ライフサイエンスコーパス: signaling system

1 eep learning will be related to the cellular signaling system.

2 ulated by the MprAB-sigma(E) envelope-stress-signaling system.

3 that noise suppression is encoded within the signaling system.

4 xogenous chemicals that can disrupt hormonal signaling system.

5 ting a potential physiological role for this signaling system.

6 gene regulatory functions of the entire Wnt-signaling system.

7 cross-regulation of this pathway by the cAMP signaling system.

8 tory effects were targeted to the Rag-MTORC1 signaling system.

9 factor 2)/ARE (antioxidant response element) signaling system.

10 es, generating a complex organization of the signaling system.

11 eceptor, as a novel modulator of the Wnt/PCP signaling system.

12 output relationship of this model eukaryotic signaling system.

13 and thus govern information flow through the signaling system.

14 dy, suggesting multifunctionality of the Crz signaling system.

15 conserved nuclear factor-kappaB (NF-kappaB) signaling system.

16 eractions in the Escherichia coli chemotaxis signaling system.

17 etween Nrps and this important developmental signaling system.

18 pheromone response pathway, an archetypical signaling system.

19 y be involved in a larger remote sensing and signaling system.

20 te cell densities and to prime the LuxI/LuxR signaling system.

21 plays a crucial part in the function of GPCR signaling system.

22 ed mutation in Shank3 partially impairs this signaling system.

23 erae biofilm formation through the NspS-MbaA signaling system.

24 rocessing components, and changes in the Wnt signaling system.

25 an alpha-ketoglutarate (alpha-KG) paracrine signaling system.

26 tion in light of its similar phosphorylation signaling system.

27 ell migration, due to activation of the uPAR signaling system.

28 implementation of synthetic light-controlled signaling systems.

29 cycle, GBS encodes a number of two-component signaling systems.

30 othesis that PrP(C) serves as a scaffold for signaling systems.

31 eep hierarchical models to simulate cellular signaling systems.

32 d muscle cells are stabilized by homeostatic signaling systems.

33 ity is used to generate precise responses in signaling systems.

34 ements for artificial molecular machines and signaling systems.

35 activation that are orthogonal to endogenous signaling systems.

36 e approach for investigating the dynamics of signaling systems.

37 cilitate the engineering of complex cellular signaling systems.

38 ility for a range of molecular processes and signaling systems.

39 enesis in NV AMD via the complement and VEGF signaling systems.

40 es of complement, lipid metabolism, and VEGF signaling systems.

41 e deleterious crosstalk with closely related signaling systems.

42 MAPK3, and other components of innate immune signaling systems.

43 accurately simulating multiscale biological signaling systems.

44 re actually operating under aberrant calcium signaling systems.

45 behavior, as well as bacterial two-component signaling systems.

46 interrogating and understanding complex cell-signaling systems.

47 principles for rational design of synthetic signaling systems.

48 y histidine kinases as part of two-component signaling systems.

49 aining multiple strains utilizing homologous signaling systems.

50 is is a regulated process analogous to other signaling systems.

51 asticity consist of multi-component hormonal signaling systems.

52 es is a commonly occurring theme in multiple signaling systems.

53 ing behavior of in vitro reconstituted H-Ras signaling systems.

54 onse regulators from bacterial two-component signaling systems.

55 ble the comprehensive understanding of other signaling systems.

56 process in biological energy conversion and signaling systems.

57 enes, ChIPseq identified novel WT1-dependent signaling systems.

58 cidating biochemical mechanisms of UB-driven signaling systems.

