ライフサイエンスコーパス: signaling complex

1 unoprecipitates with components of the IFNAR signaling complex.

2 alian target of rapamycin complex 1 (mTORC1) signaling complex.

3 the trimolecular, HS-growth factor-receptor, signaling complex.

4 or signaling via degradation of the receptor-signaling complex.

5 ved inhibitors that target the Elmo-Dock-Rac signaling complex.

6 the localization and function of the M1R/Gq signaling complex.

7 ing receptosome called the motility-inducing signaling complex.

8 mbly and activation of the Norrin-Fz4-Lrp5/6 signaling complex.

9 ellular Sema3a signals to the slit-diaphragm signaling complex.

10 cruitment of caspase-8 to the death-inducing signaling complex.

11 moreceptors and the CheA kinase in a ternary signaling complex.

12 ized aggregates ready to form death-inducing signaling complex.

13 the role of Grb2, a component of the SHPS-1 signaling complex.

14 s through the TCR is mediated by the TCR-CD3 signaling complex.

15 ated, suggesting a physical interaction in a signaling complex.

16 ting localization and function of the M1R/Gq signaling complex.

17 n, CD3deltaepsilon, and zetazeta) of the TCR signaling complex.

18 -3-3sigma proteins as new members of the TLR signaling complex.

19 ibition of the pre-B cell receptor (pre-BCR) signaling complex.

20 m to identify proteins recruited to the LMP1-signaling complex.

21 rom binding and recruiting TbetaRI to form a signaling complex.

22 l control reflected in Smad4 into the active signaling complex.

23 to mediate the endocytosis of the Bmper/Bmp4 signaling complex.

24 or endoglin into this angiogenesis-mediating signaling complex.

25 , resulting in the formation of a quaternary signaling complex.

26 o stabilization of the IL-6/IL-6Ralpha/gp130 signaling complex.

27 cur through the formation of a FAK-cortactin signaling complex.

28 2A-mediated disruption of the eNOS/Akt/Hsp90 signaling complex.

29 ng the number of associated receptors in the signaling complex.

30 dipeptide and oligomerization of NOD2 into a signaling complex.

31 the interferon response via a mitochondrial signaling complex.

32 phage expression and interaction of TLR4/MD2 signaling complex.

33 pecific chemoreceptors within the chemotaxis signaling complex.

34 n domains, and/or 3) Abl is a scaffold for a signaling complex.

35 ting that GluD1 and mGlu5 may cooperate in a signaling complex.

36 the few known biochemical regulators of this signaling complex.

37 on of K63-ubiquitinated RIP within the TNFR1 signaling complex.

38 ransduction and that they may form part of a signaling complex.

39 on of signaling coordinated through the TAK1 signaling complex.

40 high-resolution structure of this important signaling complex.

41 n of Wnt signaling by an AQP1-macromolecular signaling complex.

42 T and intact Cav-3-associated macromolecular signaling complexes.

43 his allows for integration of receptors into signaling complexes.

44 ccessory protein, which precludes functional signaling complexes.

45 d as transient platforms for the assembly of signaling complexes.

46 ngaging Src from FAK-associated adhesion and signaling complexes.

47 formation or reduced stability of CD40L-CD40 signaling complexes.

48 ly shifts the ON-OFF equilibrium of receptor signaling complexes.

49 affold proteins used for assembling synaptic signaling complexes.

50 signaling by tuning the content of CaV1.2 at signaling complexes.

51 PDZ recognition motifs to form multiprotein signaling complexes.

52 apoptosis and necroptosis through different signaling complexes.

53 rm functional, apparently ligand-independent signaling complexes.

54 yl dipeptide and assembly of NOD2-containing signaling complexes.

55 y facilitating the formation of multiprotein signaling complexes.

56 to assembling and trafficking receptor-based signaling complexes.

57 itates recruitment of MyD88 to TLR4 and TLR2 signaling complexes.

58 lization and trafficking of NHERF1 assembled signaling complexes.

59 AMP compartments and defining the functional signaling complexes.

60 multiple partners in close proximity to form signaling complexes.

61 inhibitor binding and restored fusion kinase signaling complexes.

62 a key structural component of receptor core signaling complexes.

63 imer packing and the kinase-ON state of core signaling complexes.

64 al to the formation and maintenance of these signaling complexes.

65 ions and facilitate the assembly of distinct signaling complexes.

