ライフサイエンスコーパス: signaling via

1 descending 5-HT system facilitates GRP-GRPR signaling via 5-HT1A to augment itch-specific outputs, a

2 es 5-HT2AR internalization and activates Akt signaling via a 5-HT2AR-mediated event.

3 32 in the developing zebrafish dampens Notch signaling via a cascade involving the transcriptional co

4 asis by attenuating IL-7-stimuated JAK/STAT5 signaling via a direct interaction with phosphorylated J

5 n acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely t

6 transducer inducing cis- and trans-mediated signaling via a membrane-bound or soluble form of the IL

7 brane-bound IL-6 receptor (IL-6R), and trans-signaling via a naturally occurring soluble IL-6R.

8 ly class 3 semaphorin known to be capable of signaling via a plexin receptor without a neuropilin cor

9 el ligand for GPR126 that modulates receptor signaling via a tethered agonist.

10 CR activation, in which Rictor regulates BCR signaling via actin reorganization.

11 is by promoting CSC phenotype through Notch1 signaling via activation of c-Jun and indicate that JNK/

12 IL-6.sIL-6R complexes initiate IL-6 trans-signaling via activation of the ubiquitously expressed m

13 me dependent on a small increase in TGF-beta signaling via activin receptor-like kinase 5 to maintain

14 In this study, we discovered that signaling via activin-like kinase 3 (ALK3/BMPR1A), a BMP

15 g early postnatal development in mice, NMDAR signaling via activity of long-range synaptic inputs ont

16 d in zebrafish models by rebalancing MEK/ERK signaling via administration of small molecule inhibitor

17 ow that endothelial beta-adrenergic receptor signaling via adrenergic nerve-derived noradrenaline in

18 In this study, we show that TLR2 signaling via AKT activates the beta-catenin/T cell fact

19 quired for its tumor-suppressive effects and signaling via AKT1.

20 )), which suppresses angiotensin II receptor signaling via allosteric transinhibition.

21 signaling in leukocytes and suppressed IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pat

22 M cells and simultaneously neutralize ICAM-1 signaling via an antibody blockade, demonstrating signif

23 ogic degradation and is able to perturb MAPK signaling via an uncontrolled kinase-independent functio

24 Furthermore, activation of TGFbeta signaling via angiotensin II infusion revealed a pronoun

25 ool of stabilized MT and inactivation of Rho signaling via ANP-induced, PAK1-dependent inhibitory pho

26 ed in the absence of testes and testosterone signaling via AR.

27 functionally distinct G protein-independent signaling via beta-arrestins.

28 Cell-cell signaling via both Fc receptors and NK-activating recept

29 atty acid receptor FFA2 is able to stimulate signaling via both Gi- and Gq/G11-promoted pathways.

30 We first verified that signaling via both RA and Notch ligands act together to

31 cription of the Met gene we propose that MET signaling via BRAF fuels a positive feedback loop, which

32 ic in CLL cells and disrupts B-cell receptor signaling via BTK depletion.

33 Hepatocyte growth factor (HGF) signaling via c-Met is known to promote endothelial cell

34 Genetic dissection of HGF signaling via c-MET reveals that the incorporation of th

35 genitor cell proliferation by modulating Wnt signaling via c-Myc.

36 ntral component of anti-fungal innate immune signaling via C-type lectin receptors, and several immun

37 ther C5aR or B2R, suggesting that codominant signaling via C5aR and B2R fuels production of the Th1-p

38 rinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase and phosphor

39 TIMP1 signaling via CD63 leads to activation of HSCs, which cr

40 Strategies to block TIMP1 signaling via CD63 might be developed to prevent PDAC me

41 seedling growth, supporting a role for PSKR1 signaling via cGMP in planta.

