ライフサイエンスコーパス: signal cascade

1 by enhancing its participation in biological signal cascades.

2 aluronan synthase HAS2 by activating the Akt signaling cascade.

3 ity-dependent, non-apoptotic Bax/Bak-caspase signaling cascade.

4 nt growth, driven instead by a FGFR/MAPK/ID1 signaling cascade.

5 extracellular signal-regulated kinase [ERK]) signaling cascade.

6 ally upstream of the mitochondrial apoptosis signaling cascade.

7 phospholipase (PLC)/ protein kinase C (PKC) signaling cascade.

8 position in the activating receptor-mediated signaling cascade.

9 roperties of Kv4 channels through a specific signaling cascade.

10 edgehog (HH) paracrine system as a candidate signaling cascade.

11 mbrane fraction, where it activates the cAMP-signaling cascade.

12 ds to TLR2 degradation and disruption of the signaling cascade.

13 ine kinase/phosphatidylinositol 3-kinase/Akt signaling cascade.

14 ple signalling sub-pathways involved in this signaling cascade.

15 orylates multiple proteins in the checkpoint signaling cascade.

16 lutionarily conserved peroxiredoxin-p38/MAPK signaling cascade.

17 at and cocaine on the proliferative TGF-beta signaling cascade.

18 a negative feedback mechanism in the Ain/Lux signaling cascade.

19 y constraints on the modules involved in the signaling cascade.

20 (+)-induced stimulation of the ASK1-mediated signaling cascade.

21 ma-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades.

22 ore distant cells, where they induce various signaling cascades.

23 ucrose non-fermentative-related kinase-based signaling cascades.

24 iple binding partners and integrates diverse signaling cascades.

25 tes the canonical and noncanonical NF-kappaB signaling cascades.

26 hate oxidases (NOX) control various cellular signaling cascades.

27 ost response by targeting key proteins along signaling cascades.

28 (NLR), and Toll-like receptor (TLR) protein signaling cascades.

29 insic behavior, free of complicated cellular signaling cascades.

30 classical receptor tyrosine kinase-activated signaling cascades.

31 tracellular matrix and triggering associated signaling cascades.

32 ons to regulate a multitude of intracellular signaling cascades.

33 e of ubiquitin-mediated regulation to refine signaling cascades.

34 regulatory network of apoptotic proteolytic signaling cascades.

35 ctivation of the ATM and CaMKII proapoptotic signaling cascades.

36 rs, locally amplifying ECM input to internal signaling cascades.

37 l-surface receptors to control intracellular signaling cascades.

38 and biological processes, such as intricate signaling cascades.

39 s, and regulation of inflammatory and immune signaling cascades.

40 abolic pathways, and activating inflammatory signaling cascades.

41 eby simplifying workflows in studies of cell-signaling cascades.

42 at intermediate nodes to deconvolve complex signaling cascades.

43 rotein complexes, and activation of multiple signaling cascades.

44 uction is often associated with an amplified signalling cascade.

45 on, leading to cooperative activation of the signalling cascade.

46 ype, through the inhibition of the NF-kappaB signalling cascade.

47 ays, and identifies hitherto uncharacterized signalling cascades.

48 that although TP53 elicits vastly divergent signaling cascades across cell lines, it directly activa

49 One of the signaling cascades activated by nitro-fatty acids is the

50 mitogen-activated protein kinase Sty1-driven signaling cascade activates hundreds of genes to induce

51 methods are very effective for studying cell signaling cascade activation induced by external stimuli

52 stress activates the DNA damage response, a signaling cascade allowing cell cycle arrest and repair

53 These results identify an interspecies signaling cascade allowing ticks to detect invading bact

54 ignals from the niche and the cell intrinsic signal cascades and transcriptional programs.

55 ing p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WAS

56 trol of the phototropin-dependent blue-light signaling cascade and correlated with the activity of th

57 rning this process, we here focus on the TCR signaling cascade and demonstrate that a rise in intrace

58 fic miRNAs which play a causal role in their signaling cascade and hence may regulate disease progres

59 the effects of LXA4 and BML-111 on the HMGB1 signaling cascade and inflammation in lipopolysaccharide

60 new regulatory layer of the Wnt/beta-catenin signaling cascade and provide new insight into SETD6 bio

61 ion, activation of an ILK/EGFR/Ras/NF-kappaB signaling cascade and subsequent Slug expression.

