ライフサイエンスコーパス: signal sequence

1 etory protein and was cleaved as part of the signal sequence.

2 gages translating RNCs exposing a functional signal sequence.

3 pecific activity and contain a predicted Sec signal sequence.

4 pable of secreting a related CDC without its signal sequence.

5 cysteine-rich protein harboring a predicted signal sequence.

6 e nucleus, suggesting it is a nuclear export signal sequence.

7 a blunt end on the neighboring recombination signal sequence.

8 ported that exemplifies SRP54 binding of any signal sequence.

9 protein that lacks an endoplasmic reticulum signal sequence.

10 tive Sec61 channel that has been opened by a signal sequence.

11 8, which, surprisingly, comprise most of the signal sequence.

12 mplex formation only when SRP was bound to a signal sequence.

13 system that previously did not act as a Pdu signal sequence.

14 nucleosomes 5' to each Jkappa recombination signal sequence.

15 possibly preventing premature release of the signal sequence.

16 proteins are synthesized with amino-terminal signal sequences.

17 nslocation of small proteins with N-terminal signal sequences.

18 on of precursors with marginally hydrophobic signal sequences.

19 d to any segment of the nascent chain except signal sequences.

20 able to directly and tightly bind to nascent signal sequences.

21 ociated conformational changes in downstream signal sequences.

22 epeats (TIRs) resembling V(D)J recombination signal sequences.

23 s of Vbeta14, Dbeta, and Jbeta recombination signal sequences.

24 cluding gene segment order and recombination signal sequences.

25 ypical nuclear localization and nuclear exit signal sequences.

26 uble-strand breaks at specific recombination signal sequences.

27 such as ESAT-6, are secreted despite lacking signal sequences.

28 crimination between bacterial and eukaryotic signal sequences.

29 conserved twin-arginine (RR) motif in their signal sequences.

30 together with HMGB1 bind to a recombination signal sequence (12RSS or 23RSS) to form the signal comp

31 als a small precursor containing a secretion signal sequence, a 14 amino acid N-terminal propeptide,

32 a featuring a multidomain polypeptide with a signal sequence, a passenger domain, and a translocator

33 meric structure comprising an amino-terminal signal sequence, a phytocyanin-like domain, an AGP-like

34 present in two isoforms; both isoforms had a signal sequence, a Ser-Asp-rich extracellular matrix dom

35 f a membrane glycoprotein to the cytosol via signal sequence ablation resulted in rapid processing of

36 osomes translating nascent polypeptides with signal sequences--accelerates SRP.SR complex assembly ov

37 RP, while positive charges fine-tune the SRP-signal sequence affinity and targeting to the translocon

38 ar domain and the signal leader peptide (LP) signal sequence (amino acids 1 to 22) and contained the

39 mino terminus of gK immediately after the gK signal sequence (amino acids [aa] 1 to 30), were constru

40 This protein contains an N-terminal signal sequence, an extracellular region, a transmembran

41 containing six repeat domains, an N-terminal signal sequence and a C-terminal anchoring motif (LPXTG)

42 PFA0210c is unusual in that it contains a signal sequence and a PEXEL export motif that together m

43 possesses a functional nuclear localization signal sequence and binds to chromatin.

44 rved lipobox motif within the prolipoprotein signal sequence and catalyzes the addition of diacylglyc

45 rame to the L. monocytogenes listeriolysin O signal sequence and driven by the hly promoter (h30) or

46 requires substrates to present an accessible signal sequence and is not initiated simply by substrate

47 Signal sequence and prodomain cleavage in the ER and Gol

48 In the endoplasmic reticulum (ER), signal sequence and signal anchors (SAs) facilitate tran

49 esent evidence that TssM harbors an atypical signal sequence and that its secretion is mediated by th

50 40 amino acids of gp120 were replaced by the signal sequence and the first 27 amino acids of the matu

51 C-dependent manner with both the hydrophobic signal sequence and the membrane anchor sequence promoti

52 dicted to encode an Igbeta protein lacking a signal sequence and thus unable to serve normal B cell r

53 ERdj4 was reported to retain its signal sequence and to be resistant to mild detergent ex

54 c61 protein-conducting channel by regulating signal sequence and transmembrane helix insertion in a s

55 roduced by the full system I, with a cleaved signal sequence and two covalent bonds to haem.

