ライフサイエンスコーパス: signalling

1 y(I:C))-induced necroptosis and inflammatory signalling.

2 sue inflammation, cell death and profibrotic signalling.

3 of inner ear progenitors is initiated by FGF signalling.

4 at current goals influence PE and prediction signalling.

5 ly as well as for the study of intercellular signalling.

6 the PI3K/AKT effector axis of oncogenic RAS signalling.

7 nized as a fundamental component of cellular signalling.

8 26 mediates crosstalk between drought and BR signalling.

9 el Piezo1 and involves calcium-triggered ERK signalling.

10 ulate SIRT1 and insulin-like growth factor 1 signalling.

11 aberrant mRNA translation and intracellular signalling.

12 ns/genes involved in glucocorticoid receptor signalling.

13 g alkaline tolerance circumvents calcineurin signalling.

14 f 2-OG) that modifies aspects of androgen-AR signalling.

15 n plasticity is thought to require glutamate signalling.

16 es and may play a role in downstream glucose signalling.

17 H3 expression reflecting alteration of NOTCH signalling.

18 3R1, with mediators of calcium and phosphate signalling.

19 play critical roles in plant development and signalling.

20 by the cross-talk between TLRs and estrogen signalling.

21 nslocation of FoxO1 and suppression of Notch signalling.

22 ortin-4 receptor and prokineticin receptor 1 signalling.

23 p of tumours associated with hypoxia and HIF signalling.

24 the understanding of compartmentalized cAMP signalling.

25 ake extensive use of cyclic-nucleotide-based signalling.

26 ack of homeostatic cell control through IL-7 signalling.

27 hway, linking chromatin modification and Fgf signalling.

28 , which functions as a novel regulator of Hh signalling.

29 lly required for ligand binding and cellular signalling.

30 al Fgf10, a process that requires active Erk signalling.

31 gulating several processes including calcium signalling.

32 ues the defects caused by suppression of FGF signalling.

33 opathy, suggested decreased WNT/beta-catenin signalling.

34 pd-15 modulates agonist binding affinity and signalling.

35 es in type I interferon (IFN) production and signalling.

36 hatase that antagonizes oncogenic PI3-kinase signalling.

37 on 1 (nope1) mutant to be defective in early signalling.

38 ible role for an allosteric mechanism in TCR signalling.

39 tor of stimulated cytokine and growth factor signalling.

40 a, or cytonemes, in morphogen dispersion and signalling.

41 ay a key role in cell death and inflammatory signalling(1-3).

42 ty and 46% increase in on-current magnitude, signalling a benign effect of tensile strain on the carr

43 the inhibition of cytokine-induced JAK/STAT signalling activation in DF-1.

44 asts with recombinant resistin increased Wnt signalling activation, osteoblast metabolic activity, an

45 ly that Ser269 phosphorylation impacts Notch signalling activity by inhibiting DNA-binding of Su(H),

46 Notch signalling activity governs cellular differentiation in

47 , missorting of Plexin-D1 results in loss of signalling activity.

48 eral and novel mechanism of modulating Notch signalling activity.

49 s (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicat

50 iption factor, ETV4, which is induced by FGF signalling and acts as a repressor of ZRS activity, inte

51 sfunction is characterised by aberrant redox signalling and an inflammatory phenotype.

52 and the ligand NDP are critical mediators of signalling and are mutated in familial exudative vitreor

53 evated Adcy1 translation and abnormal ERK1/2 signalling and behavioural symptoms in FXS.

54 and is involved in protein quality control, signalling and cell death.

55 RNAs), have been shown to play a role in DDR signalling and DNA repair.

56 del, stochastic extinction of oncogenic Kras signalling and emergence of Kras-independent escaper pop

57 harmacological compound that abates TGF-beta signalling and enhances ERK5 signalling may be useful to

58 lar nature of the tumour specificity of CD40 signalling and explained the differences in pro-apoptoti

59 nanoparticles to maximize receptor-mediated signalling and function in the presence of physical forc

60 with important roles in sex steroid hormone signalling and function, and offer unique opportunities

61 portant role of FZD4 endocytosis in NDP/FZD4 signalling and in CNS vascular biology and disease.