62 XS domain indicates an attenuation of the Pi signaling cascade and the up-regulation of genes involve

63 f the other members of the canonical beta2AR signaling cascade and, therefore, constitutes a novel si

64 The signaling cascades and energy-dissipating pathways that

65 eover, this approach dissects the downstream signaling cascades and facilitates identification of con

66 ntraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene

67 ha) by initiating a variety of intracellular signaling cascades and is considered to be a key element

68 Additional studies have to address the signaling cascades and mechanistic processes that form t

69 ce of retinoschisin on Na/K-ATPase-regulated signaling cascades and Na/K-ATPase localization.

70 Whereas CDK8 is linked to specific signaling cascades and oncogenesis, the cellular roles o

71 plants; however, the connection between MAPK signaling cascades and submergence tolerance is currentl

72 nts a high-quality chemical probe of the HIF signalling cascade and an attractive starting point to t

73 propose that the interplay between PI3K/SGK1 signalling cascade and KDM4A constitutes a mechanism by

74 protein-protein interactions, RNA detection, signalling cascades and cell fate.

75 DAC6 in EMT via mediating the TGF-beta-Notch signaling cascade, and support HDAC6 as a key regulator

76 ialic acid (SA)-involved signaling, the MAPK signaling cascade, and WRKY-involved transcriptional reg

77 ncluding the Raf/Mek/Erk and PI3K/Akt/mTORC1 signaling cascades, and also the WNT/beta-catenin pathwa

78 II IFNs share homology, expression patterns, signaling cascades, and antiviral functions with type I

79 ng Boolean response programs, multi-cellular signaling cascades, and self-organized cellular patterns

80 standing of the role of transporters in such signalling cascades, and discuss some of the emergent dy

81 e showed that alpha7 nAChR-dependent calcium signal cascades are downregulated in both 15q13.3 deleti

82 This study shows that a unique ligand and signaling cascade are used in immune cells to mount an i

83 ogy have been key tools to identifying which signaling cascades are controlled by G proteins or beta-

84 While complex signaling cascades are known to be involved, it remains

85 therapeutic targets that modulate disrupted signaling cascades are of significant interest.

86 Heterotrimeric G protein signaling cascades are one of the primary metazoan sensi

87 nase mitogen-activated protein kinase (MAPK) signaling cascades are present in virtually all eukaryot

88 of actin-dependent growth cone steering, via signaling cascades, are well documented.

89 We show the STAT3-mediated IGF2/IGF-1R signaling cascade as a key modulator for both acquired a

90 signaling controls a conserved PDK-TORC2-Akt signaling cascade as part of a homeostasis network that

91 least in part, via inhibition of TLR4/MyD88 signaling cascade as well as inactivation of NLRP3 infla

92 d by the downstream effectors of cytoplasmic signaling cascades as well as translocation of the cytop

93 s via adhesion, and integrates intracellular signaling cascades associated with cytoskeleton dynamics

94 ession or pharmacological inhibition of this signaling cascade at multiple levels restored pigmentati

95 peripheral T cell survival depend on several signaling cascades, but whether a dedicated mechanism ex

96 ow that binding of sCD83 to MD-2 alters this signaling cascade by rapidly degrading IL-1R-associated

97 These findings uncover a signaling cascade by which starvation promotes autophagy

98 a positive modulator of the RAS-RAF-MEK-ERK signalling cascade by favouring stable RAF1 interaction

99 Individual steps of these signaling cascades can be targeted by specific intervent

100 e for an underappreciated mechanism by which signaling cascades can potentially affect growth cone tu

101 l cells are involved in the retina-to-sclera signaling cascade causing myopia.

102 These kinases act via a three-component signaling cascade comprising Mst1 and Mst2, the protein

103 entified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 i

104 provides important clues regarding how these signaling cascades contribute to malignancy.

105 pled receptors (GPCRs), Gbetagamma-dependent signaling cascades contribute to specifying the spatiote

106 ) are ubiquitous lipid kinases that activate signaling cascades controlling cell survival, proliferat

107 eptors activate transcriptional networks and signaling cascades controlling the expression and activi

108 in interacting proteins control inflammatory signaling cascades could provide new pathways for therap

109 function by targeting key component of these signalling cascades could represent a novel direction fo

110 Targeted activation of signaling cascades coupled to mGluRIs in mice expressing

111 ese results implicate a novel ERK-S6K1-GluA1 signaling cascade critically involved in extinction.