42 ity, synthetic lethality was specific to ATR signaling via Chk1 and did not occur with ATM inhibition

43 Signaling via conjugation of surface receptors within th

44 -induced arousal requires Nmu receptor 2 and signaling via corticotropin releasing hormone (Crh) rece

45 have demonstrated that reactivation of MAPK signaling via CRAF overexpression and dysregulation is a

46 Impaired signaling via CX3CR1, the fractalkine receptor, promotes

47 , the relative contributions of dopaminergic signaling via D1- and D2-type receptors are unclear.

48 ative regulator of TLR and cytokine receptor signaling via degradation of the receptor-signaling comp

49 ur studies show that activation of NF-kappaB signaling via deletion of one allele of its inhibitor, I

50 F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific gua

51 helia in mice, and antagonizes canonical Wnt signaling via direct regulation of beta-catenin.

52 We now show that enhanced stimulation of ABA signaling via distinct ABA receptors can result in plant

53 The data implicate purinergic signaling via DORN1 in the control of stomatal aperture

54 pic E-cadherin engagement promoted apoptotic signaling via DR4/DR5, but not Fas.

55 tically, this effect is mediated by parallel signaling via either calcium or protein kinase C.

56 hrombin's activation mechanism due to biased signaling via either G proteins or beta-arrestin-2.

57 Signaling via endosomal TLRs was required for autophagy

58 vivo role for dynein in limiting LET-23 EGFR signaling via endosomal trafficking.

59 cumented an important role for Hippo pathway signaling via endothelial cell adhesion molecules in bra

60 The stimulation of ephrinB2/EphB4 signaling via ephrinB2-Fc significantly promoted EPO-med

61 how that STAT3 negatively regulates TGF-beta signaling via ERBB2-interacting protein (ERBIN), a SMAD

62 enic effects of NPY-apoB appeared to involve signaling via ERK and Akt through the NPY R1 and NPY R2

63 emotaxis and Ca(2+) mobilization, as well as signaling via ERK1/2 and the small GTPase Rac1); however

64 ptionally silent mammalian sperm require Wnt signaling via exosomes to prevent protein degradation du

65 a), and identified a new mode of EGFR ligand signaling via exosomes.

66 Intercellular signaling via extracellular vesicles (EVs) is an underap

67 (GEF) for Rap1 supports sustained downstream signaling via feedback of Rap1 to the enzyme Ras-associa

68 signaling control the duration and extent of signaling via G protein-coupled receptor (GPCR) pathways

69 bromin 1 (NF1), as a direct effector of GPCR signaling via Gbetagamma subunits in the striatum.

70 e show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (Smo) in st

71 mphocytes and instead respond exclusively to signaling via germline-encoded receptors.

72 serve as the major hubs for mechanochemical signaling via GIV.

73 modulator changes and the effect on cAMP/PKA signaling via Golf- and Gi/o-coupled GPCR are studied he

74 educed intestinal farnesoid X receptor (FXR) signaling via hepatocyte nuclear factor 1alpha (HNF-1alp

75 f keratinocyte IL-1alpha and IL-36alpha, and signaling via IL-1R and IL-36R was required for inductio

76 IL-1 signaling, via IL-1R1 and MyD88, is required for develop

77 a positive feed-forward loop to activate MYC signaling via induction of miR-33b.

78 Cell signaling via inositol phosphates, in particular via the

79 dent manner and is involved in intracellular signaling via interacting with integrin beta6.

80 , and is identified as an inhibitor of STAT3 signaling via interaction with STAT3 and inhibition of i

81 odel whereby Lrp4 modulates Wnt/beta-catenin signaling via interaction with Wnt ligands and antagonis

82 Therapy-resistant tumors often retain ER signaling, via interaction with critical oncogenic coreg

83 otic transforming growth factor-beta1/SMAD-3 signaling via interactions with SMAD-3.

84 was associated with impaired glycolysis and signaling via interleukin 2.

85 effects, such as calcium release and stress signaling, via intracellular acidification.

86 oint mutation inhibits RNF170 expression and signaling via IP3 receptors.