62 versus RSPO ligands to in vivo canonical Wnt signalling and ISC biology remain unknown.

63 a support a model where PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest th

64 in regulating niche-hematopoietic progenitor signalling and link this mechanism to immune cell produc

65 ated by mutually antagonistic signals: Notch signalling and Lmx1a.

66 These provide a mechanism for the shift in signalling and phenotypic changes we observed after prol

67 Combinatorial disruption of B-cell receptor signalling and PI3K-AKT-mTOR axis leads to release of MC

68 y other factors including diet, sex, insulin signalling and population density.

69 including the unfolded protein response, Wnt signalling and RNA metabolism, as critical cellular comp

70 Both the BRCA1 DNA repairing signalling and the Estrogen-mediated G1/S phase entry pa

71 acological agents may promote or impede such signalling and the pathogenic effects of ganglioside ant

72 Macroautophagy can regulate cell signalling and tumorigenesis via elusive molecular mecha

73 ence and (3) its ability to activate calcium signalling and/or ERK1/2 phosphorylation via PAR2.

74 st species' degree of investment in chemical signalling, and not foraging behaviour, as a leading fac

75 loop exists between telomere capping and Wnt signalling, and telomere capping can be impacted by extr

76 the TG2 GTP binding to reduce TG2-dependent signalling, and that drugs designed to target this site

77 al Wnt/planar cell polarity pathway, Shh/BMP signalling, and the transcription factors Grhl2/3, Pax3,

78 nctions to constitutively activate NF-kappaB signalling, and we observed mutual exclusivity among tum

79 cidic stores with other parts of the calcium signalling apparatus in cardiac myocytes is unknown.

80 veloping skeleton, we identify canonical Wnt signalling as a candidate for transducing mechanical for

81 Here we identify FGF receptor (FGFR) signalling as a critical regulator of vascular developme

82 ry neurons can be modulated by paracrine ATP signalling, as shown for the cochlear nucleus bushy cell

83 imeric ligand binding sites, inhibits Angpt1 signalling at seventy-fold lower concentrations.

84 nd those changes induced by estradiol in its signalling at the single cell level.

85 lizes the aberrant ERK1/2- and PI3K-mediated signalling, attenuates excessive protein synthesis and c

86 adhesion downstream of the ROCK-LIMK-cofilin signalling axis.

87 Here we present a quantum dot signalling-based cell assay carried out in a segmental m

88 tary on this article.Effective bidirectional signalling between axons and Schwann cells is essential

89 demonstrated that HisKA-Rec and the phospho-signalling between SagS and BfiS contribute to the switc

90 ML290 exhibited signalling bias at RXFP1 possessing a signalling profile

91 r chemical perturbations of calcium-mediated signalling, but abolished in null mutants of the pH-resp

92 dback role that curtails the duration of AHR signalling, but it remains unclear whether they also reg

93 , activates phosphoinositide 3-kinase (PI3K) signalling by binding to the p85alpha subunit of PI3K an

94 -specific inhibitors can inhibit GTP binding/signalling by driving a conformation change that disorga

95 ine transporter is a critical determinant of signalling by the neurotransmitter acetylcholine at both

96 l activity on BR-regulated genes and that BR signalling can also repress expression of RD26 and its h

97 therapies owing to an established network of signalling cascades with functional redundancy, which pr

98 translational regulation of most of the core signalling circuitry including Shh, Wnt, Hippo, PI3K and

99 important cellular functions, which include signalling, compartmentalization and stabilization.

100 Here, we show that interferon signalling-competent SJL mice support chronic ZIKV infec

101 Key signalling components of the senescence machinery, such

102 Emerging data promote neuromuscular signalling components, and especially G protein-coupled

103 uts, both receptors employ common downstream signalling components, which exist in plasma membrane (P

104 d specificity of selected GPCR intracellular signalling components.

105 udomonas quinolone signal (PQS), a cell-cell signalling compound.

106 NOTCH1 signalling contributes to defective remyelination by imp

107 We hypothesized that TGFbeta signalling controls expression of the miRNA genes compri

108 f this is that disruption of olivocerebellar signalling could play a major role in initiating motor d

109 nds the lifespan of ZIKV-infected interferon signalling-deficient AG129 mice.