59 ither single mutant, suggesting that the two signaling systems act independently and in parallel to d

60 reases during aging and that the homeostatic signaling system adjusts its response to accommodate the

61 This novel signaling system also provides unique functional insight

62 plantation embryo possesses a functional WNT signaling system and activation of the canonical pathway

63 This highlights a new follicular signaling system and confirms that bimatoprost offers a

64 mma subunits hold a central position in this signaling system and have been implicated in multiple as

65 with reduced abundance of megalin transport/signaling system and indicate that these changes may con

66 decomposing a complex, dynamically evolving signaling system and revealed evolving paths of causal i

67 een structural and biochemical features of a signaling system and the shape of the signal-response re

68 eroprotection that focus on the central IL-6 signaling system and ultimately on inhibition of the IL-

69 ng between different response states in cell signaling systems and enables multiple outcomes for cell

70 ngs should be applicable to a broad range of signaling systems and instrumental in synthetic TCS rewi

71 ion that B. burgdorferi utilizes its limited signaling systems and regulators to govern multiple cell

72 luminate the interface between developmental signaling systems and the fundamental machinery of cell

73 gand/receptor interactions are ubiquitous in signaling systems and their steady-state properties are

74 etwork of interactions between ciliogenesis, signaling systems and tissue patterning.

75 es suggest that manipulating the Dach2-Hdac9 signaling system, and Gdf5 in particular, might be a goo

76 T aggregation, potentiation of the BDNF-TrkB signaling system, and support of mitochondrial integrity

77 ight into the design principles of the Notch signaling system, and the specific developmental process

78 gies are being used to quantify UB-dependent signaling systems, and to integrate UB signaling with re

79 The output of this signaling system appears to be the combined phosphorylat

80 This signaling system appears to represent an ancestral mecha

81 further investigate the relationship between signaling system architecture and biological noise.

82 insulin and bone morphogenetic protein (BMP) signaling systems are important for adipocyte differenti

83 Post-transcriptional mRNA regulation and signaling systems are important to this process but thei

84 Although the proteins comprising many signaling systems are known, less is known about their n

85 Histidine-aspartate phosphorelay signaling systems are used to couple stimuli to cellular

86 mbined action of different Plexin/Semaphorin signaling systems, are required for the formation of a f

87 regulation (e.g. co-regulation via the same signaling system), as well as gene-specific determinants

88 n Neurons," a member of the "Axonal Guidance Signaling System." At 1 week postinjection a common them

89 show that plants also possess a rapid stress signaling system based on Ca(2+) waves that propagate th

90 Here we review some of the key signaling systems behaviors that have been discovered re

91 these results indicate that the CB1 receptor signaling system both on inhibitory and excitatory neuro

92 mits a better characterization of the Ca(2+) signaling system but also allows us to further understan

93 tes with exquisitely tailored perception and signaling systems, but equally important are the enzymes

94 bditis elegans, and Mus musculus, a complete signaling system can be genetically dissected, from the

95 Analysis of the time-dependent behavior of a signaling system can provide insight into its dynamic pr

96 dently identified two components of a Ca(2+)-signaling system, Cbl10 (for calcineurin B-like protein)

97 The Wnt signaling system, comprising 19 lipophilic proteins, reg

98 aled important roles for the endocannabinoid signaling system, comprising G protein-coupled cannabino

99 protein-mediated transcriptional control and signaling systems; consequently, it was thought that car

100 Cannabinoids are part of an endogenous signaling system consisting of cannabinoid receptors and

101 The Fat/Dachsous/Four-jointed (Ft/Ds/Fj) signaling system contributes to orienting those MTs.

102 Here we report a vesicle-based signaling system controlled by a metal cation binding ev

103 ption factors thereby revealing the upstream signaling systems controlling transcriptional responses.

