ライフサイエンスコーパス: signaling

1 hose complexes trigger Galphai3-mediated ERK signaling.

2 folds that integrate mechanical and chemical signaling.

3 here shown to regulate ligand-specific Notch signaling.

4 box for delineating the mechanisms of sulfur signaling.

5 n lipid rafts to inhibit raft-dependent PI3K signaling.

6 ssisting in uncovering unknown aspects of Ub signaling.

7 ugh inhibiting TAZ and YAP, effectors of WNT signaling.

8 downstream of fibroblast growth factor (FGF) signaling.

9 pment of fatty liver depends on adipocyte GH signaling.

10 ing the central role for primary cilia in Hh signaling.

11 tance in the regulation of type I interferon signaling.

12 plants respond to locally enhanced cytokinin signaling.

13 dentify MRAP2 as a partner of ghrelin-GHSR1a signaling.

14 o help scientists unravel details of Mvarphi signaling.

15 , which are crucial for initiation of CLEC-2 signaling.

16 central to PITP-mediated regulation of lipid signaling.

17 ligand-independent manner, through BMP-SMAD signaling.

18 ough preventing aberrant activation of Sema3 signaling.

19 B) along with activation of Wnt and JAK/STAT signaling.

20 ng enzyme, leading to prolonged inflammatory signaling.

21 be the toxic species that disrupt endosomal signaling.

22 he pathological, EMT-inducing arm of TGFbeta signaling.

23 among the downstream targets of mTORC1-SRPK2 signaling.

24 ich we use to tune the levels of Raf/MEK/ERK signaling.

25 esses such as neurogenesis and growth factor signaling.

26 aling a previously unrecognized P2X-mediated signaling.

27 potassium channel function and EPH receptor signaling.

28 impairs H2A ubiquitylation and perturbs ATM signaling.

29 -155) and its target, suppressor of cytokine signaling 1 (SOCS-1).

30 EBI2 signaling activated Pin1 isomerase activity through a ca

31 thus serves to precisely modulate Wnt/Norrin signaling activity in the retinal endothelium and coordi

32 (CDN) second messenger cGAMP to activate the signaling adaptor STING.

33 Inhibition of signaling after ligand exposure selectively delayed prol

34 ould be related to conformational selection, signaling amplification, and probe dependence.

35 The enzymatic time course is sigmoidal, signaling an activation step, prior to turnover.

36 itant with defective ATM-mediated DNA repair signaling and accumulation of protein-linked DNA breaks.

37 t the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block

38 This is accompanied by suppression of MYC signaling and an increase in the T cell chemoattractant

39 dentify a novel mechanism linking IL-6 trans-signaling and angiogenesis in the peritoneal membrane.

40 to the source of infection, enriched for IFN signaling and antigen presentation.

41 CR specifically required for endothelial Wnt signaling and BBB integrity under pathological condition

42 cell proteome and phosphoproteome and reveal signaling and bioenergetics pathways that mediate lympho

43 This is accompanied by increased GABAergic signaling and by enhanced responsiveness to a neurochemi

44 -specific roles for DUSP5 in controlling ERK signaling and cell fate.

45 erapy resistance by influencing compensatory signaling and expanding proliferation.

46 ein that enhances beta-catenin-dependent Wnt signaling and has previously been shown to regulate ISV

47 uced TNBC cell metastasis via PAI-1 and CCL5 signaling and illustrate the potential of developing new

48 in of the beta3 integrin prevents outside-in signaling and infection.

49 opose a role for miR-718 in controlling TLR4 signaling and inflammatory cytokine signaling through a

50 tyrosine kinase (BTK) inhibitor, targets BCR signaling and is particularly active in lymphomas with m

51 osphorylates MyD88, promoted MyD88-dependent signaling and mediates dermatosis in Ptpn6(spin) mice.

52 s bound to active receptors, augmenting PI3K signaling and oncogenic transformation.

53 ed here provides the molecular basis for the signaling and pathophysiological functions mediated by 2

54 itical effector of pro-inflammatory cytokine signaling and plays important roles in immune function,

55 n species (ROS) play a critical role in cell signaling and proliferation.

56 e prevalent in the cell, including important signaling and regulatory pathways.