112 integrins, thereby serving as a platform for signaling cascade cross-talk.

113 Hedgehog (Hh) pathway is a highly conserved signaling cascade crucial for cell fate determination du

114 potassium levels and other stimuli trigger a signaling cascade culminating in phosphoinositide-phosph

115 ed beta1 integrin levels and activation of a signaling cascade culminating in Slug induction, epithel

116 sm in which cholesterol depletion triggers a signaling cascade, culminating with contraction impairme

117 ent adenovirus (Ad.Mda-5) initiates multiple signaling cascades, culminating in cytotoxicity and type

118 nown to trigger humoral immune response, the signal cascade directing this response remains undefined

119 Collectively, our findings describe a signaling cascade downstream of PDGF that sustains prone

120 formulated a computational model for a MAPK signaling cascade downstream of the EGF receptor to inve

121 g assays, and inhibition of LRP6 or critical signaling cascades downstream of LRP6, including JNK and

122 Inflammatory signaling cascades downstream of TNF, TLR agonists, anti

123 epends on microenvironmental NLGN3, identify signalling cascades downstream of NLGN3 binding in gliom

124 the activation of the Hedgehog (Hh) and MET signaling cascades driving the epithelial-to-mesenchymal

125 nvolved, and reveal key contributors in this signaling cascade during human embryonic development.

126 sequent activation of Akt and its downstream signaling cascades (e.g. mTORC1) dominates the landscape

127 This signaling cascade enhanced the formation of an infectiou

128 tudies have elucidated the role of different signaling cascades, especially the DAF-16 cascade, on li

129 We found that mbGR/PLC/PKC signaling cascade exists in all cell types tested, sugge

130 e transforming growth factor beta (TGF-beta) signaling cascade (FBN1, TGFBR1, TGFBR2, TGFB2, TGFB3, S

131 stitutive activation of G protein downstream signaling cascades for some of the affected residues.

132 heir complex functions through activation of signaling cascades from receptors localized at the cell

133 ive regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in

134 Although several signaling cascades have been reported to be involved in

135 k1, that function at different levels of the signaling cascade; however, none have been identified th

136 hosphorylation, and activation of downstream signaling cascades, impacting neurite outgrowth and spin

137 tsynaptic compartments that host biochemical signal cascades important for synaptic plasticity and, u

138 t mutations of genes controlling the Rac/Rho signaling cascade important for proper migration and dif

139 constitutive activation of the TAK1-NFkappaB signaling cascade in CD133(+) LSCs, and this program int

140 idation ligands and activating innate immune signaling cascade in platelets.

141 y acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chem

142 de a better understanding of phosphorylation signaling cascade in symbiosis.

143 the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and response to AW

144 uronal DAF-7/TGFbeta causes a DAF-1/TGFbetaR signaling cascade in the gonadal distal tip cell (DTC),

145 in regulating proteins in the insulin/IGF-1 signaling cascade in vivo in physiological states via th

146 fy SIK2 at the apex of the adipocyte-induced signaling cascades in cancer cells and make a compelling

147 agement of G protein-coupled receptor (GPCR) signaling cascades in genetically defined GABAergic BNST

148 However, the impact of T21 on systemic signaling cascades in living individuals with DS is unde

149 ping Beauty transposons implicate additional signaling cascades in MPNST pathogenesis.

150 , these findings indicate that JAK1-mediated signaling cascades in skin regulate the expression of pr

151 mong the different PDEs that coordinate cAMP-signaling cascades in these cells.

152 agonist, sFRP2, which activates a multi-step signalling cascade in melanoma cells that results in a d

153 igand-receptor pair regulates the downstream signalling cascades in this context remains poorly under

154 transcription factor 1/2alpha (HIF-1/2alpha) signaling cascade including proteins involved in oxidant

155 n PDAC cells, leading to stimulation of HER2 signaling cascade, including ERK1/2, FAK, AKT and PAK1 a

156 PTSD was also observed converging on common signaling cascades, including cytokine, innate immune, a

157 ated in the control of plasticity-associated signaling cascades, including Pten, Spred1, and Notch1.