110 cl-xL-coding Bcl2l1 transgene into NF-kappaB signalling-deficient IkappaBDeltaN transgenic mouse resc

111 suggesting the presence of multiple cAMP/PKA signalling domains within the organelle.

112 that high-throughput systematic analyses of signalling dynamics are becoming possible.

113 Srcs are unknown and it is likely that N-Src signalling events have been misattributed to C-Src becau

114 Multiple signalling events interact in cancer cells.

115 the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs th

116 research establishes a role for specialized signalling filopodia, or cytonemes, in morphogen dispers

117 ontributed to the activation of beta-catenin signalling for the control of PD-1 and TNF receptor prot

118 nation by lateral inhibition via Notch/Delta signalling has been extensively studied.

119 pecification have been identified, and Notch signalling has been implicated in lineage allocation, bu

120 to most other species, suggesting that TLR5 signalling has evolved differently in ruminants.

121 s and to promote serum response factor (SRF) signalling has raised the question of whether MRL protei

122 lar and molecular specialization of axoglial signalling, how pharmacological agents may promote or im

123 rations, nor genes regulating glucocorticoid signalling (HSD11B-1, HSD11B-2, NR3C1, NR3C2).

124 al components of a transcriptionally centred signalling hub that pleiotropically regulates plant grow

125 t link between Phf8 expression and serotonin signalling, identifying this histone demethylase as a po

126 mpaired insulin/insulin-like growth factor-1 signalling (IGF-1) and insulin resistance (i.e. decrease

127 f new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model of fibrosis.

128 te into TH17 cells in the absence of TGFbeta signalling in a RORgammat-dependent manner.

129 own microenvironment via activation of Notch signalling in a subset of tumour cells, and the presence

130 Highly selective optical control of Ca(2+) signalling in adoptively transferred CTLs enhances T cel

131 ption 3 and mitogen-activated protein kinase signalling in an inoculum-dependent manner, and is requi

132 sses the role of astrocytes in neurovascular signalling in both physiology and pathology, and the imp

133 mplex that negatively regulates MEKK3-KLF2/4 signalling in brain endothelial cells, but upstream acti

134 y could be exploited to impair NRF2-mediated signalling in cancer cells, and thus sensitise them to c

135 a positive feedback mechanism of androgenic signalling in CRPC.

136 suggest a central role for perturbed calcium signalling in DYT2 dystonia.

137 er to activate c-Jun N-terminal kinase (JNK) signalling in glia, resulting in changes in transcriptio

138 on-cell-autonomous program to activate STAT3 signalling in hepatocytes through IL-6 produced in the l

139 To determine the role of C3a-C3a receptor signalling in ischaemia-induced neural plasticity, we su

140 voked changes in Ca(2+) (NMDAR-DeltaCa(2+) ) signalling in magnocellular neurosecretory cells (MNCs)

141 spatiotemporal dynamic of NMDAR-DeltaCa(2+) signalling in MNCs from RVH rats, partly due to blunted

142 s characterized through comparison with MeJA signalling in model plants.

143 iduals to study the role of Wnt-beta-catenin signalling in myogenic differentiation.

144 revent hyperproliferation or elevated mTORC1 signalling in Ndfip1-deficient Treg cells.

145 establish the utility of targeting oxytocin signalling in obesity.

146 egradation of Socs mRNAs in response to IL-7 signalling in order to reprogram naive T cells for proli

147 iscrepancies relating to the role of FGF/ERK signalling in PrE versus EPI specification between mouse

148 spring, along with the roles of phytohormone signalling in regulating maternal effects.

149 To establish the role of Wnt signalling in regulating the differentiation process we

150 n phenotype indicating the importance of Wnt signalling in regulating this process.

151 ver disease (NAFLD) by altering inflammatory signalling in RSF.

152 Fibroblast growth factor (FGF) signalling in the distal limb primes the ZRS at early em

153 Here we show a critical role for mTORC2 signalling in the generation of M2 macrophages.

154 e detected in the PFC and with glutamatergic signalling in the hippocampus.