57 ly; however, the underlying defects in cilia signaling and the function of INPP5E at cilia are still

58 bocytopenia by blocking thrombopoietin (TPO) signaling and therefore differentiation of stem cells in

59 f the proapoptotic proteins BIM and BAX, JNK signaling, and endoplasmic reticulum stress, explaining

60 ted by changes in host vitellogenin, insulin signaling, and gustatory response.

61 ier plant cell model for membrane transport, signaling, and homeostasis.

62 ds play central roles in metabolism and cell signaling, and thus reflect the phenotype of the tissue

63 ary proteome, reveals ancient connections to signaling, and uncovers a ciliary protein that underlies

64 ) studies in which both the receptor and its signaling are deleted, making it impossible to explore t

65 l key regulators of ciliogenesis and ciliary signaling are mutated in humans, resulting in a number o

66 es revealed G-protein-coupled receptor (GPR) signaling as a prominent EVI1 effector mechanism in brea

67 LBCL molecular subtypes and posit MYD88/p100 signaling as a regulator for B-cell activation.

68 oduction and autocrine/paracrine C3ar1/C5ar1 signaling as crucial intermediary processes that link TL

69 sult was true for the inhibition of FcgammaR signaling as well.

70 establishment of a TN-alpha2beta1-JAG1-NOTCH signaling axis as a candidate therapeutic target in glio

71 ective peptide inhibitors of the CXCL1-CXCR2 signaling axis identified HIF-2alpha-dependent neutrophi

72 cle mass via their activation of the Smad2/3 signaling axis, we used local injection of adeno-associa

73 iated cell death via the RIG-I-MAVS-IFN-beta signaling axis.

74 series of compounds spanning a wide range of signaling bias.

75 ancer cells that harbor defects in antiviral signaling, but a minority are nonpermissive because the

76 Elimination of in vivo signaling by all six of these 'lineage-specifying cytoki

77 at Nrdp1 acts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquiti

78 of regulation of G protein-coupled receptor signaling by scaffolding proteins.

79 The fact that defects in signaling can lead to malignancy illustrates the need to

80 Thus, GluN2B-driven excitotoxic signaling can proceed independently of Dapk1 or altered

81 ing p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WAS

82 Aberrant PAD exposure induces a signaling cascade that leads to disruption of axonal tra

83 Cumulatively, we identify a signaling cascade that provokes structural remodeling of

84 ereas targeted DNMT1 depletion abrogates KIT signaling cascade through Sp1/miR-29b network.

85 n PDAC cells, leading to stimulation of HER2 signaling cascade, including ERK1/2, FAK, AKT and PAK1 a

86 edgehog (HH) paracrine system as a candidate signaling cascade.

87 g assays, and inhibition of LRP6 or critical signaling cascades downstream of LRP6, including JNK and

88 ma-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades.

89 The reduction in the initiation of BCR signaling caused by actin alteration is associated with

90 trosomes and cilia and is important for cell signaling, cell cycle progression, polarity, and motilit

91 Interestingly, the cells of the posterior signaling center were preserved in these mutants.

92 ce branching is regulated by novel localized signaling centers.

93 by altered levels of pathway activation, the signaling changes in developing tissues remain largely u

94 at RARgamma initiates the formation of death signaling complexes by mediating RIP1 dissociation from

95 duce a systemic resistance that shares early signaling components with the root iron-uptake machinery

96 tumors lack deregulation of APC/beta-catenin signaling components, which are crucial gatekeepers in c

97 These findings establish that PXR signaling contributes to ALD development and suggest tha

98 tho down-regulates growth factor-driven PI3K signaling, contributing to extension of lifespan, cardio

99 ls treated with rapamycin, suggesting mTORC1 signaling controls their phosphorylation.

100 her, these results indicate that SOB3 and BR signaling converge to influence the transcription of hyp

101 In addition to TCR signaling, costimulatory pathways are involved in T cell

102 eta2AR has broad implications for adrenergic signaling, cross-talk with other signaling pathways, and

103 bule stabilization, which, together with the signaling data, suggests that the microtubule cytoskelet

104 gulate proinflammatory cytokines via a Wnt5a signaling-dependent mechanism.