56 The encoded precursor protein contained a signal sequence and was posttranslationally modified to

57 within intron 13 identified intronic poly(A) signal sequences and adjacent cis-elements as the princi

58 The isoforms have identical 66 base pair signal sequences and different numbers of subsequent ice

59 ay compensate for their poorer recombination signal sequences and for being distant from CTCF sites.

60 proteins possessing N-terminal ER targeting signal sequences and multiple hydrophobic segments, sugg

61 on channel to discriminate between authentic signal sequences and the less hydrophobic amino acid seg

62 is known about the interactions between MCP signal sequences and the protein shells of different MCP

63 ind to ribosome-nascent chain complexes with signal sequences and undergo a series of distinct confor

64 e (SRP), which recognizes ribosomes carrying signal sequences and, through interactions with the SRP

65 inner membrane translocon and, thus, have a signal sequence, and (iv) transmembrane alpha-helix pred

66 on from codon 1, possesses an amino-terminal signal sequence, and is a type one integral membrane pro

67 microsporidian hexokinases gained secretion signal sequences, and in a functional assay these were s

68 g translocation, the hydrophobic segments of signal sequences, and probably bilayer-spanning domains

69 ontrol the synapsis of distant recombination signal sequences, and regulated changes in subnuclear po

70 Nuclear localization and lack of an export signal sequence are consistent with the view of IL-33 as

71 Thus, signal sequences are functionally nonequivalent in vivo,

72 How signal sequences are recognized is poorly understood, pa

73 in flux into the ER, where mRNAs that encode signal sequences are released from the ER to the cytosol

74 SRP) recognizes polypeptide chains bearing a signal sequence as they emerge from the ribosome, and th

75 the first direct evidence that recombination signal sequence-associated restriction on the variable g

76 tion is critically affected by recombination signal sequence-associated restriction on the variable g

77 e protein have only a mild effect on the SRP-signal sequence association.

78 uced protein sequence of BYS1 has a putative signal sequence at its N terminus, opening the possibili

79 lation extends the nascent chain, moving the signal sequence away from SRP on the ribosomal surface.

80 ion of a simian virus (SV40) polyadenylation signal sequence between the LAT promoter and miR-H6 sequ

81 of the C protein (lacking the C-terminal E2 signal sequence) between the NotI sites in the P150 gene

82 ecognition particle (SRP), information about signal sequence binding in the SRP's M domain must be ef

83 op is the first structural element to detect signal sequence binding; this information is relayed to

84 universally conserved "fingerloop" lines the signal sequence-binding groove of SRP; the precise role

85 ribosomal protein L24 lead to a constricted signal sequence-binding pocket possibly preventing prema

86 ind this conserved ORE, namely recombination signal sequence-binding protein Jkappa (RBPJ), coiled-co

87 , TM3, TM7, and TM8 in Sec61p) to expose the signal sequence-binding site.

88 ubstrate proteins bearing mutant, suboptimal signal sequences both in vitro and in vivo.

89 s an ordered SRP RNA and SRP M domain with a signal sequence-bound.

90 Similar to CLICs, SspA lacks a signal sequence but contains an omega GST fold.

91 antii 3937 rhs genes do not encode secretion signal sequences but are linked to hemolysin-coregulated

92 t the position adjacent to the recombination signal sequence, but rather is trimmed back three or mor

93 P30 is predicted to have an N-terminal signal sequence, but the presence of such a motif has no

94 se displacement of SRP from the ribosome and signal sequence by SecYEG, and elongation of the nascent

95 The propilin is processed by signal sequence cleavage and covalent linkage of the N a

96 early maturation events for EDEM1 including signal sequence cleavage and glycosylation were analyzed

97 utations within YneA affect both the rate of signal sequence cleavage and the activity of YneA.

98 Together, these results demonstrated that signal sequence cleavage functionally regulated the asso

99 Signal sequence cleavage of EDEM1 was found to be a slow

100 peptide motif immediately C-terminal to the signal sequence cleavage position that regulates its tra

101 Signal sequence cleavage produced a soluble form of EDEM

102 RET-based assay using a peptide based on the signal sequence cleavage region of the secreted LasB ela

103 sites of nontryptic cleavage consistent with signal sequence cleavage, as well as C-terminal motifs t

104 secreted into the milieu subsequent to their signal sequence cleavage.

105 Moreover, the Pdu-localized signal sequences competed with native Pdu targeting sequ

106 ins of Ms1704 and Ms1712, not the N-terminal signal sequences, confer SecA2-dependent export.