104 at the PhyK-PhyR and LovK-LovR two-component signaling systems coordinately regulate stress physiolog

105 olded protein response (UPR), a multifaceted signaling system coordinating translational control and

106 r abstractions have with the cancer cellular signaling system could have a significant impact on the

107 The TGF-beta/Smad signaling system decreases its activity through strong n

108 is of interactions in the nephrin-Nck-N-Wasp signaling system, demonstrating how multivalent layered

109 The signaling system described here has far reaching implica

110 A conserved Nodal and BMP signaling system directs molecular pathways that impart

111 This phenomenon raises the question of what signaling systems do to prevent a predicted high failure

112 on is tightly coupled to activation in these signaling systems: dominant entropy-producing trajectori

113 This HARE signaling system during continuous HA clearance could mo

114 leic acids, kissing motifs, and enzyme-based signaling systems, ELAKCA opens up new prospects for dev

115 There are three intercellular signaling systems employed by P. aeruginosa, and one of

116 onarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedba

117 ociated with increased activity of two lipid signaling systems (endocannabinoids [ECs] and ceramides)

118 ty of the effects of activating mutations on signaling systems, even at the level of a single protein

119 Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with o

120 ins, thus indicating the existance of a dual signaling system for KARs.

121 By uncovering a signaling system from the Wnt5 guidance cue to an actin

122 er function of saturable, heterogeneous cell signaling systems from basal activity.

123 l membrane receptors constitute an elaborate signaling system fulfilling important functions in immun

124 The Wnt signaling network, an ancient signaling system governing ontogeny and homeostatic proc

125 The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical importance a

126 f the dynamic phosphorylation states of cell signaling systems have been applied extensively in cell

127 Several signaling systems have been linked to regulation of T4P-

128 Although NE and mediated signaling systems have been studied in relation to suici

129 t mutant phenotypes indicated that these two signaling systems have distinct and non-overlapping role

130 plants, and several different intercellular signaling systems have evolved to elicit this response.

131 It is now apparent that homeostatic signaling systems have evolved to stabilize neural funct

132 f interaction with other neuromodulatory and signaling systems have now been identified.

133 dorferi possesses a sophisticated chemotaxis signaling system; however, the roles of the majority of

134 ing evidence that the newly discovered lipid signaling system (ie, the endocannabinoid system) may si

135 upon circuit formation, suggesting that the signaling system implicated in gatekeeping puberty becom

136 mage, whereas later potentiation of the same signaling system improves functional recovery.

137 n systems biology is to reconstruct cellular signaling system in a data-driven manner.

138 Using a mathematical model of the NF-kappaB-signaling system in B cells, we demonstrated that kineti

139 trate the existence of a functional c-di-GMP signaling system in B. subtilis that directly inhibits m

140 tor ligands activate a conserved cannabinoid signaling system in C. elegans and also modulate monoami

141 This study defines a conserved cannabinoid signaling system in C. elegans, demonstrates the cannabi

142 ere we identify an oxytocin/vasopressin-like signaling system in Caenorhabditis elegans, consisting o

143 Our results define a new pheromone signaling system in Drosophila that shares characteristi

144 little is known about the effectors of this signaling system in Gram-positive species.

145 eveal that activation of the canonical TAS2R signaling system in myometrial cells produces profound r

146 nase (IKK)/nuclear factor kappaB (NF-kappaB) signaling system in neuroinflammatory processes and gene

147 uggesting that early loss of this beneficial signaling system in preclinical AD development may contr

148 Total functions of the Wnt-signaling system in regulatory gene expression throughou

149 erized the basic mechanism for a Phr-peptide signaling system in S. pneumoniae and found that it indu

150 e a role for the bidirectional EphB/ephrin-B signaling system in structural plasticity of presynaptic

151 the involvement of the proteasome-ubiquitin signaling system in temperature stress response, the dyn

152 d-fed female mosquitoes activates a nutrient signaling system in the fat bodies, which subsequently d

153 ssential upstream components of the nutrient signaling system in the fat body of fruit flies and the

154 mes is tightly controlled by a long-distance signaling system in which nodulating roots signal to sho

155 lopmental Cell, Liang et al. (2015) report a signaling system in which positional cues from muscle ar

156 Here, we developed a synthetic signaling system in which the extracellular domains of t

157 gether, these findings reveal an intertissue signaling system in which Wingless acts as an effector o

158 urther our understanding of neuropeptidergic signaling systems in Lepidoptera and aid in the design o