105 e peroxisome proliferator-activated receptor signaling-dependent switch from glycolysis to fatty acid

106 Downstream signaling determined by patch-clamp measurements showed

107 es suggest that mechanisms for neuroestrogen signaling differ between and even within brain regions.

108 We therefore conclude that PTH1R signaling directly and indirectly regulates the paracell

109 We further elucidated the signaling downstream of Gq and identified an important r

110 Btk has been demonstrated to regulate signaling downstream of the B-cell receptor (BCR), Fc re

111 s consistently shown XIAP to be critical for signaling downstream of the Crohn's disease susceptibili

112 However, the inherent complexity of Ub signaling due to the high atomic complexity of Ub conjug

113 -change response was observed throughout the signaling duration and across Tgf-beta doses, and signif

114 itch that underlies the central logic of PCP signaling during morphogenesis, and provides new insight

115 t Rab8a recruits PI3Kgamma for Akt-dependent signaling during TLR4 activation to limit the production

116 rfere with signaling dynamics, and, in turn, signaling dynamics affects inhibitor responses, we inves

117 resence of interacting signals, finding that signaling dynamics are largely robust to interference.

118 Specific parameters of signaling dynamics correlated strongly with drug sensiti

119 ngle-cell studies has begun to elucidate how signaling dynamics determine cell physiology and represe

120 Insofar as kinase inhibitors interfere with signaling dynamics, and, in turn, signaling dynamics aff

121 e.g., SV2A, synaptogyrin-1) and postsynaptic signaling (e.g., GluA1, PRRT2) with no changes in synapt

122 1486 rats identified BRaf as the key missing signaling effector in the common synaptic NMDA-R-CaMKII-

123 tionally, we observed that Olig1 and the BMP signaling effector, phosphorylated SMADs (Sma- and Mad-r

124 phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, n

125 Type I interferon (IFN) signaling engenders an antiviral state that likely plays

126 All viruses must antagonize antiviral signaling events for survival.

127 of KaiC create a hub around which nighttime signaling events revolve, including inactivation of KaiA

128 insurmountably (suppressed agonist Emax) in signaling events such as guanosine 5'-3-O-(thio)triphosp

129 m salt and MRS2365 (5'-diphosphates) in some signaling events, such as extracellular signal-regulated

130 , a protein complex that mediates downstream signaling events.

131 CD8(+) T cells require sustained Ca(2+) signaling for inflammatory cytokine production and the k

132 ad, we have identified other features of PKA signaling for reducing catalytic subunit diffusion and i

133 and S. cerevisiae The converse direction of signaling from TORC1 to the PHO regulon previously obser

134 reading, and fusion of myoblasts through the signaling function of the cytoplasmic domain of ICAM-1.

135 These signaling functions of BHB broadly link the outside envi

136 t have intracellular sequences with opposing signaling functions.

137 nt up-regulation of nitrate assimilation and signaling genes and down-regulation of the G2/M cell-cyc

138 on factors and B cell receptor (BCR)/pre-BCR-signaling genes.

139 Dysregulated catecholamine signaling has long been implicated in drug abuse.

140 by DC-bound IL-6Ralpha (called 'IL-6 cluster signaling' here) was needed to prevent premature inducti

141 e functional relevance of the observed tonic signaling heterogeneity remain open questions today.

142 ional mechanisms by which lysine methylation signaling impacts on cell fate decisions.

143 TNC as a pivotal initiator of elevated NOTCH signaling in BTIC and define the establishment of a TN-a

144 er, whether and to what extent TRAIL/TRAIL-R signaling in cancer cells can affect the immune microenv

145 nder stressful conditions, maintained mTORC1 signaling in cancer cells promotes survival by suppressi

146 Blocking RAGE signaling in cell and animal models has revealed that ta

147 ther disruption of endogenous glucocorticoid signaling in chondrocytes also modulates the course and

148 gs identify specific roles for p100 and p105 signaling in defining DLBCL molecular subtypes and posit

149 ponse to therapeutic inhibition of tonic BCR signaling in DLBCL.