66 lates its function via formation of distinct signaling complexes.

67 ts M1 and K63 chain formation in TLR induced signaling complexes.

68 ability to stabilize regulator of G protein signaling complexes.

69 ich assemble cognate kinases into productive signaling complexes.

70 ion forks to initiate assembly of checkpoint signaling complexes.

71 ulation, dynamics, and function of LAT-based signaling complexes.

72 tors, phosphorylation of membrane-associated signaling complexes, activation of mitogen-activated pro

73 This shared signaling complex allowed IL-33 to induce the EGFR-media

74 , suggesting specificity for the MDP-induced signaling complex and activator-dependent differences in

75 ndothelial growth factor receptor 2 (VEGFR2) signaling complex and attenuates vascular endothelial gr

76 ing input into the target of rapamycin (TOR) signaling complex and changes in the activity of its dir

77 assembly of an activated VEGFR2/GIV/Galphai3 signaling complex and enhancing downstream PI3K/Akt surv

78 s, SPATA2 is recruited to the TNF receptor 1 signaling complex and is required for CYLD recruitment.

79 dings suggest that EFNB1 is part of the EGFR signaling complex and may mediate drug resistance in HNS

80 ever, in contrast to WASp, WAVE2 leaves this signaling complex and migrates peripherally together wit

81 tion of the hexameric, IL-6/IL-6Ralpha/gp130 signaling complex and strategies for therapeutic targeti

82 The nature of the TCR signaling complex and subunit arrangement in different s

83 a component of the FER-regulated RHO GTPase signaling complex and that fer and llg1 mutants display

84 d are based on structural information of the signaling complex and the dynamics of the underlying bio

85 ed association of SHP-1 with the VEGFR2/CD36 signaling complex and thereby suppressed VEGFR2 phosphor

86 thematically modeled TRAF1.NIK as a coupling signaling complex and validated computational inference

87 phase separation occurs within a variety of signaling complexes and cellular structures.

88 hanced K63-linked ubiquitination of proximal signaling complexes and elevated NF-kappaB activity, lea

89 dered phase platforms that serve to localize signaling complexes and modulate the intrinsic activitie

90 the structure and function of core receptor signaling complexes and the architecture of higher-order

91 icking vesicles, is required to assemble DLK signaling complexes and, unexpectedly, is essential for

92 sults in recruitment of Src and DUOX1 into a signaling complex, and transient siRNA silencing or stab

93 g of Girk channel structure, organization in signaling complexes, and plasticity, as well as progress

94 he cell membrane and specifically to the TCR signaling complex are largely unknown.

95 Dynamic assembly/disassembly of signaling complexes are crucial for cellular functions.

96 (3FRET) technology, we demonstrate how WAVE2 signaling complexes are dynamically regulated during lym

97 allows for dynamic visualization of distinct signaling complexes as microclusters (MCs).

98 he formation of an active ErbB2/PKCdelta/Src signaling complex, as depletion of PKCdelta disrupts ass

99 e mechanisms of nucleic acid recognition and signaling complex assembly involving the AIM2 (absent in

100 0-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly, membrane targeting, and stim

101 that PhoU is involved in the formation of a signaling complex at the cytoplasmic membrane that respo

102 The formation of a store-dependent signaling complex at the plasma membrane provides for se

103 Organization of signaling complexes at excitatory synapses by membrane-a

104 uantify the coformation of multiprotein EGFR signaling complexes at the plasma membrane in response t

105 The assembly of signaling complexes at the plasma membrane is required f

106 Disruption of the Na/K-ATPase.c-Src signaling complex attenuated ouabain-stimulated protein

107 ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR.

108 re tumor-derived microvesicles that transmit signaling complexes between cell and tissue compartments

109 and STAT5, failure to exclude SHP-1 from the signaling complex blunts their type I IFN response.

110 sites is fundamental to the function of the signaling complex but not to its assembly.