159 the architecture and diversity of chemotaxis signaling systems in model beneficial plant-associated b

160 atenin signaling pathway is one of the major signaling systems in stem and progenitor cells, and aber

161 es the interplay between two neuromodulatory signaling systems in the brain through which nicotine ac

162 raction between BDNF/TrkB and the Eph/ephrin signaling systems in the coordination of presynaptic and

163 s of cannabinoids and endogenous cannabinoid signaling systems in the regulation of biological proces

164 ceptor form a key component of intercellular signaling systems in the SCN and critically control cell

165 ich is one of the most important and complex signaling systems in vascular development.

166 echanism may also operate at other levels in signaling systems in which a slow activation step couple

167 m sensing and signaling (PRESS), operates in signaling systems in which the kinetics of ligand-recept

168 , a key mediator of the TGF-beta superfamily signaling system, in the embryonic mouse retina.

169 ototypical G protein-coupled receptor (GPCR) signaling system, in which light-activated rhodopsin (Rh

170 nd satiety, exerting their influence through signaling systems including mammalian/mechanistic target

171 ith bladder mechanosensory, transduction and signaling systems including pannexin 1 (Panx1) and Gja1

172 olecules through activation of innate immune signaling systems, including toll-like receptor 4 (TLR4)

173 gher false alarm metric in this abnormal TNF signaling system indicates perceiving more cytokine sign

174 ause severe short stature, but how these two signaling systems interact to regulate bone growth is po

175 Therefore, signaling systems involved in detecting and interpreting

176 d a surprising conservation in the intrinsic signaling systems involved in early patterning of bilate

177 ved to occur primarily via the two-component signaling system involving histidine kinases and cognate

178 The phosphoinositide signaling system is a crucial regulator of neural develo

179 gth is not known, despite the fact that this signaling system is an important target for the developm

180 InC. elegans, the ephrin-Eph signaling system is conserved and is best characterized

181 ds, suggesting that the architecture of this signaling system is stable and not subject to rapid, dyn

182 The BR signaling system is well established in Arabidopsis (Ara

183 lators activation in two-component bacterial signaling systems is the "Y-T coupling" mechanism, where

184 RcsB, the response regulator of this signaling system, is a pleiotropic transcription regulat

185 In budding yeast, a signaling system known as the spindle position checkpoin

186 e, we used the IDA peptide HAE/HSL2 receptor signaling system known to regulate floral organ abscissi

187 The core and Fat-Dachsous signaling systems locally align planar cell polarities i

188 Two distinct but interrelated pheromone-signaling systems, LuxI/LuxR and AinS/AinR, positively c

189 The intricacies of the purinergic signaling system make it well-suited for the unique conc

190 otic genomes possess at least one chemotaxis signaling system, many of those genomes contain multiple

191 opose a model illustrating how the NspS-MbaA signaling system may communicate exogenous polyamine con

192 velope stress response, suggesting that this signaling system may elicit the repair of division machi

193 Assembly of this signaling system may have been facilitated by the bifunc

194 nomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly

195 Two different signaling systems may emerge depending on Nature's most

196 he origin and evolution of the two-component signaling system members in plants, we conducted a compr

197 udy has revealed that an interleukin-17-like signaling system modulates a neural circuit that control

198 between these central and peripheral emotion-signaling systems, most prominent at the level of cardia

199 S T (FT), components of the plant florigenic signaling system, move long-distance through the phloem

200 netic circuitries that control the stringent signaling systems of a copiotroph, a bacteriovore, an ol

201 Bacterial two-component signaling systems offer a rich diversity of sensory syst

202 Biological signaling systems often rely on complexes of biological

203 ) networks, derived from the T-cell receptor signaling system, on supported membranes.

204 We infer that a DA-dependent signaling system operates in hemocytes to mediate phagoc

205 represented, or encoded, in the output of a signaling system over time.

