ライフサイエンスコーパス: signaling mechanism

1 is unknown whether they can exploit this new signaling mechanism.

2 tion Signal Binding Protein Jkappa-dependent signaling mechanism.

3 ast acting, GluN2A-dependent neuroprotective signaling mechanism.

4 oduced genes in trans by an mTOR-independent signaling mechanism.

5 resence of a mitochondrial autonomous Ca(2+) signaling mechanism.

6 experimental evidence for the UVR8 molecular signaling mechanism.

7 tivation, via a distinct nonstimulatory CD40 signaling mechanism.

8 permeabilization and explain the underlying signaling mechanism.

9 d play an important role as an intracellular signaling mechanism.

10 , suggesting a possible intracrine/autocrine signaling mechanism.

11 in signaling F-box protein)]-dependent auxin signaling mechanism.

12 r PI3K, suggesting a biased selection in the signaling mechanism.

13 istantly located ischemic tissue by a remote signaling mechanism.

14 a document a novel AA-activated MEK-ERK-ELK1 signaling mechanism.

15 ses that are each mediated by a distinct Wnt signaling mechanism.

16 esistance through a compensatory prosurvival signaling mechanism.

17 , suggesting the possibility of an alternate signaling mechanism.

18 lt in lower DegU-P levels through an unknown signaling mechanism.

19 AR requirement is consistent with a nonionic signaling mechanism.

20 odulation (AON) integrated with nitrogen (N) signaling mechanisms.

21 erent cAMP sources are involved in different signaling mechanisms.

22 e role of the recently described ER membrane signaling mechanisms.

23 ced airway disease (AIAD) and its underlying signaling mechanisms.

24 vagal afferents and the possible downstream signaling mechanisms.

25 nd other methods to determine the underlying signaling mechanisms.

26 tein-dependent and internalization-dependent signaling mechanisms.

27 level, little is known about the underlying signaling mechanisms.

28 nesis, and inflammation through two distinct signaling mechanisms.

29 ates AKAP79/150 to regulate these plasticity signaling mechanisms.

30 act in upstream drought-related sensing and signaling mechanisms.

31 to take place largely through Akt-dependent signaling mechanisms.

32 ing diversity of function and sensitivity to signaling mechanisms.

33 ich environments and in response to receptor-signaling mechanisms.

34 lular mechanisms that control these opposing signaling mechanisms.

35 suggest new paradigms in cardiac adrenergic signaling mechanisms.

36 rized membrane-associated drought sensing or signaling mechanisms.

37 nd thus enable the distinction between PP-IP signaling mechanisms.

38 r other proteins directly involved in GTPase signaling mechanisms.

39 ral importance in biological light-activated signaling mechanisms.

40 nge is crucial to biological light-activated signaling mechanisms.

41 P) pathway remains one of the most enigmatic signaling mechanisms.

42 involving multiple neurocrine and endocrine signaling mechanisms.

43 r vascular niche through HIF-1alpha-mediated signaling mechanisms.

44 ides on insulin secretion and the underlying signaling mechanisms.

45 ough two molecularly and temporally distinct signaling mechanisms.

46 nhibiting NETosis via receptor-mediated cell signaling mechanisms.

47 ovel ischemia/reperfusion-induced microglial signaling mechanisms.

48 iveness of ovarian cancer, including hypoxic signaling mechanisms.

49 rve as lipid recognition and controlled cell signaling mechanisms.

50 are likely recognized through highly similar signaling mechanisms.

51 To elucidate the signaling mechanism, a gene expression time course revea

52 Thus, we have identified a novel signaling mechanism activating PKA in diabetes (downregu

53 d Orai1 binding interfaces have been mapped, signaling mechanisms activating STIM1 recruitment of Ora

54 Given that Src serves as a hub of various signaling mechanisms affecting GluN2 phosphorylation, we

55 al Journal, advance our understanding of the signaling mechanism, although the physiological signific

56 c-FMS signaling mechanism and for the development of target-sp

57 However, the signaling mechanisms and modes of regulation of this rec

58 on) and P2X7-independent (CD80 upregulation) signaling mechanisms and raise the possibility that acti

59 that dysregulate N-arachidonoylethanolamine signaling mechanisms and reduce neuronal inhibitory cont

60 A limited understanding of ANG signaling mechanisms and the orphan receptor Tie1 has hi

61 better understand cell- and tissue-specific signaling mechanisms and their disease-relevant phenotyp

62 implicate Galpha12:Hsp90 interaction in this signaling mechanism, and illuminate structural features

63 onas wsp operon but with a distinct terminal signaling mechanism, and their parallel evolution sugges

64 cavity is regulated by multiple cell types, signaling mechanisms, and matrix interactions.

