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1 the ultimate effector protein of this stress signaling cascade.
2 icant role of Y954 in influencing downstream signaling cascade.
3 is, and the mitogen-activated protein kinase signaling cascade.
4 rmacologically tractable Prion Protein (PrP) signaling cascade.
5 reases ENaC activity independent of the RAAS signaling cascade.
6 echanisms, proliferative pathway and the Wnt signaling cascade.
7 T303 in the DCT of mouse kidney via the PTH signaling cascade.
8 ferentiation depends on a Dll4-Jag1-EphrinB2 signaling cascade.
9 t links Ras family members with the MAPK/ERK signaling cascade.
10 N) classically counteracts the PI3K/AKT/mTOR signaling cascade.
11 potent and selective antagonist of the CCR3 signaling cascade.
12 tune a fast reactive but potentially harmful signaling cascade.
13 tumor by inhibiting the NF-kappaB-IL-6-STAT3 signaling cascade.
14 ly regulated by TORC1 through the Rim15-Ume6 signaling cascade.
15 SG formation by inhibiting the PKR-triggered signaling cascade.
16 activity of the RTK-RAS-RAF and RTK-PI3K-AKT signaling cascade.
17 edgehog (HH) paracrine system as a candidate signaling cascade.
18 ity-dependent, non-apoptotic Bax/Bak-caspase signaling cascade.
19 orylates multiple proteins in the checkpoint signaling cascade.
20 survival by exerting dual effects on the BCR signaling cascade.
21 at and cocaine on the proliferative TGF-beta signaling cascade.
22 a negative feedback mechanism in the Ain/Lux signaling cascade.
23 Mtb gains survival advantage through ATM-Akt signaling cascade.
24 promote Treg-cell generation through the BMP signaling cascade.
25 nism, coupled with the insulin receptor (IR) signaling cascade.
26 the mitogen-activated protein kinase (MAPK) signaling cascade.
27 d to identify additional players in the cAMP-signaling cascade.
28 ion of ATM-FOXO3a association and downstream signaling cascade.
29 -alpha and induced a PI3K/PDK1/PKA-dependent signaling cascade.
30 tively disrupting a previously unappreciated signaling cascade.
31 a dominant astrocyte-mediated glutamatergic signaling cascade.
32 latelets, an essential component of the ITAM-signaling cascade.
33 lly affect processes downstream of the auxin signaling cascade.
34 sms, and nonequilibrium effects in a dynamic signaling cascade.
35 y nutrient-sensing mechanisms and cell death signaling cascades.
36 ized properties to help orchestrate multiple signaling cascades.
37 y in vivo and alters multiple immune-related signaling cascades.
38 ch several are found on proteins involved in signaling cascades.
39 sine receptor subtypes that induce different signaling cascades.
40 otic mitogen-activated protein kinase (MAPK) signaling cascades.
41 n through activation of FGFR4 and downstream signaling cascades.
42 g with activated downstream protein kinase B signaling cascades.
43 ly through convergence of multiple perturbed signaling cascades.
44 inase (IKK)/nuclear factor-kappaB (NFkappaB) signaling cascades.
45 bind to phosphothreonine (pThr) residues in signaling cascades.
46 t/beta-catenin and noncanonical Wnt/Ror2/Jnk signaling cascades.
47 h include activating several proteolytic and signaling cascades.
48 tegy to restore balance to these hyperactive signaling cascades.
49 nodine receptor and Ulk-1-PERK and AMPK-mTOR signaling cascades.
50 s stomatal closure via multifarious cellular signaling cascades.
51 /p50) is involved in both NF-kappaB and MAPK signaling cascades.
52 ell surface receptors to activate downstream signaling cascades.
53 enzymatic activities, which initiate various signaling cascades.
54 h) by the Hh ligands relieves suppression of signaling cascades.
55 ma-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades.
56 classical receptor tyrosine kinase-activated signaling cascades.
