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1 eavage with complete removal of the bombyxin signal peptide.
2 gion, which potentially acts as GPI-addition signal peptide.
3 ceptor expression through binding to the CD4 signal peptide.
4 associates with plasma HDL via its uncleaved signal peptide.
5 map to the C1 region of gp120 and one to the signal peptide.
6 splanted into a variant form of FGF4 without signal peptide.
7 media and the impact of either PelB or DsbA signal peptide.
8 al secretion in the absence of an N-terminal signal peptide.
9 2 to 27 that may represent an unconventional signal peptide.
10 ing a prodomain in addition to an N-terminal signal peptide.
11 cifically bind the RR proximal region of the signal peptide.
12 hibits processing of a potentially cleavable signal peptide.
13 e relies on T cell epitopes contained in its signal peptide.
14 vector, pCI-neo, with and without a collagen signal peptide.
15 owing transport of a Tat substrate lacking a signal peptide.
16 s observed when it was expressed without its signal peptide.
17 signal peptidase II (LspA) that removes the signal peptide.
18 gineered ruminant expressed CD18 without the signal peptide.
19 Targeting to the translocase is mediated by signal peptides.
20 captures substrate proteins by binding their signal peptides.
21 arginine-containing sequence motif in their signal peptides.
22 s the primary docking site for twin-arginine signal peptides.
23 binding cavity for twin-arginine-containing signal peptides.
24 ere found in 463 of these putative secretory signal peptides.
25 ed as putative secretory proteins containing signal peptides.
26 l or the ER using ER-targeting and retention signal peptides.
27 s, glycoproteins, as well as flavonoids, and signaling peptides.
28 a few QS circuits known to utilize multiple signaling peptides.
29 cted by a limited set of naturally occurring signaling peptides.
30 large-scale discovery of O-glycosylation on signaling peptides.
31 ing cell wall-associated extensins and small signaling peptides.
32 al consensus domain architecture comprises a signal peptide, a 60-90-residue globular prodomain with
33 glycoprotein complex consisting of a stable-signal peptide, a receptor-binding subunit, GP1, and a v
34 el missense mutations were discovered in the signal peptide (A13V) and the extracellular domains (E31
37 o HDL is mediated by its retained N-terminal signal peptide, an unusual feature for a secreted protei
38 ipt encodes a precursor protein comprising a signal peptide and 5 repeats of variegin-like sequences
39 precursor containing a 15-residue secretory signal peptide and a 90-residue peptidase inhibitor I9 d
40 regions: an N-terminal region codifying for signal peptide and a C-terminal (C-term) region, which p
41 rs (i.e., they contain a putative N-terminal signal peptide and a C-terminal conserved 13-amino-acid
42 g glycine (G) results in the cleavage of the signal peptide and abrogation of leukotoxin-induced cyto
43 requires both a unique 90-residue N-terminal signal peptide and an adjacent 24-residue segment (the A
44 glucanotransferase, devoid of its N-terminal signal peptide and C-terminal nonconserved regions, was
45 Pasteurella) haemolytica binds to the intact signal peptide and causes cytolysis of ruminant leukocyt
46 served hairpin-like structure comprised of a signal peptide and early mature region initiates protein
47 port through interactions with the substrate signal peptide and other Tat components, notably the Tha
48 antagonist, all IL-1 family cytokines lack a signal peptide and require proteolytic processing into a
50 plasmic reticulum (ER) upon emergence of the signal peptide and return to the cytosol after terminati
53 Clustering strictly required an intact RR signal peptide and the presence of the TatABC subunits,
54 ctional significance, interposed between the signal peptide and the start of the conserved catalytic
57 d ProtComp v9.0 were utilized to predict the signal peptides and the signal peptide-dependent secrete
58 Forty-four possess identifiable Sec-type signal peptides and thus are likely canonically secreted
59 involving a complex ensemble of host-derived signaling peptides and bacterial modifier enzymes capabl
60 distribution of a set of negatively charged signaling peptides and proteins - known as the HS intera
61 native receptor for growth factors and other signaling peptides and sequestering and localizing them,
62 e the likelihood of capturing these modified signaling peptides and to provide improved sequence cove
63 equiring an intact translocase, a functional signal peptide, and a correctly folded substrate protein
64 ino-acid precursor consists of an N-terminal signal peptide, and mature Crz followed by Crz-associate
65 9 amino acids, reveals a predicted cleavable signal peptide, and suggests structural homology with th
69 ulation in Medicago truncatula in which root signaling peptides are translocated to the shoot where t
70 thermore, our results highlight the bombyxin signal peptide as a reliable secretion sequence applicab
72 rminal amino acids 35-80 of DGAT1, but not a signal peptide at the N terminus of MGAT2, is required f
74 om plants, and in addition to removal of the signal peptide, at least one cleavage processing step be
75 d hypothesized that, given the presence of a signal peptide, BB0744 may be a surface-exposed protein.