155 w that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation sensing in

156 d roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular dise

157 he amount of active Ras, inhibits downstream signalling, in particular the levels of phosphorylated E

158 Here we co-expressed different types of signalling-incompetent DDR1 mutants ('receiver') with fu

159 Constitutive Akt signalling increases expression of EC morphogenesis gene

160 mRNAs of SOCS family genes encoding the STAT signalling inhibitory proteins SOCS1, SOCS3 and CISH wer

161 decrease in HK2 levels in the absence of FGF signalling inputs results in decreased glycolysis, leadi

162 (WNT), and bone morphogenetic protein (BMP) signalling interactions capable of spontaneously produci

163 volved in lipid turnover (ACADM) and insulin signalling (IRS2) in subcutaneous abdominal adipose tiss

164 egypti, we test the hypothesis that acoustic signalling is a determinant of swarm morphology and pres

165 ll-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the neoplastic B lym

166 However, it is unclear whether predictions signalling is an automatic brain function or depends on

167 We propose that semaphorin-plexin signalling is an essential platform for the stabilizatio

168 Dysregulation of mTOR signalling is associated with a variety of human disease

169 or growth factor starvation, where PI3K/mTOR signalling is decreased, matrix-attached human mammary e

170 Dopaminergic signalling is established as playing an important role i

171 s like schizophrenia in which gluatamatergic signalling is implicated may be caused by aberrant salie

172 In such DCs, glucose-dependent signalling is inhibited, altering DC outputs and enhanci

173 and dysregulation of AMPA receptor-mediated signalling is linked to numerous neurological diseases.

174 A key component of mitochondrial Ca(2+) signalling is the mitochondrial Ca(2+) uniporter complex

175 Our results demonstrate that cellular signalling is vulnerable to trade-offs in performance, b

176 reveal that hydrotropism depends on the ABA signalling kinase SnRK2.2 and the hydrotropism-specific

177 lling posttranscriptionally attenuates Notch signalling levels, thus regulating lineage allocation.

178 loss of Tie2 ectodomain can suppress Angpt1 signalling locally in the cells in which the receptor is

179 MF7-mediated phagocytosis was independent of signalling lymphocyte activation molecule-associated pro

180 abates TGF-beta signalling and enhances ERK5 signalling may be useful to counteract endothelial dysfu

181 h a non-canonical, transcription-independent signalling mechanism that drives assembly of adherens ju

182 We illustrate how distinct signalling mechanisms direct stress-dependent versus hom

183 dy advances our understanding of the complex signalling mechanisms involved in regulating uterine end

184 In addition, when comparing the signalling mechanisms of the catecholoestradiols, to 17b

185 uronal activity, in which synapse to nucleus signalling, mediated via NMDAR and L-type calcium channe

186 Hence, dopamine signalling mediates an energy switch in the mushroom bod

187 n 3D electron tomography indicates a genuine signalling microdomain between these organelles.

188 t force development is regulated by distinct signalling modules involving protein phosphorylations.

189 ways are evolutionarily conserved eukaryotic signalling modules that are essential for the virulence

190 ds on RelA-directed synthesis of (p)ppGpp, a signalling molecule that reduces replication-transcripti

191 directly measure binding and dissociation of signalling molecules from early endosomes in a dense cyt

192 suggest that chemical mimicry of eukaryotic signalling molecules may be common among commensal bacte

193 Therapies that target signalling molecules that are mutated in cancers can oft

194 hylococcal phage-encoded dUTPases (Duts) are signalling molecules that induce the cycle of some Staph

195 t proteins (PCPs), are emerging as important signalling molecules that regulate the pollen-stigma int

196 eptides represent a new class of circulating signalling molecules.

197 rabidopsis (Arabidopsis thaliana) retrograde signalling mutants.

198 find potentially clinically actionable PI3K signalling mutations in 16% of cases.

199 ability to infer the activity of unmeasured signalling network components was also validated using o

200 smotic stress and show how the corresponding signalling network increases cellular survival both by a

201 The nutrient-coupled Ca(2+) signalling network integrates transcriptome and cellular

202 Metazoan signalling networks are complex, with extensive crosstal

203 context will likely be crucial for targeting signalling networks.

