ライフサイエンスコーパス: signaling factor

1 and extrinsic signals (e.g., soluble growth/signaling factors).

2 EGF-CFC protein Cripto can act as a secreted signaling factor.

3 ficient and stringent regulation of a potent signaling factor.

4 d to release Endostatin, an antiangiogenesis signaling factor.

5 e to regulate the surface recruitment of key signaling factors.

6 we detect altered levels of selected soluble signaling factors.

7 Y) sites for the binding of a diverse set of signaling factors.

8 scription factors, proto-oncogenes, and cell signaling factors.

9 microenvironment by secretion of an array of signaling factors.

10 nd shows dependence upon the same downstream signaling factors.

11 rs, extracellular ligands, and intracellular signaling factors.

12 pends on the actions of several hormones and signaling factors.

13 ding a member of the Wnt family of cell-cell signaling factors.

14 rs for the ubiquitous family of secreted WNT signaling factors.

15 ted genes that encode secreted extracellular signaling factors.

16 nvolved in transducing signals for any known signaling factors.

17 luence of neurotransmitters and a variety of signaling factors.

18 ion by controlling the fate of intracellular signaling factors.

19 nd there are different requirements for some signaling factors.

20 ped expression patterns of transcription and signaling factors.

21 D88 but not in macrophages deficient in both signaling factors.

22 ail, even in the absence of externally added signaling factors.

23 helium that function by releasing diffusible signaling factors.

24 ly by the inheritance of the Gal3p and Gal1p signaling factors.

25 n mice deficient for SMAD2, an intracellular signaling factor activated by TGF-beta signals.

26 at heat disrupts or alters the regulation of signaling factors activated by IR, the effect of heat sh

27 lly regulated translation of a maternal cell-signaling factor along the vertebrate dorsal-ventral axi

28 division is tightly controlled via secreted signaling factors and cell adhesion molecules provided f

29 xpansion by continuously diluting inhibitory signaling factors and maintaining stem cell density.

30 We then investigated which potential signaling factors and pathways are capable of modulating

31 Also included are signaling factors and some pigment cell differentiation

32 E), which contains diverse cell populations, signaling factors and structural molecules that interact

33 e nuclear accumulation rate of change of the signaling factor, and not actual protein levels, correla

34 and transcriptional regulators, splicing and signaling factors, and glucose/mitochondria regulators.

35 functions to recruit and spatially organize signaling factors, and was recently identified as a supp

36 pothalamic neurohormone; BAX, a proapoptotic signaling factor; and CDK4 and PAL31, cell cycle progres

37 rowth and cell fates, and genes encoding Wnt-signaling factors are expressed in the pancreas.

38 of red blood cells, and at least 15 distinct signaling factors are now known to assemble within activ

39 Nodal-related signaling factors are required for axis formation and ge

40 ts provide further evidence implicating MAPK signaling factors as obligate regulators of cardiac grow

41 es self-renewal (e.g., representative of Wnt signaling factors), as well as a long-range inhibitor of

42 tems biology approach to identify functional signaling factors associated with a cellular phenotype,

43 d microtubules (MTs), as well as a number of signaling factors at the leading edge.

44 mes in cell lines deficient in each of three signaling factors, ATM, ATR, and DNA-PK(CS), orchestrati

45 oxin (TRX) is a cytoplasmic, redox-sensitive signaling factor believed to participate in the regulati

46 tal muscle, known as myokines, are important signaling factors, but it is largely unknown whether the

47 luding both chromatin-associated and diffuse signaling factors, but may not be universal.

48 coupled by localized secretion of paracrine signaling factors by the differentiating hMSCs and ECFCs

49 During development, secreted signaling factors, called morphogens, instruct cells to

50 We show that developmentally relevant signaling factors can induce mouse embryonic stem (ES) c

51 suggest that the Wnt-5A functional class of signaling factors can interact with the Wnt-1 class in a

52 tumor microenvironment-derived extracellular signaling factors capable of provoking such a phenotypic

53 d at least three-fold in response to Eyeless+signaling factors compared to Eyeless alone; (3) based o

54 ) is involved in the retention of repair and signaling factor complexes at sites of DNA damage.