107 were used to evaluate cryptic recombination signal sequences (cRSS), and significant cRSS pairs in t

108 kpoints are flanked by cryptic recombination signal sequences (cRSSs) and frequently have non-templat

109 Importantly, blocking this signalling sequence decreased the dilatation to skeletal

110 azide resistance (Azi(r)) and suppression of signal sequence defects (PrlD).

111 ubiquitin ligase, and define the degradation signal sequence (degron) of HOXB4 required for CUL4-medi

112 be explored, we show that the Pdu-localized signal sequences described herein allow control over the

113 he endoplasmic reticulum-targeting prolactin signal sequence did not affect StAR association with the

114 Cues in the signal sequence direct the membrane translocation of sur

115 An N-terminal signal sequence directs the secretion of the major curli

116 Although signal sequences do not have homology, they have similar

117 y analyzing in transgenic mice the impact of signal sequence efficiency for mammalian prion protein (

118 Remarkably, improving signal sequence efficiency mitigated these effects of ag

119 highest affinity shortly after a functional signal sequence emerges from the ribosome.

120 y displaces NAC from RNCs; however, when the signal sequence emerges further, trimeric NAC.RNC.SRP co

121 e signal recognition particle (SRP) binds to signal sequences emerging from the ribosomal tunnel and

122 Signal sequence-encoding mRNAs undergo translation-depen

123 whose cleavable N-terminal cpSecA-dependent signal sequence engages the thylakoid membrane cotransla

124 ted by HLA-DQ2/8 DC: an HLA-DQ8trans-binding signal-sequence epitope previously identified as CD8 T-c

125 multiple splice forms, polymorphisms, intron signal, sequencing errors, alignment errors, annotation

126 The C-terminal signal sequence facilitates secretion of SidJ into host

127 When mutant signal sequences fail to bind to the signal recognition

128 t all of them contain a nuclear localization signal sequence flanking to the K1 segment and a novel c

129 n, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen receptor V, D, and J g

130 a glycosylphosphatidylinositol (GPI) anchor signal sequence followed by GPI-phospholipase D digestio

131 Thus, when signal sequence follows SA-I immediately, the interactio

132 IC) are non-classical ion channels lacking a signal sequence for membrane targeting.

133 ACBP lacks a signal sequence for secretion through the endoplasmic re

134 erminal region of the core protein acts as a signal sequence for the E1 glycoprotein and undergoes du

135 at has two known functions: E3 serves as the signal sequence for translocation of the E3-E2-6K-E1 pol

136 annexin 2, and p11, all proteins which lack signal sequences for cell surface export.

137 The hydrophobic core of the signal sequence forms a helix that sits in a groove outs

138 RP effectively distinguish RNCs displaying a signal sequence from those that are not?

139 xplained by the demonstration that efficient signal sequence function precludes generation of a cytos

140 tial rearrangements from V(D)J recombination signal sequence fusions.

141 defined by retaining its GPI anchor peptide signal sequence (GPI-PSS).

142 ylphosphatidyl-inositol (GPI) anchor peptide signal sequence (GPI-PSS).

143 pro-PrP and retaining its GPI anchor peptide signal sequence (GPI-PSS).

144 1 influenza virus in which the hemagglutinin signal sequence has been suppressed (S-FLU), when admini

145 at accessible and inaccessible recombination signal sequences has been lacking.

146 The positive charges in the signal sequence helped it to override the function of si

147 fusions provided the initial support for the signal sequence hypothesis in prokaryotes and allowed fo

148 A hydrophobic segment downstream of the signal sequence impeded complete translocation of Pink1

149 spite the presence of a nuclear localization signal sequence in Gag, we observed no foamy virus Gag i

150 n IFITM3, the conserved YXXtheta endocytosis signal sequence in the N-terminal domain of duck IFITM3

151 minal region of Vfr comprising the secretion signal sequence in trans restored a wild-type speB expre

152 We identified a third signaling sequence in CD3 epsilon, termed the basic-rich

153 D1 receptor-expressing neurons and that this signaling sequence induced aversion through GABA-mediate

154 ut not KFMDeltaSS, which lacks the secretion signal sequence, induced re-sensitization of cells to an

155 Channel opening allows signal sequence insertion into a gap between the N- and

156 site-specific photocrosslinking to study SRP-signal sequence interactions.