87 These data indicate that signaling via IR is more important than IGF1R in control

88 quantitative example of differential biased signaling via isoforms of the same G protein-coupled rec

89 We conclude T cell receptor signaling via Itk controls the development of natural Th

90 ExoT also affects PI3K signaling via its ADP-ribosyltransferase activity but do

91 ata indicate that Semapimod desensitizes TLR signaling via its effect on the TLR chaperone gp96.

92 s upon TCR stimulation, inhibiting NF-kappaB signaling via its effects on the IkappaB kinase complex

93 The cytokine IL-17, and signaling via its heterodimeric IL-17RA/IL-17RC receptor

94 signals using two distinct modes: classical signaling via its membrane-bound IL-6 receptor (IL-6R),

95 vl) mediates canonical and non-canonical Wnt signaling via its PDZ domain.

96 opoietic cells and suppresses thrombopoietin signaling via its receptor myeloproliferative leukemia v

97 airment of brain-derived neurotrophic factor signaling via its receptor, TrkB.

98 er vascular endothelial growth factor (VEGF) signaling via its receptor, VEGFR2, regulates senescence

99 y symbiotic receptor kinases, and downstream signaling via its ubiquitination activity to fine-tune b

100 Notch signaling, via Jagged1 ligand on Sus cells and Notch1 an

101 i, but not cgt mutants, blocked IFNG-induced signaling via JAK and STAT.

102 results indicate that conserved IL-2Rgammac signaling via JAK3 plays a key role during early zebrafi

103 Furthermore, inhibition of Notch signaling, via knockdown of Notch1 or by gamma-secretase

104 eta-adrenergic signaling, and altered Ca(2+) signaling via leaky RyR2 channels.

105 Here we show that signaling via ligand-induced receptor dimerization-a ver

106 ults suggest that autocrine and/or paracrine signaling via locally generated SPMs in the vasculature

107 This study reveals that LPA signaling via LPA receptor type 1 activation causes demy

108 , we demonstrate for the first time that LPA signaling via LPA1 contributes to secondary damage after

109 IFN-gamma signaling via Mal was required for phagosome maturation

110 te for GDP --> GTP exchange, KRAS-GTP-driven signaling via MAP kinases and PI3 kinases and mitogen-st

111 membrane and plays a role in late endosomal signaling via MAPK and mammalian target of rapamycin.

112 pressed nigericin-induced NLRP3 inflammasome signaling via mechanisms dissociated from their canonica

113 ress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1

114 Our findings provide rationale for targeting signaling via MET and CD44 during anti-EGF receptor ther

115 Disruption of the DATE increased HGF signaling via MET and reduced levels of receptor-interac

116 HGF signaling via MET reduced levels of the receptor-interac

117 xpression of HGF, resulting in its autocrine signaling via MET.

118 ocortical development is a transient peak in signaling via metabotropic glutamate receptor 5 (mGluR5)

119 ZBTB46, which is negatively regulated by AR signaling via microRNA (miR)-1-mediated downregulation.

120 pathway involves dsRNA-induced innate immune signaling via mitochondrial antiviral signaling (MAVS) a

121 egrin-dependent adhesion to niches augmented signaling via mitogen-activated protein kinases, prolife

122 teins whose synthesis is upregulated by BDNF signaling via MNK1 in neurons.

123 Signaling via MPK4a may therefore be specific to immunit

124 sting that TFAP2C negatively regulates HIPPO signaling via multiple pathways.

125 his inflammasome priming was due to oxLDL IC signaling via multiple receptors, because inhibition of

126 s: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth,

127 cterial-specific adaptive responses but also signaling via MyD88 and Fas molecules.