55 Chlamydomonas orthologs of UVR8 and the key signaling factor CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1)

56 protein tyrosine phosphatase 2 (SHP-2) is a signaling factor critical for regulating sympathetic neu

57 s the post-transcriptional expression of key signaling factors critical for the regulation of the ang

58 s the post-transcriptional expression of key signaling factors critical for the regulation of the ang

59 Although much is known about signaling factors downstream of Rho GTPases that contrib

60 vator receptor (uPAR) and activation of cell signaling factors downstream of uPAR, including Akt and

61 cterium, mediated by a fatty acid Diffusible Signaling Factor (DSF), is required to colonize insect v

62 The diffusible signaling factor (DSF)-based quorum sensing (QS) system

63 We examined these signaling factors during hyperinsulinemic-euglycemic cla

64 nal cytoskeletal proteins and apoptotic cell signaling factors during hypoxia-induced retinal cell de

65 the myofiber, facilitating the evaluation of signaling factors during muscle remodeling.

66 acts in the localization of determinants and signaling factors during oogenesis.

67 However, our knowledge of bystander signaling factors, especially those having long half-liv

68 log of FHY1 named FHL (FHY1-like) as a novel signaling factor essential for complete responsiveness t

69 a and notum, encoding conserved antagonistic signaling factors expressed at opposite brain poles.

70 Here, we identify a set of signaling factors expressed in mouse embryonic mesenchym

71 nals come from a surprisingly limited set of signaling factor families, indicating that the competenc

72 entiation including myocardin/Mrtf-B and the signaling factor Fgf10.

73 for the expression of Bmp4, which is the key signaling factor for progression to the next step of too

74 emonstrate the potential utility of myogenic signaling factors for decreasing EOM strength.

75 s identical to that of mouse; therefore, the signaling factors for SSC self-renewal are conserved in

76 AF2-TRAF3 E3 complex also targets additional signaling factors for ubiquitin-dependent degradation, t

77 rs (inheritance), or later in development by signaling factors from neighboring tissues (induction).

78 the genes upregulated in response to Eyeless+signaling factors had a greater diversity of functions c

79 The FGF family of extracellular signaling factors has been proposed to play multiple rol

80 essel structures, and disruption of critical signaling factors has dramatic effects on blood vessel d

81 Few families of signaling factors have been implicated in the control of

82 larly in vertebrates, the conserved core PCP signaling factors have recently been found to be associa

83 to apoptosis, the cell cycle and DNA repair, signaling factors, immune modulators, cytokines and grow

84 iological role in macrophage responses, is a signaling factor in CD3(+)NK1.1(+) iNKT cells and mediat

85 ever, Cripto can also function as a secreted signaling factor in cell coculture assays, suggesting th

86 suPAR may function as an important paracrine signaling factor in EGFRvIII-positive GBMs, inducing an

87 hlights the potential importance of Akt as a signaling factor in leukemia survival, and supports the

88 In contrast, CKIepsilon is a mandatory signaling factor in the Fz/PCP pathway, possibly through

89 ntify a novel function of the TR enzyme as a signaling factor in the regulation of AP-1 activity via

90 argeted T98G cells and plays a key role as a signaling factor in the RIBE by further inducing free ra

91 Here, we examined insulin signaling factors in brains of insulin-resistant high-fa

92 bB2 activity and its interactions with other signaling factors in carcinoma cells.

93 leotides function as autocrine and paracrine signaling factors in many tissues.

94 l migration and the involvement of a host of signaling factors in orchestrating the migration, as wel

95 sed concurrently with Aurora A and NF-kappaB signaling factors in patients with de novo AML relative

96 ether the proteome of secreted cytokines and signaling factors in peripheral blood can be used to dis

97 ytes accumulate in the microvasculature, and signaling factors in the angiogenesis pathway (Akt and e

98 reased expression of EGFR and its downstream signaling factors in the lung of Tip30(-/-) mice.

99 talk between salt stress response and other signaling factors including H2O2.

