ライフサイエンスコーパス: signal transduction

1 ators of B-cell proliferation, survival, and signal transduction.

2 traditional transcriptional regulation, and signal transduction.

3 esion, new ideas were shared in the field of signal transduction.

4 ta subunits, which are invariable and ensure signal transduction.

5 s regulate communications, excitability, and signal transduction.

6 highlight the impact of ROS localization on signal transduction.

7 abour could function broadly within cellular signal transduction.

8 gh-throughput data in the context of Mvarphi signal transduction.

9 antigens to CD4(+) T cells through Jak-STAT signal transduction.

10 ction, control of stomata aperture and light signal transduction.

11 sensing units to an electronic platform for signal transduction.

12 C-terminal extension, which is important for signal transduction.

13 ivity, leading to deregulation of downstream signal transduction.

14 fficient TNF/TNFR2 clustering and subsequent signal transduction.

15 es, cycling between ON and OFF states during signal transduction.

16 an scattering (SERS) is utilized for sensing signal transduction.

17 titutes a central mechanism of intracellular signal transduction.

18 ent for pollen tube guidance and involved in signal transduction.

19 entation into biological systems in vivo for signal transduction.

20 ially utilized by IFN-beta and IFN-alpha for signal transduction.

21 an NTF impairs endosomal trafficking and BCR signal transduction.

22 investigation of the scaffold protein in the signal transduction.

23 hemical networks in ways that broadly impact signal transduction.

24 cell proliferation, cytokine production, and signal transduction.

25 ial role of fullerene as nanomediator in the signal transduction.

26 roenvironment essential for effective axonal signal transduction.

27 functions, including protein homeostasis and signal transduction.

28 ir endosomal morphology, BCR expression, and signal transduction.

29 voted to the scaffold proteins that medicate signal transduction.

30 teract with proteins involved in presynaptic signal transduction.

31 ulatory network connecting sugar uptake with signal transduction.

32 cond receptor for IL-12 and IL-23R for IL-23 signal transduction.

33 s setting in motion the downstream events in signal transduction.

34 tion efficiency and, most recently, receptor signal transduction.

35 ze protein phosphorylation as a mechanism of signal transduction.

36 of myocytes and alteration of intracellular signal transduction.

37 ed activation loop yields precise control of signal transduction.

38 hese are all response regulators involved in signal transduction.

39 gulatory associations between metabolism and signal transduction.

40 ulates bioenergetics, cell death, and Ca(2+) signal transduction.

41 ncovering strategies deployed for allosteric signal transduction.

42 sed by defective primary cilia morphology or signal transduction.

43 d rotary machine facilitating locomotion and signal transduction.

44 mong ion channels and is crucial to modulate signaling transduction.

45 e (MPK) cascades are conserved mechanisms of signal transduction across eukaryotes.

46 actions and can further our understanding of signal transduction across the plasma membrane.

47 th and virulence, including nutrient uptake, signal transduction, adhesion, conjugation, sporulation,

48 to liquid crystals likely enable long-range signal transduction along meiotic chromosomes and underl

49 cological inhibition of PGE2 biosynthesis or signal transduction ameliorated loss-of-DUSP2-induced tu

50 ore, we identified a gene subcore containing signal transduction and activator of transcription 3, in

51 zed immune receptors undergo endocytosis for signal transduction and activity regulation while cell w

52 ng of the molecular mechanisms linking auxin signal transduction and auxin transport is still fragmen

53 restored the expression of genes involved in signal transduction and axonal elongation.

54 romolecules in complex cellular networks for signal transduction and biological function.

55 binding and activation dynamics of Ca2+/CaM signal transduction and can be used to guide focused exp

56 ance and elongation, cell cycle progression, signal transduction and cell proliferation.

57 photochemical basis of how they orchestrate signal transduction and control gene expression.

58 greatly facilitated our understanding of the signal transduction and cytoskeletal pathways that gover

59 te how the LBD gating ring is fundamental to signal transduction and gating in NMDARs.