128 o the dsRNA mimetic poly I:C is dependent on signaling via MyD88 when it is delivered centrally, wher

129 R1 receptor complex, induction of downstream signaling via MyD88/TIRAP, phosphorylation of IRAK4, and

130 ucing interferon-beta (TRIF) but less so for signaling via myeloid differentiation primary response 8

131 ned adjuvant is dependent upon TLR4 and TLR7 signaling via myeloid differentiation primary response g

132 ta promotes invasion and crosstalks with Eph signaling via N-cadherin to drive collective migration o

133 -conditional mTOR deficiency interrupts TACI signaling via NF-kappaB and cooperation with TLRs, there

134 Signaling via NF-kappaB has been linked to the developme

135 both IL-1beta production and regulated death signaling via NLRP3 inflammasomes.

136 pecifically opens by cleavage of NPY by CD26 signaling via NPY2 and NPY5 receptors.

137 ing a facilitation of endogenous cannabinoid signaling via one of its metabolites.

138 ERK1/2 cascade was activated by Ca(2+) signaling via opening of the calcium-homeostasis modulat

139 Conversely, signaling via other C-type lectin receptors did not alte

140 prisingly, loss of RhoA causes increased Rho signaling via overcompensation by RhoB because of reduce

141 is study, we investigated PDGF-AA/alphaalpha signaling via P-Akt(T308) and P-Akt(S473) in distinct ci

142 KRAS signaling, via p110alpha to activate RAC1, is required f

143 ing evidence suggests that extracellular ATP signaling via P2 purinergic receptors may be involved in

144 of purinergic signaling that sustains Ca(2+) signaling via P2X receptor-mediated Ca(2+) influx and ma

145 phate (ATP) release and autocrine purinergic signaling via P2Y2 receptors at the front and A2a recept

146 NSC59984 restores wild-type p53 signaling via p73 activation, specifically in mutant p53

147 Targeting biased PAR-1 signaling via parmodulin-2 restricted mTORC1 and Nlrp3 i

148 erile inflammation, which established danger signaling via pattern recognition receptors as a new con

149 Sfrp inhibitors, together with intercellular signaling via PCP proteins, polarize node cells along th

150 First, signaling via PD-1H coinhibitory receptor potently arres

151 Depletion of CD44 by siRNA increased signaling via PDGFRbeta and TbetaRI by stabilizing the r

152 In conclusion, internalization as well as signaling via PDGFRbeta are controlled by ubiquitination

153 rgeted nuclear genes in concert with reduced signaling via peroxisome proliferator-activated receptor

154 Moreover, activation of HIF2alpha/VE-PTP signaling via PHD2 inhibition has the potential to preve

155 ere important negative regulators of insulin signaling via phosphatidylinositol 3-kinase regulation.

156 uired interaction between TIMP1 and CD63 and signaling via phosphatidylinositol 3-kinase, but not TIM

157 n and its upstream regulation by insulin/IGF signaling via phosphatidylinositol-3 kinase/mammalian ta

158 wly identified as a type of cue that induces signaling via phosphatidylserine receptors to promote fu

159 is mediated by immunoreceptor activation and signaling via PI3K.

160 Vasopressin (AVP) signaling via PKA and other kinases activates NKCC2.

161 dney disease has been linked to dysregulated signaling via PKC in kidney cells such as podocytes.

162 The underlying canonical Galphaq signaling via production of inositol phosphates mediated

163 n anticoagulant protease that initiates cell signaling via protease-activated receptor 1 (PAR1) to re

164 Furthermore, matriptase elicited signaling via protease-activated receptor-2 (PAR-2), and

165 aling pathways, including ERK, mTOR, and Akt signaling, via PTPN13-mediated phosphorylation.

166 r regeneration of IHBDs independent of Notch signaling via Rbpj and Hnf6.

167 Signaling via receptor-interacting serine/threonine prot

168 is inhibited canonical nuclear factor-kappaB signaling via reduced phosphorylative activation, reduci

169 In this case, classical signaling via RelA was essential for proliferating cells

170 or the activation of epithelial beta-catenin signaling via repression of Wnt antagonists.