111 dy, we determined the topology of the T cell signaling complex by examining the respective relation o

112 Disruption of this signaling complex by knocking down PTK2, YWHAZ, or MED1

113 MAD2 and the meiotic HORMADs, assemble into signaling complexes by binding short peptides termed "cl

114 at RARgamma initiates the formation of death signaling complexes by mediating RIP1 dissociation from

115 Pharmacological enhancement of the mGlu5/eCB signaling complex, by positive allosteric modulation of

116 RP3 is a key component of the macromolecular signaling complex called the inflammasome that promotes

117 nous "danger" signals activate innate immune signaling complexes called inflammasomes to process IL-1

118 ters recruited two conserved furrow-inducing signaling complexes, chromosome passenger complex (CPC)

119 ibiting the formation of a poly(I:C)-induced signaling complex composed of TAK1, TAB1 (TAK1 binding p

120 ke and mTORC1 activation also required a TCR signaling complex composed of the scaffold protein CARMA

121 d protein kinase A (PKA) within an assembled signaling complex comprising pTyr-PAK1, Etk/Bmx, the het

122 nd promoted the assembly of a macromolecular signaling complex consisting of LPA(2), Na(+) - H(+) exc

123 We propose that membrane-proximal signaling complexes constrained by AKAP220 impact the ac

124 Core signaling complexes contain two trimers of transmembrane

125 y controlled assembly of a TGF-beta receptor signaling complex containing alpha3beta1 integrins, beta

126 ain, the anchoring protein gravin recruits a signaling complex containing PKA, PKC, calmodulin, and P

127 s by promoting formation of a death-inducing signaling complex containing receptor-interacting serine

128 Furthermore, CD147 promotes assembly of signaling complexes containing CD147, CD44, and EGFR in

129 e association of individual molecules within signaling complexes containing ion channels (M-type K(+)

130 , and Stat6) and prevents the formation of a signaling complex (containing p38MAPK, PKCdelta, and Sta

131 Rubicon thus differentially targets signaling complexes, depending on environmental stimuli,

132 us suggests that activity of heteromeric NLR signaling complexes depends on the sum of activation pot

133 tor-mediated formation of the death-inducing signaling complex (DISC) and by the inflammasome adaptor

134 R5) leads to the formation of death inducing signaling complex (DISC) for apoptotic signaling.

135 The death-inducing signaling complex (DISC) initiates death receptor-induce

136 Formation of the death-inducing signaling complex (DISC) is a critical step in death rec

137 lustering and assembly of the death-inducing signaling complex (DISC), increasing caspase-8 activatio

138 rylation and formation of the death-inducing signaling complex (DISC).

139 ignaling proteins to form the death-inducing signaling complex (DISC).

140 y recruiting caspase-8 into a death-inducing signaling complex (DISC).

141 adaptor protein that nucleates the proximal signaling complex downstream of the TCR, were unable to

142 ndings suggest that SASH1 acts to assemble a signaling complex downstream of TLR4 to activate early e

143 Multi-molecular signaling complexes drive the earliest events of immune

144 Additionally, PG102-induced CD40 signaling complexes failed to recruit TRAF6 to detergent

145 dentified by immunoprecipitation of the TRIF signaling complex, followed by protein identification us

146 s induced the formation of dsDNA-Rad50-CARD9 signaling complexes for activation of the transcription

147 a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics.

148 tivation by soluble TWEAK impairs CD40L-CD40 signaling complex formation and inhibits CD40 signaling

149 with procaspase-8, inhibiting death-inducing signaling complex formation in response to Fas/Fas ligan

150 to TbetaRIII competes with TbetaRI/TbetaRII signaling complex formation, thus inhibiting TGF-beta-me

151 m of cytokine capable to disrupt gp130/IL11R signaling complex formation, thus serving as a high-affi

152 sms involve the inhibition of death-inducing signaling complex formation.

153 egradation and decreased EGFR/Grb2/Shp2/Gab1 signaling complex formation.

154 s regarding the supramolecular nature of the signaling complex formed by receptor and G protein.

155 Finally, affinity of PDE10A to the signaling complexes formed around AKAP150 was reduced by

156 the more primitive ancestral form of the TCR signaling complex found in chickens.

157 ciently and can signal via vIL-6(2):gp130(2) signaling complexes from the endoplasmic reticulum (ER)

158 ings demonstrate that the Scrib-betaPIX-PAK2 signaling complex functions as an essential modulator of

159 The mTORC2 signaling complex functions as the regulatory kinase of

160 erefore, it is possible that the NR2A/PSD-95 signaling complex has a role in adolescent MS effects.