150 By comparing relative bias for MOR-mediated signaling in each pathway, we demonstrate a strong corre

151 apid activation of STAT3, NFkappaB, and MAPK signaling in HMVP2 cells, which was again attenuated by

152 requirement for primary cilia-mediated GPCR signaling in interneuronal connectivity and inhibitory c

153 del for DM1 (HSALR mice), activation of AMPK signaling in muscle was impaired under starved condition

154 AT-c2, reflecting increased calcineurin/NFAT signaling in myocyte hypertrophy.

155 1R(-/-) mice, suggesting the role of SP-NK1R signaling in ocular surface homeostasis under steady-sta

156 protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus

157 Gbeta1 protein enlists PP1c to modulate GPCR signaling in platelets.

158 xacerbated D1-cAMP/protein kinase A dopamine signaling in pyramidal neurons that in turn pathological

159 The comparison of ABA metabolism and signaling in roots of flooded and water stressed plants

160 Most methods for inducing Wnt signaling in stem cell cultures do not control the spati

161 We investigated the role of steroid hormone signaling in the brain on distinct features of birdsong

162 ion of tau protein as a regulator of insulin signaling in the brain.

163 dependence of paraventricular nucleus GLP-1 signaling in the coordination of neuroendocrine, autonom

164 ed by estrogen-induced repression of TGFbeta signaling in the local fibroblasts.

165 teins regulating GABAergic and glutamatergic signaling in the prefrontal cortex.

166 Hedgehog (Hh) signaling in vertebrates depends on primary cilia.

167 making it impossible to explore the possible signaling-independent functions of the receptor, which a

168 iRNAs to type I and II BMP receptors and the signaling intermediaries (Smads), we demonstrated a key

169 Thus, genomic DNA DSBs act as signaling intermediates in murine macrophages, regulatin

170 tion of tumor necrosis factor (TNF) receptor signaling is a key feature of various inflammatory disor

171 Notch signaling is a ubiquitous signal transduction pathway fo

172 Considering that Notch signaling is commonly activated in cancer, tankyrase inh

173 Here we report that PI3K signaling is critical for the control of West Nile virus

174 cells (alphaRaptorKO), we showed that mTORC1 signaling is dispensable for alpha cell development, but

175 This NMDA receptor-signaling is prerequisite for developmental programs ult

176 us, we sought to determine if intrinsic MAVS signaling is required for participation of Tregs in anti

177 we demonstrated that T-cell intrinsic MyD88 signaling is required for proliferation, protection from

178 Hh signaling is triggered at the primary cilium.

179 o affect vascular integrity and regenerative signaling, is here shown to regulate ligand-specific Not

180 Hyperactive Hnf4 signaling leads to up-regulation of lipase 3 and enzymes

181 nstrate a FOXC1-elicited non-canonical WNT5A signaling mechanism comprising NF-kappaB and MMP7 that i

182 is unknown whether they can exploit this new signaling mechanism.

183 4 as a master controller of Wnt/beta-catenin signaling-mediated breast cancer tumorigenesis, metastas

184 Collectively these data demonstrate MyD88 signaling mediates early inflammatory responses in the j

185 r molecule has tremendous importance in cell signaling, medical diagnostics, and therapeutics.

186 ing GBAi in vivo, we show that GBA-dependent signaling modulates phenotypes during Xenopus laevis emb

187 Since the Sema3 subfamily of signaling molecules plays diverse roles in the regulatio

188 rom stem cell metabolism has been emerged as signaling molecules to regulate stem cell behaviors such

189 etic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive PCa

190 cytes (IHH) and activation of its downstream signaling molecules.

191 tein farnesylation as a potential hub of the signaling network affecting multiple aspects of metaboli

192 These results define a new component of the signaling network by which activating mutations in the F

193 The Abl tyrosine kinase signaling network controls cell migration, epithelial or

194 e computational model of the cardiac mechano-signaling network in order to elucidate the mechanisms u

195 adding an important component to the nitrate signaling network.

196 prisingly, these synthetic ligands modulated signaling of a GPR56 mutant defective in autoproteolysis

197 ntal roles in the structure, energetics, and signaling of cells and organisms.

198 We show that signaling of CyaA-generated cAMP blocks the oxidative bu

199 s and platelets, the impact of CK2-dependent signaling on MK/platelet (patho-)physiology has remained

200 ces of light, metabolic, and circadian clock signaling on rates of cellulose biosynthesis and cell wa

201 portant beta-catenin interaction partner and signaling opponent of other PKC isoforms in podocytes.

