ライフサイエンスコーパス: signal

1 ntaining the N-terminal nuclear localization signal.

2 cterization of new members of this family of signals.

3 DNA conformation can provide key regulatory signals.

4 5% CI, 83.0% to 88.7%), with no major safety signals.

5 ting broad control of CCP assembly by Ca(2+) signals.

6 oximately 50 distinct mass spectrometry (MS) signals.

7 t meaning for the encoding of time-dependent signals.

8 to calibrate growth responses to temperature signals.

9 ich we use to tune the levels of Raf/MEK/ERK signaling.

10 among the downstream targets of mTORC1-SRPK2 signaling.

11 potassium channel function and EPH receptor signaling.

12 esses such as neurogenesis and growth factor signaling.

13 aling a previously unrecognized P2X-mediated signaling.

14 impairs H2A ubiquitylation and perturbs ATM signaling.

15 hose complexes trigger Galphai3-mediated ERK signaling.

16 folds that integrate mechanical and chemical signaling.

17 here shown to regulate ligand-specific Notch signaling.

18 box for delineating the mechanisms of sulfur signaling.

19 n lipid rafts to inhibit raft-dependent PI3K signaling.

20 ssisting in uncovering unknown aspects of Ub signaling.

21 ugh inhibiting TAZ and YAP, effectors of WNT signaling.

22 downstream of fibroblast growth factor (FGF) signaling.

23 he pathological, EMT-inducing arm of TGFbeta signaling.

24 aberrant mRNA translation and intracellular signalling.

25 the understanding of compartmentalized cAMP signalling.

26 pd-15 modulates agonist binding affinity and signalling.

27 ible role for an allosteric mechanism in TCR signalling.

28 -155) and its target, suppressor of cytokine signaling 1 (SOCS-1).

29 ay a key role in cell death and inflammatory signalling(1-3).

30 This signals a new chapter in the long and unusual story of G

31 nhancement or mass effect, and homogenous T2 signal abnormality not significantly exceeding the T1 en

32 or dissociating them from the head direction signal, according to their directional stability and/or

33 EBI2 signaling activated Pin1 isomerase activity through a ca

34 thus serves to precisely modulate Wnt/Norrin signaling activity in the retinal endothelium and coordi

35 (CDN) second messenger cGAMP to activate the signaling adaptor STING.

36 The key signal amplification reaction for the checkpoint is the

37 ould be related to conformational selection, signaling amplification, and probe dependence.

38 The enzymatic time course is sigmoidal, signaling an activation step, prior to turnover.

39 t the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block

40 This is accompanied by suppression of MYC signaling and an increase in the T cell chemoattractant

41 dentify a novel mechanism linking IL-6 trans-signaling and angiogenesis in the peritoneal membrane.

42 to the source of infection, enriched for IFN signaling and antigen presentation.

43 CR specifically required for endothelial Wnt signaling and BBB integrity under pathological condition

44 cell proteome and phosphoproteome and reveal signaling and bioenergetics pathways that mediate lympho

45 This is accompanied by increased GABAergic signaling and by enhanced responsiveness to a neurochemi

46 -specific roles for DUSP5 in controlling ERK signaling and cell fate.

47 erapy resistance by influencing compensatory signaling and expanding proliferation.

48 ein that enhances beta-catenin-dependent Wnt signaling and has previously been shown to regulate ISV

49 in of the beta3 integrin prevents outside-in signaling and infection.

50 s bound to active receptors, augmenting PI3K signaling and oncogenic transformation.

51 ed here provides the molecular basis for the signaling and pathophysiological functions mediated by 2

52 itical effector of pro-inflammatory cytokine signaling and plays important roles in immune function,

53 n species (ROS) play a critical role in cell signaling and proliferation.

54 harmacological compound that abates TGF-beta signalling and enhances ERK5 signalling may be useful to

55 versus RSPO ligands to in vivo canonical Wnt signalling and ISC biology remain unknown.

56 g electrochemical access to redox-based cell signals and behaviours.

