ライフサイエンスコーパス: signal amplification

1 binding motifs to enable robust fluorescent signal amplification.

2 e, thereby activating the enzyme to initiate signal amplification.

3 ps are necessary for protein recognition and signal amplification.

4 ions, is sufficient to create high-frequency signal amplification.

5 ells-1 (TREM-1) is critical for inflammatory signal amplification.

6 with hybridization chain reaction (HCR) for signal amplification.

7 ent of any enzyme or nanomaterial labels for signal amplification.

8 results using enzymes or nanomaterials-based signal amplification.

9 s serve as signal molecular nanocarriers for signal amplification.

10 rs to achieve functional readouts and robust signal amplification.

11 ker by exploiting movement-triggered cascade signal amplification.

12 icant time delay or significant noise during signal amplification.

13 ndonuclease-assisted isothermal fluorescence signal amplification.

14 d secondary antibody solution and subsequent signal amplification.

15 gnostic tool for both linear and exponential signal amplification.

16 increment of Rct thus obtaining significant signal amplification.

17 cascade that yielded upward of 600,000-fold signal amplification.

18 and specific assay utilizing liposome-based signal amplification.

19 g-edge equipment, time-consuming washing, or signal amplification.

20 surfaces sensitively and selectively without signal amplification.

21 tes an additional category of macromolecular signal amplification.

22 hemical reduction of Au surface and used for signal amplification.

23 assemblies and gold nanoparticles (GNPs) for signal amplification.

24 sed technology that uses branched DNA (bDNA) signal amplification.

25 hieves substantial but fundamentally limited signal amplification.

26 corporated into our feedback loop system for signal amplification.

27 species and without the need for spacers or signal amplification.

28 through a positive feedback loop leading to signal amplification.

29 sexta's sensitization occurs through central signal amplification.

30 p38(MAPK) to MK2 is characterized by strong signal amplification.

31 latent HIV reservoirs from patients without signal amplification.

32 h Au nanoparticles/graphene-chitosan for the signal amplification.

33 ay reduce functional perturbation and enable signal amplification.

34 nitiated enzymatic polymerization (SIEP) for signal amplification.

35 t achieved by cocaine aptasensors relying on signal amplification.

36 e effectively, which subsequently results in signal amplification.

37 sents lower signal spread ~0.08 x and higher signal amplification ~1.4 x , compared with conventional

38 we have combined two approaches for optical signal amplification: (1) a computational approach based

39 By signal amplification achieved with autometallography, a

40 iotin groups were attached to promote strong signal amplification after binding to the target HIV RNA

41 ication of the target molecules or molecular signal amplification after target recognition.

42 a two-layer cascade that yielded 7,000-fold signal amplification and a two-stage, four-layer cascade

43 role in multiple cellular functions such as signal amplification and activation of T cells.

44 the bacterial chemotaxis signaling pathway: signal amplification and adaptation.

45 y, the developed sensor showed a substantial signal amplification and consequently improved sensitivi

46 nism and plays important roles in chemotaxis signal amplification and coordination of multiple motors

47 id chromatography (HPLC) analyses, enhancing signal amplification and detection by increasing probe-h

48 multaneously achieving approximately 20-fold signal amplification and diffraction-limited spatial res

49 pathways might employ similar mechanisms for signal amplification and dispersion.

50 of p-LAT and p-SLP nanoclusters driving TCR signal amplification and diversification.

51 They have the advantage of signal amplification and highly specific recognition.

52 miRNA) and they often use cryostat sections, signal amplification and hybridization or washes of 50-6

53 nanocomposites enable higher sensitivity by signal amplification and introduce several novel transdu

54 ter kinetochore proteins promotes checkpoint signal amplification and lateral attachment, whereas the

55 in electrodes and associated electronics for signal amplification and multiplexed readout.

56 a latent source of fluoride is reported for signal amplification and optical detection of fluoride.

57 sing the measurement speed, parallelization, signal amplification and preconcentration.

58 poly-L-lactide nanoparticles (PLLA NPs) for signal amplification and PSA detection.

59 This event is required for subsequent signal amplification and recruitment of additional DDR p

60 sors by coupling their catalytic activity to signal amplification and reporting.

61 ed to engineer donor photophysics for facile signal amplification and selective fluorescence recovery

62 y antigen-antibody interactions for enhanced signal amplification and selectivity.

63 scuss the importance of ROS in regulation of signal amplification and specificity in guard cells.

64 he heterotrimeric G-protein complex provides signal amplification and target specificity.

