ライフサイエンスコーパス: signaling event

1 elucidate the role of that substrate in the signaling event.

2 ive allosteric modulatory impact on the same signaling event.

3 st that Univin is a relevant ligand for this signaling event.

4 s or enable them to regulate other important signaling events.

5 s approach to better characterise downstream signaling events.

6 ers spatio-temporal control over down-stream signaling events.

7 by enhancing oxidative stress and associated signaling events.

8 re the best characterized receptor-regulated signaling events.

9 lized enzymes or to convey specific cellular signaling events.

10 llular antioxidants that also regulate redox signaling events.

11 significance for understanding the cellular-signaling events.

12 e with opsonized S. aureus require different signaling events.

13 tor fAR1 is required for folic acid-mediated signaling events.

14 ghly local or cell-wide physiological Ca(2+) signaling events.

15 ing protein concentrations but also periodic signaling events.

16 -1 can allosterically activate AT1-dependent signaling events.

17 on, ATP production, and a myriad of cellular signaling events.

18 lt of cell-autonomous, Rhophilin-1-dependent signaling events.

19 dentify the set of kinases that underlie key signaling events.

20 uronal damage, to induction of intracellular signaling events.

21 erosmotic Ntcp regulation and the underlying signaling events.

22 ry, cell-cell transmission and virus-induced signaling events.

23 ty of specifically inhibiting trans-mediated signaling events.

24 , a protein complex that mediates downstream signaling events.

25 r targets, which trigger distinct downstream signaling events.

26 biofilm tower structures that triggers these signaling events.

27 "oxoform" of PTP1B generated during insulin signaling events.

28 s or to trigger gene circuits using measured signaling events.

29 confers hypermorphic induction of downstream signaling events.

30 ted proteins directly modulate developmental signaling events.

31 B (calcineurin) to modulate second messenger signaling events.

32 m of PTP1B generated in cells during insulin signaling events.

33 to the onset of stress tolerance-regulating signaling events.

34 kinase networks and their influence in cell signaling events.

35 caveola formation and in regulating cellular signaling events.

36 downstream of many migratory and chemotaxis signaling events.

37 trategy for selectively targeting downstream signaling events.

38 not to be associated with specific cytokine signaling events.

39 L-1Rs from the initiation of proinflammatory signaling events.

40 have a significant impact on the cascade of signaling events.

41 [Ca(2+)]o and amino acids into intracellular signaling events.

42 istidine kinases that convert red light into signaling events.

43 onent may reflect a general feature of rapid signaling events.

44 etermined how Iloprost reverses ADP-mediated signaling events.

45 en extracellular ATP and JA in intracellular signaling events.

46 hile also providing a conduit for allosteric signaling events.

47 ed as qualitative markers of tissue ethylene signaling events.

48 coupling between metabolic demand and Ca(2+) signaling events.

49 llination and fertilization and involve many signaling events.

50 e protein 24 (TMEM24) helps coordinate these signaling events.

51 ouple extracellular stimuli to intracellular signaling events.

52 onal consequences of the up- and down-stream signaling events.

53 ids that control diverse cellular downstream signaling events.

54 gulate both gene expression and extranuclear signaling events.

55 Heart development is tightly regulated by signaling events acting on a defined number of progenito

56 Our findings help elucidate the paracrine signaling events activated by a compromised mucosal barr

57 ent, the dynamics and relative importance of signaling events activated immediately downstream of GPC

58 toxin listeriolysin O (LLO) to identify key signaling events activated upon plasma membrane perforat

59 g the ability to correlate the duration of a signaling event and a cellular response.

60 is and the stresses that activate pathologic signaling events and aberrant angiogenesis in ROP.

61 he same receptor can produce highly distinct signaling events and arrestins are a major mediator of t

62 es a powerful, versatile means to direct key signaling events and biological outcomes such as stem ce

63 ing the link between early membrane-proximal signaling events and changes in many inflammatory genes.

64 s employed to suppress apoptosis, elicit WNT signaling events and drive naive-type piPSC along the me

65 s on how these processes respond to cellular signaling events and how they affect metabolism.

66 utation of Y192 blocks critical TCR-proximal signaling events and impairs thymocyte development in re

67 olysaccharide (LPS) triggers a wide range of signaling events and morphological changes to induce the

68 eading to calcium influx and downstream cell signaling events and neurotoxicity.

69 Skap2 regulates integrin-mediated outside-in signaling events and neutrophil functions.

70 POFUT1 inactivation disrupts signaling events and results in excessive angiogenic cel

71 ranslational modifications during GH-induced signaling events and show that relatively simple cytokin

72 riptional events in chromatin in response to signaling events and suggest a model for regulation of h

73 apses, regulating both pre- and postsynaptic signaling events and synaptic plasticity.