158 eviewed here, multiple components of the RAS signaling cascade influence inflammatory cell phenotype

159 Blocking any step of this signalling cascade inhibits Hh signalling and correspond

160 This inhibition is exerted both on the signaling cascade initiated by the lipopolysaccharide wi

161 in induction of distinct but interdependent signaling cascades instrumental in adaptive responses.

162 ion has addressed early steps in the insulin signaling cascade, insulin resistance in obesity seems t

163 are important downstream targets of a CSF-1 signaling cascade involved in myeloid development.

164 ultiple pathways, including stimulation of a signaling cascade involving AMP-activated protein kinase

165 In the case of starvation, a signaling cascade involving AMPK and histone deacetylase

166 ibition of TRPM3 channels occurs via a short signaling cascade involving Gbetagamma proteins, which f

167 tes an intrinsic pro-degenerative axon death signaling cascade involving loss of the NAD(+) biosynthe

168 process occurs via an MR-dependent, genomic signaling cascade involving SGK1 and a functioning TRPM7

169 Here, we identify a new neuroprotective signaling cascade involving the activity-induced transcr

170 Activation of the PI3K-AKT signaling cascade is a common critical event during mali

171 The NF-kappaB signaling cascade is comprised of two branches, the cano

172 neurons and conclude that an ETH-JH-dopamine signaling cascade is required during a critical period f

173 ically, our data indicate that the NF-kappaB signaling cascade is significantly upregulated in Nlrx1(

174 he biological importance of a WHSC1-mediated signaling cascade is substantiated by patient sample ana

175 Whereas the vertebrate JAK/STAT signaling cascade is transduced via multiple receptor co

176 ey act downstream of separate or overlapping signaling cascades is still unclear.

177 This proliferative signalling cascade is upregulated in breast cancer patie

178 network (MEN), an essential Ras-like GTPase signaling cascade, is inhibited by the spindle position

179 though TLR TIR is central to a number of TLR signaling cascades, its role in sensory neurons is poorl

180 It operates a mechanosensitive signaling cascade known as the spindle assembly checkpoi

181 Although many LC8-interactors have roles in signaling cascades, LC8's role in developing epithelia i

182 In apoptotic cells, caspase-initiated signaling cascades lead to the downstream production of

183 ol of the gain of spike firing depended on a signaling cascade leading to extracellular signal-relate

184 ase 1)-IRF3 (interferon regulatory factor 3) signaling cascade leading to IFN-beta production and the

185 tical contractility during mitosis through a signaling cascade leading to multipolar divisions, and i

186 promoting a protein kinase A (PKA)-dependent signaling cascade leading to phosphorylation of serine S

187 rs P2Y1 and P2Y12, stimulating intracellular signaling cascades, leading to integrin alphaIIbbeta3 ac

188 n to prompting a diverse range of downstream signaling cascades, LFA-1 stimulation in T lymphocytes m

189 e data showing that AGE induces several cell signaling cascades, like NF-kappaB, PKC, ERK, and MAPK,

190 ignaling pathway; however, the early nuclear signaling cascade linking DNA damage and NF-kappaB activ

191 This signaling cascade may be relevant to other diseases invo

192 ive oxygen species-triggered LKB1/CaMKK-AMPK signaling cascade may provide a quick, adaptable switch

193 the possibility that MOR and its downstream signaling cascades may be novel targets for antidepressa

194 Consequently, these signaling cascades may represent potential therapeutic t

195 s take into account the dynamic responses of signaling cascades measured from in vivo cellular system

196 -irradiated cells also activate a checkpoint signaling cascade mediated by the ATM and Rad3-related (

197 , pathophysiologic activity can also trigger signaling cascades mediating potentially compensatory ne

198 These Tec kinases are involved in signaling cascades mediating T-lymphocyte proliferation,

199 ceptor genes, upstream effectors of the MAPK signaling cascade, might be novel target genes for pain

200 proteins in the RLR, NLR, and TLR antiviral signaling cascades modulate IFN-I expression.