157 p into the SecY channel with the hydrophobic signal sequence intercalated into the open lateral gate.

158 city threshold for functional insertion of a signal sequence into the Sec61 complex, thereby allowing

159 TCDD+Endosulfan elicit a complex signaling sequence involving reticulum endoplasmic desta

160 characterization established that the ERdj4 signal sequence is cleaved to yield a soluble protein.

161 having a CTCF site near their recombination signal sequence is critical, suggesting that being posit

162 cinity of the ribosome exit tunnel where the signal sequence is extending beyond its hydrophobic bind

163 Interestingly, only the internal signal sequence is necessary for complementation of the

164 We show that an exogenously added signal sequence is not sufficient for Sec-dependent Ply

165 If signal sequence is placed far enough from SA-I, then it

166 Thus, the hydrophobic core of the signal sequence is primarily responsible for its recogni

167 de complex in the dimer, which reveals how a signal sequence is recognized by SRP54.

168 The signal sequence is then cleaved by signal peptidase II (

169 trix protein p17 (p17), although devoid of a signal sequence, is released by infected cells and detec

170 the N terminus of SrtC2, which contains the signal sequence, is required for proper protein transloc

171 cision circles, genomic intron recombination signal sequence k-deleting element coding joint, genomic

172 n TCR excision circles, intron recombination signal sequence k-deleting element signal joints on Igka

173 In this study, we report that another signal sequence lacking cytoplasmic protein, superoxide

174 As Nmnat2 is not predicted to contain a signal sequence, lipid-binding domain, or transmembrane

175 /Icm substrate being secreted by an internal signal sequence, many other substrates may be exported i

176 ly points of infection, whereas the internal signal sequence mediates secretion at later time points.

177 uss a tentative model of how a twin arginine signal sequence might be accommodated in the Tat translo

178 onal process, characterized by recombination signal sequence motifs near breakpoints, incorporation o

179 Severity of signal sequence mutations correlated with increased prox

180 ion particle, which recognizes a hydrophobic signal sequence near the protein N terminus.

181 3 rule is intrinsic neither to recombination signal sequences nor to the catalytic process of recombi

182 Analysis of the signal sequence of CD18 of eight ruminants and five nonr

183 ants and five nonruminants revealed that the signal sequence of CD18 of ruminants contains "cleavage-

184 ified a peptide, STVVLITAYGLVLVW, within the signal sequence of gK as an immunodominant gK T-cell-sti

185 for the first time that mutations within the signal sequence of gK blocked cell surface expression of

186 point to a key role for the 8mer within the signal sequence of gK in HSV-1-induced pathogenicity.

187 Mutation in the signal sequence of gK in MgK virus blocked cell surface

188 that the 8mer peptide (ITAYGLVL) within the signal sequence of gK promotes cell surface expression o

189 cule Qa-1 bound to peptides derived from the signal sequence of Hsp60 (Hsp60sp) contribute to self/no

190 of naturally occurring mutations within the signal sequence of insulin.

191 he unrelated transmembrane domain of NarX or signal sequence of PhoA, showed that the transmembrane d

192 d that replacement of the average efficiency signal sequence of PrP with more efficient signals rescu

193 highly dependent on their structure and the signal sequence of targeted proteins and can be narrowed

194 viruses with or without mutations within the signal sequences of gK.

195 To investigate the role of the signal sequences of herpes simplex virus 1 (HSV-1) gK on

196 at are based upon the hydrophobic N-terminal signal sequences of human apolipoproteins.

197 particle (SRP) cotranslationally recognizes signal sequences of secretory proteins and targets ribos

198 ated into the middle of wild-type or mutated signal sequences of the secretory protein preprolactin b

199 pies of ESAT-6 plus CFP-10 fused to the OmpC signal sequence (OmpC(SS)-E2C) and amino acids 44 to 338

200 , is targeted for secretion via a C-terminal signal sequence on CFP-10 that is recognized by the cyto

201 terial inner membrane through recognition of signal sequences on cargo proteins.

202 ing either a C-terminal wild-type GPI anchor signal sequence or a nonraft transmembrane sequence cont

203 at charged residues at the N-terminus of the signal sequence or in the early part of the mature prote

204 Although it has no obvious signal sequence or transmembrane-spanning domains, CtpA

205 omains (e.g., a membrane surface), by adding signal sequences or fusing the sensors to specific prote

206 hain length and the exposure of a functional signal sequence outside the ribosome.