65 veral other cancers, its functional role and signaling mechanisms are largely unknown.

66 an behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood.

67 anisms allow CA1 neurons to flexibly utilize signaling mechanisms best tuned to temporal pattern of s

68 ing this wave front requires fast and robust signaling mechanisms between CMs.

69 The molecular signaling mechanisms between glomerular cell types durin

70 To elucidate the signaling mechanisms between human NSCs and endothelial

71 bB3 responsive to HRG-beta1-induced enhanced signaling mechanism, but also analysis by siRNA-knockdow

72 ildup limits the speed of this intercellular signaling mechanism, but for tonic signals such as gravi

73 However, the signaling mechanism by which exRNA exhibits its pro-infl

74 rcia et al. (2014) reveal a neuropeptidergic signaling mechanism by which interneurons of the olfacto

75 Together, these data outline a new signaling mechanism by which KCa1.1 regulates beta1-inte

76 We have identified a unique signaling mechanism by which RSK2 promotes cell motility

77 ists of TGR5 and TRPA1, or inhibitors of the signaling mechanism by which TGR5 activates TRPA1, might

78 These findings reveal an unprecedented signaling mechanism by which two protein kinases fulfill

79 CRs) exhibit highly conserved activation and signaling mechanisms by which agonist stimulation leads

80 and little is known about the intracellular signaling mechanisms by which cytokines instruct lineage

81 However, the receptors and signaling mechanisms by which FGF22 and FGF7 induce exci

82 hepatocyte cytoplasm, and define the distal signaling mechanisms by which trehalose induces autophag

83 The signaling mechanisms by which VGSCs promote oncogenesis

84 ed Ca(2+) entry (SOCE), a fundamental Ca(2+) signaling mechanism, by affecting the translocation of t

85 However, many signaling mechanisms cannot be described using these rep

86 However, signaling mechanisms causing increased expression of TRP

87 ts suggest that in addition to Akt-dependent signaling mechanisms, CCR7 can also promote survival of

88 l-or-none, global electrical and biochemical signaling mechanism clearly distinguishes LTS from other

89 nstrate a FOXC1-elicited non-canonical WNT5A signaling mechanism comprising NF-kappaB and MMP7 that i

90 t/beta-catenin and sonic hedgehog-Smoothened signaling mechanisms control the specification and expan

91 ed if TLR activation regulates NGF and which signaling mechanisms control this response in interverte

92 g the emergence of stochastic concurrency in signaling mechanisms controlling leukocyte trafficking.

93 ptors failed to properly engage postsynaptic signaling mechanisms controlling the induction of potent

94 Despite the importance of miRNA biogenesis, signaling mechanisms controlling this process are poorly

95 that, in the early embryonic heart tube, the signaling mechanism coordinating beats is mechanical rat

96 A more comprehensive understanding of signaling mechanisms (cross-talk) between the mitochondr

97 and comprehensively investigated downstream signaling mechanisms currently targetable with small mol

98 nfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial hom

99 The exact signaling mechanisms downstream of LAG3 and interplay wi

100 ities, yet recent studies indicated distinct signaling mechanisms (e.g. tumor-derived VEGF-C promoted

101 In this study, we describe a cell-autonomous signaling mechanism explaining how tenascin-C promotes c

102 actors (IRFs) for its transcription, but the signaling mechanism for IFN-beta induction by S. aureus

103 old Ca(2+) spikes (LTS) are an indispensible signaling mechanism for neurons in areas including the c

104 ase-mediated cleavage provides an additional signaling mechanism for numerous human RTKs.