161 ate that FRMPD2 spatially assembles the NOD2-signaling complex, hereby restricting NOD2-mediated immu

162 platform for an intracellular death-inducing signaling complex (iDISC) that recruits self-associated

163 any expressed AKAPs in neurons target PKA to signaling complexes important for long-lasting forms of

164 Reconstitution of the IL7 receptor signaling complex in 293T cells showed that JAK3 mutants

165 ryophytes, we evaluated the presence of this signaling complex in a charophyte green alga, Chara brau

166 r of G-protein signaling 4 (RGS4) to the M3R signaling complex in an agonist-dependent fashion.

167 The basic structural unit of the signaling complex in bacterial chemotaxis consists of th

168 nexpectedly need ALK6 as a coreceptor in the signaling complex in granulosa cells.

169 ic signaling through the Neurexin-Neuroligin signaling complex in hippocampal neurons of Rattus norve

170 Although a role for the Scrib-betaPIX-PAK signaling complex in promoting membrane protrusion at wo

171 le of the PDZ-dependent CXCR2 macromolecular signaling complex in regulating neutrophil functions and

172 eromer and challenge the existence of such a signaling complex in the adult animals that we used for

173 TOR is found in two distinct signaling complexes in cells, TOR complex 1 (TORC1) and

174 l sequences of partner proteins and assemble signaling complexes in multicellular organisms.

175 to recruit FSN-1 and RAE-1 into independent signaling complexes in neurons.

176 ted specifically in alpha6 integrin receptor signaling complexes in the lens equatorial region, where

177 into the 3D map provides a model of the core signaling complex, in which a CheA/CheW dimer bridges tw

178 ponents of the N-methyl-D-aspartate receptor signaling complex, including the PSD-95 complex, activit

179 Here we report a novel endosome-based signaling complex induced by MACs to stabilize NIK.

180 ocation of alpha5beta1 integrin-acylated Fyn signaling complexes into lipid rafts upon uPAR ligation

181 eveal how SAP nucleates a previously unknown signaling complex involving NTB-A and LCK to potentiate

182 prisingly, we found that 2 types of proximal signaling complexes involving SLP-76 were formed.

183 roviding insights into how this multiprotein signaling complex is assembled and functions via multiva

184 the phagosome, indicating that the TLR-MyD88 signaling complex is assembled at a prelysosomal stage a

185 mammals, the alphabetaT cell receptor (TCR) signaling complex is composed of a TCRalphabeta heterodi

186 The IL-6 signaling complex is described as a hexamer, formed by t

187 glutamate confirms that the central core of signaling complex is dimeric.

188 imic a cell-cell junction, we found that the signaling complex is not efficiently internalized when l

189 ns that controls the coordinated assembly of signaling complexes, is regulated by phosphorylation of

190 phosphorylate DCC and form a receptor-bound signaling complex leading to activation of downstream ef

191 es trimeric G proteins and CARMA1-associated signaling complex, leading to NF-kappaB activation.

192 levels but also recruits IQGAP1 into the Wnt signaling complex, leading to potent and robust potentia

193 on reactions that recruited NEMO to the MAVS signaling complex, leading to the activation of IKK and

194 0 suggesting the existence of a multiprotein signaling complex localizing PDE10A to a specific functi

195 o alpha-syn in PD and suggest that the MHCII signaling complex may be a target of neuroprotective the

196 sting that small-molecule inhibitors of this signaling complex may have therapeutic utility.

197 tes different environmental cues via the two signaling complexes mTOR complex 1 (mTORC1) and mTORC2.

198 Thus, GluRdelta2 is part of the mGluR1 signaling complex needed for cerebellar synaptic functio

199 l summarize current views on the assembly of signaling complexes nucleated by LAT.

200 four ligands, indicating that activation of signaling complexes occurs after endocytosis.

201 esults define the functional properties of a signaling complex of CaMKII and Ca(V)2.1 channels in whi

202 tt may lead to formation of a death-inducing signaling complex of Hip1, Hippi, and Caspase-8.