57 ctivation of the ATM and CaMKII proapoptotic signaling cascades.
58 rs, locally amplifying ECM input to internal signaling cascades.
59 l-surface receptors to control intracellular signaling cascades.
60 and biological processes, such as intricate signaling cascades.
61 y, integrates multiple inputs from different signaling cascades.
62 essions, post-translation modifications, and signaling cascades.
63 the mitogen-activated protein kinase and AKT signaling cascades.
64 strating the transduction of a repertoire of signaling cascades.
65 nd act as scaffolds to enhance intracellular signaling cascades.
66 multiple levels of NF-kappaB, STAT and AP-1 signaling cascades.
67 t-pathogen interaction through activation of signaling cascades.
68 on to output a specific cell lineage through signaling cascades.
69 neural repair but does not pin down specific signaling cascades.
70 cover two crucial properties of the core SAC signaling cascade: (1) a cellular limit on the maximum a
72 ernal negative charge of the cell triggers a signaling cascade activating an innate immune response c
73 stress activates the DNA damage response, a signaling cascade allowing cell cycle arrest and repair
74 ption, the Fzr-ubiquitinated H2B (H2Bub)-Myc signaling cascade also positively regulates the transcri
75 gh this canonical pathway is the predominant signaling cascade, alternative pathways also affect ethy
76 er cancer treatment: targeting the ErbB/MAPK signaling cascade and (2) establish the utility of canin
77 the cytoplasm downstream of Fzd7 in the Wnt signaling cascade and APC mutations activate Wnt/beta-ca
78 ing p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WAS
79 sponse to IL-15, CD122+Macs activate the ERK signaling cascade and enhance production of proinflammat
82 nrelated receptors can change the downstream signaling cascade and regulate neuronal growth through a
83 romotes cell proliferation by activating AKT signaling cascades and augmenting cell cycle progression
84 naling, which cooperated with other cellular signaling cascades and cytoskeletal remodeling to suppor
88 te to deregulation of critical developmental signaling cascades and inflammatory responses following
89 ntraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene
90 change detection may be important in diverse signaling cascades and multiple biological contexts.
91 e kinases, activates various proinflammatory signaling cascades, and concomitantly stimulates Wnt and
92 , depending on behavioral context, G-protein-signaling cascades, and DA neuron efferent targets, high
95 esponse to genotoxic stress, multiple kinase signaling cascades are activated, many of them directed
96 embryos of unknown sex, whether BDNF-induced signaling cascades are altered when early and recycling
97 Our discovery highlights this NAC42-NPF6.1 signaling cascade as a strategy for high NUE and yield b
98 hate-mediated signaling and calcineurin-NFAT signaling cascade as important biological process associ
99 entify activation of the NF-kappaB/LIF/STAT3 signaling cascade as involved in inducing antibody-media
100 least in part, via inhibition of TLR4/MyD88 signaling cascade as well as inactivation of NLRP3 infla
101 of radiation dose fractionation on the KLF2 signaling cascade at early time points (up to 24 h).
102 Extracellular Signal-Regulated Kinase (ERK)-signaling cascade at the most proximal step of effector
105 L5 (HY5) represents a major hub in the light-signaling cascade both under visible and UV-B light.
106 ha-actin cytoskeleton and classic fibrogenic signaling cascades, but also emphasize the relationship
107 mplicated in the regulation of critical cell-signaling cascades, but most OTUs functions remain to be
108 terferons (IFNs) activate similar downstream signaling cascades, but unlike type I IFNs, type III IFN
109 actors to the DNA damage site, initiation of signaling cascades, chromatin remodeling, cell-cycle che
110 STATEMENT At the neuronal membrane, protein signaling cascades consisting of ion channels and metabo
111 ne evasion strategies but also of the immune signaling cascades controlling antiviral immunity and th
112 athway represents one of the best-understood signaling cascades controlling epithelial morphogenesis.