204 Therefore, the apelin/apelin receptor signalling nexus may operate as a paracrine signal that

205 ide-mediated vasodilatation and angiopoietin signalling (NO-Tie-mediated arteriogenesis).

206 The glycopeptide nanostructures amplified signalling of bone morphogenetic protein 2 significantly

207 Furthermore, the convergent signalling of MAPKs involved in catecholoestradiol-, 17b

208 e genetics approach to silence glutamatergic signalling only at olivocerebellar synapses.

209 g cells was independent of conventional AMPK signalling or the mTORC1-HIF-1alpha axis, but contribute

210 derlie the differing efficacies for cellular signalling outputs for these ligands.

211 Intriguingly, despite inducing distinct signalling outputs, both receptors employ common downstr

212 Scaffold proteins modulate signalling pathway activity spatially and temporally.

213 th a global suppression of type I interferon-signalling pathway and an aberrant expression of host ge

214 pt we have investigated the role of p38 MAPK signalling pathway and have shown a subpopulation- and p

215 e receptors that signal through the JAK/STAT signalling pathway are important for disease, informing

216 in the [Ca(2+)]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that

217 To further investigate the signalling pathway involved in HpSlyD-induced IM, CDX2 a

218 Our study reveals that the Mesh-mediated signalling pathway is a central homeostatic mechanism of

219 Thus, therapeutic control of the TLR4 signalling pathway is of major interest.

220 The Notch signalling pathway is repressed by Myt1l through silenci

221 ar progenitors and that members of the Notch signalling pathway regulate further differentiation of t

222 study highlights an important innate immune signalling pathway that functions in intestinal epitheli

223 in signalling pathways in which the PI3K-Akt signalling pathway was identified as a hub.

224 that Satb1 is a downstream target of the Fgf signalling pathway, linking chromatin modification and F

225 s ICAM1 overexpression through a GP130-STAT1 signalling pathway, which facilitates endothelial adhesi

226 nate receptor and the downstream JAK2-STAT5a signalling pathway.

227 g is prevented by inhibition of the FGF/MAPK signalling pathway.

228 egulated the IFN-stimulated response element signalling pathways and activated a panel of IFN-regulat

229 ules that control multiple cancer-associated signalling pathways and cellular processes.

230 lifespan is regulated by conserved metabolic signalling pathways and specific transcription factors,

231 hangions to propel lymph, but the underlying signalling pathways are unknown.

232 ment in axon guidance and actin cytoskeleton signalling pathways as well as activation of inflammator

233 lay the common activation of multiple stress signalling pathways before cell competition and find tha

234 server with a bewildering array of potential signalling pathways by which a fall in oxygen levels mig

235 can be mimicked by drugs acting on serotonin signalling pathways e.g. trazodone and lorcaserin.

236 enhanced the activation of canonical growth signalling pathways ERK1/2 and AKT.

237 holamines, we observed that convergent MAPKs signalling pathways facilitate P-UAEC proliferation indu

238 Complementary endothelial signalling pathways for ascending vasodilatation ensure

239 d altered expression of growth and metabolic signalling pathways in maternal tissues.

240 termining the specificity of a vast array of signalling pathways in plants.

241 our approach to control mechanotransductory signalling pathways in time and space.

242 d that they play important roles in multiple signalling pathways in vivo.

243 ese transcriptional changes were enriched in signalling pathways in which the PI3K-Akt signalling pat

244 Abnormalities in signalling pathways required for postnatal hypertrophic

245 VC) via several astrocytic Ca(2+) -dependent signalling pathways such as K(+) release through BK chan

246 ducing upstream resistance via complementary signalling pathways that reflect the intensity and durat

247 poptosis and inflammation, and modulators of signalling pathways that regulate stem-cell pluripotency

248 ic insults are well understood, the upstream signalling pathways that trigger repair are established

249 Moreover, the photoreceptor signalling pathways underlying the circadian regulation

250 promiscuously used-and frequently oncogenic-signalling pathways, via a novel combination of epigenet

251 orks are integral to host defence and immune signalling pathways, which are often hijacked by viruses

252 ent cells, suggesting a convergence of these signalling pathways.