57 otency-associated genes, integrates external signals and exerts control over the decision between sel

58 es contain repair Schwann cells that provide signals and spatial clues for promoting regeneration, th

59 f the proapoptotic proteins BIM and BAX, JNK signaling, and endoplasmic reticulum stress, explaining

60 ier plant cell model for membrane transport, signaling, and homeostasis.

61 l key regulators of ciliogenesis and ciliary signaling are mutated in humans, resulting in a number o

62 These signals are potential key players in the activation of b

63 o revealed novel mechanisms by which TGFbeta signals are transduced.

64 Signals arising from measurement using multiple ion chan

65 idence that distribution of the [18F]AV-1451 signal as seen on results of PET imaging is a valid mark

66 es revealed G-protein-coupled receptor (GPR) signaling as a prominent EVI1 effector mechanism in brea

67 sult was true for the inhibition of FcgammaR signaling as well.

68 It thus provides a more confident signal assignment than 1D (31)P NMR, although currently

69 establishment of a TN-alpha2beta1-JAG1-NOTCH signaling axis as a candidate therapeutic target in glio

70 ective peptide inhibitors of the CXCL1-CXCR2 signaling axis identified HIF-2alpha-dependent neutrophi

71 cle mass via their activation of the Smad2/3 signaling axis, we used local injection of adeno-associa

72 iated cell death via the RIG-I-MAVS-IFN-beta signaling axis.

73 ancer cells that harbor defects in antiviral signaling, but a minority are nonpermissive because the

74 Elimination of in vivo signaling by all six of these 'lineage-specifying cytoki

75 of regulation of G protein-coupled receptor signaling by scaffolding proteins.

76 The integration of morphogenic signals by cells is not well understood.

77 The fact that defects in signaling can lead to malignancy illustrates the need to

78 Thus, GluN2B-driven excitotoxic signaling can proceed independently of Dapk1 or altered

79 sure overload, both hypertrophic and hypoxic signals can stimulate angiogenesis, both of which stimul

80 Aberrant PAD exposure induces a signaling cascade that leads to disruption of axonal tra

81 Cumulatively, we identify a signaling cascade that provokes structural remodeling of

82 ereas targeted DNMT1 depletion abrogates KIT signaling cascade through Sp1/miR-29b network.

83 edgehog (HH) paracrine system as a candidate signaling cascade.

84 g assays, and inhibition of LRP6 or critical signaling cascades downstream of LRP6, including JNK and

85 ma-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades.

86 The reduction in the initiation of BCR signaling caused by actin alteration is associated with

87 Interestingly, the cells of the posterior signaling center were preserved in these mutants.

88 ce branching is regulated by novel localized signaling centers.

89 , alpha-related blood oxygen level-dependent signal changes demonstrated lower decreases relative to

90 by altered levels of pathway activation, the signaling changes in developing tissues remain largely u

91 at RARgamma initiates the formation of death signaling complexes by mediating RIP1 dissociation from

92 eriments reveal the extensive integration of signals concerning the light environment by a single sig

93 Thus, cAMP-independent signals contribute to the induction of hyphal responses.

94 These findings establish that PXR signaling contributes to ALD development and suggest tha

95 tho down-regulates growth factor-driven PI3K signaling, contributing to extension of lifespan, cardio

96 ged as an excellent example of how ubiquitin signals control inflammatory responses.

97 he regulatory elements and the environmental signals controlling the expression of Longus-encoding ge

98 to do so depends on the relationship between signal correlations, associated with neuronal receptive

99 naptic effector molecule of the Wingless/Wnt signal, Cortactin.

100 In addition to TCR signaling, costimulatory pathways are involved in T cell

101 eta2AR has broad implications for adrenergic signaling, cross-talk with other signaling pathways, and

102 bule stabilization, which, together with the signaling data, suggests that the microtubule cytoskelet

103 gulate proinflammatory cytokines via a Wnt5a signaling-dependent mechanism.

104 e peroxisome proliferator-activated receptor signaling-dependent switch from glycolysis to fatty acid

105 vel of consciousness - as measured by neural signal diversity.