100 regulatory activity and competes with animal signaling factors, including BMP2/4, to specify the endo

101 gnaling, or by targeting uPAR-activated cell signaling factors, including phosphatidylinositol 3-kina

102 was not simply a result of enhanced soluble signaling factors, including vascular endothelial growth

103 Multiple signaling factors, including Wnt proteins, operate durin

104 is, we sought to determine the pro-apoptotic signaling factors induced by RANKL in IKKbeta-null osteo

105 ds into each cerebral ventricle and secretes signaling factors into the CSF.

106 phyrin IX, which may act as a light-specific signaling factor involved in coordinating intercompartme

107 enriching system that enables us to identify signaling factors involved in germ cell-fate induction f

108 Reactive oxygen species (ROS) are signaling factors involved in many intracellular transdu

109 APPswe) mice and non-transgenic (NT) mice on signaling factors involved in neuronal plasticity and su

110 derate hypoxia and expression of the primary signaling factors involved in the process.

111 To identify the signaling factors involved, cerebral cortical cultures p

112 signaling via negative feedback input to the signaling factor IRS-1.

113 ound that the relationship between these two signaling factors is not symmetric: loss of Fgf9 in XX W

114 PDGFRalpha with binding sites for these two signaling factors is sufficient for this activity.

115 dent of DLK-1/DLK, KGB-1/JNK, and other MAPK signaling factors known to mediate regeneration in Caeno

116 NF receptors involves the recruitment of key signaling factors, leading to the activation of both the

117 orally and spatially regulated expression of signaling factors, many of which are synthesized and/or

118 ined release of BMP-4 suggests that myogenic signaling factors may provide a more biological method o

119 Nitric oxide (NO), a pro-inflammatory signaling factor, may regulate COX-2 expression and acti

120 d growth via the regulation of two important signaling factors, microphthalmia-associated transcripti

121 l-established potent autocrine and paracrine signaling factor modulating a variety of cellular functi

122 n in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis.

123 on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stag

124 s from the mesoderm and to the intercellular signaling factor noggin.

125 At these low levels of insulin/IGF-1 signaling, factors normally provided by the somatic gona

126 Moreover, studies to identify the PRRs and signaling factors of the host cell that mediate inflamma

127 Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies

128 g the impact of drugs, growth substrates and signaling factors on cell receptors and subcellular syst

129 to virtually any bioactive molecule such as signaling factors or drugs.

130 The involvement of signaling factors or integrins was probed using specific

131 Dynamic spatial patterns of signaling factors or macromolecular assemblies in the fo

132 is by measuring the local concentration of a signaling factor, or morphogen, that is secreted by an o

133 ression of the BR-synthesis gene D11 or a BR-signaling factor OsBZR1 results in higher sugar accumula

134 These data reveal that Mdka and Mdkb are signaling factors present in the retinal stem cell niche

135 rently, in vivo and ex vivo studies of these signaling factors present some inherent ambiguity.

136 The model accounts for protein signaling factors produced by cells in lineages, and nut

137 Thus, ATP may function as an autocrine signaling factor promoting Cl- secretion in normal but n

138 Our studies indicate that ROS is a signaling factor promoting maintenance of normal as well

139 s resulting from co-misexpression of Eyeless+signaling factors provide a more complete picture of eye

140 Redox-sensitive signaling factors regulate multiple cellular processes,

141 To determine whether TGFbeta2 or other signaling factors regulate Slug expression during EMT in

142 xclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and

143 way intersects with the complex interplay of signaling factors regulating dental morphogenesis has be

144 n CNS homeostasis as well as Spz3 as a novel signaling factor required for maintenance of cortex glia

145 In this study, we examined signaling factors required for insulin-stimulated glucos

146 about the downstream events following Notch signaling, factors responsible for negatively regulating

147 ially depends on two novel activities of the signaling factor retinoic acid (RA): one specifying the

148 A secondary siRNA screen of the identified signaling factors revealed several new mediators of HIV-

149 mas, it suggests that a unique mitochondrial signaling factor(s) is responsible for the defect in cyt

150 echanisms, including targeted proteolysis of signaling factors, sequestering cellular factors, and up

151 I expression is increased and its downstream signaling factor, SMAD1, is activated in reovirus-infect

152 ) expression is increased and its downstream signaling factor, SMAD3, is activated in the brains of r

153 s region to recruit a suppressor of cytokine signaling factors SOCS1 and SOCS3.