76 d proteins, which are targeted by N-terminal signal peptides bearing conserved SRRxFLK 'twin-arginine
78 act sites on cpTatC and assessed the role of signal peptide binding on Tha4 assembly with the cpTatC-
80 rt of substrate proteins cross-linked to the signal peptide binding site tentatively identified mutan
83 d silkworm expression system with its innate signal peptide, bombyxin, secures structural homogeneity
85 its sequence orthologue hFPR3 also react to signal peptides but are much more narrowly tuned in sign
86 e that CD4(+) T cell epitopes present in the signal peptide can be accessible to recognition by CD4(+
88 ysis mapped structural microheterogeneity of signal peptide cleavage at the amino terminus of FGF2, w
89 d via the general secretory pathway and that signal peptide cleavage is a required step in the produc
90 byxin, secures structural homogeneity at the signal peptide cleavage site regardless of the native se
91 Q), at amino acid position 5 upstream of the signal peptide cleavage site, with cleavage-inducing gly
92 ing sequon and blocking glycosylation allows signal peptide cleavage, indicating that carbohydrate at
98 rboring a more hydrophobic h-region in their signal peptides confirmed that unlike in TorA[KQ]-30aa-M
99 but does not affect binding indicates that a signal peptide conformational change is required during
105 re corroborated by experiments redirecting a signal-peptide-containing FGF family member from the end
106 features of FGF2 as they are absent from all signal-peptide-containing members of the FGF protein fam
110 atocyte S1P secretion and that its uncleaved signal peptide delays apoM trafficking out of the cell,
111 However, when KISS1 is missing the secretion signal peptide (DeltaSS), invasion and metastasis are no
113 lized to predict the signal peptides and the signal peptide-dependent secreted proteins among the 35,
116 central role in Tat operation: It binds the signal peptide, directs translocase assembly, and may fa
117 ein insertion into the translocon, including signal-peptide docking at the translocon lateral gate (L
123 e of naturally O-linked glycosylation on the signaling peptides extracted from mouse and human pancre
124 VEN (GLV)/ROOT GROWTH FACTORS/CLE-Like small signaling peptide family is encoded by 11 genes in Arabi
125 protein (AhAI) encoding a 26 amino acid (aa) signal peptide followed by the 43 aa region and the prev
128 ave been described that harbor an N-terminal signal peptide for release along the classical secretory
129 extension protein (UBCEP) that consists of a signal peptide for secretion, a mono-ubiquitin domain, a
130 38 amino acids long, possessed an N-terminal signal peptide for secretion, and contained a conserved
131 788 amino acids in P. jirovecii, including a signal peptide for the former 2 but not the latter.
133 vides an increased level of understanding of signal peptide function on the bacterial Tat pathway.