106 Btk has been demonstrated to regulate signaling downstream of the B-cell receptor (BCR), Fc re

107 s consistently shown XIAP to be critical for signaling downstream of the Crohn's disease susceptibili

108 annels responsible for generating electrical signals downstream of MRGPRD remain unclear.

109 However, the inherent complexity of Ub signaling due to the high atomic complexity of Ub conjug

110 -change response was observed throughout the signaling duration and across Tgf-beta doses, and signif

111 resence of interacting signals, finding that signaling dynamics are largely robust to interference.

112 1486 rats identified BRaf as the key missing signaling effector in the common synaptic NMDA-R-CaMKII-

113 Type I interferon (IFN) signaling engenders an antiviral state that likely plays

114 All viruses must antagonize antiviral signaling events for survival.

115 of KaiC create a hub around which nighttime signaling events revolve, including inactivation of KaiA

116 , a protein complex that mediates downstream signaling events.

117 Srcs are unknown and it is likely that N-Src signalling events have been misattributed to C-Src becau

118 Three signals explained late-onset degradation: miR-430 seeds,

119 l propagation in the presence of interacting signals, finding that signaling dynamics are largely rob

120 varying particle size and shape on the SERS signal, focusing on the most common anisotropic morpholo

121 ad, we have identified other features of PKA signaling for reducing catalytic subunit diffusion and i

122 hancement of vertebral bodies, heterogeneous signal from the vertebral bodies on T2 TIRM images, well

123 and S. cerevisiae The converse direction of signaling from TORC1 to the PHO regulon previously obser

124 ypes of crustaceans, and yielded much higher signals from commercial food products listing crab as an

125 verse transcription co-factors and integrate signals from multiple pathways to control metabolism, ox

126 The PI3K/Akt/mTOR pathway mediates signals from multiple receptors including insulin recept

127 ate fMRI data from 176 subjects to show that signals from the human white-matter contain meaningful i

128 omplex that plays a key role in transferring signals from transcriptional regulators to RNA polymeras

129 Tumors contain hostile inflammatory signals generated by aberrant proliferation, necrosis, a

130 on factors and B cell receptor (BCR)/pre-BCR-signaling genes.

131 Dysregulated catecholamine signaling has long been implicated in drug abuse.

132 pecification have been identified, and Notch signalling has been implicated in lineage allocation, bu

133 by DC-bound IL-6Ralpha (called 'IL-6 cluster signaling' here) was needed to prevent premature inducti

134 e functional relevance of the observed tonic signaling heterogeneity remain open questions today.

135 Applied to quantum-mechanical signals, however, these phenomena face fundamental chall

136 ional mechanisms by which lysine methylation signaling impacts on cell fate decisions.

137 insignificant nonspecific binding and false signal in undiluted serum.

138 TNC as a pivotal initiator of elevated NOTCH signaling in BTIC and define the establishment of a TN-a

139 er, whether and to what extent TRAIL/TRAIL-R signaling in cancer cells can affect the immune microenv

140 nder stressful conditions, maintained mTORC1 signaling in cancer cells promotes survival by suppressi

141 ther disruption of endogenous glucocorticoid signaling in chondrocytes also modulates the course and

142 ponse to therapeutic inhibition of tonic BCR signaling in DLBCL.

143 requirement for primary cilia-mediated GPCR signaling in interneuronal connectivity and inhibitory c

144 del for DM1 (HSALR mice), activation of AMPK signaling in muscle was impaired under starved condition

145 AT-c2, reflecting increased calcineurin/NFAT signaling in myocyte hypertrophy.

146 1R(-/-) mice, suggesting the role of SP-NK1R signaling in ocular surface homeostasis under steady-sta

147 Gbeta1 protein enlists PP1c to modulate GPCR signaling in platelets.

148 Most methods for inducing Wnt signaling in stem cell cultures do not control the spati

149 ion of tau protein as a regulator of insulin signaling in the brain.

150 establish the utility of targeting oxytocin signalling in obesity.