60 ntial for methionine metabolism to influence signal transduction and gene expression in budding yeast

61 e developed an experimental assay to measure signal transduction and implement a theoretical model of

62 Enforced KLF4 expression blocked TGF-beta signal transduction and inhibited cell migration and inv

63 artment through both gp130 receptor-mediated signal transduction and interaction of vIL-6 with the ER

64 resents a specialized organelle dedicated to signal transduction and mechanosensing.

65 l and its environment, hosting extracellular signal transduction and nutrient transport among a varie

66 d/or preventing MC activation, modulating MC signal transduction and protection from the effects of M

67 s a key role in a wide variety of biological signal transduction and protein turnover processes.

68 ctivation may represent a novel mechanism of signal transduction and receptor cross-talk.

69 otential for UV-B photoreception, initiating signal transduction and responses in plants.

70 motile organelle that is specialized for Shh signal transduction and responsible, when defective, for

71 quence diversity is required for optimal TCR signal transduction and subsequent T cell maturation.

72 of finely regulated endosomal traffic in TCR signal transduction and T cell activation leading to IL-

73 s that range from cell envelope structure to signal transduction and transport, lipoproteins constitu

74 ly detoxify damaging peroxides and/or affect signal transduction and, thus, have roles in proliferati

75 h the activators and the inhibitors of IL-17 signal transduction, and also the physiological implicat

76 involvement of lincRNAs in stress response, signal transduction, and developmental processes.

77 etabolism, how it intersects with angiogenic signal transduction, and how alterations in metabolic pa

78 enhances calcineurin-dependent hypertrophic signal transduction, and its knockdown repressed hypertr

79 lectivity, inexpensive instrumentation, fast signal transduction, and low limit of detection (0.12 pp

80 for the organization of the plasma membrane, signal transduction, and membrane trafficking.

81 f Src, an initial transmitter in Na/K-ATPase signal transduction, and of Ca(2+) signaling marker Camk

82 o-localize all circuit sensing, computation, signal transduction, and output elements in the same sel

83 rogrammable toehold-mediated strand-exchange signal transduction, and standard pregnancy test strips.

84 tyrosine-based activation motifs involved in signal transduction, and this subunit by itself is suffi

85 nsors are reviewed, and different methods of signal transduction are evaluated.

86 t the conformational changes associated with signal transduction are subtle, constraining models of a

87 tion by maternal melatonin and establish TSH signal transduction as a key substrate for the encoding

88 function of enzymes could be as important in signal transduction as its catalytic activity, which is

89 ellular Wg ligand and nuclear trans-synaptic signal transduction, as well as downstream misregulation

90 sphatases is central to our ability to model signal transduction at a system level.

91 Spatiotemporal interrogation of signal transduction at the single-cell level is necessar

92 a domain architecture that includes a STAND (signal transduction ATPases with numerous domains) famil

93 en reported to possess multiple functions in signaling transduction based on its interaction with dif

94 Although the insulin signal transduction between IR and GLUT4 has been thorou

95 Little is known, however, about the signal transduction between stress cues and exosome secr

96 ts was determined by analysis of Wnt pathway signal transduction, bone nodule formation, and osteobla

97 oligomerization or control other aspects of signal transduction, but a lack of structural informatio

98 Skeletal myogenesis is regulated by signal transduction, but the factors and mechanisms invo

99 of Sevenless (SOS) plays a critical role in signal transduction by activating Ras.

100 ty and 38 residues whose mutation eliminated signal transduction by all ligands, providing a comprehe

101 of MOF sensory materials utilizing advanced signal transduction by devices based on MOF photonic cry

102 Here, we show that signal transduction by H2O2 depends on entry into the ce

103 Signal transduction by receptor tyrosine kinases (RTKs)

104 lay vital roles in inside-out and outside-in signal transduction by responding to inputs that include

105 ever, autophagy does not terminate cytosolic signal transduction by TGFbeta.