171 Signaling via Rho-family small GTPases, their upstream g

172 MAD4-independent BMP signaling activated Rho signaling via ROCK and LIM domain kinase (LIMK).

173 lar transportation of S1P and its inside-out signaling via S1P1.

174 S1P similarly activated Galpha12/13/Rho/ROCK signaling via S1P2 receptors, whereas the two selective

175 Targeting LCK signaling via saracatinib, an inhibitor currently underg

176 This reduction required intracellular signaling via second messengers-cytosolic calcium, react

177 Our results suggest that signaling via SH2 domain binding is buffered over a rela

178 signaling through the preTCR, with impaired signaling via ShcA leading to a developmental block at t

179 lpha, IFNbeta, IFNL1, IFNL2, or Janus kinase signaling via signal transducer and activator of transcr

180 Signaling via SLAMF4 controls expansion of cytotoxic CD8

181 lted in defective secretion of BMP6; reduced signaling via SMAD1, SMAD5, and SMAD8; and loss of hepci

182 n-A-induced TFH programming was dependent on signaling via SMAD2 and SMAD3 and was blocked by pharmac

183 t transforming growth factor-beta (TGF-beta) signaling via Smad3 integrates with the trithorax comple

184 mouse genetics, we show increasing Hedgehog signaling via Smoothened M2 expression rescues some Inpp

185 physical basis for intra- and intercellular signaling via sound waves at interfaces, where not molec

186 domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a

187 In the present study, we show that CLEC-2 signaling via Src family and Syk tyrosine kinases promot

188 Based on these findings, gp130 signaling via STAT3 activation is suggested not only to

189 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor gro

190 clinical success, the inactivation of kinase signaling via stimulation of endogenous phosphatases has

191 activation of NF-kappaB in response to dsDNA signaling via STING through the IKKalphabeta activation

192 KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells.

193 the consequence of derepression of vitamin D signaling via suppression of CYP24A1, a rate-limiting en

194 y which endotoxin tolerance re-programs TLR4 signaling via suppression of Pellino-1, a positive regul

195 Instead, signaling via surface receptors expressed on NK-92 cells

196 ominantly recognition via Fcgamma receptors, signaling via Syk, PI3K, and protein kinase C to trigger

197 ion of lung fibroblasts by inhibiting NFATc2 signaling via targeting Frizzled receptor 4/6 and the TG

198 of lung fibroblasts by inhibition of SMAD2/3 signaling via targeting the TGF-beta receptor 1.

199 n of mitogen-activated protein kinase (MAPK) signaling (via the MAPKs ERK1 and ERK2; hereafter referr

200 Endothelin signaling via the activation of the endothelin-A recepto

201 tin ligases down-regulate JAK2 stability and signaling via the adaptor protein LNK/SH2B3.

202 -4 receptors, which potentiated neurotrophin signaling via the AKT and MAPK pathways.

203 Signaling via the Akt/mammalian target of rapamycin path

204 IRF8 dampened signaling via the B cell antigen receptor (BCR), facilit

205 Transient neonatal disruption of signaling via the C-terminal domain of "disrupted in sch

206 tween the fractional helicity and potency in signaling via the cAMP pathway.

207 ability is reversible and dependent on CCL5 signaling via the chemokine receptor, CCR5.

208 ion state with time, providing evidence that signaling via the DCC intracellular domain triggers DCC

209 EMT selectively attenuated apoptosis signaling via the death receptors DR4 and DR5.

210 ate G proteins and trigger non-canonical Wnt signaling via the Dishevelled-binding protein, Daple.

211 ycle checkpoint activation due to persistent signaling via the DNA damage response (DDR).

212 Thus, DA signaling via the DOP1 receptor may contribute to early

213 Using this tool, we show that signaling via the Ecdysone Receptor (EcR), a known regul

214 Second, global signaling via the ecdysone receptor, EcR, establishes a

215 receptor internalization and for functional signaling via the ERK pathway in early Xenopus embryos.