134 Tha4-cpTatC contact data suggest a model for signal peptide-gated Tha4 entry into the chamber to form
135 ex (GPC) of arenaviruses, composed of stable signal peptide, GP1, and GP2, is the only antigen correl
136 BC complex catalyzes insertion of a pre-SufI signal peptide hairpin that penetrates about halfway acr
137 ge, a novel hairpin-hinge model in which the signal peptide hairpin unhinges during movement of the m
143 coli trimethylamine N-oxide reductase (TorA) signal peptide in TatBC receptor binding in vivo and in
144 mRNAs containing an amber-stop codon in the signal peptide in the presence of the N(epsilon)-(5-azid
145 stable signal peptide (SSP) is unique among signal peptides in that it is an integral component of t
148 e required for generating amidated bioactive signaling peptides, in Chlamydomonas and mammalian cilia
149 titutive secretion of FGF1 with an exogenous signal peptide increased beta-cell number in the absence
150 that the TatB F13Y substitution resulted in signal peptide-independent assembly of the Tat transloca
151 vitro overexpression of G1 or G2 lacking the signal peptide inhibited cell viability, triggered phosp
154 vely impermeable macromolecule tagged with a signal peptide is chaperoned through the nanopore by nuc
155 s reveal that the processing of the TtrB Tat signal peptide is dependent on the successful assembly o
158 motif, a minimal, functional h-region in the signal peptide is required for Tat-dependent export in E
159 igotes indicate that although the N-terminal signal peptide is responsible for targeting TcSMUG produ
161 sides the Tat motif, the h-region of the Tat signal peptides is another important binding determinant
162 ions results in a GhV-F that now possesses a signal peptide, is efficiently cell surface expressed, e
163 CR1 was expressed in N. benthamiana with its signal peptide, it provoked the plant immune system, whe
164 attention has been directed to glycosylated signaling peptides, largely due to lack of enabling anal
165 ptide forms present today and the protonated signalling peptides likely to be dominating in future oc
167 N-terminal signal peptide; second, internal signal peptide-mediated secretion and third, non-convent
168 leased from a reporter construct by internal signal peptide-mediated secretion it can be incorporated
169 lar space was believed to strictly depend on signal peptide-mediated translocation into the lumen of
170 Overexpression of p.Gly97Arg and another signal peptide mutation, p.Gly29Asp, caused cellular ret
171 pically synthesized as preproteins, carrying signal peptides N-terminally fused to their mature domai
172 by these results, we discover that bacterial signal peptides, normally used to translocate proteins a
174 ed to a single-point mutation, rendering the signal peptide of a seed storage protein kafirin resista
175 atidylinositol anchor signal region with the signal peptide of cell wall protein alpha-agglutinin of
176 downregulation of the fusion activity by the signal peptide of F, which has not been reported for oth
177 and secretion experiments revealed that the signal peptide of Gp3 does not act as a membrane anchor,
181 reported that, contrary to the paradigm, the signal peptide of ruminant CD18, the beta subunit of bet
183 lysis of chimeric proteins revealed that the signal peptide of the bat MuV fusion protein is responsi
184 binds the Sec61 translocon and prevents the signal peptide of the nascent HER3 protein from initiati
185 that sequence these events, for example the signal peptide of the periplasmic nitrate reductase (Nap
187 38 or residue 17 excluding the 21-amino acid signal peptide of THPO receptor binding domain (RBD).
191 This signaling pathway consists of small signaling peptides of the CLE family interacting with CL
192 s in protease cleavage, glycosylation sites, signal peptides or trans-membrane domains between Africa
193 rized plant peptides to date acting as small signaling peptides or antimicrobial peptides are derived
194 essing either wild-type DeltaspAvr2 (deleted signal-peptide) or the DeltaspAvr2(R45H) variant become
195 d protein substrates we show that the native signal peptide, or any N-terminal extension, has an inhi
197 factor activated upon binding of its cognate signaling peptide PapR on a tetratricopeptide repeat-typ
198 P and ATP-gammaS-bound states shows that the signal peptide partially inserts into the SecY channel i
199 in the bacterial periplasm with the help of signal peptide paves the way for a large scale identific
201 ctive center of the gamma-secretase complex, signal peptide peptidase (SPP), and its homologues, the
202 arget a putative protease component of ERAD, signal peptide peptidase (SPP), have high selectivity an
203 the intramembrane-cleaving aspartyl protease signal peptide peptidase (SPP), is involved in this path
207 butes to nisin resistance by regulation of a signal peptide peptidase (SppA), phage shock proteins (P
208 d by a host intramembrane-cleaving protease, signal peptide peptidase, and is required for cell fusio
210 74 is mediated by the intramembrane protease signal peptide peptidase-like (SPPL)2a, a process critic
211 ating mutation in the intramembrane protease signal peptide peptidase-like 2A (SPPL2A) unexpectedly e
212 ion was mapped to the intramembrane protease signal peptide peptidase-like 2a (Sppl2a), a gene not pr
216 tub of NRG1 type III is further processed by signal peptide peptidase-like proteases SPPL2a and SPPL2
217 equences delayed processing of SP(UL40) by a signal peptide peptidase-type intramembrane protease.