106 bitor reduced Src activation and blocked the signaling transduction by integrin alphaV, inhibited mig

107 tumor cell motility through a nonproteolytic signal transduction cascade involving activation and pho

108 The WNT signal transduction cascade is a main regulator of devel

109 hGHR bioassay demonstrated initiation of the signal transduction cascade, after binding of all invest

110 is regulated by the bacterial quorum-sensing signal transduction cascade, which allows bacteria to as

111 are downstream effectors in the Eph-induced signal transduction cascade.

112 ignant cells by RT initiates one or multiple signal transduction cascades that drive a permanent prol

113 These gases play a pivotal role in signal transduction cascades, leading to adaptive proces

114 itiation factor 2 alpha (eIF2alpha) or other signal transduction cascades.

115 OM on a number of experimental and in silico signal transduction case-studies, including the recent H

116 Caveolae are signal transduction centers, yet their subcellular distr

117 A glucose-sensitive signal transduction circuit involving the mTOR complex 1

118 inding sites of the symmetric FGF2-FGFR2-HS2 signal transduction complex.

119 A novel approach to signal transduction concerning solid-contact ion-selecti

120 nder stress showed functional enrichment for signal transduction, DNA-dependent regulation and transp

121 s and that the well known high speed of GPCR signal transduction does not require preassembly between

122 to the primary cilium, a key platform for HH signal transduction, does not correlate with HH signal p

123 a regulatory nexus between solar UV, ROS and signal transduction during skin carcinogenesis.

124 E STATEMENT We describe a novel mechanism of signal transduction enriched in medium spiny neurons of

125 ectronic signal without the use of expensive signal transduction equipment and facilitates the immobi

126 exosome biogenesis, protein trafficking, and signal transduction, especially in viral-associated tumo

127 to chemoattractants, the shear flow-induced signal transduction events displayed features of excitab

128 lagen (Shc) family are typically involved in signal transduction events involving Ras/MAPK and PI3K/A

129 Here we examined the signal transduction events that occur during TLR9-induce

130 me duplication provided the means to improve signal transduction for enhanced perception of environme

131 fasting conditions, resulting from impaired signal transduction from beta-adrenergic receptors to ad

132 This analysis showed that, in hepatocytes, signal transduction from IL-1beta via p38(MAPK) to MK2 i

133 ich helped separate crosstalk due to initial signal transduction from subsequent post-transcriptional

134 e P450 active site and different pathways of signal transduction from the allosteric site to the acti

135 ed for all RCK-regulated channels, involving signal transduction from the RCK domain to the gating ar

136 as no intrinsic enzymatic activity, and thus signal transduction from the receptor relies on addition

137 oteins serve as adapter molecules to mediate signal transduction from Tumor Necrosis Factor Receptor

138 n how, ultimately, Si3N4 influences cellular signal transduction functions and differentiation mechan

139 mic data revealed significant alterations in signal transduction, G protein coupled receptors, seroto

140 toskeletal dynamics, cell-cycle progression, signal transduction, gene expression, and apoptosis.

141 le) adaptive responses (both biochemical and signal transduction/gene expression-based) to changing i

142 eptors/co-stimulators, T cell activation and signal-transduction genes.

143 scade proteins (GO: 0007242) and Ras protein signal transduction (GO: 0007265), and contain active Ra

144 Gi/o-GPCR coupling and the high rate of Gi/o signal transduction have been hypothesized to be enabled

145 kinase modules and different models for SHK signal transduction have been proposed.

146 ears, inflammasome activation and subsequent signal transduction have emerged as an excellent example

147 r BR perception and initiation of subsequent signal transduction in Arabidopsis.

148 ation from one enzyme to another facilitates signal transduction in biological systems providing for

149 been particularly instrumental to realizing signal transduction in biosensors and bioelectronics.

150 ased inflammatory cell recruitment and CSF1R signal transduction in both macrophages and endothelial

151 emporal kinetics and spatial coordination of signal transduction in cells are vital for cell fate det

152 s essential for fast, specific, and accurate signal transduction in cells.