105 r results validate a trimerization-dependent signaling mechanism for PRL and offer proof of concept f

106 oncogenic scaffolds and demonstrate a novel signaling mechanism for pseudokinases whereby homotypic

107 cascade and, therefore, constitutes a novel signaling mechanism for this receptor.

108 ta suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with othe

109 biota on ASD-associated symptoms, drawing on signaling mechanisms for reciprocal interactions among t

110 e conserved phosphorylation and phospholipid signaling mechanisms for regulating uneven distribution

111 on its SPR response thus indicating distinct signaling mechanisms for the two ligands.

112 mory, it did so by activating different cell-signaling mechanisms from ERalpha, ERbeta, or 17beta-est

113 of autophagy by glycoconjugates focusing on signaling mechanisms from the extracellular surface and

114 Collectively, these signaling mechanisms function to tightly regulate the se

115 The primary signaling mechanism has long been identified as electric

116 ing oligomerization domain 2 (NOD2)-mediated signaling mechanisms have been extensively studied indiv

117 generate these hormones and their downstream signaling mechanisms have been extensively studied, the

118 Although numerous signaling mechanisms have been identified that act direc

119 Most studies of its angiogenic signaling mechanisms have been in endothelial cells.

120 nal that initiate this behavior-that is, the signaling mechanism-have not been definitively identifie

121 air based on geometry rather than a specific signaling mechanism, highlighting the importance of stud

122 The signaling mechanism, however, is unclear.

123 A central common signaling mechanism in cancer is proline-directed phosph

124 In this study, we identified a novel signaling mechanism in CLEC-2-mediated Syk activation.

125 We confirm the crucial facets of the signaling mechanism in heterologously expressing oocytes

126 uss the potential applications of this novel signaling mechanism in the field of point-of-care diagno

127 These findings unveil a novel signaling mechanism in the heart that is activated by BD

128 work has investigated an activity-dependent signaling mechanism in the peripheral nerve.

129 ngus Allomyces reticulatus [4]; however, the signaling mechanism in these fungi remains unknown.

130 rther evidence for the complexity of calcium signaling mechanisms in CNS astroglia.

131 3 expression is essential for protecting the signaling mechanisms in pharmacologically and pressure o

132 arper identification of mitochondrial-driven signaling mechanisms in specific lung cell types will be

133 erization and understanding of the intricate signaling mechanisms in stem-like cells is crucial for t

134 ective observations suggest that neuroimmune signaling mechanisms in the NAc are shaped by early-life

135 e insights into hormone and neurotransmitter signaling mechanisms, in particular those mediated by th

136 Classical signaling mechanisms, including Ca-activated protein kin

137 The rapid signaling mechanism induced by testosterone affects nume

138 In this study, we determined the signaling mechanisms induced by alpha5beta1 integrin int

139 t intercellular communication is an emerging signaling mechanism involved in tissue repair and regene

140 differences in both health and disease, the signaling mechanisms involved are complex and are not ye

141 ase microtubules during cell stress, but the signaling mechanisms involved are poorly defined.

142 Finally, we explored signaling mechanisms involved in cholangiocyte senescenc

143 cells and detached cells suggest distinctive signaling mechanisms involved in collective and individu

144 The intracellular signaling mechanisms involved in differential effects of

145 provide important insights into the calcium signaling mechanisms involved in early developmental pro

146 cancer progression, and highlights two major signaling mechanisms involved in the cross-talk with TER

147 The signaling mechanism involves the proteolytic unmasking o

148 rite formation evoked by serum starvation by signaling mechanisms involving Galpha12/13 but not Galph

149 nmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (V

150 The signaling mechanism is based on the interactions between

151 This signaling mechanism is dependent on IFN-alpha/beta recep

152 present at the cell surface by an inside-out signaling mechanism is important in cancer.

