ライフサイエンスコーパス: sigma receptor

1 hine (ligands that bind to both dopamine and sigma receptors).

2 eptide Y), were screened for activity at the sigma receptor.

3 with the same molecular weight as the cloned sigma receptor.

4 o proposed that PCP may induce c-fos via the sigma receptor.

5 ial cells through the binding to its cognate sigma receptor.

6 F10 murine melanoma cells, which express the sigma receptor.

7 thus was blocked by antagonists for CCR2 or sigma receptor.

8 nels are modulated by a single population of sigma receptors.

9 ere conducted to test for the involvement of sigma receptors.

10 inity drug binding site similar to mammalian sigma receptors.

11 ling behavior, indicating the involvement of sigma receptors.

12 transduction mechanisms of NPY receptors and sigma receptors.

13 matches the reported binding specificity for sigma receptors.

14 Sigma receptor 1 (sigmaR1) is expressed abundantly in th

15 One promising target of METH is the sigma receptor, a chaperone protein located on the membr

16 ies or affinities of 5-HT(1), muscarinic, or sigma receptors across these strains, suggesting that de

17 Other mechanisms of sigma receptor action may involve interaction with ankyr

18 ine release and basal efflux is dependent on sigma receptor activation.

19 In contrast, haloperidol, and other sigma receptor-active agents, were relatively inactive a

20 tuted analogues were shown to have increased sigma receptor affinity and represent the most potent an

21 ues were synthesized and optimized for their sigma receptor affinity and selectivity.

22 sigma receptor affinity was recorded using receptor mate

23 In vitro sigma-receptor affinity measurements indicate these comp

24 compare mechanisms by which the prototypical sigma receptor agonist (+)-pentazocine, and the proposed

25 In the presence of 10 microM sigma-receptor agonist BD737 or 10 microM sigma-receptor

26 cytes without receptors were unresponsive to sigma receptor agonists, ruling out inhibition through a

27 Recently, molecules active at both sigma receptors and NMDA receptor sites were investigate

28 5 = Br, R3 = C2H5) exhibited potency at both sigma receptors and NMDA receptor sites; 27b also showed

29 vel of G-protein activation, suggesting that sigma receptors and NPY receptors do not represent a com

30 hereas the precise molecular mechanism(s) of sigma receptors and their involvement in cancer cell bio

31 The sigma (sigma) receptor and its agonists have been implicated in

32 y site or state of the dopamine transporter, sigma receptors, and their potential roles in modulating

33 Unilateral injections of the sigma receptor antagonist BD-1063 prior to METH administ

34 zole (rimcazole) has been characterized as a sigma receptor antagonist that binds to the dopamine tra

35 attenuated by pretreatment of mice with the sigma receptor antagonist.

36 oM sigma-receptor agonist BD737 or 10 microM sigma-receptor antagonist haloperidol, the distribution

37 on [(3)H]dopamine release is not reversed by sigma receptor antagonists.

38 that this enhancement is reversed by sigma (sigma) receptor antagonists.

39 affected by micromolar concentrations of the sigma-receptor antagonists Dup734 or haloperidol.

40 Sigma receptors are known to be expressed in a variety o

41 Sigma receptors are unique endoplasmic reticulum protein

42 Sigma receptors bind a diverse group of chemically unrel

43 quirements of a molecule necessary to elicit sigma receptor binding activity.

44 Variation in sigma receptor binding labeled by [3H]nemonapride was st

45 125I]IPBS in guinea pig brain membranes with sigma receptor binding ligands confirmed its sigma pharm

46 ese results demonstrate the potential use of sigma receptor binding ligands in non-invasive diagnosti

47 el halogenated arylsulfonamides (HAS) as new sigma receptor binding tumor imaging agents is described

48 The sigma-receptor binding affinity of (19)F-FBZA was determ

49 ogether, the data suggest that modulation of sigma receptors can mitigate methamphetamine-induced cyt

50 However, the only sigma receptor characterized at the molecular level has

51 ity appears to correlate with differences in sigma receptor coupling rather than levels of expression

52 10 mRNA and protein production in vitro in a sigma receptor-dependent, pertussis toxin-sensitive mann

53 hibited very high potency for binding to the sigma receptors (e.g.28).

54 SH-SY5Y cells are suitable for investigating sigma receptor effects and whether any sigma receptors p

55 To further evaluate the properties of sigma receptors, especially sigma-1 and sigma-2 subtypes

56 ligands used here are known to bind also to sigma receptors, experiments were conducted to test for

57 Altogether, these findings show that the sigma receptor has a key role in METH dysregulation of d

58 sigma receptors have been found to be frequently up-regu

59 heterogeneous and their function is unknown, sigma receptors have been proposed as potential targets

60 sigma Receptors have been the focus of extensive studies

61 a) receptor ligands may share a putative NPY/sigma receptor in rat brain.

62 mma S binding, suggesting a broader role for sigma receptors in modulating G-protein-coupled receptor

63 Radioligand binding results for sigma receptors indicated that the structure of the amin

64 The sigma receptor is a novel protein that mediates the modu

65 s study, we show that a very high density of sigma receptors is also expressed in an androgen-indepen

66 dentity of the endogenous ligands for sigma (sigma) receptors is unknown, neuropeptide Y (NPY) has be

67 ggest that interactions between METH and the sigma receptor lead to oxidative species (most likely su

68 es demonstrated the ability of the selective sigma receptor ligand N-phenethylpiperidine oxalate (AC9

69 (+)-pentazocine, and the proposed endogenous sigma receptor ligand NPY regulate potassium-stimulated

70 sulpiride (dopamine receptor ligand), PPAP (sigma receptor ligand) and haloperidol (mixed dopaminerg

71 assess the effect of SR 31742A, a selective sigma receptor ligand, on N-methyl-d-aspartate (NMDA) an

72 orted tumour-selective killing by the sigma (sigma) receptor ligand rimcazole.