207 xisomal protein import, the variant receptor-signal sequence pair forms the basis of a system in whic

208 activity related to the start/stop activity signaling sequence parsing, we found neurons displaying

209 TDE and E. coli expressing MOSP with a PelB signal sequence (PelB-MOSP), MOSP(C) is OM-embedded and

210 d from those processed by B lymphocytes; PPI signal-sequence peptides were eluted from HLA-DR4 and -D

211 roduced into E. coli carrying a p66 promoter-signal sequence-phoA (alkaline phosphatase, or AP) fusio

212 , with the PEXEL motif repositioned near the signal sequence, prevented PMV cleavage.

213 ted only at regions containing recombination signal sequences, RAG2 binds at thousands of sites in th

214 rotein S4, Y linked; solute carrier 1A5; and signal sequence receptor 1) were found in the syncytiotr

215 inefficient due to the small time window for signal sequence recognition by the signal recognition pa

216 a balance between translocation activity and signal sequence recognition fidelity.

217 sec61 alleles, which reduce the fidelity of signal sequence recognition.

218 rs before the first transmembrane helix, the signal sequence recognized by the signal recognition par

219 Mutations in the C-terminal signal sequence region of cdE2 affected E2 protein trans

220 gly, only secretion mediated by the internal signal sequence requires IcmS/IcmW.

221 ing gene segments and flanking recombination signal sequences (RS), with the two coding ends and two

222 mediated looping can influence recombination signal sequence (RSS) accessibility by regulating enhanc

223 ment, directly adjacent to the recombination signal sequence (RSS), placing the RSS in a position acc

224 aled distinct bending modes at recombination signal sequence (RSS)-conserved regions before nicking a

225 cutting DNA at the borders of recombination signal sequences (RSS) and their neighboring gene segmen

226 ated genomic rearrangements at recombination signal sequences (RSS) in human lymphocytes.

227 ess by binding to two types of recombination signal sequences (RSS), 12RSS and 23RSS, and cleaving at

228 ine gene segment is flanked by recombination signal sequences (RSs).

229 teractions with their flanking recombination signal sequences (RSS).

230 A containing a pair of cleaved recombination signal sequences (RSS).

231 ins, which recognize conserved recombination signal sequences (RSSs) adjoining variable (V), diversit

232 essible chromatin structure at recombination signal sequences (RSSs) but how this accessibility is ge

233 2 recombinase (RAG) recognizes recombination signal sequences (RSSs) containing a heptamer, a spacer

234 t relies on the recognition of recombination signal sequences (RSSs) flanking the individual elements

235 Inefficient Vbeta/VH recombination signal sequences (RSSs) have been hypothesized to cause

236 the RAG1 and RAG2 proteins to recombination signal sequences (RSSs) that consist of conserved heptam

237 RAG)1 and RAG2 bind and cleave recombination signal sequences (RSSs), aided by the ubiquitous DNA-bin

238 ) containing two complementary recombination signal sequences (RSSs), the 12RSS and 23RSS, which diff

239 gets, and predicted quality of recombination signal sequences (RSSs).

240 ving DNA adjacent to conserved recombination signal sequences (RSSs).

241 at matched pairs of bona fide recombination signal sequences (RSSs).

242 n suppression of the A/PR/8/34 hemagglutinin signal sequence (S-FLU) that can infect cells and expres

243 for structure and topology prediction, (iii) signal sequence score because most TMBBs are secreted th

244 d residues in the hydrophobic portion of the signal sequence severely affect SRP binding.

245 Finally, overexpression of the Vfr secretion signal sequence significantly decreased speB transcript

246 fied mature Bacillus cereus SleB without its signal sequence (SleB(M)) and the SleB C-terminal cataly

247 cal E-box within the Dbeta2 12-recombination signal sequence spacer prior to Tcrb recombination.