202 attenuated the upregulation of the TGF-beta signaling pathway and alpha1-antitrypsin protein (a seri

203 inc-induced cancer prevention and Orai1-SOCE signaling pathway in cancer cells.

204 gs that inhibit important kinases in the BCR signaling pathway inhibit activation of lytic viral expr

205 ial-to-mesenchymal transition and the ERK1/2 signaling pathway inversely affected by miR-519d or EphA

206 mouse infection models, we show that the SIP signaling pathway is active during infection and contrib

207 tion of the presence of WNV through the MAVS signaling pathway is not required for generation of effe

208 Although the canonical Notch signaling pathway is well characterized, accumulating ev

209 This unconventional signaling pathway offers an innovative therapeutic targe

210 ng genetic aberrations that impair the Hippo signaling pathway showed heightened sensitivity to gemci

211 significance, as therapeutic targeting of a signaling pathway such as NG2/CSPG4 may have different e

212 LTCCs) in the plasma membrane can initiate a signaling pathway that ultimately increases nuclear CREB

213 EVs secreted by AFSC could target a specific signaling pathway within the glomerulus, thus representi

214 mber of the Bone Morphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp), specifically i

215 was shown to be interference with the lipid signaling pathway, leading to reduced expression of MDR

216 ng the last years in understanding the SnRK1 signaling pathway, many of its components remain unident

217 1, 0007155) and pathways in cancer, PI3K-Akt signaling pathway, metabolic pathways (pathway IDs: 5200

218 liferation of PDGFRalpha+ cells via PI3K/Akt signaling pathway.

219 riation in 40 of 41 genes comprising the NOD signaling pathway.

220 ion in the murine lung via a TLR2/TLR4/MyD88-signaling pathway.

221 cogenic dependency from the BCL-2 to the ERK signaling pathway.

222 tivating a Calcineurin-FoxO-MuRF1-proteosome signaling pathway.

223 ell growth involves inhibition of the p70S6K signaling pathway.

224 nes with aberrant activation of the Hedgehog signaling pathway.

225 AP4Ks as important regulators of the DLK/JNK signaling pathway.SIGNIFICANCE STATEMENT Neuronal degene

226 ndicated an upregulation of "Axonal Guidance Signaling" pathway.

227 in this study between cell-specific dynamic signaling pathways and drug sensitivity.

228 c progression of HCC by integrating multiple signaling pathways and suggest that Gab2 might be a powe

229 d endocrine systems, by influencing cellular signaling pathways and sulfhydration of target proteins.

230 Surprisingly, what signaling pathways are active in the basal state and the

231 activation of epithelial NF-kappaB and PI3K signaling pathways are restricted by the M-ILK deficienc

232 Both signaling pathways have been predicted previously using

233 growth factor 21 (FGF21), and activation of signaling pathways in adipose tissue.

234 ns was a result of activation of alternative signaling pathways mediated by factors secreted by BM st

235 In an attempt to identify novel actin signaling pathways regulated by NPM-ALK, a comprehensive

236 activin and TGF-beta are strongly connected signaling pathways that are important in advanced CRC.

237 mily of nonreceptor tyrosine kinases acts in signaling pathways that regulate cell migration, cell ad

238 identified multiple candidates in many cell signaling pathways that were able to mediate significant

239 n upstream regulators of the TORC1 and TORC2 signaling pathways to coordinate cellular stress respons

240 of a variety of genes and identify multiple signaling pathways underlying taste cell differentiation

241 adrenergic signaling, cross-talk with other signaling pathways, and the effects of betaAR-directed d

242 se and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as increased total and activ

243 13 also linked SMYD2 to other PKD-associated signaling pathways, including ERK, mTOR, and Akt signali

244 metric to study information transmission in signaling pathways, it does not capture the overlap betw

245 Although much is known about the underlying signaling pathways, it remains unclear how macroscopic f

246 to be spatially regulated through two myosin-signaling pathways, myosin light chain kinase and Rho-as

247 reciprocal feedback between AR and PI3K/AKT signaling pathways, pAKT levels were increased in androg

248 antagonism patterns could vary in different signaling pathways, which could be related to conformati

249 be correlated to restoration of ERK and AKT signaling pathways.