65 Such arrangement may facilitate signal amplification and the integration of multiple sti

66 Lumi4-Tb complex is compatible with tyramide signal amplification and, unlike conventional organic dy

67 tion and fast magnetic separation, AgNPs for signal amplification, and an electrochemical stripping v

68 n reaction, horseradish peroxidase (HRP) for signal amplification, and magnetic beads for the easy se

69 ould be related to conformational selection, signaling amplification, and probe dependence.

70 Therefore, the hematin-based signal amplification approach has great potential in cli

71 In this work, we presented a novel signal amplification approach to construct an electroche

72 The combination of the two signal amplification approaches enables a ~1000x increas

73 es that receptor and G-protein signaling and signal amplification are highly time-dependent phenomena

74 In our approach, protein recognition and signal amplification are modulated by a simple dual-func

75 acceptor (1) as a latent source of thiol for signal amplification, as well as optical detection of th

76 We design and implement a multiplexed signal amplification assay in which gel-bound enzymes tu

77 ase-related changes, as well as the inherent signal amplification associated with antigen-stimulated

78 insight into how Mrc1 facilitates checkpoint signal amplification at stalled replication forks.

79 Here we present tyramide signal amplification based method of multiple marker imm

80 he specific carbohydrate recognition and the signal amplification based on the gold-promoted reductio

81 or home and field usage, we demonstrate here signal amplifications based on enzymatic turnovers, maki

82 The signal amplification because of redox cycling makes it p

83 dback circuits may have evolved not only for signal amplification but also for robustly generating bi

84 e amplitudes of several degrees, and suggest signal amplification by a complex interplay of ecologica

85 g of specific DNA targets and the subsequent signal amplification by a secondary DNA probe linked to

86 regulatory mode explains the paradox of cAMP signal amplification by accelerated PDE-mediated cAMP tu

87 tes cannot be achieved directly but requires signal amplification by catalysts, macromolecules, metal

88 Signal amplification by heterophilic antibodies was bloc

89 sed MSI method that combines the strength of signal amplification by immuno-enzymatic reactions with

90 threshold response due to cooperativity and signal amplification by polymerization.

91 , early Ca(2+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCga

92 s, fragmentation of the 16s rRNA and further signal amplification by QDs were found to be the main pa

93 Signal amplification by reversible exchange (SABRE) is a

94 Signal amplification by reversible exchange (SABRE) of a

95 We use the signal amplification by reversible exchange (SABRE) tech

96 (1)H NMR signal amplification by reversible exchange (SABRE) was

97 The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was

98 nidazole is demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange in SHield En

99 ize the low-cost parahydrogen-based approach signal amplification by reversible exchange with studies

100 tinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at

101 can be circularized and subjected to massive signal amplification by rolling circle amplification, le

102 ultrasensitive sensory systems, the 10-fold signal amplification by the GC receptor is surprisingly

103 We show that LPHN-CHDC biochip with signal amplification capability could selectively and se

104 The proposed strategy renders the signal amplification capacities of TPrA and combines LAM

105 sly shown that enzyme-free DNA circuits with signal-amplification capacity can be designed using a me

106 l membrane binding proteins with high degree signal amplification carried out in an all-aqueous condi

107 This study describes a novel isothermal signal amplification cascade called EzyAmp (enzymatic si

108 tion and high sensitivity through the use of signal amplification chemistry with high target specific

109 The signal amplification circuit was built based on the biol

110 m water resonance, with more than 1000 times signal amplification compared to the direct NMR detectio

111 d DNA chain by SIEP translated to a ~45 fold signal amplification compared to the incorporation of a

112 Tyramide signal amplification coupled with group-specific fluores

113 phore (analyte receptor) display significant signal amplification due to enhanced intermolecular ener

114 rode array has been used to study effects of signal amplification due to redox cycling in a confined,

115 Thanks to the signal amplification due to the large number of 1,2-diox

116 e quantitatively determined by measuring the signal amplification during FRET.

117 Heo et al. (2015) uncover a new mechanism of signal amplification during mitophagy through cooperativ

118 a recent report by others that the olfactory-signal amplification effected by the Ca(2+)-activated Cl

119 The signal amplification efficiency of LPHN-CHDC is demonstr

120 The resulting signal amplification facilitates the detection of sensor

121 tes as a radio frequency receiver performing signal amplification, filtering and downconversion mixin

122 in situ hybridization coupled with tyramide signal amplification (FISH-TSA), that this gene is locat

123 S) technology in combination with a tyramide signal amplification fluorescence in situ hybridization

124 eparation and subsequent efficient enzymatic signal amplification for high sensitivity.

125 and cycle to produce exponential fluorescent signal amplification for miRNA detection.