74 findings, with special emphasis on critical signaling events and their potential as therapeutic targ

75 receptor activation is coupled to downstream signaling events and to functional cellular responses.

76 The signaling events and transcriptional regulators driving

77 deltaPKC regulates many signaling events and we hypothesized that a docking inhi

78 ctivates Src and focal adhesion kinase (FAK) signaling events, and inhibition of both kinases is requ

79 PG102 did not induce early CD40-induced signaling events, and it inhibited early kinase and tran

80 een used to study a wide range of outside-in signaling events, and it is now well appreciated that ma

81 of cell cycles copes with flexible orders of signaling events, and unveil a new and important dimensi

82 Many cell signaling events are coordinated by intrinsically disord

83 riety of other messengers, and whether these signaling events are interconnected has long remained un

84 The rapid signaling events are mediated in large part through the

85 meric analysis showed that oxLDL-induced AT1 signaling events are mediated via interactions between t

86 r, these results suggest that Shp2-dependent signaling events are necessary for changes in foot proce

87 subsets, yet the molecular players in these signaling events are not fully understood.

88 re suggest nephrin phosphorylation-dependent signaling events are primarily involved in regulation of

89 ypothesize that alpha2M*/CS-GRP78-evoked key signaling events are required for transcriptional activa

90 appreciated, it is unclear which downstream signaling events are responsible.

91 These early signaling events are thought to be essential for the org

92 and binding reactions, an important class of signaling event, are needed to determine mechanisms.

93 Rap1 activity was assessed, and signaling events, as well as differentiation in EPAC1/2-

94 The underlying signaling events associated with endothelial proinflamma

95 the intracellular phosphorylation-dependent signaling events at a single-cell resolution and studied

96 mechanisms of cannabinoid receptor-mediated signaling events at critical stages of fetal brain devel

97 s to regulate gene expression in response to signaling events at distal neuronal ends.

98 We conclude that cytoskeletal and signaling events at endfeet may be controlled through tr

99 COR-induced signaling events at stomata remain unclear.

100 y tuned regulatory mechanism for controlling signaling events at the leading edge of directionally mi

101 tween proteins and a plethora of biochemical signaling events based on the development of specific bi

102 e of filopodia-like protrusions in mediating signaling events between distant epithelial cells during

103 y pathogens continuously, and the subsequent signaling events between host and microbe are complex, u

104 arefully orchestrated dialog of adhesion and signaling events between leukocyte and endothelial cell.

105 ry effects result from an array of molecular signaling events between macrophages, dying cells, and o

106 e CNS angiogenesis by mediating adhesion and signaling events between neuroepithelial cells and vascu

107 almitoylation not only disrupts proximal Fas signaling events, but also renders cells resistant to Fa

108 mporal distribution of many molecules during signaling events, but as of yet no methods have been des

109 cted relationships given that better studied signaling events can mask condition- or cell-specific 'n

110 and activator of transcription 3 (STAT3), a signaling event conducive to the intracellular growth of

111 To understand Spry1 regulation of signaling events controlling breast cancer phenotype, we

112 with the well-known role of ECM in eliciting signaling events controlling cell behavior and tissue ho

113 The p53-activated downstream signaling events correlated with suppression of abnormal

114 The results reveal that CK2 regulates signaling events critical to LID in each of the two main

115 ght on the mechanisms of intracellular Cl(-) signaling events crucial for regulating tissue architect

116 ctions suggest that PknB-mediated growth and signaling events differ in virulent compared with avirul

117 estricted to discrete sites, governing local signaling events distinct from those induced by soluble

118 Signaling events downstream of GPVI are influenced by hy

119 ng components downstream of Gq We quantified signaling events downstream of GqPCR activation with FRE

120 Lck SH2-binding monobody inhibited proximal signaling events downstream of the T-cell receptor compl

121 Signaling events driving integrin activation have previo

122 r the formation of functional cilia, and for signaling events during development.

123 coupling membrane dynamics to the cytosolic signaling events during macropinocytosis of KSHV.

124 Early ET signaling events during these biotic interactions involv

125 onse was distinguished from the signature of signaling events elicited by proinflammatory LRP1 ligand

126 h other HOG pathway proteins to mediate cell signaling events, ensuring that yeast cells can adapt an

127 elial basement membrane and that they induce signaling events essential for corneal wound healing.

128 This transmembrane signaling event facilitates an interaction between BtuB

129 Mechanistically, silencing MOSPD2 inhibited signaling events following chemokine receptor ligation.

130 of abnormalities, including increased early signaling events following engagement of the TCR.