153 i-protein complexes that function as hubs of signal transduction in eukaryotic cells.

154 , outcomes suggest stroke acutely influences signal transduction in hindlimb skeletal muscle.

155 at allows label-free real-time monitoring of signal transduction in living cells.

156 we show that ECM stiffness leads to mechano-signal transduction in MSC, which promotes mammary tumor

157 ensable gases, and for several principles of signal transduction in multivariable sensors that result

158 studies, which have reported that TNF blocks signal transduction in response to IFNs.

159 Signal transduction in response to stimuli relies on the

160 structural mechanism presents a template for signal transduction in sensor histidine kinases.Sensor h

161 eric G protein activation is a major mode of signal transduction in the cell.

162 ove the discovery of the molecular basis for signal transduction in the initiation of sporulation in

163 yosin and suggest that altered regulation of signal transduction in the muscles within the spine may

164 h Galphaolf and can amplify odorant receptor signal transduction in vitro To explore the function of

165 esent selected examples of atypical modes of signal transduction including inactivation of HK activit

166 genes were distinct for genetic exchange and signal-transduction, indicating adaptation to specific c

167 suggests therapeutic approaches to treatment signal transduction inhibition.

168 Recent studies have demonstrated that the signal transduction initiated by these sensors is sophis

169 receptor, fostering transphosphorylation and signal transduction into the cell.

170 The role of endosomes in receptor signal transduction is a long-standing question, which r

171 G-protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and d

172 on of chemical signals across membranes, and signal transduction is often associated with an amplifie

173 The contribution of these TCR residues to signal transduction is supported by mutagenesis and T-ce

174 The hypoxia-induced signal transduction is transcriptionally mediated by hyp

175 olarizing steps, suggesting that cholinergic signal transduction itself is not voltage-sensitive, but

176 nt shaky Structural data suggest that during signal transduction, large transitions of the beta8-beta

177 brane and in endosomal compartments, (c) TCR signal transduction leading to T cell activation, and (d

178 gens and pharmaceutical interventions at the signal transduction level is still far from complete.

179 hronic inflammation or blocking inflammatory signal transduction may prevent cancer development.

180 nd the ATP-binding site are important in the signal transduction mechanism of AfGcHK.

181 lts are confirmation of a hallmark of the HK signal transduction mechanism with atomic resolution on

182 nal by employing an artificial transmembrane signal transduction mechanism.

183 solution, we investigated the intramolecular signal transduction mechanisms.

184 r, these data provide new information on the signal-transduction mechanisms that modulate the rewardi

185 metabolic processes but can also function as signal transduction mediators.

186 ignaling 9-2 (RGS9-2) is a striatal-enriched signal-transduction modulator known to have a critical r

187 tion probe, while keeping TaqMan probe-based signal transduction module as a universal signaling tool

188 composed of separated target recognition and signal transduction modules, it could be universally emp

189 on also increased the phosphorylation of the signal transduction molecule ERK2, activation of the tra

190 apentaplegic (SMAD) proteins are a family of signal transduction molecules in transforming growth fac

191 They primarily function as signal transduction molecules that regulate different pa

192 n active-state specific antibodies for other signal transduction molecules.

193 ntous actin-based protrusions, and increased signal transduction network activity.

194 nical stimuli trigger activation of a common signal transduction network that integrates external cue

195 Signal transduction networks allow eukaryotic cells to m

196 lucidates the influence of node abundance on signal transduction networks and will further our unders

197 The nature of signal transduction networks in the regulation of cell c

198 se findings can be used to decompose natural signal transduction networks into modules, and at the sa

199 e (NMDA) receptors activates Ca2+/calmodulin signal transduction networks that either increase or dec

200 llular energy homeostasis and in controlling signal transduction networks.

201 nce of mRNAs, lncRNAs and miRNAs on cellular signal transduction networks.

202 which shows how these metrics depend on the signal transduction noise level.

