ライフサイエンスコーパス: sigma-2 receptor

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1 have a high affinity and selectivity for the sigma(2)-receptor.

2 acterization of sigma-2 receptor ligands and sigma-2 receptors.

3 fold selectivity for VAChT over sigma(1) and sigma(2) receptors.

4 liver and guinea pig liver membranes and the sigma-2 receptor (18 kDa) in rat liver membranes with hi

5 l metabolite II (sigma-1 receptor antagonist/sigma-2 receptor agonist ligand) obtained by conjugation

6 Sigma-2 receptor agonists have been shown to induce cell

7 We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mech

8 emonstrated high affinities for sigma(1) and sigma(2) receptors and thus failed to show significantly

9 hemical compounds with high affinity for the sigma-2 receptor and showed rapid internalization of the

10 We have reported previously that sigma-2 receptors are expressed in high densities in a v

11 romatic substitution patterns on sigma-1 and sigma-2 receptor binding affinity and selectivity.

12 Two sigma(2)-receptor-binding ligands were prepared, from th

13 The identification of the putative sigma-2 receptor-binding site as PGRMC1 should stimulate

14 photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site.

15 sed to study the subcellular localization of sigma-2 receptors by two-photon and confocal microscopy.

16 t 66 P cells had approximately 10 times more sigma 2 receptors/cell than the 66 Q cells from 10-day c

17 The results indicate that sigma-2 receptors colocalize with fluorescent markers of

18 onradioactive) glucose in blood, sigma-1 and sigma-2 receptor expression in the tumor, animal weight,

19 The sigma(2)-receptor has been shown to be upregulated in pr

20 The sigma-2 receptor has been identified as a biomarker in p

21 sigma 1 and sigma 2 receptors have been shown to exist in a number o

22 itting radionuclides, which selectively bind sigma 2 receptors, have the potential to noninvasively a

23 In this study, the density of sigma 2 receptors in proliferative (P) and quiescent (Q)

24 rs have demonstrated increased expression of sigma-2 receptors in rapidly proliferating tumors and th

25 in isothiocyanate group, irreversibly labels sigma-2 receptors in rat liver; the membrane-bound prote

26 The localization of sigma-2 receptors in several organelles known to have a

27 In the case of pancreatic cancer, the sigma-2 receptor is a unique target that triggers apopto

28 ls that both PGRMC1 and SW120, a fluorescent sigma-2 receptor ligand, colocalize with molecular marke

29 ll facilitate functional characterization of sigma-2 receptor ligands and sigma-2 receptors.

30 clusions of previous studies suggesting that sigma-2 receptor ligands should be evaluated as potentia

31 These observations further suggest that sigma-2 receptors may be targets that can be therapeutic

32 ontrast, caspase inhibitors had no effect on sigma-2 receptor-mediated (CB-64D and CB-184) cytotoxici

33 S2R (sigma-2 receptor)/Pgrmc1 (progesterone receptor membrane

34 ents and cancer therapeutics that target the sigma-2 receptor/PGRMC1 complex.

35 The involvement of sigma-2 receptors remains unclear.

36 d in vitro in human sigma(1)R and guinea pig sigma(2) receptor (sigma(2)R) binding assays.

37 One particular specific ligand of the sigma-2 receptor, SV119, binds to pancreatic cancer cell

38 ormation regarding the molecular function of sigma-2 receptors that can explain these results.

39 their binding affinities to the sigma-1 and sigma-2 receptors, we show that both photoaffinity label

40 Scatchard analyses of sigma 2 receptors were performed on membrane preparation

41 Binding affinities for sigma(1) and sigma(2) receptors were also determined, and several of

42 aspase-independent apoptotic pathway used by sigma-2 receptors, which is distinct from mechanisms use

43 The sigma-2 receptor, whose gene remains to be cloned, has b

44 yield and specific activity that target the sigma(2) receptor with high affinity and selectivity.

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