216 choline, a lipid product of cellular injury, signaling via the G protein-coupled receptor G2A on myel

217 ment, required sphingosine 1-phosphate (S1P) signaling via the G protein-coupled S1P receptor 1 in th

218 tream activators and downstream effectors of signaling via the GEF Epac2 in the neuroendocrine NS-1 c

219 tein 90 (Hsp90) regulates downstream hormone signaling via the glucocorticoid receptor (GR), but the

220 ithelial cells showed that in the absence of signaling via the IL-17 receptor adaptor protein Act-1,

221 s and activators of transcription (JAK/STAT) signaling via the IL-22 receptor, resulting in enhanced

222 functional relevance of these cytokines and signaling via the IL-4-associated transcription factor S

223 osinophil-derived type 2 cytokines stimulate signaling via the IL-4Ralpha in PDGFRalpha(+) APs to pro

224 IL-6 signaling via the IL-6 signal transducer GP130 has been

225 he striatum, markers of medium spiny neurons signaling via the indirect pathway, associated with beha

226 Signaling via the inducible costimulator ICOS fuels the

227 aired mechanistic target of rapamycin (mTOR) signaling via the inhibitory REDD1/TSC2 axis.

228 Signaling via the insulin-like growth factor (IGF) pathw

229 Activating FcgammaRs elicit intracellular signaling via the ITAM domain of the associated FcRgamma

230 Endogenous dynorphin signaling via the kappa-opioid receptor (KOR) in the nuc

231 Although signaling via the lipid kinase PI(3)K (phosphatidylinosi

232 myces pombe), and this response is driven by signaling via the MAPK Sty1.

233 tion at BDNF-responding sites and downstream signaling via the MAPK-phosphatase DUSP1 triggers tau ph

234 This suggests that HS augmented ANG-(1-7) signaling via the Mas/eNOS/SIRT1 pathway.

235 , which results in an increase in downstream signaling via the mitogen-activated protein kinase and A

236 ory receptor that contributes to nociceptive signaling via the modulation of macrophages, whereas in

237 Signaling via the MyD88/IRAK pathway in T cells is indis

238 Plant microRNAs play vital roles in auxin signaling via the negative regulation of auxin response

239 Here we show that signaling via the NFkappaB-inducing kinase (NIK) is esse

240 Hence, blocking signaling via the NRP1-VEGF axis significantly reduced t

241 Auxin signaling via the nuclear AUXIN RESPONSE FACTOR7 (ARF7)/

242 to OFF DS tuning matured earlier than direct signaling via the OFF pathway.

243 In this article, we show that signaling via the p110delta isoform of PI3K is critical

244 roliferation and self-renewal and attenuated signaling via the pre-B cell signaling complex (pre-BCR)

245 Signaling via the pre-T cell antigen receptor (pre-TCR)

246 Signaling via the pre-T-cell receptor (pre-TCR), along w

247 hus, IL-7 critically acts cooperatively with signaling via the pre-TCR and Notch1 to coordinate proli

248 cess that critically depends upon productive signaling via the preTCR at the beta-selection stage, as

249 Here, we examine the role of cell-based signaling via the receptor tyrosine kinase EphA7 in guid

250 ow that in advanced ovarian cancers NFkappaB signaling via the RelB transcription factor supports TIC

251 Signaling via the retinoid X receptor gamma (RXR-gamma)

252 s junctions is dependent on GAP activity and signaling via the RhoA pathway.

253 unctions, the role of noncanonical NF-kappaB signaling via the serine/threonine kinase NIK (NF-kappaB

254 TbetaRI in the membrane, balancing TGF-beta signaling via the Smad and JNK pathways.

255 Variable strengths of signaling via the T cell antigen receptor (TCR) can prod

256 Although heightened signaling via the T cell antigen receptor (TCR) is criti

257 tes many cellular processes, but its role in signaling via the T cell antigen receptor (TCR) remains

258 ar bodies, as a key sensor of thresholds for signaling via the T cell antigen receptor (TCR) that was

259 eficient T cells displayed enhanced proximal signaling via the T cell antigen receptor (TCR) without

260 ressor function of Treg cells separable from signaling via the T cell antigen receptor.