131 odocytes as a significant contributor to the signaling events following LPS challenge and suggest tha

132 The NLRP3 inflammasome activation is a key signaling event for activation and secretion of pro-infl

133 All viruses must antagonize antiviral signaling events for survival.

134 emonstrated the importance of TLRs and IL-1R signaling events for the establishment of an effective i

135 Ongoing receptor-proximal signaling events from activating NK cell receptors and a

136 molecular mechanisms underlying the cellular signaling events governing water-stress responses, it is

137 ism underlying this quintessential molecular signaling event has remained unclear.

138 TCR-dependent signaling events have been observed to occur in TCR micr

139 mbrane microdomains, while integrin-mediated signaling events have inhibitory effects on the activati

140 nelle's small size and the dynamic nature of signaling events have posed obstacles to dissecting crit

141 poor prognosis in cancer patients, and their signaling events have recently been linked to malignant

142 Because upstream signaling events have the potential to modulate either a

143 distinguishes a SUMO ligase that may mediate signaling events important in PML-NB-mediated intrinsic

144 3 Thr(991)/Thr(1048) phosphorylation - a key signaling event in cell swelling-induced regulatory volu

145 compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-direct

146 tative picture of an ERK-dependent inductive signaling event in the early Drosophila embryo, an exper

147 levation of cytosolic Ca(2+) is an important signaling event in this process, yet the fundamental mec

148 analyzing and ultimately understanding lipid signaling events in a comprehensive manner.

149 e first genetic dissection of the downstream signaling events in a multicellular eukaryote.

150 teomics analysis of Syk-dependent downstream signaling events in B cells, focusing on serine and thre

151 control of membrane excitability and Ca(2+) signaling events in beta-cells.

152 species polypharmacology with PZQ modulating signaling events in both host and parasite.

153 GTPases act as important switches in many signaling events in cells.

154 oxLDL-induced signaling events in human vascular endothelial cells wer

155 ors that are being used to monitor G protein signaling events in live cells.

156 negative regulation of FcepsilonRI-mediated signaling events in mast cells.

157 CD8(+) T cells and evaluated IL-7-dependent signaling events in patients at different clinical stage

158 K3/MPK6 activation are two independent early signaling events in plant immunity, downstream of FLS2.

159 er, characterizing the in vivo role of these signaling events in proximal tubule responses to kidney

160 ontinuum model that incorporates microscopic signaling events in single cells into macroscopic popula

161 Signaling events in spines involve a signaling network c

162 Confirming the importance of these signaling events in the context of acute MI, Emc10 stimu

163 arization into precisely timed intracellular signaling events in the mammalian brain.

164 and cell type-dependent profile of molecular signaling events in the striatum.

165 ext of recent studies implicating purinergic signaling events in this process.

166 These signaling events, in turn, promote pancreatic carcinoma

167 rosine kinase cascade, and facilitate distal signaling events including PLCgamma1 activation and subs

168 ion modulates BLT1 engagement and downstream signaling events, including 1,4,5-triphosphate productio

169 ferentiated neuron is determined by multiple signaling events, including activity dependent calcium t

170 Diverse cellular signaling events, including B cell receptor (BCR) activa

171 also required for several NGF-TrkA-dependent signaling events, including calcium release, calcineurin

172 rray of stimuli remains elusive, but several signaling events, including cytosolic efflux and influx

173 Proximal IGF-1R signaling events, including IRS tyrosine phosphorylation

174 the intracellular tail of nephrin initiates signaling events, including recruitment of cytoplasmic a

175 of TNFR1 had no effect on early TNF-induced signaling events, including the rapid activation of NF-k

176 1A (Coro1A) is involved in cytoskeletal and signaling events, including the regulation of Rac1 GTPas

177 jor mechanism through which common oncogenic signaling events induce de novo lipid synthesis to promo

178 ubstrate of the p38 MAPK responsible for the signaling events influencing inflammation, cell division

179 nes and to the influence of these changes on signaling events initiated at the membrane.

180 The precise downstream signaling events initiated by alphavbeta3 may depend on

181 Resolving how the early signaling events initiated by cell-cell interactions are

182 ffects occur through autocrine and paracrine signaling events initiated by interactions between secre

183 Yet the signaling events involved in chronic pancreatitis and pa

184 nduce this pathway; a second virus-initiated signaling event involving release of transcriptional pau

185 s barrier disruption, leads to a coordinated signaling events involving cytokines between keratinocyt

186 proteins, connexins, plays a role in global signaling events involving kinases.