206 nts with sepsis lack this standby purinergic signaling system owing to defects in mitochondrial funct

207 Ubiquitin (UB)-driven signaling systems permeate biology, and are often integr

208 ain mathematically, how even in the simplest signaling systems, perturbation methods may lead to para

209 The orexin/hypocretin peptide signaling system plays a neuromodulatory role in motivat

210 The Wnt/beta-catenin signaling system plays essential roles in embryonic deve

211 e studies demonstrate that the vitamin D-VDR signaling system possesses direct, antihypertrophic acti

212 This signaling system promotes rapid paternity enforcement wi

213 pressions of emotion provide a sophisticated signaling system, questioning the widely accepted notion

214 Coupled, but mutually inhibitory, Wnt-FGF signaling systems regulate proto-neuromast formation in

215 The signaling systems regulating B. subtilis differentiation

216 nd the contribution of several two-component signaling systems regulating developmental transcription

217 hank3 is a key component of a zinc-sensitive signaling system, regulating synaptic strength that may

218 Such signaling systems rely on the interaction between recept

219 are part of an evolutionary ancient genetic signaling system, resemble the plant pathogens known as

220 rst description of a complete HPA equivalent signaling system resident within the cochlea.

221 under tonic inhibition by a local purinergic signaling system responding to changes in dietary sodium

222 -proteobacteria, the PhoQ-PhoP two-component signaling system responds to low extracellular Mg(++) an

223 Thus, homeostatic signaling systems responsible for rebalancing ion channe

224 tterning cues normally provided by a Wnt/Fgf signaling system, rosettes still self-organize in the pr

225 We review how these signaling systems sense and relay these signals to drive

226 Cell signaling systems sense and respond to ligands that bind

227 Homeostatic signaling systems stabilize neural function through the

228 Bacterial signaling systems such as protein kinases and quorum sen

229 Endogenous cell signaling systems such as Roundabout (Robo)4-dependent S

230 dynamics of processes relying on juxtacrine signaling systems, such as axon guidance mediated by Eph

231 e parallels between this mechanism and other signaling systems suggest that diverse organisms may per

232 ther tissues, the presence of a cochlear HPA signaling system suggests important roles for CRFR1 acti

233 ubunit pilA requires the PilSR two-component signaling system (TCS).

234 mmensal organism, depends on a two-component signaling system (TCS-17) for sensing EA and regulating

235 plest strategies, is able to evolve a costly signaling system that allows individuals to respond appr

236 ature constitutes a dynamic and regionalized signaling system that carries out multiple and changing

237 w for the ubiquitous and fundamental calcium signaling system that cells monitor cytosolic and endopl

238 the P. tricornutum P-responsive sensory and signaling system that combines bacterial two-component s

239 tor that functions downstream of dek1 in the signaling system that controls aleurone specification an

240 yrosine phosphatase Lar function in a planar signaling system that coordinates leading and trailing e

241 protein response (UPR) is an essential cell signaling system that detects the accumulation of misfol

242 cell has a complex, hierarchically organized signaling system that encodes and assimilates diverse en

243 gnaling network demonstrate a robust steroid signaling system that has evolved in plants to orchestra

244 attraction represents a novel, non-classical signaling system that has therapeutic potential as a dis

245 ags to the lysosome, and the v-ATPase form a signaling system that is necessary for amino acid sensin

246 Thus, PPARgamma represents a signaling system that is not crucial for normal cognitio

247 or antagonist IL-1F5 constitute a novel IL-1 signaling system that is poorly characterized in skin.

248 tagonist IL-36Ra (IL-1F5) constitute a novel signaling system that is poorly understood.