153 demonstrate that although IL-6 and the trans-signaling mechanism is mandatory for cellular infiltrati

154 This cell-signaling mechanism is required to maintain optimal leve

155 We show that a Ca(2+)-dependent glial cell signaling mechanism is responsible for regulating capill

156 One of these main signaling mechanisms is the nuclear factor-kappa B (NF-k

157 l stresses, eukaryotes have evolved a set of signaling mechanisms known as the unfolded protein respo

158 Deficits in this signaling mechanism may contribute to social impairment

159 This novel signaling mechanism may have a major impact on understan

160 mechanism mediated by distinct intracellular signaling mechanisms may account for this regulation by

161 identical or nearly identical canonical WNT signaling mechanisms mediate neural tube and retinal vas

162 To reveal the potential signaling mechanism mediating these effects, levels of p

163 responses are dominated by non-conventional signaling mechanisms: melanopsin phototransduction in ip

164 nstrate that TXNIP binding to NLRP3 is a key signaling mechanism necessary for hHcys-induced NLRP3 in

165 hosphate (ATP) production to fuel purinergic signaling mechanisms necessary for adequate T cell respo

166 Thus, the cAMP-Ca(2+) signaling mechanisms, needed for flexibly modulating net

167 m-positive bacteria, suggesting that similar signaling mechanisms occur in other, mainly pathogenic,

168 We further investigated the signaling mechanism of Ang II regulation of EPO in 786-O

169 These results elucidate the signaling mechanism of extracellular H2O2 in the colonic

170 e initial characterization of the cell death/signaling mechanism of pep5 include caspase 3/7 and 9 ac

171 results reveal a new, dimerization-dependent signaling mechanism of Ras, and suggest Ras dimers as a

172 Despite the differences, the signaling mechanism of these sensors remains essentially

173 tural insights into the photo-perception and signaling mechanism of UVR8.

174 dominated by neurophysiological targets and signaling mechanisms of alcohol.

175 , has led to new insights into the molecular signaling mechanisms of chemoreceptor networks.

176 There are striking parallels in the signaling mechanisms of karrikins, strigolactones, and o

177 , we examined the functional involvement and signaling mechanisms of MAGEA1 in breast and ovarian can

178 ECs provides a novel platform to investigate signaling mechanisms of normal and perturbed EC function

179 ed insights into the regulatory networks and signaling mechanisms of the ER stress responses in plant

180 potential sites of phosphorylation, but the signaling mechanisms of these systems are unknown.

181 L-associated hypertrophy stems from aberrant signaling mechanisms originating in developing endocardi

182 Until now, no signaling mechanisms originating within the plastid have

183 rovide an assay to assess the structural and signaling mechanisms patterning the human gastrula.

184 We have provided evidence for a signaling mechanism (PKA) and a molecular target (TIM) b

185 ced cell death, again by two wholly separate signaling mechanisms, PKA-dependent for cAMP and PKA-ind

186 t a novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling mechanism potentially critical for breast canc

187 Thus, signaling mechanisms previously ascribed to the immune s

188 The hallmarks of this signaling mechanism provide a blueprint for chemical sen

189 sources, and we hypothesize that pleiotropic signaling mechanisms regulate allocation of that resourc

190 therapies; however, the complex and diverse signaling mechanisms regulated by oncogenes and potentia

191 Our data uncover a novel signaling mechanism regulating TRPM3 channels.

192 ng with mGluRs and mERalpha, suggesting that signaling mechanisms regulating analgesic effectiveness

193 These studies reveal age-dependent signaling mechanisms regulating human beta cell prolifer

194 However, the signaling mechanisms regulating LRRK2 and the pathogenic

195 We provide important insight into the signaling mechanisms regulating myelination and propose

196 tte-like superstructures, but the underlying signaling mechanisms remain obscure.

197 of growth-defense tradeoffs, the underlying signaling mechanisms remain obscure.

198 However, these signaling mechanisms remain unknown.

199 ecruits the adaptor protein ACT1, the IL-25R signaling mechanism remains poorly understood.

200 that regulation of the regeneration-related signaling mechanisms require Nrf2 for normal functioning

201 dative stress and by initiating ROS-mediated signaling mechanisms required for the differentiation of

202 a may have facilitated the rapid and complex signaling mechanisms required for the evolution of multi

203 platelet purinergic receptors and associated signaling mechanisms (RhoA) were assessed.