203 localization of RhoA and the formation of a signaling complex of RhoA/ROCK2/myosin phosphatase-targe

204 iated through the assembly of a multiprotein signaling complex on the EC surface that includes annexi

205 cuous, while their clustering into nanoscale signaling complexes on the plasma membrane, termed nanoc

206 ling cascades coalesce into large oligomeric signaling complexes, or signalosomes, for signal propaga

207 autophosphorylation, and the kinase-channel signaling complex persists after dephosphorylation and r

208 In this study, we show that the TWEAK/Fn14 signaling complex plays a protective role during the acu

209 and attenuated signaling via the pre-B cell signaling complex (pre-BCR) and the differentiation of p

210 ion of insulin-like growth factor 1 receptor signaling complexes present in perinuclear invaginations

211 d OFF signaling states, suggesting that core signaling complexes produce kinase activity over a range

212 Formation of the Wnt-induced LRP6-Axin signaling complex promoted Axin dephosphorylation by pro

213 detailed molecular insight into the Ras-PI3K signaling complex, provide a framework for screening Ras

214 ient activation of Src and p38 in a specific signaling complex, providing a tool for targeted regulat

215 Notably, these perinuclear signaling complexes (PSC) are present in tumor cell line

216 B (PKB or Akt)/protein phosphatase 2A (PP2A) signaling complex regulates dopamine (DA)- and lithium-s

217 kinase anchoring protein 79/150 (AKAP79/150) signaling complex regulates excitatory synaptic transmis

218 Taken together, a Sema3A-initiated apoptotic signaling complex regulates the apoptosis of sympathetic

219 dermal growth factor receptor (EGFR) forms a signaling complex regulating epidermal homeostasis.

220 atform for the assembly of the mitochondrial signaling complex required for maximal activation of RIG

221 etwork function rely on how we conceptualize signaling complexes, resolving this issue is a central p

222 UBAC components as interacting with the TLR3-signaling complex (SC), thereby enabling TLR3-mediated g

223 o adherens junctions, the Scrib-betaPIX-PAK2 signaling complex serves as a key determinant of anoikis

224 ular signals are often transduced by dynamic signaling complexes ("signalosomes") assembled by oligom

225 We conclude that this is a signaling complex specialized for sensing adhesion under

226 ned that the mitochondria-localized PKCdelta signaling complex stimulates the conversion of pyruvate

227 on platform for the assembly of large innate signaling complexes such as the inflammasomes.

228 are important in the assembly of oligomeric signaling complexes such as the PIDDosome that acts as a

229 n of autophagy requires several multiprotein signaling complexes, such as the ULK1 kinase complex and

230 ift in EGFR dimerization partners within the signaling complex, suggesting that targeted drugs may tr

231 ly regulate the assembly of a macromolecular signaling complex termed the necrosome.

232 teracting with FN and enhancing beta-catenin signaling, complexed TG2 stimulates OC cell proliferatio

233 au, thereby contributing to recruitment of a signaling complex that amplified downstream signals and

234 PG102 induced the formation of a CD40 signaling complex that contained decreased amounts of bo

235 ause it participates in a membrane-delimited signaling complex that forms after store depletion and b

236 Unlike IL-1beta, IL-33 does not have a signaling complex that includes both its cognate recepto

237 odendrocyte cells induced the formation of a signaling complex that includes the AMPA receptor, integ

238 re: 1) NHE3 basal activity is regulated by a signaling complex that is controlled by sequential effec

239 as-GTP in live cells, resulting in a ternary signaling complex that is further regulated by GPCRs.

240 eterodimers assemble into a 2:2 tail-to-tail signaling complex that is stabilized by quaternary conta

241 ave identified a membrane structure and Ca2+-signaling complex that may enhance the speed of atrial c

242 These proteins formed a signaling complex that mediates these oncogenic processe

243 ls are embedded in a multicomponent membrane signaling complex that plays a crucial role in cellular

244 kinase C (PKC)epsilon to the downstream TLR-signaling complex that translocated PKCepsilon into the

245 and the CheW coupling protein assemble into signaling complexes that allow bacteria to modulate thei

246 hat TLR4 induces assembly of caspase-8-based signaling complexes that become licensed as IL-1beta-con

247 Targeting of signaling complexes that contain select kinase isoforms

248 Inflammasomes are large macromolecular signaling complexes that control the proteolytic activat

249 ) elicits the spatiotemporal assembly of two signaling complexes that coordinate the balance between

250 rticipate in the formation of macromolecular signaling complexes that include protein kinases, ion ch

251 Inflammasomes are oligomeric signaling complexes that promote caspase activation and

252 Bacterial chemotaxis is mediated by signaling complexes that sense chemical gradients and di

253 l components of post-synaptic macromolecular signaling complexes that serve to propagate glutamate re

254 lipidated microbial products to various TLR signaling complexes that subsequently induce intracellul