261 ed tumor-necrosis factor (TNF) necessary for signaling via the TNF receptors in stromal cells.

262 s regeneration independently of age and FOXO signaling via the TOR pathway.

263 during logarithmic growth and reduced stress signaling via the TORC1-Rim15-Msn2/Msn4 axis.

264 inhibited interferon-regulatory factors and signaling via the transcription factor NF-kappaB by degr

265 iquitin-chain-assembly complex that promotes signaling via the transcription factor NF-kappaB.

266 IL-1 receptor signaling via the transcription factors AhR and RORgamma

267 Signaling via the transient receptor potential (TRP) ion

268 unctional retinal changes by disrupting BDNF signaling via the TrkB receptor.

269 e innate immune response by interfering with signaling via the UPR.

270 nical and noncanonical nuclear factor kappaB signaling via their ubiquitin-E3 ligase activity.

271 is study further suggests that by augmenting signaling via these pathways, GnRH secretion can be enha

272 broblasts and that CD44 negatively modulates signaling via these receptors.

273 2 (FRS2alpha) plays a critical role in cell signaling via these receptors.

274 -viral and anti-proliferative responses, but signaling via this interaction can be detrimental if dys

275 Signaling via this pathway inhibited telomerase activity

276 ant of macrophage polarization and show that signaling via this pathway is required to prevent hepati

277 Signaling via this receptor results in reduced lung infl

278 downstream effector of TGF-alpha but not EGF signaling via threonine 308-phosphorylated Akt.

279 complex in platelets and activate downstream signaling via TIRAP (Toll-interleukin 1 receptor domain

280 Here, we delineate a role for coagulation signaling via tissue factor (TF) and proteinase-activate

281 responses to lipoteichoic acid and poly(I:C) signaling via TLR2 and TLR3, respectively, was significa

282 trafficking of CpG and TLR9 to lysosomes and signaling via TLR9 were enhanced in DCs and in mice foll

283 It exists as a transmembrane form tmTNF, signaling via TNF receptor 2 (TNFR2) and TNFR1, and a so

284 NFR2) and TNFR1, and a soluble form, solTNF, signaling via TNFR1.

285 The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible

286 -negative bacteria activates plasma membrane signaling via Toll-like receptor 4 (TLR4) on host cells

287 ptor binding, endosomal uptake, and probably signaling via Toll-like receptor 7 (TLR7) were critical

288 LR4 is important for achieving LPS-inducible signaling via Toll/IL-1 receptor (TIR) domain-containing

289 The molecular mechanisms by which signaling via transforming growth factor-beta (TGF-beta)

290 ion directly disrupts cilium maintenance and signaling via Tulp3, essential for intraflagellar transp

291 proliferation, tissue development, and cell signaling via two pathways: a nuclear receptor mechanism

292 Here we found that deficiency in signaling via type I interferon receptor led to deregula

293 Setdb2 expression depended on signaling via type I interferons, and Setdb2 repressed e

294 Spatially restricted signaling via tyrosine phosphorylated GIV at the FAs is

295 a cell proliferation by activating NF-kappaB signaling via UNC5A, netrin-1 may be a potential therape

296 We demonstrate that NMI blocks TGF-beta/SMAD signaling via upregulation of SMAD7, a negative feedback

297 g angiogenesis and lymphangiogenesis through signaling via VEGF receptor (VEGFR)-2 and VEGFR-3, respe

298 VEGFC signaling via VEGFR3 promotes lymphangiogenesis and meta

299 Conversely, inhibiting BMP signaling via viral overexpression of noggin in the hipp

300 We investigated the effects of hippo signaling via YAP on chromosome stability and hepatocarc

301 T3 pathway was a downstream effector of KRAS signaling via YAP1 and TAZ.