126 lytes to take advantage of the DNAzyme-based signal amplification for more sensitive detections.

127 ethod could be rationally evaluated, and the signal amplification for PQQ detection down to the picom

128 en, the efficiency of the Ag-FON surfaces in signal amplification for the detection of low ochratoxin

129 O channel, in the mechanotransduction and/or signal amplification for the detection of sound by the l

130 the gold nanoparticles were used as cascade signal amplification for the detection of target DNA.

131 ious functions ranging from DNA computing to signal amplifications for biosensing.

132 n, to evaluate the role of Galpha subtype on signal amplification from different GPCRs in the same ce

133 ate experiments showed approximately 15-fold signal amplification from the templated fluorogenic prob

134 ent with a low threshold of activation, high signal amplification gain, and slow kinetics of inactiva

135 rapidly progressing field of macromolecular signal amplification has been advanced using conjugated

136 which is suitable for single-tube isothermal signal amplification, has increased sensitivity of plain

137 The HCVcAg assays with signal amplification have high sensitivity, high specifi

138 Together with signal amplification, HCR can serve as a confirmation of

139 Clusters enable signal amplification, high sensitivity and adaptational

140 nefits of this signaling strategy, including signal amplification, host evolutionary advantage, and m

141 as a reagent provides two opportunities for signal amplification: (i) the replication of phage insid

142 ng-induced conversion (RT-QuIC) and tyramide signal amplification immunohistochemistry (TSA-IHC).

143 A dual signal amplification immunosensing strategy that offers

144 sembly is suitable for analyte detection and signal amplification in a 'plug-and-play' fashion.

145 liposomes served to provide recognition and signal amplification in a competitive assay for maltose

146 ctivation and leads to direction sensing and signal amplification in cAMP gradients.

147 ) is one of the most common enzymes used for signal amplification in ELISA.

148 A new approach to signal amplification in fluorescence-based assays for se

149 transducin gamma-subunit drastically reduces signal amplification in intact mouse rods.

150 (LSPR)-coupled fluorescence enhancement for signal amplification in molecular beacon detection.

151 These insights reveal the mechanism of signal amplification in NAIP-NLRC4 inflammasomes.

152 agents effectively suppressed this erroneous signal amplification in the multiplex platforms tested.

153 on pattern of endogenous DUX4, its method of signal amplification in the unique shared cytoplasm of t

154 od, as well as preferential accumulation and signal amplification in tumours.

155 ed a new strategy for attaining higher-order signal amplification, in which a target sequence templat

156 expectations arising from considerations of signal amplification, inhibitory interactions between re

157 Signal amplification is a key component of molecular det

158 The signal amplification is based on Pt-Au bimetal NPs posse

159 the combined capillary and image processing signal amplification is capable of measuring weak fluore

160 rotrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-define

161 Enzyme-free signal amplification is especially appealing for the dev

162 The principle of control signal amplification is found in all actuation systems,

163 signaling prefer the interface center, while signal amplification is localized in the transient lamel

164 Signal amplification is presumably obtained from the fac

165 and build interkinase connections that allow signal amplification, it is not yet clear why many syste

166 ative, allele-specific, real-time target and signal amplification; it also quantifies hemoglobin.

167 c pain, evidence suggests a common thread of signal amplification, leading to the unifying term 'ampl

168 find use for various research topics such as signal amplification, light-emitting new materials, and

169 phorylation of autophagy receptors creates a signal amplification loop operating in selective autopha

170 iRNA deregulations often establish a vicious signal-amplification loop in lymphoma associated with ad

171 Catalysis-based signal amplification makes optical assays highly sensiti

172 etween Dishevelleds, which may function as a signal amplification mechanism in filopodia where PCP si

173 ement method, providing key insight into the signal amplification mechanism of a microlens, and point

174 ry complex provides a novel ligand-dependent signal amplification mechanism that is required for LPA(

175 n response to target molecules and provide a signal amplification mechanism that results in high sens

176 A new signal amplification mechanism without the need of a red

177 this work, we applied the nanocrystal-based signal amplification method to tetra(4-carboxyphenyl)por

178 Using this enzyme-free and isothermal signal amplification method, we were able to detect targ

179 etection often requires the use of labels or signal amplification methodologies, resulting in both di

180 vo multiplex targeting, magnetic enrichment, signal amplification, multicolor recognition, and feedba

181 Thus any signal amplification must occur downstream of TCR trigge

182 als have facilitated achievement of enhanced signal amplification needed for the construction of ultr

183 role that ubiquitination plays in promoting signal amplification, novel protein interactions, and pr

184 The level of signal amplification obtained from templated reactions i

185 on of HER2 can be attributed to the multiple signal amplification of MB during its accumulation to th

186 mass tags were attached in order to achieve signal amplification of nearly 3 orders of magnitude.