151 w that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation sensing in

152 we investigate the roles of tumor-associated signals in regulating endothelial cell contractility and

153 ay of conformations to respond to regulatory signals in signaling pathways.

154 Constitutive Akt signalling increases expression of EC morphogenesis gene

155 ches to interpret the phase images including signal intensity histograms and texture analysis.

156 iRNAs to type I and II BMP receptors and the signaling intermediaries (Smads), we demonstrated a key

157 Thus, genomic DNA DSBs act as signaling intermediates in murine macrophages, regulatin

158 tion of tumor necrosis factor (TNF) receptor signaling is a key feature of various inflammatory disor

159 Notch signaling is a ubiquitous signal transduction pathway fo

160 Here we report that PI3K signaling is critical for the control of West Nile virus

161 us, we sought to determine if intrinsic MAVS signaling is required for participation of Tregs in anti

162 Hh signaling is triggered at the primary cilium.

163 Dysregulation of mTOR signalling is associated with a variety of human disease

164 s like schizophrenia in which gluatamatergic signalling is implicated may be caused by aberrant salie

165 ost-microbe communication via small molecule signals is important for both symbiotic and pathogenic r

166 o affect vascular integrity and regenerative signaling, is here shown to regulate ligand-specific Not

167 Hyperactive Hnf4 signaling leads to up-regulation of lipase 3 and enzymes

168 abates TGF-beta signalling and enhances ERK5 signalling may be useful to counteract endothelial dysfu

169 nstrate a FOXC1-elicited non-canonical WNT5A signaling mechanism comprising NF-kappaB and MMP7 that i

170 h a non-canonical, transcription-independent signalling mechanism that drives assembly of adherens ju

171 We illustrate how distinct signalling mechanisms direct stress-dependent versus hom

172 r molecule has tremendous importance in cell signaling, medical diagnostics, and therapeutics.

173 rom stem cell metabolism has been emerged as signaling molecules to regulate stem cell behaviors such

174 etic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive PCa

175 cytes (IHH) and activation of its downstream signaling molecules.

176 These results define a new component of the signaling network by which activating mutations in the F

177 The Abl tyrosine kinase signaling network controls cell migration, epithelial or

178 e across space provides the fastest reliable signal of true population change for species whose dynam

179 prisingly, these synthetic ligands modulated signaling of a GPR56 mutant defective in autoproteolysis

180 ntal roles in the structure, energetics, and signaling of cells and organisms.

181 ction isotherms were derived from analytical signals of immunosensor.

182 ree of symmetry in order to isolate spectral signals of interest.

183 s and platelets, the impact of CK2-dependent signaling on MK/platelet (patho-)physiology has remained

184 have been engineered to visualize molecular signals or manipulate cellular functions.

185 ed residues, which may be a means to amplify signals or stabilize a particular protein conformation.

186 attenuated the upregulation of the TGF-beta signaling pathway and alpha1-antitrypsin protein (a seri

187 inc-induced cancer prevention and Orai1-SOCE signaling pathway in cancer cells.

188 gs that inhibit important kinases in the BCR signaling pathway inhibit activation of lytic viral expr

189 ial-to-mesenchymal transition and the ERK1/2 signaling pathway inversely affected by miR-519d or EphA

190 mouse infection models, we show that the SIP signaling pathway is active during infection and contrib

191 tion of the presence of WNV through the MAVS signaling pathway is not required for generation of effe

192 This unconventional signaling pathway offers an innovative therapeutic targe

193 significance, as therapeutic targeting of a signaling pathway such as NG2/CSPG4 may have different e

194 LTCCs) in the plasma membrane can initiate a signaling pathway that ultimately increases nuclear CREB

195 EVs secreted by AFSC could target a specific signaling pathway within the glomerulus, thus representi

196 mber of the Bone Morphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp), specifically i

197 ng the last years in understanding the SnRK1 signaling pathway, many of its components remain unident

198 nes with aberrant activation of the Hedgehog signaling pathway.

199 liferation of PDGFRalpha+ cells via PI3K/Akt signaling pathway.