187 How cells integrate antagonistic receptor signaling events is enigmatic.

188 t of haloperidol antagonism on D2R metabolic signaling events is largely mediated by acute blockade o

189 protein-coupled receptors controls specific signaling events, it is unclear how the spatiotemporal c

190 During autophagy, signaling events lead to the formation of a cup-shaped s

191 -mediated activation of mast cells initiates signaling events leading to Ca(2+) response, release of

192 Cellular signaling events leading to immunosuppression in sepsis

193 Among the signaling events leading to mammalian sperm capacitation

194 thrombus formation or by initiating various signaling events leading to metastatic cancer progressio

195 rther show that ARF activation regulates key signaling events leading to migration, we also examined

196 By mimicking key signaling events leading to muscle formation in the embr

197 Although the initial signaling events leading to pneumococcal competence for

198 g intermediate for several receptor-mediated signaling events leading to the context-dependent activa

199 hat glycolysis inhibition is able to trigger signaling events leading to the reduction of N-Myc prote

200 The impact of TRAF3 on this very early signaling event led to the hypothesis that TRAF3 restrai

201 However, the signaling events linking JAKs to rho small GTPase activa

202 dout makes it difficult to capture transient signaling events (<1 min); 3) The experimental environme

203 n and the PPR are established in response to signaling events mediated by BMPs, FGFs and Wnts, which

204 sine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP.

205 ding edge, both of which processes are early signaling events necessary for proper epithelial wound h

206 The identity of the signaling events needed for the activation of integrins

207 ating that caveolae formation and downstream signaling events occur through independent mechanisms.

208 with the plasma membrane where KRAS-mediated signaling events occur.

209 In contrast to the signaling events occurring at the plasma membrane, as a

210 Here, we review the subsequent IFN signaling events occurring through unique receptors lead

211 ock-out of sdc-1 abolished several key early signaling events of endothelial cells in response to she

212 otein binding, and allows activation of cell signaling events of HS-deficient cells.

213 hway is a central axis in mediating proximal signaling events of TCR and CD28 engagement in T cells.

214 As a consequence, aberrant signaling events often underlie human disease.

215 ial sense and response cascades to transduce signaling events over multiple length and time scales.

216 This approach identified a key signaling event, phosphorylation of a desmosome componen

217 ular nucleotides to adenosine, and adenosine signaling events play additional functional roles in leu

218 nstrate that a complex network of purinergic signaling events plays a key role in these trafficking e

219 ated by its ligand angiotensin II, generates signaling events promoting vascular dysfunction and the

220 Lipid-mediated signaling events regulate many cellular processes.

221 oteins in cells and illuminate a fundamental signaling event regulated by GIV during diverse cellular

222 kinson's disease (PD), but the key molecular signaling events regulating persistent microglial activa

223 Recently, the view that innate immune signaling events rely on and operate within a complex ce

224 , a DNA virus, and the subsequent downstream signaling events remain to be fully clarified.

225 h how motile cells spatiotemporally activate signaling events remains largely unknown.

226 genesis are well established, the downstream signaling events repressing gluconeogenic gene expressio

227 This is the first example of a signaling event required for patterning of a specific pa

228 metric Dll4-Notch and subsequent BMP/TGFbeta signaling events required for neuronal diversity in the

229 s (SNX) orchestrate membrane trafficking and signaling events required for the proper distribution of

230 id secretion depended on canonical molecular signaling events responsible for ETEC-induced diarrhea,

231 It is controlled by hierarchical signaling events resulting in a focused response as the

232 Second, the spatiotemporal orders of key signaling events reveal a robust pattern of lateral inhi

233 of KaiC create a hub around which nighttime signaling events revolve, including inactivation of KaiA

234 ions associated with obesity, and to certain signaling events routed through PPARgamma, the "master-r

235 Despite the importance of MPK proteins in signaling events, specific roles for many Arabidopsis MP

236 Signaling events stimulate serial phosphorylation of 4E-

237 also indispensable for early and distal TCR signaling events such as CD3zeta, Zap70, and Erk activat

238 insurmountably (suppressed agonist Emax) in signaling events such as guanosine 5'-3-O-(thio)triphosp

239 liogenesis and receptor localization for key signaling events such as sonic hedgehog signaling.

240 molecular patterns to activate innate immune signaling events, such as bursts of reactive oxygen spec

241 m salt and MRS2365 (5'-diphosphates) in some signaling events, such as extracellular signal-regulated

242 e raft structure and feed-forward downstream signaling events, such as rho and PI3K activation.