204 However the signaling mechanism(s) that leads to spatial and tempora

205 mains involved in a proliferation-associated signaling mechanism(s), we constructed chimeric Kv1.3-Kv

206 t PNP- and vertebrate NP-receptors and their signaling mechanisms share surprising similarities.

207 ion of complex scenes in primates may employ signaling mechanisms similar to those used during explor

208 nmental Design (LEED) buildings due to green signaling mechanisms, specifically related to the certif

209 the molecular determinants of this essential signaling mechanism still remain largely unknown.

210 s of breast cancer cells, but the underlying signaling mechanisms still remain elusive.

211 activity by HIF-2alpha was not via canonical signaling mechanisms such as Src (non-receptor tyrosine

212 cellular clock or intercellular neuropeptide signaling mechanisms, such as VIP-VPAC2 signaling, can l

213 t JAK/STAT signaling represents an important signaling mechanism supporting AML LSC growth and surviv

214 that GPER enhances memory via different cell-signaling mechanisms than E2.

215 Quorum sensing (QS) is a chemical signaling mechanism that allows bacterial populations to

216 am1 to define membrane identity, revealing a signaling mechanism that can be exploited by human mucos

217 Thus, the current study identified a novel signaling mechanism that controls IP-10 expression in mo

218 s emerging as a key evolutionarily conserved signaling mechanism that controls organ size.

219 These findings thus reveal a YAP/TAZ signaling mechanism that coordinates stem cell expansion

220 nds represents a feature of the cryptochrome signaling mechanism that has important consequences for

221 Thus, mitochondrial remodeling is a signaling mechanism that instructs T cell metabolic prog

222 important consequence of gliotransmission, a signaling mechanism that involves glial release of activ

223 Before fusion, the cells use an unusual signaling mechanism that involves the coordinated and al

224 The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue develop

225 n lipid rafts support an extrinsic apoptotic signaling mechanism that is mediated by phosphaplatins.

226 2X1 receptors represent a standby purinergic signaling mechanism that is necessary for antigen recogn

227 this interaction and thus identify an active signaling mechanism that maintains quiescence in the air

228 ovements, angular information), as well as a signaling mechanism that may enhance detection by intend

229 ns led us to discovery of a network-buffered signaling mechanism that mediates HR signaling and is st

230 However, the signaling mechanism that mediates this regulation is not

231 The green signaling mechanism that occurs at the certification thr

232 Thus, our results identify a compensatory signaling mechanism that prevents lineage-fate errors by

233 es showed that BMX is part of a compensatory signaling mechanism that promotes AML cell survival duri

234 development and suggest a Golgi-specific ERK signaling mechanism that regulates thymocyte development

235 suggesting a postsynaptic nongenomic steroid signaling mechanism that stimulates the release of a ret

236 However, the signaling mechanism that temporally and spatially restri

237 enable the inhibition of other TNF receptor signaling mechanisms that are associated in a wide range

238 ecause it is critical to impede compensatory signaling mechanisms that can engender drug resistance t

239 The signaling mechanisms that choreograph the assembly of th

240 vide an opportunity to define intrinsic cell signaling mechanisms that chronically drive SA in pain p

241 Knowledge of the signaling mechanisms that communicate iron demand from s

242 However, the signaling mechanisms that directly regulate this process

243 much theoretical and experimental work, the signaling mechanisms that disperse these morphogen signa

244 Understanding the intracellular signaling mechanisms that govern growth cone motility wi

245 nd maintenance of cell polarity and regulate signaling mechanisms that guide cell behavior, shape, an

246 ries with a focus on the central phytochrome signaling mechanisms that have a profound impact on plan

247 the microbiota-triggered pattern recognition signaling mechanisms that impact thrombosis are poorly d

248 onsiderable in type 1 diabetes, however, the signaling mechanisms that induce oxidative stress culmin

249 hese data provide new insights into cellular signaling mechanisms that influence resistance to PI3K/m

250 ent to the NKT cell lineage, but the precise signaling mechanisms that instruct their lineage choice

251 lability of nutrients, such as iron, but the signaling mechanisms that link the nutritional state to

252 d synaptic specification depends on specific signaling mechanisms that occur in growth cones.