200 riation in 40 of 41 genes comprising the NOD signaling pathway.

201 ell growth involves inhibition of the p70S6K signaling pathway.

202 AP4Ks as important regulators of the DLK/JNK signaling pathway.SIGNIFICANCE STATEMENT Neuronal degene

203 th a global suppression of type I interferon-signalling pathway and an aberrant expression of host ge

204 in the [Ca(2+)]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that

205 nate receptor and the downstream JAK2-STAT5a signalling pathway.

206 that were associated with IL6, AMPK and PPAR signal pathways.

207 c progression of HCC by integrating multiple signaling pathways and suggest that Gab2 might be a powe

208 d endocrine systems, by influencing cellular signaling pathways and sulfhydration of target proteins.

209 Surprisingly, what signaling pathways are active in the basal state and the

210 Both signaling pathways have been predicted previously using

211 growth factor 21 (FGF21), and activation of signaling pathways in adipose tissue.

212 activin and TGF-beta are strongly connected signaling pathways that are important in advanced CRC.

213 mily of nonreceptor tyrosine kinases acts in signaling pathways that regulate cell migration, cell ad

214 identified multiple candidates in many cell signaling pathways that were able to mediate significant

215 n upstream regulators of the TORC1 and TORC2 signaling pathways to coordinate cellular stress respons

216 adrenergic signaling, cross-talk with other signaling pathways, and the effects of betaAR-directed d

217 13 also linked SMYD2 to other PKD-associated signaling pathways, including ERK, mTOR, and Akt signali

218 metric to study information transmission in signaling pathways, it does not capture the overlap betw

219 Although much is known about the underlying signaling pathways, it remains unclear how macroscopic f

220 to be spatially regulated through two myosin-signaling pathways, myosin light chain kinase and Rho-as

221 antagonism patterns could vary in different signaling pathways, which could be related to conformati

222 ions, which, in turn, may reveal further Wnt signaling pathways.

223 sias often due to interacting or overlapping signaling pathways.

224 be correlated to restoration of ERK and AKT signaling pathways.

225 ns 273 scaffold proteins and 1118 associated signaling pathways.

226 n if they are mediated by shared or distinct signaling pathways.

227 rmations to respond to regulatory signals in signaling pathways.

228 rom mouse tracheas were assayed in vitro for signaling pathways.

229 ment in axon guidance and actin cytoskeleton signalling pathways as well as activation of inflammator

230 can be mimicked by drugs acting on serotonin signalling pathways e.g. trazodone and lorcaserin.

231 d that they play important roles in multiple signalling pathways in vivo.

232 ing is a technique for capturing fluorescent signal patterns of long DNA molecules (in the range of 0

233 poprotein signal peptide recognition site of signal peptidase II (SpII).

234 ment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a.

235 55 proteins contained the lipoprotein signal peptide recognition site of signal peptidase II (

236 Behavioral studies suggest that vestibular signals play a role in dissociating object motion and se

237 The SPR signal processing using integration area under the refle

238 Hedgehog (Hh) signaling promotes B lymphopoiesis in a non-cell-autonom

239 tient-derived glioma stem cells (GSCs), EGFR signaling promotes H3K23 acetylation and association wit

240 We quantified the robustness of signal propagation in the presence of interacting signal

241 Signaling properties of G protein complexes carrying mut

242 Signaling proteins such as protein kinases adopt a diver

243 ocal regulation of the mutually antagonistic signaling proteins, SasA and CikA.

244 romosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2.

245 -PRC1-mediated ubiquitylation of histone H2A signals recruitment of other noncanonical PRC1 complexes

246 tors, including phosphorylated extracellular signal-regulated kinase, phosphorylated protein kinase B

247 esults identify mechanisms through which FGF signaling regulates inner cell mass lineage restriction

248 Activation of apoptosis signal-regulating kinase 1 (ASK1) in hepatocytes is a ke

249 ctive in transducing signals through primate signal regulatory protein alpha.

250 aired under starved conditions, while mTORC1 signaling remained active.

251 tor and mammalian target of rapamycin (mTOR) signaling, respectively.