243 ependent Lck localization controls early TCR signaling events, such as tyrosine phosphorylation of TC

244 7 is a more specific reporter of Ag-specific signaling events than the commonly used CD69 activation

245 ns appears to be an important downstream IFN signaling event that discriminates cellular and pathogen

246 ation of tyrosine residues in protrusions, a signaling event that was not observed in HeLa229 cells b

247 These findings identify rapid signaling events that 5 GFs elicit directly in the most

248 otility is regulated by a complex network of signaling events that affect protein activity and locali

249 earch has focused on the gene expression and signaling events that are modulated by SINE ncRNAs, part

250 mphatic endothelial cells initiates platelet signaling events that are necessary for prevention of bl

251 enerate directed cell migration by eliciting signaling events that bias intrinsic motility and favor

252 existence of a previously unknown branch of signaling events that can regulate the TSC2/mTOR pathway

253 Biological and signaling events that connect developmentally induced hy

254 However, the signaling events that control NKT sublineage specificati

255 What are the molecular and cellular signaling events that control the aging process and how

256 Activation of these receptors initiates signaling events that culminate in an effective immune r

257 function of ISG15 and the initial outside-in signaling events that drive ISG15-dependent cytokine sec

258 However, the signaling events that drove hepatic expression of eosino

259 by a multiplicity of molecular and cellular signaling events that interface with environmental facto

260 However, the early signaling events that lead to cell-cycle activation duri

261 pts to highlight the importance of different signaling events that mediate a beneficial plant microbe

262 gy reserves, and possibly triggered indirect signaling events that modified mortality through develop

263 Thus, after SAH, signaling events that normally lead to vasodilation and

264 Animal development is characterized by signaling events that occur at precise locations and tim

265 This study aimed to determine the molecular signaling events that originate from the ICAM-1-mediated

266 polarized cell behavior, but the downstream signaling events that promote cell polarity are not well

267 ular respiration and suppresses pathological signaling events that promote inflammation in asthma.

268 uring cytotoxic treatment activate paracrine signaling events that promote the growth of surviving tu

269 creased aerobic glycolysis, but the upstream signaling events that regulate the PI3K pathway, and thu

270 primes) the Ca(2+)-sensitivity of downstream signaling events that result in activation of S-type ani

271 Signaling events that result in the inhibition of glycog

272 omplex, leading to E3 ligase activation, but signaling events that trigger signalosome dissociation f

273 st a negative feedback loop that responds to signaling events that tune active Lck amounts and TCR se

274 ll, this analysis provides new insights into signaling events that underlie metastasis in ovarian can

275 valuable for analysis of the recognition and signaling events that underlie SI in the Brassicaceae.

276 nct tissue-, temporal-, and pathway-specific signaling events, the progression of reproductive aging

277 omics analyses, we identified the downstream signaling events these drugs affect.

278 ADP) and subsequent autocrine and paracrine signaling events through nucleotide receptors.

279 tracellular signaling molecule adenosine and signaling events through the A2B adenosine receptor in l

280 a novel mechanism that activates PI3-kinase signaling events, thus highlighting tTG as a potential t

281 ted to serve as a major site for active TRIF signaling events, thus linking phagosomal maturation to

282 ion at serine 15 is the most responsive cell signaling event to manganese exposure (of 18 tested) in

283 ietic tissue, relying on structure-dependent signaling events to promote blood homeostasis, creates a

284 o directly visualize thymocyte migration and signaling events, together with a living thymic slice pr

285 ment and activation, initiating a cascade of signaling events ultimately leading to proliferation, di

286 This report defines the signaling events underlying Ag-induced chemokine recepto

287 We investigated cell-specific signaling events underlying the immunosuppressed phenoty

288 nt progress in identifying the molecular and signaling events underlying these traits downstream of e

289 lso a master regulator of the spatiotemporal signaling events underpinning mammary alveolar unit cont

290 ticipates in intracellular and extracellular signaling events unrelated to metabolism.

291 tabolism, which is a marker for NRF2-related signaling events, was affected.

292 To portray the serial signaling events, we studied a T-cell-mediated model of

293 ssion, specific endoplasmic reticulum stress signaling events were significantly increased.

294 ellates is mediated by complex inter-partner signaling events, where the host cnidarian innate immune

295 s in suboptimal activation of the downstream signaling events, which correlates with the preferential

296 controlling receptor-mediated intracellular signaling events, which have a central role in Alzheimer

297 o activating their own G protein-independent signaling events, which have been shown to mediate locom

298 antibody responses by linking proximal TACI signaling events with distal immunometabolic transcripti

299 tension, triggering long-lasting downstream signaling events with effects on the sperm's mitochondri

300 second messenger production, and downstream signaling events with high spatial resolution and fast k