248 A distinct peptide in the Vfr secretion signal sequence specifically bound to recombinant RopB.

249 Nonetheless, when E3 is replaced with an ER signal sequence, spikes do not form and infectious parti

250 8 of antigen 85A (Ag85A(294)) flanked by the signal sequence (SS) and C-terminal peptide (CT) of beta

251 aged the ER immediately after or even before signal sequence (SS) emergence, a class of Sec66-depende

252 Specifically, an outer membrane (OM) type II signal sequence (SS) fused to the heterologous mCherry f

253 he cglE and cglF genes instead encode type I signal sequences, suggesting that nonlipoproteins are al

254 Tgl, the cglC and cglD genes encode type II signal sequences, suggesting that they are also lipoprot

255 via a large nuclear complex that recognizes signal sequences surrounding a poly(A) site on mRNA prec

256 Hydrophobic signal sequences target secretory polypeptides to a prot

257 Mislocalized proteins bearing a signal sequence that did not successfully translocate th

258 protein GspB has a 90-residue amino-terminal signal sequence that is essential for transport by SecA2

259 been proposed to contain a carboxy-terminal signal sequence that is necessary and sufficient for exp

260 tract and did not appear to have a predicted signal sequence that might suggest the possibility of it

261 background, which contains a polyadenylation signal sequence that stabilizes DUX4 mRNA.

262 d breaks adjacent to conserved recombination signal sequences that contain either 12- or 23-nucleotid

263 rt of the substrate SidJ is mediated by dual signal sequences that include a conventional C-terminal

264 lar experiments on nascent chains containing signal sequences that may form compacted structural moti

265 nto the endoplasmic reticulum is mediated by signal sequences that vary widely in primary structure.

266 te homologues, which have typical N-terminal signal sequences, the precursor form of Drosophila Hh co

267 ation of unfolded preproteins containing Sec signal sequences through the SecYEG membrane channel.

268 EsxB binds via its signal sequence to an empty pocket on the C-terminal ATP

269 s to the translating ribosome displaying the signal sequence to deliver it to the SRP receptor (SR) o

270 ra transgene is fused with an amino-terminal signal sequence to facilitate delivery of the chimera to

271 (APP47) and Abeta1-42 (APP48) with a cleaved signal sequence to insert both peptides during synthesis

272 We have mapped IRS1 degradation signal sequence to its N-terminal 574 amino acid residue

273 ascent chain complexes (RNCs) that display a signal sequence to protein translocation channels in tar

274 The transfer of this signal sequence to the N terminus of heterologous amyloi

275 Many secretory proteins are targeted by signal sequences to a protein-conducting channel, formed

276 reby permitted D(H)-associated recombination signal sequences to initiate the second step of Igh gene

277 me-nascent chain complexes (RNCs) displaying signal sequences to protein translocation channels in th

278 Accessibility of chromosomal recombination signal sequences to the RAG protein complex is known to

279 can modify the availability of recombination signal sequences to the RAG recombinase.

280 and the RAPTOR subunit that binds to the Tor signalling sequence (TOS) motif of substrates and regula

281 When expressed in Escherichia coli with PelB signal sequences, TprC and TprI localize to the outer me

282 provides new insights into the mechanism of signal sequence transfer from the SRP to the translocon.

283 ties are similar to those of R14W CA IV, the signal sequence variant found in the original patients w

284 In vitro studies suggest that such signal sequence variations may correspond to subtly diff

285 use for L lactis and joined with a linker; a signal sequence was added to allow for product secretion

286 -region of the alpha-mating factor secretion signal sequence was performed in order to determine the

287 embrane form of EDEM1 was generated when the signal sequence was uncleaved, creating an N-terminal tr

288 hich lacks a classical, cleavable N-terminal signal sequence, was found to be secreted during the sta

289 binding domains that are distinct from both signal sequences were elucidated and, interestingly, onl

290 It was initially proposed that SRP binds the signal sequence when it emerges from an RNC and that suc

291 ntronic region containing the distal poly(A) signal sequences, when transferred to a heterologous min

292 ith specific variations in its recombination signal sequence, which renders it poorly compatible for

293 hBFIT2) constitutes a mitochondrial location signal sequence, which undergoes mitochondrion-dependent

294 of nucleosomes with respect to recombination signal sequences, which could be nucleosomal or internuc

295 All the proteins had an N-terminal signal sequence with a putative sorting signal of L(P/T/

296 es could be bypassed by replacing the PrP(C) signal sequence with that of prolactin or osteopontin.

297 mplex formation occurs between recombination signal sequences with unequal 12 and 23 base spacer sequ

298 Only recombination between signal sequences with unequal spacers results in product

299 dergo synapsis with a standard recombination signal sequence within the cells, in a RAG-dependent man

300 arly recruitment of SRP to RNCs containing a signal sequence within the ribosomal tunnel is NAC depen