187 Electrochemical experiments demonstrate signal amplification of the ALP activity assay by nanoce

188 alytical sensing as a result of the inherent signal amplification of the resistive pulse method.

189 e that transducin betagamma-complex controls signal amplification of the rod phototransduction cascad

190 ling method, we also quantified TdT mediated signal amplification on the surface by immobilizing ssDN

191 pe output dynamics in distinct ways, such as signal amplification or overshoot minimization.

192 ectly to enzyme labels like HRP that provide signal amplification or with nanoparticles functionalize

193 d electrode (PDNA/ZnO/Pt-Pd/FTO) served as a signal amplification platform for the detection of the t

194 an electrochemical method based on liposomal signal amplification platform is proposed for simple, PC

195 ting as both a glycan recognition unit and a signal amplification probe.

196 Moreover, the dual-signal amplification process can be completed one-step i

197 izes a novel biotin-labeled polymer-mediated signal amplification process combined with targeting rRN

198 on the inside of a vesicle, which leads to a signal-amplification process analogous to the biological

199 els without the use of catalytic enzymes and signal amplification processes.

200 ne aptamer-based sensors that do not rely on signal amplification, producing an apparent K(d) of 27 +

201 Thus, the signal amplification properties of liposomes can be adju

202 0 nM for Pb(2+)) and selectivity without any signal amplification, rapid detection (within 13 min per

203 The key signal amplification reaction for the checkpoint is the

204 irpin assembly (CHA) is a robust enzyme-free signal-amplification reaction that has a wide range of p

205 y changing the composition and quantity of a signal amplification reagent or by modifying the configu

206 icle label, (ii) a rinse buffer, and (iii) a signal amplification reagent to the capture region.

207 riven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and

208 omous VEGF:VEGFR2 feed-forward loop provides signal amplification required for the establishment of f

209 of intracellular organization that allow for signal amplification, response to stimuli, cell division

210 Signal amplification schemes that do not rely on protein

211 e of short artificial DNA sequences or novel signal amplification schemes which improve sensitivity w

212 We demonstrate how it can lead to efficient signal amplification schemes, including stochastic reson

213 st in the design of chemical logic gates and signal amplification schemes.

214 o which have been added enhanced features of signal amplification, sensory adaptation, molecular memo

215 Such signal amplification should also be feasible in other bi

216 The proposed model predicts that such signal amplification should be also feasible in the case

217 radical polymerization reactions are used in signal amplification significantly limits the mobility o

218 -radical polymerization reactions to provide signal amplification so that molecular recognition event

219 ection sensitivity of pico-molar without any signal amplification step and a dynamic range of at leas

220 otocol without the use of a complex assay or signal amplification step.

221 ISA) without the need for an enzyme-mediated signal amplification step.

222 noparticles only after DNA hybridization and signal amplification steps effectively avoids steric hin

223 kers, followed by mRNA labeling and multiple signal amplification steps.

224 invasive imaging, we specifically employed 2 signal amplification strategies, namely the Two Step Tra

225 roach to this issue is development of stable signal amplification strategies.

226 A detection and signal amplification strategy aimed toward threshold dia

227 g the telomerase and EXO III based two-round signal amplification strategy as the signal enhancement

228 wich-based immunoreaction couple with double signal amplification strategy based on catalytic enlarge

229 Based on a new signal amplification strategy by the toehold strand disp

230 An enzyme-free signal amplification strategy for colorimetric detection

231 A novel signal amplification strategy for ultrasensitive multipl

232 was the first report on the integration of a signal amplification strategy into a microfluidic paper-

233 The proposed signal amplification strategy is more straightforward an

234 On the basis of the dual signal amplification strategy of graphene sheets and the

235 Based on a novel signal amplification strategy the carbon dots (CDs) func

236 tracted from chilli fruits, based on a novel signal amplification strategy using enzyme technology.

237 A multiple signal amplification strategy was designed for an ultras

238 In the present study, a triple signal amplification strategy was developed for ultrasen

239 Based on this designed two-round signal amplification strategy, both the sensing range an

240 gned capture, detector probes, and a QD SPRi signal amplification strategy.

241 Au) for LPS detection without any additional signal amplification strategy.

242 duplex-specific nuclease (DSN)-assisted dual signal amplification strategy.