203 lphas subunit is classically involved in the signal transduction of G protein-coupled receptors (GPCR

204 ine-DNA alkyltransferase) led to LAMP-to-hCG signal transduction on low-cost, commercially available

205 sers to assess potentially functional sites, signal transduction or allosteric communication mechanis

206 unctions of proteins, such as in metabolism, signal transduction or immunity.

207 roles in beta-oxidation, lipid biosynthesis, signal transduction, or insulin exocytosis.

208 re we characterise a multi-step phosphorelay signal transduction pathway consisting of TcsA, TcrA, Fs

209 tors of the phosphoinositide 3-kinase (PI3K) signal transduction pathway contribute to the hypothalam

210 ed, indicating that targeting a specific D2R signal transduction pathway could allow for more precise

211 Notch signaling is a ubiquitous signal transduction pathway found in most if not all met

212 Our data describe a novel signal transduction pathway in neurons whereby ApoE acti

213 arious BMP receptors and members of the SMAD signal transduction pathway in nociceptive sensitization

214 Emerging work points to Nrf2-Keap1 signal transduction pathway inhibitors, including Bach1

215 view Ca2+/CaM as a limiting resource in the signal transduction pathway owing to its low abundance r

216 gonadotropes, we investigated the potential signal transduction pathway that conveys the inhibitory

217 tch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazo

218 ieA is part of an operon encoding the VieSAB signal transduction pathway that is nearly silent in V.

219 3/phosphoinositide 3-kinase/protein kinase B signal transduction pathway, and that can be overcome by

220 bly through a hitherto unknown communication signal transduction pathway.

221 the immunoreceptor tyrosine-based activation signal transduction pathway.

222 used these genes to investigate the c-di-GMP signal transduction pathway.

223 including those involved in the phytochrome signal transduction pathway.

224 diated by toll-like receptor 4 (TLR-4)/MyD88 signal-transduction pathway up-regulation of MLCK expres

225 nal permeability was mediated by TLR-4/MyD88 signal-transduction pathway up-regulation of MLCK.

226 ent analysis reveals that the 'plant hormone signal transduction' pathway is enhanced during pollen-p

227 w-abundance signaling molecules that control signal transduction pathways and are necessary for cellu

228 ting actin cytoskeletal dynamics, regulating signal transduction pathways and inhibiting host secreto

229 ulated kinase 1/2, and ribosomal S6 kinase 1 signal transduction pathways and subsequent increase in

230 t the role of the ERM proteins in regulating signal transduction pathways and suggests that modulatio

231 comprised different, functionally unrelated signal transduction pathways and were expressed in diffe

232 Ras is at the hub of signal transduction pathways controlling cell proliferat

233 However, the signal transduction pathways culminating in the biologic

234 s, cytoskeletal protein networks and complex signal transduction pathways driven by localized protein

235 dissect in vivo the requirement of different signal transduction pathways emanating from KIT for tumo

236 mprehensive, validated, and annotated map of signal transduction pathways in inflammatory Mvarphis ba

237 We also found signal transduction pathways tend to show extensive dyna

238 om cytotoxin-induced death by stimulation of signal transduction pathways that are linked to prion pr

239 r recovery from pneumonia, and modulation of signal transduction pathways that have been linked to pr

240 Targeting signal transduction pathways which promote therapy resis

241 veal a cross-talk among the external milieu, signal transduction pathways, and transcription factors

242 ein methylation is an important modulator of signal transduction pathways, but methyltransferases the

243 NPM-ALK co-opts several intracellular signal transduction pathways, foremost being the STAT3 p

244 entified crucial pathways, including several signal transduction pathways, hormone response, oxidativ

245 suppressed following stimulation by multiple signal transduction pathways, our findings also suggest

246 or internalization and activation of several signal transduction pathways, such as phosphoinositide 3

247 factors act indirectly via receptor-mediated signal transduction pathways.

248 thyroid carcinoma and describe the involved signal transduction pathways.

249 rocesses as a mediator of cross-talk between signal transduction pathways.

