophore -

174 tiologic agent of tuberculosis, produces the siderophores mycobactin and carboxymycobactin.

175 erium tuberculosis) produces two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cM

176 phore production reveals that investments in siderophore N can represent as much as 35% of fixed N, w

177 in nature where it serves as a precursor to siderophores, neurotoxins and antibiotics.

178 nonribosomal peptide synthetase independent siderophore (NIS) synthetase, including SbnE in staphylo

179 We identified related siderophore NRPS gene clusters that encoded modular and

180 ther in concert with soluble iron-scavenging siderophores or through direct interaction and extractio

181 Here we show that siderophores, organic compounds synthesized by microbes

182 roof of principle for the rational design of siderophore pathways, a compelling model for the evoluti

183 of both host-guest complexation and a strong siderophore pendant from a polymer backbone.

184 in B (SB) is a citrate-based polycarboxylate siderophore produced and utilized by the human pathogen

185 The siderophore aerobactin is the dominant siderophore produced by hypervirulent Klebsiella pneumon

186 Recently, a siderophore produced by uropathogenic Escherichia coli,

187 Pyoverdines are high affinity siderophores produced by a broad range of pseudomonads t

188 ind that cells retain the ability to take up siderophores produced by conspecifics, even after they h

189 cobactins are small-molecule iron chelators (siderophores) produced by Mycobacterium tuberculosis (Mt

190 Notably, 42% of the isolates were siderophore producers.

191 cific seawater and from culture media of the siderophore producing cyanobacteria Synechococcus sp. PC

192 considered readily bioavailable to aerobic, siderophore-producing microorganisms.

193 We show that the proportion of siderophore-producing taxa increases along a natural hea

194 d for the overwhelming majority of increased siderophore production and that this was not due to gene

195 e whether conflicting selection pressures on siderophore production by heavy metals - a detoxifying e

196 However, regulation of siderophore production by Mo- and V-limitation has been

197 terrestrial diazotroph well studied for its siderophore production capacity and its role as a model

198 and distinguishing 6- to 10-fold increase in siderophore production compared to that for 14 cKP strai

199 brosis, lose cooperative iron acquisition by siderophore production during infection.

200 yses demonstrated a significant reduction of siderophore production during the course of CF lung infe

201 pport that aerobactin accounts for increased siderophore production in hvKP compared to cKP (a potent

202 ormation, we conducted an extensive study of siderophore production in N2 -fixing A. vinelandii under

203 ses, while under Mo-limitation only catechol siderophore production is increased, with the strongest

204 mination of the potential nitrogen 'cost' of siderophore production reveals that investments in sider

205 Finally, siderophore production was shown to vary with the origin

206 causal link between metal contamination and siderophore production was subsequently demonstrated in

207 clusters responsible for carbon utilization, siderophore production, and pilus assembly demonstrate f

208 The siderophore-protein conjugates elicited an adaptive immu

209 siderophore, is a chimera of two well-known siderophores: putrebactin and bisucaberin.

210 t, Pf-5 continues to secrete its own primary siderophore, PVDPf-5 , despite the capability and opport

211 Fluorescent siderophore pyoverdin (PVD) was produced from a soil iso

212 The iron-binding siderophore pyoverdin is a key virulence mediator of the

213 al cooperation, the secretion of the peptide siderophore pyoverdine by Pseudomonas aeruginosa, under

214 The iron binding siderophore pyoverdine constitutes a major adaptive fact

215 stem, the authors show that secretion of the siderophore pyoverdine only incurs a fitness cost and fa

216 iron for virulence and uses the fluorescent siderophore pyoverdine to scavenge and solubilize ferric

217 Other siderophores (pyoverdine, ferrichrome, deferoxamine) lik

218 ulated onto culture plates supplemented with siderophores (pyoverdines-Fe complex or desferricoprogen

219 nimal studies revealed that vaccination with siderophore receptor proteins protects against UTI.

220 elate and transport ferric iron (Fe(3+)) via siderophore receptor systems, and pathogenic bacteria ha

221 Herein we describe the first application of siderophore receptor-mediated drug uptake of lactivicin

222 secretion, cell-cell signalling and classic siderophore receptors for iron acquisition in P. aerugin

223 Uropathogenic E. coli mutants in siderophore receptors for salmochelin, aerobactin, or ye

224 the expression of six pyoverdine-type (PVD) siderophore receptors in response to their cognate PVD.

225 or a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug

226 ed intracellularly, indicating a blockade of siderophore recycling.

227 gent yqjH gene, which encodes a novel ferric siderophore reductase.

228 a siderophore(-) mutant were used to monitor siderophore -related and -independent Fe acquisition fro

229 Expression patterns of siderophore- related genes offer evidence for bacterial

230 he prevalence of total V. vulnificus and the siderophore-related viuB gene also increased with temper

231 trate that enterobactin (Ent), a catecholate siderophore released by E. coli, is a potent inhibitor o

232 In addition, mice lacking the mammalian siderophore resist E. coli infection.

233 illustrate the novel concept that microbial siderophore's iron-scavenging property may serve as an a

234 monstrate that the efflux transporter of the siderophore SA contributes to the ability of S. aureus t

235 secrete siderophores, and additionally, the siderophore secreted by Candida is not sequestered by 24

236 entous Anabaena sp. PCC 7120 as a model of a siderophore-secreting cyanobacterium.

237 e rate, a key component of the Gram-positive siderophore-shuttle mechanism.