250 ns 273 scaffold proteins and 1118 associated signaling pathways.

251 n if they are mediated by shared or distinct signaling pathways.

252 rmations to respond to regulatory signals in signaling pathways.

253 rom mouse tracheas were assayed in vitro for signaling pathways.

254 ccording to a mechanism involving endogenous signaling pathways.

255 ions, which, in turn, may reveal further Wnt signaling pathways.

256 sias often due to interacting or overlapping signaling pathways.

257 Here, we show that BMP signaling plays a critical role in looping morphogenesis

258 Hedgehog (Hh) signaling promotes B lymphopoiesis in a non-cell-autonom

259 tient-derived glioma stem cells (GSCs), EGFR signaling promotes H3K23 acetylation and association wit

260 Signaling properties of G protein complexes carrying mut

261 Signaling proteins such as protein kinases adopt a diver

262 ocal regulation of the mutually antagonistic signaling proteins, SasA and CikA.

263 romosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2.

264 esults identify mechanisms through which FGF signaling regulates inner cell mass lineage restriction

265 Receptor signaling relays on intracellular events amplified by se

266 aired under starved conditions, while mTORC1 signaling remained active.

267 propose that deficits in IP3-mediated Ca(2+) signaling represent a convergent hub function shared acr

268 tor and mammalian target of rapamycin (mTOR) signaling, respectively.

269 cluding the kinases CK2 and p-ERK1/2 and the signaling scaffold KSR1.

270 we examined the effect of this nitric oxide signaling score on cardiometabolic and other diseases.

271 nase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion

272 phosphorylation of downstream targets of AXL signaling such as AKT and P70S6K.

273 e latter term describing the brain's chronic signaling systems that function to slowly degrade molecu

274 We have identified a number of neuropeptide signaling systems with both oncogenic and tumour-suppres

275 However, few such signaling targets have been identified for exploitation.

276 w focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspect

277 monstrate a concurrent increase in NF-kappaB signaling that is correlated with aneurysm severity in t

278 CRF1 coupling translates into divergent cell signaling that is expressed as different brain phosphopr

279 s as an intrinsic negative regulator of TLR4 signaling that targets TIRAP.

280 Thus, TTM reduces copper levels and MAPK signaling, thereby inhibiting BRAF(V600E)-driven melanom

281 ing TLR4 signaling and inflammatory cytokine signaling through a negative feedback regulation loop in

282 creatic cells is regulated by Ca(2+) and ROS signaling through Ca(2+)-induced structural changes prom

283 Signaling through cGMP has therapeutic potential in the

284 s fully competent to support Hsp90-dependent signaling through heterologously expressed glucocorticoi

285 nal K(+) into rapid, 'inside-out' electrical signaling to direct blood flow to active brain regions.

286 nsulin-signaling cascade and connecting PAK1 signaling to N-WASP-cortactin-mediated actin polymerizat

287 he important contributions of TGFbeta family signaling to normal development, adult homeostasis and d

288 o require ETS1-mediated transduction of VEGF signaling to release paused RNAPII.

289 uired for mechanosensitive ICAM-1 downstream signaling toward activation of the PI3K, and recruitment

290 asion, increased stemness, increased calcium signaling, transformation, and novel E-cadherin-RalBP1 i

291 its N terminal and modulates STAT3 and TBK1 signaling, triggering a switch from proinflammatory to a

292 thways through which parallel biogenic amine signaling tunes behavior appropriately to nutrient condi

293 rchitecture dictates essential aspects of Ca signaling under both normal and diseased conditions.

294 This reduction required intracellular signaling via second messengers-cytosolic calcium, react

295 g angiogenesis and lymphangiogenesis through signaling via VEGF receptor (VEGFR)-2 and VEGFR-3, respe

296 aling pathways, including ERK, mTOR, and Akt signaling, via PTPN13-mediated phosphorylation.

297 IL-6 signaling was increased by Gab2 overexpression and impai

298 dectin 1-or blockade of dectin 1 downstream signaling was protective.

299 e physiological relevance of noncanonical TR signaling, we generated knockin mice with a mutation in

300 Inhibition of ILK signaling, which is involved in cell motility and cytosk