253 r effects, suggesting they activate distinct signalling pathways.

254 RHIM-dependent inflammatory and necroptotic signalling pathways.

255 owth and development in response to multiple signalling pathways.

256 ked to a dysregulation of the cell cycle and signalling pathways.

257 ects bioactive lipids that activate specific signalling pathways.

258 ing that GRIKs are also involved in salinity signalling pathways.

259 nto the clinic including context dependency, signalling plasticity, and tumour heterogeneity, and we

260 emporal separation between immune and growth signalling platforms.

261 , supporting the concept that TRIF-dependent signalling plays an important role in the transcription

262 Finally, we found that S1pr2 signalling posttranscriptionally attenuates Notch signal

263 Endogenous VEGF signalling prevents excess neovessel pericyte coverage,

264 ibited signalling bias at RXFP1 possessing a signalling profile indicative of vasodilator and anti-fi

265 Thus, NMUR1 signalling promotes inflammatory ILC2 responses, highlig

266 will compete with the endogenous TCR for the signalling proteins and carries the potential risk of mi

267 novel acetyltransferase domain to acetylate signalling proteins from plant and animal hosts.

268 rning fasting is unlikely to be explained by signalling proximal to Akt.

269 o not necessarily require changes in insulin signalling proximal to Akt.

270 Disrupting IL-17 signalling reduces RMG responsiveness to input from oxyg

271 Overlapping and unique purinergic signalling regions exist at the apical border of differe

272 tromal cell (macrophage) gene regulation and signalling represent valid targets for chemoprevention o

273 a secondary mechanism to extend the hypoxic signalling response.

274 P. syringae, enhances SA biosynthesis and SA signalling responses; e.g. in response to P. syringae, P

275 Here, we characterized the dynamics of TLR5 signalling, responsible for the recognition of flagellat

276 lusion, our findings indicate that ER stress signalling results in loss of Apc mutated intestinal epi

277 ics to identify selective degradation of the signalling scaffold TRAF3.

278 Calcium signalling silencing is a part of the mechanisms that co

279 (CaCCs) encoded by TMEM16A control neuronal signalling, smooth muscle contraction, airway and exocri

280 We propose that CML41 enables Ca(2+) -signalling specificity during bacterial pathogen attack

281 We observe a correlation between signalling state in cell pairs and their contact area.

282 by assigning the opposing tasks to different signalling subnetworks.

283 Components of the 5-HT signalling system (5-HT, 5-HIAA, SERT) and TNF-alpha exp

284 Homeostatic signalling systems ensure stable but flexible neural act

285 have fused a soluble TCR construct to a CAR-signalling tail and named the final product TCR-CAR.

286 involved and highlight a tonic SFK-mediated signalling that precedes pathogen encounter, raising the

287 inoma by inducing a further increase in MAPK signalling that results in oncogenic toxicity; this effe

288 In response to extracellular matrix signalling, these cells undergo epithelialization and cr

289 n contact areas, which affects the effective signalling threshold of individual cells.

290 This phenomenon means that signalling through Eph receptors is largely dependent on

291 t LOX regulates EGFR by suppressing TGFbeta1 signalling through the secreted protease HTRA1.

292 e the authors show that ERG balances TGFbeta signalling through the SMAD1 and SMAD3 pathways, protect

293 We show that signalling through the TrpA1 thermo-sensor is required f

294 We propose a model based on paracrine signalling to account for the separation of the two doma

295 damaged mitochondria by augmenting autophagy signalling via activation of autophagy receptors (OPTN a

296 chanism that harnesses synergistic paracrine signalling via IL-6/8, which is amplified by cell prolif

297 studies, we show that ENb-TRAIL blocks EGFR signalling via the binding of ENb to EGFR which in turn

298 rongly suggests that the principle of honest signalling via vocal tract resonances may be a broadly s

299 ssociated with mammalian target of rapamycin signalling were detected in the PFC and with glutamaterg

300 combined inhibition of EGFR, HER2, and HER3 signalling with the tyrosine kinase inhibitor AZD8931 wi