73 Using the sigma-receptor ligand anisamide as an example, we descri

74 Thus, physiological responses to sigma receptor ligands are mediated by a protein with th

75 Recent work has indicated that sigma receptor ligands can modulate potassium channels.

76 To study whether NPY and sigma receptor ligands have an inverse agonism at this p

77 Sigma receptor ligands inhibited current through two dis

78 The sigma receptor ligands N-allylnormetazocine (SKF10047),

79 The sigma receptor ligands pentazocine and SKF10047 modulate

80 In rat neurohypophysis the sigma receptor ligands SKF10047, pentazocine, and ditoly

81 The phenylethylene diamines are a class of sigma receptor ligands with excellent selectivity over o

82 Fifteen candidate endogenous sigma receptor ligands, including biogenic amines (e.g d

83 d to the purported neuroprotective action of sigma receptor ligands.

84 ggested that neuropeptide Y (NPY) and sigma (sigma) receptor ligands may share a putative NPY/sigma r

85 ], have been identified as new potent sigma (sigma) receptor ligands.

86 we did not see an inverse agonism of NPY and sigma-receptor ligands at the putative NPY/sigma recepto

87 Since no significant effects by sigma-receptor ligands on NPY-induced G-protein activati

88 d sigma-receptor ligands at the putative NPY/sigma receptor measured at the level of G-protein activa

89 Release of a sigma receptor-mediated brake on apoptosis may offer a n

90 These experiments indicate that sigma receptor-mediated signal transduction is membrane

91 e used to investigate the mechanism by which sigma receptors modulate K+ channels in peptidergic nerv

92 clamp technique was used to demonstrate that sigma receptors modulate K+ channels in rodent neurohypo

93 Thus, sigma receptors modulate opioid transduction without inf

94 Sigma receptors modulated voltage-gated K+ channels (Kv1

95 udies using glutamate and KCl and identify a sigma receptor modulation of functional NMDA responsiven

96 For the first time, a combination of sigma receptor moieties and a NO photodonor is reported,

97 e NO under visible light and possess overall sigma receptor nanomolar affinity, with one of them (8b)

98 sigma Receptors, once considered a class of opioid recep

99 study the regulation of dopamine release by sigma receptors or by NPY receptors, but this population

100 m (RES) and anisamide (AA) for targeting the sigma receptor over-expressed in H460 human lung cancer

101 vel hybrid compounds that conjugate a sigma (sigma) receptor pharmacophore and a nitric oxide (NO) ph

102 The sigma receptor photoprobe iodoazidococaine labelled a pr

103 Iodoazidococaine (IAC), a high affinity sigma receptor photoprobe, produced a similar inhibition

104 The sub-cellular distribution studied in the sigma receptor positive human H460 lung cancer cells ind

105 ating sigma receptor effects and whether any sigma receptors present are of the subtype responsive to

106 with the same molecular mass (26 kDa) as the sigma receptor protein identified by cloning.

107 The exact function of sigma receptors remains to be elucidated.

108 METH-induced activation of sigma receptors results in oxidation of a cysteine resid

109 h as fibroblasts, epithelial cells, and even sigma receptor-rich neurons are resistant to the apoptot

110 Yet sigma receptor selective antagonists, but not agonists,

111 independent effects on channels suggest that sigma receptors serve as auxiliary subunits to voltage-g

112 Sigma receptors (sigmaRs) are nonopioid, nonphencyclidin

113 Sigma receptors (sigmaRs) are nonopioid, nonphencyclidin

114 The present study investigated sigma receptor signal transduction by reconstituting res

115 unt of specific binding for dopaminergic and sigma receptor sites was observed.

116 idol, a multifunctional D2-like dopamine and sigma receptor subtype antagonist, has neuroprotective p

117 of these compounds at the sigma1 and sigma2 sigma receptor subtypes.

118 expression and functional changes by cocaine/sigma receptor system may provide insights into the deve

119 of D(2) receptors were independent of final sigma receptor systems because the final sigma agonist (

120 o further define the molecular physiology of sigma receptors, their involvement in the cellular patho

121 Sigma receptors thus modulate ion channels by a novel tr

122 odent microglia through translocation of the sigma receptor to the lipid raft microdomains of the pla

123 dothelial cells through the translocation of sigma receptor to the plasma membrane, followed by phosp

124 14 cells (a tumor cell line known to express sigma receptors) to investigate the role of the 26-kDa p

125 density (1.0-1.5 million receptors/cell) of sigma receptors was also reported in a human androgen-de

126 Association between Kv1.4 channels and sigma receptors was demonstrated by coimmunoprecipitatio

127 The particularly rich hit subset for sigma receptors was expanded with two focused library se

128 ]24b (Ki = 0.78 nM for VAChT, 1200-fold over sigma receptors) was successfully synthesized and evalua

129 have an inverse agonism at this putative NPY/sigma receptor, we measured their effects on G-protein a

130 The sigma receptor, which modulates voltage-gated K+ channel

131 NPY as an endogenous ligand for a subtype of sigma receptor with characteristics different from Y1, Y

132 ty experiments suggested a structure for the sigma receptor with two cytoplasmic termini and two memb

133 nhibition of voltage-activated K+ current by sigma receptors would be expected to enhance the secreti