221 subunit genes) with AAF/III, as well as the signal peptide present in the beginning of the agg3A gen
222 ow that a second antagonistic "self-sensing" signaling peptide, previously known to suppress self-ind
223 fied crucial residues required for efficient signal peptide processing by SPP, which in turn has an e
224 tified crucial residues required for core-E1 signal peptide processing, including a GT3a sequence-spe
225 hains while the incomplete processing of the signal peptide produces N-terminal elongated polypeptide
226 f protease cleavage sites, identification of signal peptides, protein interactions, determination of
227 nalysis of a synthetic HCV JFH1 GT2a core-E1 signal peptide provides an essential structural template
228 her study shows that FER is a receptor for a signaling peptide (Rapid Alkalinization Factor 1 [RALF1]
233 t is caused by co-translational insertion of signal peptides recognized by the signal-recognition par
235 l patterning factor (EPF) family of secreted signaling peptides regulate the frequency of stomatal de
236 Truncations, N-terminal methionine excision, signal peptide removal, and some post-translational modi
237 h post-translational modifications including signal peptide removal, N-terminal methionine excision,
238 least 175,542 predicted sequences, bacterial signal peptides represent the largest and structurally m
240 ssical secretion by virtue of the N-terminal signal peptide; second, internal signal peptide-mediated
242 amine the effect of a cleavable leucine-rich signal peptide sequence (Lucy tag) on OR surface express
243 e pathway combined with reengineering of the signal peptide sequence results in display levels 24-fol
244 l canine MDA-7 has a potential 28 amino acid signal peptide sequence that can target it for active se
245 rotein isoforms have a conserved N-terminus (signal peptide sequence) and are dissimilar in amino aci
246 iation of this pathway normally requires two signals: peptide sequences in unassembled outer-membrane
247 eted to the yeast cell wall by replacing its signal peptide, serine-threonine-rich region, and glycop
250 ry receptor-1 (CD85j, ILT2, or LILRB1) and a signal peptide (SP(UL40)) that acts by upregulating cell
251 escent protein mCherry, linked to endogenous signal peptide (SP) and glycophosphatidylinositol-anchor
252 s B GPCRs, the GLP-1R contains an N-terminal signal peptide (SP) and undergoes N-linked glycosylation
253 ssense mutations upstream of preproinsulin's signal peptide (SP) cleavage site were reported to cause
255 y is initiated when a hydrophobic N-terminal signal peptide (SP) on the nascent protein emerges from
258 proteins were cleaved at their own internal signal peptides (SPs), in which NSm domain I functions a
259 ly understood interaction between the stable signal peptide (SSP) and the transmembrane fusion subuni
260 iral fusion proteins, GPC retains its stable signal peptide (SSP) as an essential third subunit in th
261 roteins, GPC contains a myristoylated stable signal peptide (SSP) as an essential third subunit.
262 in that the mature complex retains a stable signal peptide (SSP) in addition to the conventional rec
264 serine mutation at position 33 in the stable signal peptide (SSP) subunit of GPC, and we demonstrate
265 strate that the resulting hydrophobic-region signal-peptide substitution (p.Thr17Arg) decreases MT1-M
267 Identification of splice variants lacking a signal peptide suggests the existence of novel intracell
269 ocalization did not depend on the N-terminal signal peptide that mediates APOL1 secretion into the ci
270 tions as well as the effect of inverting the signal peptide that reflects the "positive-inside" rule.
271 an overlapping sequon, NNTT, adjacent to the signal peptide that we show to be glycosylated at both a
272 conserved twin-arginine (RR) motif in their signal peptides that is involved in their binding to the
273 t INS-IGF2, which contains the preproinsulin signal peptide, the B-chain, and eight amino acids of th
276 e produced as preproproteins consisting of a signal peptide, the thionin domain, and an acidic domain
277 ging TaFAR enzyme with peroxisomal targeting signal peptides, the TaFAR could be compartmentalized in
278 thesis and the glycosylation of proteins and signaling peptides, the identification of these transpor
281 of NKG2A(+) NK cells mediated by MHC class I signal peptides through the engagement of CD94 without a
283 rescent protein (mRFP) fusion protein with a signal peptide to secrete it from plant cells, did not p
286 o map the recognition site for twin arginine signal peptides to the cytosolic N-terminal region and f
287 ge sites, Pfam domains, glycosylation sites, signal peptides, trans-membrane protein domains, and pho
292 d imply a code of conduct exists between the signal peptides where one can compensate for inactivity
293 tural genetic mutation (T to C) within FBN30 signal peptide, which changes the position 10 amino acid
294 Glycoprotein 3 (Gp3) contains an N-terminal signal peptide, which is not removed, although bioinform
296 TatB that restored transport activity to Tat signal peptides with inactivating twin arginine substitu
297 ecessary recognition, the interaction of Tat signal peptides with the receptor complex plays a critic
299 imultaneous generation and purification of a signal peptide within a multifunctional resin can very l
300 an acute peripheral injection of the satiety-signaling peptide YY 3-36 increased 5-HT turnover in the
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