115 in interacting proteins control inflammatory signaling cascades could provide new pathways for therap
116 sm in which cholesterol depletion triggers a signaling cascade, culminating with contraction impairme
117 ion factor downstream of the RAS-RAF-MEK-ERK signaling cascade directly transactivates the xCT promot
118 mily that signal via the BMP receptor (BMPR) signaling cascade, distinct from canonical TGF-beta sign
119 ement is facilitated through a switch in the signaling cascade downstream of CaSR (i.e., from the PI3
121 and mammalian target of rapamycin-dependent signaling cascade downstream of Toll-like receptors (TLR
122 ath pathway mediated by the RIPK1-RIPK3-MLKL signaling cascade downstream of tumor necrosis factor al
123 rative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate
124 g assays, and inhibition of LRP6 or critical signaling cascades downstream of LRP6, including JNK and
126 ns similar to Mp1p can severely disturb host signaling cascades during proinflammatory responses by r
128 ography, we found that loss of this critical signaling cascade exaggerated the vasoconstrictor respon
129 This redox-auxin-strigolactone systemic signaling cascade facilitates eCO(2) -induced AMF symbio
131 ctor receptor (EGFR), and activates cellular signaling cascades for host invasion, cytoskeletal remod
133 ke receptors (TLRs) coupled to intracellular signaling cascades function as central elements of innat
136 sms by which they can be coupled to neuronal signaling cascades highlights the desirability of contin
137 t mutations of genes controlling the Rac/Rho signaling cascade important for proper migration and dif
139 , we identified a dysregulated miR-486/DOCK3 signaling cascade in dystrophin-deficient muscle, which
140 indings establish the role of GBP2/Stat3/FN1 signaling cascade in GBM invasion and suggest GBP2 may s
142 study has uncovered a novel PKCbeta-Lyn-Pyk2 signaling cascade in primary monocytes that regulates MC
143 macrophages that activate the intracellular signaling cascade in response to pathogenic stimuli.
145 the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and response to AW
146 uronal DAF-7/TGFbeta causes a DAF-1/TGFbetaR signaling cascade in the gonadal distal tip cell (DTC),
148 ncing broadly implicates TrkB.T1 in the PI3K signaling cascades in a ligand-independent fashion.
150 n the one hand, the virus highjacks cellular signaling cascades in order to support its propagation;
151 Growing evidence implicates altered mTORC1 signaling cascades in the pathophysiology of depression,
154 n PDAC cells, leading to stimulation of HER2 signaling cascade, including ERK1/2, FAK, AKT and PAK1 a
155 f post-transcriptional regulation of the ECF signaling cascade, including the previously reported pos
156 R can also act in a variety of intracellular signaling cascades independently of RAS in the renal med
157 at the endosomal pathway is required for the signaling cascade initiated by BDNF and its receptors at
158 ion has addressed early steps in the insulin signaling cascade, insulin resistance in obesity seems t
159 and that its role depends on activation of a signaling cascade involving apoptosis signaling kinase 1
160 ibition of TRPM3 channels occurs via a short signaling cascade involving Gbetagamma proteins, which f
161 rch in the mouse embryo have revealed that a signaling cascade involving the Bone Morphogenic Protein
162 sa, expression of the T3SS is regulated by a signaling cascade involving the proteins ExsA, ExsC, Exs
166 The epidermal growth factor receptor (EGFR) signaling cascade is known to drive cell migration and p
167 g of the structural elements regulating this signaling cascade is limited, hindering structure-based
170 ically, our data indicate that the NF-kappaB signaling cascade is significantly upregulated in Nlrx1(
174 ues by binding with cytokines to transduce a signaling cascade leading to gene transcription in cells
175 tical contractility during mitosis through a signaling cascade leading to multipolar divisions, and i
176 promoting a protein kinase A (PKA)-dependent signaling cascade leading to phosphorylation of serine S
177 interferon genes (STING), which activates a signaling cascade leading to the production of type I in
178 d FPR2/ALX receptors and the downstream AMPK signaling cascade, leading to macrophage skewing, dampen
179 utation results in dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodie
180 ogy, suggesting that modulation of glutamate signaling cascades may offer novel therapeutic potential
181 -irradiated cells also activate a checkpoint signaling cascade mediated by the ATM and Rad3-related (
182 a novel non-cell autonomous neuroprotective signaling cascade mediated through PI3K that requires re
183 negatively regulates the NF-kappaB pathway-a signaling cascade necessary for HIV-1 replication and in
184 signaling but also neomorphic, as it enables signaling cascades not canonically mediated by JAK1.