154 ultipotent stem cells, suggesting that local signaling factors specify cell fate.

155 helial/mesenchymal interactions, mediated by signaling factors such as Bmps made in both cell populat

156 ic allele display reduced phosphorylation of signaling factors such as Chk1, but not of chromatin-ass

157 Notch signaling factors such as Hes1 and Mash1 are present in

158 oduction of IFN-gamma-inducing extracellular signaling factors such as IL-12 and TNF-alpha.

159 For example, signaling factors such as redox factor-1 (Ref-1) and tra

160 ancer: TGFbeta is an autocrine and paracrine signaling factor that drives cell invasion and metastasi

161 st growth factor 10 (FGF10) is a mesenchymal signaling factor that guides the morphogenesis of multip

162 es induced by added pMesogenin1 is Xwnt-8, a signaling factor that induces a similar repertoire of ma

163 TMS1/ASC is a novel proapoptotic signaling factor that is subject to epigenetic silencing

164 Extracellular ATP is a potent signaling factor that modulates a variety of cellular fu

165 These findings establish NIK as an important signaling factor that regulates Th17 differentiation and

166 e mandibular arch were investigated, and two signaling factors that act as repressors were identified

167 approaches, including identification of key signaling factors that act during the initial stages of

168 e degranulation of neutrophils by generating signaling factors that are expressed differentially depe

169 s of the extracellular matrix and associated signaling factors that are linked to the observed non-ce

170 Pituitary organogenesis is dependent on signaling factors that are produced in and around the de

171 domain (BET) proteins function as epigenetic signaling factors that associate with acetylated histone

172 Signaling factors that associate with activated erythrop

173 To determine the source of other signaling factors that could modulate increased hedgehog

174 Morphogens are signaling factors that direct cell fate and tissue devel

175 e of these mutant genes appear to be general signaling factors that function in other Ras1 pathways,

176 activation of other PI 3-kinase-independent signaling factors that have been found to be required du

177 ltures, we treated the cultures with various signaling factors that have been shown to be present in

178 The rise in adipocyte number is triggered by signaling factors that induce conversion of mesenchymal

179 C (aPKC) and protein kinase B (PKB), two key signaling factors that operate downstream of phosphatidy

180 of cytosolic free Ca2+ activates downstream signaling factors that promote long term survival of unm

181 Several extracellular signaling factors that regulate hippocampal neurogenesis

182 on of genes encoding secretory machinery and signaling factors that regulate insulin release.

183 itary gland, which is an essential source of signaling factors that regulate pituitary organogenesis.

184 We identified 147 transcription and signaling factors that varied in spatial and temporal ex

185 nists regulate the activity of intercellular signaling factors, thereby modulating cell fate specific

186 y act in combination with a variety of other signaling factors to determine neuronal phenotype specif

187 ar factor kappaB and interacts with the IL-1 signaling factors Toll-interacting protein and tumor nec

188 TNFR1 signaling factors TRADD and Fas-associated death domain

189 rchical clustering revealed that the Eyeless+signaling factor transcriptomes are closer to the eye co

190 lated ischemia/reperfusion and characterized signaling factors triggering cytoprotection by NO.

191 al polarity, they exhibited many of the same signaling factors used by the vitelline and cardiovascul

192 A recently identified class of signaling factors uses critical cysteine motif(s) that a

193 To identify candidate nipple-specific signaling factors, we compared gene expression signature

194 require Ire1p or Hac1p, and Ca2+ influx and signaling factors were not required for initial UPR sign

195 response to TGF-betas may explain why these signaling factors wield such diverse cellular effects.

196 genes identified as potential targets of Ey+signaling factors will provide novel insights to our und

197 of the spatiotemporal expression of the Wnt signaling factors with respect to the different tissue l

198 al progenitors which transiently express the signaling factor Wnt1.

199 We demonstrate that embryos lacking the signaling factor Wnt3 exhibit defects in this axial real