238 ound to the protein, the first Gram-positive siderophore-shuttle system.

239 Aspergillus fumigatus siderophore (SidA), a member of class B flavin-dependent

240 an ascites fluid supplemented with exogenous siderophores, siderophores increased the growth of hvKP1

241 Recent work shows that immunizing mice with siderophores (small molecules that microbes produce to c

242 spectral comparison of the IEF extract and a siderophore standard (desferrioxamine; DFO) suggested th

243 The siderophores staphyloferrin A (SA) and staphyloferrin B

244 nt system), it produces two carboxylate-type siderophores staphyloferrin A and staphyloferrin B (SB),

245 Targeted inhibition of the biosynthesis of siderophores staphyloferrin B of Staphylococcus aureus a

246 ngth of five matches that present in natural siderophores such as enterobactin and azotochelin.

247 Siderophores, such as enterobactin (Ent), are small mole

248 e produced in the majority of mixed function siderophores, such as pyoverdines, which bear a photoact

249 showing that taxa producing large amounts of siderophore suffered less growth inhibition in toxic cop

250 ethionine recycling pathway as well as phyto-siderophore synthesis genes.

251 he host responds to infection by suppressing siderophore synthesis while up-regulating lipocalin 24p3

252 ncodes a pleiotropic enzyme also involved in siderophore synthesis, impacted virulence to a greater e

253 t senses heme to control gene expression for siderophore synthesis.

254 Pyoverdines are siderophores synthesized by fluorescent Pseudomonas spp.

255 o confirm and knowledge of the full suite of siderophores synthesized by this organism has only recen

256 ibitor of the virulence-associated pyochelin siderophore system in Pseudomonas aeruginosa.

257 The number of siderophore systems was associated with increasing bacte

258 n by siderophore-based immunization or other siderophore-targeted approaches may represent a novel st

259 hypothesize that hvKP strains produced more siderophores than cKP strains and that this trait enhanc

260 owth in the presence of a limiting amount of siderophores than iron-loaded siderophores alone.

261 duces staphyloferrin B, a citrate-containing siderophore that delivers iron back to the cell.

262 gous to the imide forms of other citric acid siderophores that are often observed when these molecule

263 ry epithelial cells can respond to bacterial siderophores that evade or overwhelm Lcn2 binding by inc

264 Pyoverdines are important siderophores that guarantee iron supply to important pat

265 and it expresses transporters for many other siderophores that it does not synthesize.

266 robes optimize iron acquisition by producing siderophores that minimize diffusive losses to the envir

267 sis of iron-chelating hydroxamate-containing siderophores that play a role in microbial virulence.

268 t such defenses by secreting iron-scavenging siderophores that promote iron uptake and alleviate iron

269 e elements, e.g. vitamin B12, heme, and iron-siderophores) the role of ATP remains debatable.

270 nd amphibactins as well as a novel family of siderophores, the crochelins.

271 he binding ability of these proteins for apo-siderophores, the iron-free chelators.

272 ereus YxeB facilitates iron-exchange from Fe-siderophore to apo-siderophore bound to the protein, the

273 Microbes use siderophores to access essential iron resources in the e

274 utrophil degranulation sequesters iron-laden siderophores to attenuate bacterial growth.

275 Bacteria use siderophores to mediate the transport of essential Fe(II

276 Many cyanobacteria secrete siderophores to sequester iron.

277 thogens secrete small iron-binding moieties, siderophores, to acquire host iron.

278 Similar to LbtU, LbtP is a siderophore transport protein and is required for robust

279 Siderophore treatment caused local modifications of iron

280 nce the probability for mutations within the siderophore uptake systems of bacteria is very low.

281 ort system, has adapted to bind tetradentate siderophores using a His and a Tyr side chain to complet

282 find that the newly discovered A. vinelandii siderophore vibrioferrin is almost completely repressed

283 pt that natural product inhibitors targeting siderophore virulence factors can provide access to nove

284 s revealed that the lack of the enterobactin siderophore was linked to a reduced CPS expression, whic

285 Intracellular accumulation of siderophores was toxic despite the use of an alternative

286 Exogenous siderophores were bactericidal for the export mutant in

287 onstrate its applicability, metal scavengers siderophores were imaged directly from agar culture of S

288 Small iron-chelating molecules called siderophores were selected as antigens to vaccinate agai

289 Exogenous siderophores were taken up by the export mutant, and sid

290 Previously, we showed that a cytosolic siderophore, which resembles a bacterial siderophore, fa

291 report an immunization approach that targets siderophores, which are small molecules exported by ente

292 al ferric iron transporter and also required siderophores, which capture ferric iron.

293 were dominated by amphibactins, amphiphilic siderophores with cell membrane affinity.

294 ential Fe(III), bacteria produce and secrete siderophores with high affinity and selectivity for Fe(I

295 ghly conserved calyx-like cavity, among them siderophores with the strongest known capability to comp

296 ow molecular weight (MW) organic ligands, or siderophores, with extremely high Fe-binding affinities.

297 gene encoding the synthetase (HMWP2) for the siderophore yersiniabactin (Ybt) is required for growth

298 the high-pathogenicity island, encoding the siderophore yersiniabactin, which belongs to the same ch

299 ains of hvKP commonly produce the additional siderophores yersiniabactin, salmochelin, and enterobact

300 ylated Ent (salmochelin) and non-catecholate siderophores (yersiniabactin and ferrichrome) fail to in