252 By assessing the signals responsible for induction of the Notch ligand de

253 ral synchronization on propagation of neural signals.SIGNIFICANCE STATEMENT By comparing brain tumor

254 he decision, such as interpreting the visual signals so that evidence for a decision can be accumulat

255 phosphorylation of downstream targets of AXL signaling such as AKT and P70S6K.

256 e latter term describing the brain's chronic signaling systems that function to slowly degrade molecu

257 We have identified a number of neuropeptide signaling systems with both oncogenic and tumour-suppres

258 w focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspect

259 CRF1 coupling translates into divergent cell signaling that is expressed as different brain phosphopr

260 s as an intrinsic negative regulator of TLR4 signaling that targets TIRAP.

261 We report 106 genome-wide significant signals that have not been previously identified, includ

262 In response to extracellular matrix signalling, these cells undergo epithelialization and cr

263 We show that signalling through the TrpA1 thermo-sensor is required f

264 been shown to be ineffective in transducing signals through primate signal regulatory protein alpha.

265 IFNgamma signals through the IFNgamma receptor, a protein complex

266 and/or require a continuous, real-time error signal to guide learning.

267 he reflectivity curve is applied for optimum signal to noise ratio (SNR) enhancement.

268 capable of transmitting the hormone binding signal to the catalytic domain.

269 he important contributions of TGFbeta family signaling to normal development, adult homeostasis and d

270 We propose a model based on paracrine signalling to account for the separation of the two doma

271 C plexus to contribute precise object motion signals to diverse targets without distorting target-spe

272 not only to hormones but also to FA nutrient signals to modulate food-directed behavior.

273 They transmit their signals to the cell interior by interacting with G prote

274 reflected in increased behavioural surprise signals to the conditioned stimulus during subsequent re

275 ond to the external stimuli and transmit the signals to the olfactory bulb (OB) where they are integr

276 In-stent noise, signal-to-noise ratio(SNR), stent-lumen attenuation incr

277 lysis, which has been shown to have enhanced signal-to-noise ratio, thus optimizing visualization of

278 by Gab2 deletion via regulation of Jak2 and signal transducer and activator of transcription 3 phosp

279 hGHR bioassay demonstrated initiation of the signal transduction cascade, after binding of all invest

280 ears, inflammasome activation and subsequent signal transduction have emerged as an excellent example

281 ove the discovery of the molecular basis for signal transduction in the initiation of sporulation in

282 The nature of signal transduction networks in the regulation of cell c

283 Notch signaling is a ubiquitous signal transduction pathway found in most if not all met

284 Targeting signal transduction pathways which promote therapy resis

285 ellular Wg ligand and nuclear trans-synaptic signal transduction, as well as downstream misregulation

286 asion, increased stemness, increased calcium signaling, transformation, and novel E-cadherin-RalBP1 i

287 its N terminal and modulates STAT3 and TBK1 signaling, triggering a switch from proinflammatory to a

288 thways through which parallel biogenic amine signaling tunes behavior appropriately to nutrient condi

289 rchitecture dictates essential aspects of Ca signaling under both normal and diseased conditions.

290 Because previous work investigating BOLD signal variability has been conducted within task-based

291 garding regional changes in spontaneous BOLD signal variability in the human brain across the lifespa

292 o axons and presynaptic terminals where they signal via ErbB3/4 receptors in paracrine or juxtacrine

293 This reduction required intracellular signaling via second messengers-cytosolic calcium, react

294 apted even to highly variable, unknown input signals via a feedback loop.

295 aling pathways, including ERK, mTOR, and Akt signaling, via PTPN13-mediated phosphorylation.

296 this has enabled accurate three-dimensional signal visualization and quantification of complex biolo

297 perative navigation, a specific fluorescence signal was detected in PSMA-expressing tissue.

298 IL-6 signaling was increased by Gab2 overexpression and impai

299 dectin 1-or blockade of dectin 1 downstream signaling was protective.

300 e physiological relevance of noncanonical TR signaling, we generated knockin mice with a mutation in