250 ity and trafficking, and the organization of signal transduction pathways.

251 ted proteins into complexes, organelles, and signal transduction pathways.

252 d that Epr3 is integrated into the symbiosis signal transduction pathways.

253 arcinoma cells and for the study of involved signal transduction pathways.

254 ment of cancer is to understand the cellular signaling transduction pathways that cause cancer at the

255 h contribute to TAV by initiating outside-in signaling transduction pathways that elicit monocyte rec

256 e a role in regulating protein stability and signaling transduction pathways.

257 ynamics from metabolic, gene regulatory, and signal transduction perspectives.

258 cle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic sy

259 While FLT3(ITD) can activate STAT5 signal transduction prior to birth, this signaling does

260 roximity of the cell membrane as part of the signal transduction process.

261 of 'pseudoenzymes' with a regulatory role in signal transduction processes but without catalytic acti

262 terminal src-homology 3 domain of Drosophila signal transduction protein drk is used as the test prot

263 ependent "redoxosomes," contribute to proper signal transduction.Protein-tyrosine phosphatases (PTPs)

264 ses by modulating metabolic and inflammatory signal transduction reactions.

265 ular organelles contain proteins that enable signal transduction, regulation of morphology and traffi

266 ogs had limited effect on G protein-mediated signal transduction, removal of positive charge from thi

267 Signal transduction requires reorganization of receptors

268 Single amino-acid mutation of potential signal-transduction residues resulted in severely impair

269 reds of disparate observations regarding ABA signal transduction responses underlying stomatal closur

270 m, stress response, biomass degradation, and signal transduction, revealed both conservation and dive

271 and the design principles orchestrating the signal transduction roles of the Hha protein family.

272 at many lncRNAs were associated with hormone signal transduction, secondary metabolites biosynthesis,

273 lymerase activity is monitored in the second signal transduction step based on primer extension react

274 llular and intercellular processes including signal transduction, subcellular localization, and regul

275 al basis for this unprecedented mechanism of signal transduction suggests new modalities for the trea

276 ine kinase AfGcHK is part of a two-component signal transduction system in bacteria.

277 ci is regulated by the VanSARA two-component signal transduction system.

278 rception is often regulated by two-component signal transduction systems (TCSTs).

279 Bacterial signal transduction systems commonly use receiver (REC)

280 ir response to these signals through complex signaling transduction systems.

281 Moreover, PKA-Smurf1-PIPKIgamma signal transduction takes a significant part in lung can

282 of protein-tyrosine phosphatase oxidation in signal transduction, the cell biological details of reac

283 tatin/activin binding site, hence preventing signal transduction through either ActRII.

284 chemical systems that initiate transmembrane signal transduction through molecular binding events is

285 , for example, cell-fate decision-making and signal transduction, through multiple layers of regulati

286 PRKs and NET2A implicate a role for NET2A in signal transduction to the actin cytoskeleton during fer

287 One group of likely candidates for signal transduction to the circadian clock are the PHYTO

288 .reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabol

289 an T cells: UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulati

290 Agonist binding leads to rapid signal transduction via an allosteric mechanism, where g

291 eart failure (HF) is associated with altered signal transduction via beta-adrenoceptors and G protein

292 Signal transduction via calcium ions (Ca2+) represents a

293 ntigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions.

294 culum (ER)-localized vIL-6, which can induce signal transduction via the gp130 signaling receptor, ac

295 Sonic hedgehog (Shh) signal transduction was downregulated in the mutant fore

296 istic target of rapamycin complex 1 (mTORC1) signal transduction was unleashed, and this coincided wi

297 te the prevalence of PDZ/14-3-3 switching in signal transduction, we built a protein domain microarra

298 vity', 'ribosomal subunit' and 'phosphorelay signal transduction', were overrepresented in Namikonga

299 ence response) and GO:0035556 (intracellular signal transduction) were significantly overrepresented

300 ceptors are versatile regulators of platelet signal transduction, with functions beyond inhibiting IT