253 Little is known about intracellular signaling mechanisms that persistently excite neurons in

254 , or biological insults can initiate complex signaling mechanisms that promote kidney repair and func

255 Fundamental cell signaling mechanisms that regulate dynamic remodeling of

256 nce in malignancies; however, the underlying signaling mechanisms that regulate EMT are poorly unders

257 Signaling mechanisms that regulate mammary stem/progenit

258 s, we must increase our understanding of the signaling mechanisms that regulate proliferation and dif

259 hondrial ATP production fuels the purinergic signaling mechanisms that regulate T cells and define th

260 Our aims were to delineate the upstream signaling mechanisms that regulate the TNF-alpha modulat

261 cells that drive stomatal movements and the signaling mechanisms that regulate them.

262 e maintenance of energy homeostasis, but the signaling mechanisms that stimulate LD metabolism in hep

263 ts provide fundamental new insights into the signaling mechanisms that support experience-dependent c

264 However, the signaling mechanisms that trigger cellular senescence ar

265 ess that can be toggled through a variety of signaling mechanisms that ultimately downregulate the RA

266 With the goal of identifying signaling mechanisms that underlie neuronal circuit inte

267 As expected given the proposed sensor signaling mechanism, the magnitude of the binding-induce

268 Because of this signaling mechanism, there are several approaches to max

269 endent CypA secretion by ECs is an important signaling mechanism through which EC ROS regulate suscep

270 Cells of the neural crest employ multiple signaling mechanisms to control migration and differenti

271 Successful pathogens use complex signaling mechanisms to monitor their environment and re

272 Such systems use cellular signaling mechanisms to regulate gene expression across

273 However, the molecular signaling mechanisms triggered by TG2 that mediate this

274 V2 cells, suggesting the MAPK pathway as the signaling mechanism underlying the effect of DMP.

275 However, the signaling mechanisms underlying food-choice behaviors ar

276 To determine the signaling mechanisms underlying incomplete tumor cell ki

277 AR that mediates this effect, as well as the signaling mechanisms underlying increased tumor cell dis

278 processes in PD; however, the key molecular signaling mechanisms underlying microglial activation ar

279 However, the signaling mechanisms underlying PDE10A inhibitor-induced

280 We study the signaling mechanisms underlying sensorimotor integration

281 he functional neuroanatomy and intracellular signaling mechanisms underlying the impact of AR activat

282 The signaling mechanisms underlying the observed cellular ef

283 ontrol of lactation, an understanding of the signaling mechanisms underlying the production and expul

284 The molecular signaling mechanisms underlying this decision remain lar

285 in DeltaF508-CFTR mice and characterized the signaling mechanisms underlying this phenotype.

286 The signaling mechanisms underlying this, however, are also

287 Here, we identify a signaling mechanism, unlike that previously known for an

288 s, suggesting the hypothesis that functional signaling mechanisms upstream of synaptic and circuit ma

289 Thus, the signaling mechanisms used by BMPs and TGF-beta superfami

290 ply that aCRY might have evolved a different signaling mechanism via a light-triggered redox cascade

291 o test tissue specificity of this nongenomic signaling mechanism, we tested retinal and bronchial hum

292 To identify the cellular source of potential signaling mechanisms, we assessed HBC activation after n

293 To identify underlying E2 signaling mechanisms, we intrathecally applied BSA-conju

294 Underlying signaling mechanisms were identified in cultured trachea

295 Our results reveal a signaling mechanism whereby proline cis-trans isomerizat

296 f BLA firing to mPFC input provides a safety-signaling mechanism whereby the mPFC taps into the micro

297 man et al. (2016) demonstrate a feed-forward signaling mechanism wherein F-actin and integrin recepto

298 hosphoinositide 3-kinases (PI3Ks) is a major signaling mechanism whose deregulation contributes to se

299 umor growth that orchestrates a feed-forward signaling mechanism with EGFRvIII and STAT3 to drive tum

300 Integration of knowledge of signaling mechanisms with that of phytobiome members and