243 This can be achieved by a viable signal amplification strategy.

244 for the cancer biomarker is based on a dual signal amplification strategy: first, the synthesized CN

245 Use of a dual hot-spot signal-amplification strategy based on AuNP-AgNP heterod

246 ew also discusses various strategies used in signal amplification such as nanomaterials, redox mediat

247 Under optimized conditions, the exponential signal amplification system shows a good linear range of

248 By using a tyramide-based signal amplification system, TNF-alpha was detected in d

249 s well as for the development of sensing and signal amplification systems.

250 ated to gold nanoparticles (AuNPs) used as a signal amplification tag.

251 tibodies (TiP-Cd(2+)-MalphaPA antibodies) as signal amplification tags.

252 could be easily developed to be a universal signal amplification technique and applied to detection

253 This dual signal amplification technique was achieved by employing

254 the enzyme-assisted target recycling (EATR) signal amplification technique.

255 catalysis, in particular, is integral to the signal amplification that allows for biological informat

256 to the sandwich ELISA assays, as a means of signal amplification that also reduced the occurrence of

257 plification cascade called EzyAmp (enzymatic signal amplification) that is being developed for detect

258 ce the enzymatic action of TDP1 is the only "signal amplification" the increase in fluorescence may e

259 t Ca(2+) influx triggers adaptation but also signal amplification, the latter by opening a Ca(2+)-act

260 Compared to enzyme-based signal amplifications, the assay can detect the target R

261 and its interaction with Lys leds to a great signal amplification through measuring changes in differ

262 nated protein-protein interactions imparting signal amplification to different networks for physiolog

263 receptor-effector coupling efficiency links signal amplification to signal sensitization between rec

264 and the other being linked to an enzyme for signal amplification, to sandwich a DNA target, allowing

265 N(-1) at a bias of 1.0 V) without using any signal amplification tools.

266 e in Situ hybridization (FISH) with tyramide signal amplification (TSA) to achieve unequivocal detect

267 In this study, we applied tyramide signal amplification (TSA) to fluorescence enzyme-linked

268 on, whereas FISH detection involves tyramide signal amplification (TSA).

269 fied gold nanoparticles (AuNPs) were used as signal amplification unit because the DNA strands in thi

270 dical polymerization (AGET ATRP), to achieve signal amplification upon DNA hybridization.

271 This leads to large signal amplification upon monitoring by voltammetry.

272 aspanin CD81, thus providing a mechanism for signal amplification upon surface-bound antigen stimulat

273 n this work, we report a simple strategy for signal amplification using appropriately functionalized

274 Here, the possibility of label-free signal amplification using end-point polymerase chain re

275 ystem provides an enzyme free means of rapid signal amplification using inexpensive materials.

276 munoassay was implemented for TGF-beta1 with signal amplification using V-Phe-SWCNT(-HRP)-anti-TGF co

277 ined to be about 10 Hz, potentially allowing signal amplification via chemical exchange saturation tr

278 stem loop primer that facilitates downstream signal amplification via enzymatic turnover and improves

279 studied and increasingly used alternative to signal amplification via fluorescent labels and enzymati

280 One universal mechanism relies on signal amplification via intracellular cascades mediated

281 Signal amplification via self assembling co-polymerizati

282 In addition, signal amplification was accomplished by using a commerc

283 Signal amplification was achieved through catalysis, by

284 Signal amplification was achieved through dilution of ph

285 High intrinsic signal amplification was achieved through the combined u

286 Signal amplification was achieved through the use of gra

287 enzyme-assisted strand cycle for exponential signal amplification was designed.

288 This degree of erroneous signal amplification was less frequent in low-titer RF s

289 immunosensing system with voltage-controlled signal amplification was used to detect Shigella in stoo

290 Using highly sensitive tyramide signal amplification, we determined that LANA localizes

291 cial surfaces for potential interactions and signal amplification when activation is initiated.

292 are modified (methylated) and the other for signal amplification when they are unmodified (unmethyla

293 This leads to Notch1 signal amplification, which can promote melanoma tumor g

294 ent non-PCR detection methods rely on linear signal amplification, which hinders the detection of sma

295 tification, and nonlinear nanobubble-induced signal amplification with a tunable pulsed nanosecond la

296 Enzyme-catalyzed signal amplification with an antibody-enzyme conjugate i

297 t allows coupling of the restriction cascade signal amplification with any DNA target of interest.

298 Integrating this strategy for signal amplification with microengraving (a soft lithogr

299 ge of air-to-liquid impedance conversion and signal amplification, with the use of a distinct tympana

300 ocatalysis offers a means of electrochemical signal amplification, yet in DNA-based sensors, electroc