249 ical and biochemical basis of a dynamic GnRH signaling system that is robust to changes in pulse ampl

250 fore, Reelin functions as part of a polarity signaling system that links dendritogenesis in the MZ wi

251 d histidine protein kinase, EspC, to the Esp signaling system that negatively regulates progression t

252 hank3 is a key component of a zinc-sensitive signaling system that regulates excitatory synaptic tran

253 GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors

254 B. burgdorferi also has a c-di-GMP signaling system that regulates the tick side of the enz

255 Plants exhibit rapid, systemic signaling systems that allow them to coordinate physiolo

256 d receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number o

257 in particular on the functions of a class of signaling systems that are ubiquitous in bacteria.

258 on for four-layered phosphorelays, which are signaling systems that are ubiquitous in prokaryotes and

259 man genome encodes proteins used to assemble signaling systems that can transduce signals with divers

260 "Hippo" pathways are ancient protein kinase signaling systems that control cell proliferation and mo

261 there is great interest in understanding the signaling systems that control MAPK function.

262 tuberculosis constitutes very sophisticated signaling systems that convert the environment signals i

263 i-GMP) and quorum sensing (QS) are important signaling systems that enable V. cholerae to alternate b

264 e latter term describing the brain's chronic signaling systems that function to slowly degrade molecu

265 hensive overview of the specific factors and signaling systems that govern edn1 activity at the molec

266 thrombus formation are under the control of signaling systems that integrate cellular homeostasis wi

267 raction between the nicotinic and neurokinin signaling systems that may form the basis for some sympt

268 uxtacrine signaling is an important class of signaling systems that plays a crucial role in various d

269 sequently, extensive research has focused on signaling systems that promote myelinating activity of o

270 ryotic cells commonly use protein kinases in signaling systems that relay information and control a w

271 en the TOR kinase and inositol polyphosphate signaling systems that we propose governs carbon metabol

272 Of the three signaling systems that were represented extensively in t

273 In this spatially constrained signaling system, the dynamics of Ras nanocluster assemb

274 In the bacterial chemotaxis two-component signaling system, the histidine-containing phosphotransf

275 As a sensitive signaling system, the mitotic checkpoint ensures faithfu

276 Like other signaling systems, the ability of signal-receiving cells

277 By analogy to natural signaling systems, the insights from this study further

278 The two-component signaling system--the major signaling pathway of bacteri

279 O to feedback regulation of the cell surface signaling system through HasA allows P. aeruginosa to ra

280 ns suggests that PRESS operates in many cell signaling systems throughout biology.

281 Thus, by linking a complex signaling system to a simpler intermediate response map,

282 Vibrio fischeri uses the AinS/AinR pheromone-signaling system to control bioluminescence and other sy

283 ously unknown peptide-mediated intercellular signaling system to control SpeB production, alter globa

284 e the inherent non-linearity of a biological signaling system to identify functions that can potentia

285 Eukaryotic cells utilize complex signaling systems to detect their environments, respondi

286 and others irreversible, to manipulate host signaling systems to subvert the host response.

287 roach, which sees ethnic group building as a signaling system, to place it within a framework that dr

288 Cell signaling systems transmit information by post-translati

289 Basal activity is widespread in signaling systems under physiological conditions, has ph

290 ese targets included components of the Hippo signaling system, underscoring the power of genome-wide

291 To better understand the mechanism of GPCR signaling system, we integrated five independent genome-

292 ing is a component of the quorum-sensing agr signaling system, which serves as an intrinsic checkpoin

293 s are patterned by coordinated activities of signaling systems, which can be integrated by a regulato

294 ey features of the juxtacrine EphA2-ephrinA1 signaling system while maintaining the ability to pertur

295 nce the cAMP response element-binding (CREB) signaling system, while higher, neurotoxic doses stimula

296 nctional nature of ROC provides the RA-based signaling system with robustness by safeguarding appropr

297 tion has been studied extensively as a model signaling system with similarity to processes of hyphal

298 show that mitochondrial PDE2A forms a local signaling system with soluble adenylyl cyclase in the ma

299 We have identified a number of neuropeptide signaling systems with both oncogenic and tumour-suppres

300 from individual phosphorylation events endow signaling systems with plasticity that evolution may exp