185 e governed in part by complex interconnected signaling cascades occurring between stromal and tumor c
188 ders, such as autism and schizophrenia, this signaling cascade offers new avenues to modulate synapti
189 RasGRF2), upstream regulators of the Ras-ERK signaling cascade, on cocaine self-administration (SA) i
191 mRNA and miRNA gene annotation information, signaling cascade pathways and direct cancer association
192 he cyclooxygenase-2 (COX-2)/prostaglandin E2 signaling cascade (phospholipase A2, COX-2, multidrug re
193 Thus, our results highlight that alternative signaling cascades play a predominant role in the resist
195 model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) and Ras protein
197 rugs can tune rather than completely inhibit signaling cascades, providing information on the relatio
200 We further found that the Fzr-H2Bub-Myc signaling cascade regulating endoreplication progression
202 phasis is given to the trigger molecules and signaling cascades regulating exit from host cells.
203 ial gene and protein expression profiles for signaling cascades related to neuroendocrine and inflamm
207 STING pathway is an essential innate immune signaling cascade responsible for the sensing of aberran
208 translational efficiency via an AKT/HSF1/HuR signaling cascade resulting in enhanced mTORC2 activity
209 for ligands targeting orphan GPCRs since the signaling cascade(s) of the majority of these receptors
210 statement and synaptic enlargement through a signaling cascade selectively in D1-expressing neurons r
212 ilencing of major inflammatory intracellular signaling cascades (STAT1, STAT3, STAT5, p38, and ERK1/2
214 disruption of S100A8/A9 and their downstream signaling cascade suppress MI-induced granulopoiesis and
215 ts whereby reexposure to cocaine activates a signaling cascade that alters synaptic strength in the N
216 and promotes activation of an SRC-dependent signaling cascade that controls YAP nuclear shuttling.
217 electins also trigger an immunoreceptor-like signaling cascade that converts integrin alphaLbeta2 to
218 ound that components of a G(12/13)-dependent signaling cascade that culminates in activation of the H
219 Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an
221 the levels of pluripotency factors through a signaling cascade that includes epidermal growth factor
223 n-R plants constitutively activate an immune signaling cascade that induces temperature-sensitive res
224 eic acids during viral infection activates a signaling cascade that induces type I and type III IFNs
225 ts receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar
226 ustains a mast cell and macrophage-dependent signaling cascade that is amenable for the treatment of
228 mbined with overexpression of EGFR induces a signaling cascade that leads to hyperactivation of NFkB
229 aining adaptor protein (TIRAP), triggering a signaling cascade that leads to innate immune responses.
230 independent GOF mutant p53-AMPK-FOXO3a-FOXM1 signaling cascade that plays an important role in mediat
231 port a previously unknown Ca(2+)-CaMKK2-AMPK signaling cascade that protects stalled forks from degra
235 in the ER, resulting in the activation of a signaling cascade that restores proper homeostasis in th
236 nitiation of the feedforward chemoattractant signaling cascade that results in neutrophil swarms.
238 idopsis (Arabidopsis thaliana), triggering a signaling cascade that shares some similarities to respo
239 ppo pathway of multicellular organisms, is a signaling cascade that triggers node dispersal, CR assem
240 ooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibiti
241 taining protein 3 (PD-L1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment
242 YSLTR2 -> GNAQ/11 -> PLCbeta act in a linear signaling cascade that, via protein kinase C (PKC), acti
243 ng to nucleic acids, these proteins initiate signaling cascades that activate host defense responses.