201 rotein Tau, has been shown to participate in signaling cascades, modulate microtubule dynamics, and p

202 The mechanistic target of rapamycin (mTOR) signaling cascade modulates experience-dependent synapti

203 negatively regulates the NF-kappaB pathway-a signaling cascade necessary for HIV-1 replication and in

204 tro, baicalein down-regulated the TLR4/MyD88 signaling cascades (NF-kappaB and MAPKs) in lipopolysacc

205 ell lineage, and ectopic stimulation of this signalling cascade obviates the need for tuft cells in t

206 Viral infection of cells initiates a signal cascade of events that ultimately attempts to lim

207 ng to the Crk family that is involved in the signaling cascade of IL-2, stromal cell-derived factor 1

208 In this study, we report a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek

209 ith reduced side effects have focused on the signaling cascades of the mu-opioid receptor (MOR).

210 ders, such as autism and schizophrenia, this signaling cascade offers new avenues to modulate synapti

211 e role of KORs and KOR-coupled intracellular signaling cascades on reinstatement of nicotine CPP.

212 distinguishes two separate Abetao-dependent signaling cascades, one dependent on extracellular Ca(2+

213 es such that alpha-arrestins, stimulated via signaling cascades or in their basal state, recognize tr

214 n enhance insulin receptor and post-receptor signalling cascades or directly promote selected pathway

215 the results together, this work depicts the signaling cascades orchestrating Rps6 phosphorylation in

216 he cyclooxygenase-2 (COX-2)/prostaglandin E2 signaling cascade (phospholipase A2, COX-2, multidrug re

217 and cross-talk between proteins within these signaling cascades potentiate IFN-I expression, and inve

218 ctivation of c-Jun NH2-terminal kinase (JNK)-signaling cascades, pro-inflammatory effectors/cytokines

219 the calcineurin/NFAT, FasL/Fas, and caspase signaling cascades promote neonatal pig GMC apoptosis.

220 the 'vertical' inhibition of the downstream signalling cascade promoted by hsa-miR-302a-3p and hsa-m

221 model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) and Ras protein

222 +) leakage, or blocking the beta2-adrenergic signaling cascade reduced betaAPP processing and the pro

223 It is implicated as suppressed TCR-signaling cascades, reduced alterations in activation ma

224 These results reveal that different signaling cascades regulate cerebral blood flow at the c

225 The partially understood phosphoinositide signaling cascade regulates multiple aspects of cellular

226 This signaling cascade regulates the fate of its targets thro

227 Reelin is known to activate signalling cascades regulating neuronal migration by bin

228 ute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survi

229 The NF-kappaB signaling cascade relays external signals essential for

230 dentified chemical moieties activate the IMD signalling cascade remains unknown.

231 Therefore, the AKT/WHSC1/mTORC2 signaling cascade represents a vicious feedback loop tha

232 Notch and ERBB are evolutionarily conserved signaling cascades required for the maintenance of melan

233 c GEFs, promote Rac1 anti- and pro-migratory signalling cascades, respectively, through regulating th

234 translational efficiency via an AKT/HSF1/HuR signaling cascade resulting in enhanced mTORC2 activity

235 in of RAGE initiates a complex intracellular signaling cascade, resulting in the production of reacti

236 cursor cells, RIT1 controls an Akt-dependent signaling cascade, resulting in the stabilization and tr

237 ropic glutamate receptors (mGluRs) activates signaling cascades, resulting in calcium release from in

238 ilencing of major inflammatory intracellular signaling cascades (STAT1, STAT3, STAT5, p38, and ERK1/2

239 Here, a novel signal cascade strategy is reported via an ultrasensitiv

240 lts demonstrate that targeting the BRD4-p300 signaling cascade supports the generation of superior an

241 wnstream of Abeta through a beta2-adrenergic signaling cascade that activates PKA.

242 messenger in phototransduction, a G-protein signaling cascade that conveys photon absorption by rhod

243 -HETE binds and through which it activates a signaling cascade that culminates in many of the functio

244 The Wnt signaling pathway is one such signaling cascade that enables hepatic homeostasis and c

245 RIG-I like receptor family, that activate a signaling cascade that induces IFN production.

246 p1 in promoting the dermal papilla inductive signaling cascade that initiates HF growth.

247 an essential node within the RAS/RAF/MEK/ERK signaling cascade that is commonly activated by oncogeni

248 rovides insight into a non-canonical TGFbeta signaling cascade that is responsible for inducing EMT b

249 Aberrant PAD exposure induces a signaling cascade that leads to disruption of axonal tra

250 aining adaptor protein (TIRAP), triggering a signaling cascade that leads to innate immune responses.