255 Inflammasomes are multiprotein signaling complexes that ultimately lead to caspase acti

256 fic in vivo cross-linking assays, and formed signaling complexes that were dispersed around the cell

257 FNAR1 is an essential component of the IFNAR signaling complex, the key residues underpinning the IFN

258 Moreover, analogous to the human TCR signaling complex, the presence of two copies of CD3epsi

259 ytoskeleton, supporting the formation of the signaling complex, the signalosome, on the IL-7 receptor

260 LGR4 with IQGAP1 brings RSPO-LGR4 to the Wnt signaling complex through enhanced IQGAP1-DVL interactio

261 ay regulate degradation of the IL-4 receptor-signaling complex through interactions with NEDD4.2.

262 NFalpha leads to the formation of the TNF-R1 signaling complex (TNF-RSC) to mediate downstream cellul

263 However, the relevance of this signaling complex to the long-term consequences of traum

264 bsequent retrograde translocation of the JNK signaling complex to the nucleus.

265 cilitates the assembly of the TNF receptor-I signaling complex to trigger NF-kappaB activation.

266 tubule (DCT), potassium imbalance causes WNK signaling complexes to concentrate into large discrete f

267 ptor clustering, and dynamic organization of signaling complexes to elicit and sustain downstream sig

268 hosphorylated and were recruited within Grb2 signaling complexes to LAT following TCR engagement.

269 nsplanted cells deliver activated Wnt7a/Fzd7 signaling complexes to recipient myofibers.

270 ectors, and other key proteins form specific signaling complexes to regulate specific cell responses

271 The evidence of specific, dynamic signaling complexes underlying aPC-mediated cytoprotecti

272 e cytoskeletal protein talin assemble into a signaling complex upon E-cadherin loss.

273 romoted the formation of hERG/beta1-integrin signaling complexes upon extracellular matrix stimulatio

274 characterization of the assembly of the FGF signaling complex using isothermal titration calorimetry

275 ttling factor that nucleates the assembly of signaling complexes using a bilayered mechanism of phosp

276 h the controlled assembly and disassembly of signaling complexes using a stereotypical "safety belt"

277 t of light makes visualization of individual signaling complexes using visible light extremely diffic

278 tion between ARGOS and the ethylene receptor signaling complex via AtRTE1 and maize RTL proteins, sup

279 Assembly of active signaling complexes was confirmed by immunostaining of p

280 , and IGF-I facilitated its recruitment to a signaling complex where it oxidized src, leading to AKT

281 cruited to the T cell antigen receptor (TCR) signaling complex, where it reversed inhibitory phosphor

282 and endogenous formation of a death-inducing signaling complex which activated caspase-8.

283 lizes beta-catenin through the LRP6 receptor signaling complex, which antagonizes the beta-catenin de

284 The inflammasome is an intracellular signaling complex, which on recognition of pathogens and

285 Ra) are all important regulators of the IL-1 signaling complex, which plays a role in inflammation.

286 that the GABAB receptor forms part of larger signaling complexes, which enable the receptor to mediat

287 PAS domains are in contact and form the core signaling complex, while the alpha1 H-NOX domain can be

288 ng Gbetagamma and PLCbeta but still formed a signaling complex with Gbetagamma and PLCbeta2 probably

289 GPR161 forms a signaling complex with the scaffold proteins beta-arrest

290 phrin phosphorylation through formation of a signaling complex with the Src family kinase Fyn.

291 eta superfamily, is a homodimer that forms a signaling complex with two type I and two type II recept

292 Formation of signaling complexes with arrestins often requires recrui

293 n sulfate as a coreceptor in the assembly of signaling complexes with FGF-receptors on the plasma mem

294 TRPC1 channels and MARCKS form signaling complexes with PI(4,5)P2 bound to MARCKS; in t

295 s required for the assembly of high affinity signaling complexes with their cognate FGF receptor.

296 ptors (caALK2) can function independently of signaling complexes with type II receptors and ligands.

297 12Rbeta1) as one component of their receptor signaling complexes, with IL-12Rbeta2 as second receptor

298 nraveling the spatiotemporal organization of signaling complexes within the context of plasma membran

299 ion (BiFC) to study the assembly of the LMP1 signaling complexes within the plasma membrane of mammal

300 ustering and formation of the death-inducing signaling complex, yet the underlying regulatory mechani