244 ough our work, we have now identified 2 main signaling cascades that are activated during MRP-induced
246 egrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular func
247 how passive and active forces induce similar signaling cascades that drive self-renewal, migration, d
248 gnals, like activation of specific genes and signaling cascades that enable cells to adapt to their p
249 al step for the initiation of the downstream signaling cascades that guide various cellular mechanism
252 lial cell (EC) adaptation by activating gene-signaling cascades that promote endothelial migration, g
254 pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton,
255 e postsynaptic neuron and trigger downstream signaling cascades that regulate the synaptic state.
256 lation as a tractable tool for modulation of signaling cascades that rely on calcium as a transductio
257 erated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robu
258 other Syk-coupled CLRs, including Dectin-1, signaling cascade through DC-ASGPR did not trigger NF-ka
260 ergic receptors in these neurons initiates a signaling cascade through which Gi-protein reduces cAMP
262 This work describes how C1P activates a signaling cascade to dynamically regulate P-glycoprotein
264 s from canonical activation of the NF-kappaB signaling cascade to increase PLPP3 expression through n
265 This induces the conserved left-sided Nodal signaling cascade to initiate asymmetric organogenesis.
266 ferentially signal through the canonical BMP signaling cascade to instruct inflammatory-type LCs and
268 tilized ovules and developing seeds initiate signaling cascades to coordinate and promote the growth
269 show that OXT recruits several intracellular signaling cascades to induce protein synthesis, which me
270 ases in AMP/ATP ratio by activating multiple signaling cascades to overcome the energetic deficiency.
271 h specific machinery that initiates discrete signaling cascades to produce a localized response.
272 pattern recognition and triggers downstream signaling cascades to promote inflammation and immune de
273 where its overexpression activates multiple signaling cascades to promote malignant progression and
274 (miRNAs) - which are critical regulators of signaling cascades - to identify so far uncharacterized
275 ted receptors can integrate their individual signaling cascades toward a nonadditive effect and thus
277 ptor proteins that orchestrate transmembrane signaling cascades triggered by the 7-transmembrane G pr
278 s that differentially inhibit these discrete signaling cascades, understanding the source and signali
279 ivity, a shift from PKA to ERK intracellular signaling cascades upon D1R activation, and a reduction
280 G protein-coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (be
282 emical or physical perturbations via complex signaling cascades which can simultaneously affect multi
283 of tumors is dependent on a pro-inflammatory signaling cascade, which begins with the disruption of e
284 on in activating an evolutionarily conserved signaling cascade, which ensures that continuous uptake
286 stimulation of the beta1-adrenoreceptor (AR) signaling cascade, which leads to activation of cAMP-dep
287 ress hormone abscisic acid (ABA) initiates a signaling cascade, which leads to increased H(2)O(2) and
288 axial length of the eye occurs via a complex signaling cascade, which originates in the retina and pr
289 mitotic progression by interfering Mps1-MAP4 signaling cascade, which results in an extended infectio
290 at can block the Hh pathway along its entire signaling cascade, which, in light of emerging drug resi
291 y amplifying the infection-induced host cell signaling cascade, which, in turn, induces the nuclear t
292 with IAVs leads to the induction of complex signaling cascades, which apparently serve two opposing
293 dence that Shp1 regulates the TCR and Slamf6 signaling cascades, which have been suggested to promote
295 -apoptotic activities of JNK1/2 and MAPK p38 signaling cascades while partially downregulated the pro
296 and 2 (ERK1/2) pathway is a highly conserved signaling cascade with numerous essential functions in d
297 from embryonic stem cells also hinders these signaling cascades, with detrimental effects on cell sur
298 llular signal-regulated kinase (ERK) protein signaling cascade within the brain is crucial for optima