251 tor neurons (ORNs) involves primarily a cAMP-signaling cascade that leads to the opening of cyclic-nu

252 independent GOF mutant p53-AMPK-FOXO3a-FOXM1 signaling cascade that plays an important role in mediat

253 Cumulatively, we identify a signaling cascade that provokes structural remodeling of

254 4-1BB ligation on T cells triggers a signaling cascade that results in upregulation of antiap

255 idopsis (Arabidopsis thaliana), triggering a signaling cascade that shares some similarities to respo

256 essive pathways, as well as mechanosensitive signaling cascades that are activated by increased tissu

257 rtain growth factors but also the fine-tuned signaling cascades that are initiated by hypoxia.

258 olytopic membrane proteins impacts the redox signaling cascades that control cell proliferation and d

259 ues in receptor tyrosine kinases and trigger signaling cascades that control critically important cel

260 egrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular func

261 how passive and active forces induce similar signaling cascades that drive self-renewal, migration, d

262 Signaling cascades that localize to cholesterol-rich reg

263 Stress-activated MAP kinase signaling cascades that mediate cytokine synthesis are w

264 However, the intracellular signaling cascades that mediate the osteoblastogenic fun

265 However, the precise signaling cascades that mediate the TNF-alpha-induced ac

266 t roles in the initiation and progression of signaling cascades that regulate cell functions.

267 ructure of distinct scaffolds induces unique signaling cascades that regulate migration and morpholog

268 pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton,

269 e postsynaptic neuron and trigger downstream signaling cascades that regulate the synaptic state.

270 verned by combinatorial inputs from numerous signaling cascades that ultimately dictate lineage-speci

271 Once activated, they trigger a signalling cascade that leads to NF-kappaB translocation

272 izes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type

273 , increasing intraluminal pressure engages a signalling cascade that stimulates cation influx through

274 pathway is clearly distinct from other GPCR signalling cascades that are operative in AgRP neurons.

275 erated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robu

276 rucial role for PTEN in the early DNA damage signalling cascade, the inhibition of which promotes tum

277 critical proteins of the NF-kappaB and MAPK signaling cascade, thereby blocking inflammatory cytokin

278 APP-CTF accumulation initiates CREB signaling cascade through an association of APP-CTF with

279 ereas targeted DNMT1 depletion abrogates KIT signaling cascade through Sp1/miR-29b network.

280 This work describes how C1P activates a signaling cascade to dynamically regulate P-glycoprotein

281 OCK5-dependent activation of the Crk-p130Cas signaling cascade to promote Rac1-mediated lamellipodial

282 where its overexpression activates multiple signaling cascades to promote malignant progression and

283 (miRNAs) - which are critical regulators of signaling cascades - to identify so far uncharacterized

284 The signal cascade toward the expression of biosynthetic enz

285 d JNK mitogen-activated protein (MAP) kinase signaling cascades trigger specific cellular responses a

286 approach, we identified a robust and diverse signaling cascade triggered by HIV-1 upon entry into hum

287 ng at the Golgi, where betagamma activates a signaling cascade, ultimately resulting in vesicle fissi

288 he first time we have identified the precise signalling cascade underpinning mCD40L-mediated death as

289 ce of T lymphocytes that initiates cytosolic signaling cascades upon binding antigens presented by MH

290 an upstream component of the integrin Tyr(P) signaling cascade, was diminished in GIV-depleted cells,

291 of inhibitors against components of the TCR signaling cascade, we demonstrate that Notch activation

292 togen-activated protein (MAP) kinase (MAK-1)-signaling cascade, whereas a second MAP kinase pathway (

293 egulation can lead to changes in the insulin signaling cascade, which can translate to insulin resist

294 on in activating an evolutionarily conserved signaling cascade, which ensures that continuous uptake

295 These factors are regulated via a signaling cascade, which includes mobile EPIDERMAL PATTE

296 on-dependent cell proliferation is the Hippo signaling cascade, which is coregulated by the transcrip

297 ponses mediated through the PI3K/TOR or MAPK signaling cascades, which act to protect the parasite fr

298 Activation of signaling cascades, which mediate inflammasome responses

299 therapies owing to an established network of signalling cascades with functional redundancy, which pr

300 llular signal-regulated kinase (ERK) protein signaling cascade within the brain is crucial for optima