ライフサイエンスコーパス: signalosome

1 s the triad of CARMA3, Bcl10, and MALT1 (CBM signalosome).

2 g axis and the composition of the c-Kit/STAT signalosome.

3 ved protein-protein interactions of the BRL3 signalosome.

4 m of the kinases must also be present in the signalosome.

5 ogues in the proteasome lid complex and COP9 signalosome.

6 stabilization of the SP-NK(1)R-beta-arrestin signalosome.

7 nses by recruiting effector molecules to the signalosome.

8 of Rbpj through an association with the IKK signalosome.

9 g partner of TA, the subunit 4 (CSN4) of CSN signalosome.

10 ( approximately 1500 kDa) known as the ASK1 signalosome.

11 expression of COPS7B, a subunit of the COP9 signalosome.

12 g evidence that XIAP associates with the NOD signalosome.

13 nteracts with Csn12, a component of the COP9 signalosome.

14 t-receptor signal transducers into a complex signalosome.

15 poptotic mechanism activated within the RANK signalosome.

16 interaction with the I kappa B kinase (IKK) signalosome.

17 an essential component of the IKK complex or signalosome.

18 mily, whereas CSN-5 is a subunit of the COP9 signalosome.

19 n with the Jab1/CSN5 subunit of the COP9/CSN signalosome.

20 the membrane-associated IkappaB kinase (IKK) signalosome.

21 ulates TBK1 ubiquitination through the NLRP4 signalosome.

22 alytic activity and association with the LAT signalosome.

23 TP synthesis in the presence of the PKCdelta signalosome.

24 ibitory destruction complex to a stimulatory signalosome.

25 CD247 and ZAP70, encoding members of the LAT signalosome.

26 ediates RSPO-LGR4's interaction with the Wnt signalosome.

27 stasis and thrombosis by stabilizing the LAT signalosome.

28 the expression of key components of the TCR signalosome.

29 AP2 were required for the formation of LRP6 signalosomes.

30 ted tonic signaling and the formation of BCR signalosomes.

31 daptor protein 2 (AP2) were part of the LRP6 signalosomes.

32 on of Erk1/2 downstream of NOD alphabeta-TCR signalosomes.

33 icity by forming selective complexes, termed signalosomes.

34 ity and subcellular localization of receptor signalosomes.

35 brane translocation of the IKK and NF-kappaB signalosomes.

36 d it from the centrosome to cytoplasmic LRP6 signalosomes.

37 f membrane domains segregating receptors and signalosomes.

38 to scaffold and localize activated ERK1/2 to signalosomes.

39 goes head-to-tail polymerization to assemble signalosomes.

40 ination at B-cell receptor microclusters and signalosomes.

41 w but persistent increases in F-actin at BCR signalosomes.

42 SH2-containing inositol 5-phosphatase to BCR signalosomes.

43 to form a previously unknown antiapoptotic "signalosome."

44 /MAPK kinase-3/p38 MAPK (ASK1/MKK3/p38 MAPK) signalosome, 4) cell polarization, and 5) distinct actin

45 Constitutive photomorphogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neura

46 We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-kappaB p65, is requi

47 PKA complex acts as cilium-compartmentalized signalosome, a concept that now needs to be considered i

48 CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemic

49 Here, we show that the viral signalosome activated by HCMV binding to its entry recep

50 indispensable for downstream FcvarepsilonRI signalosome activity.

51 of the kinase with key components of the TCR signalosome and abrogates ITK function in T cells.

52 tion of the linker of activated T-cell (LAT) signalosome and activation of downstream signaling prote

53 sites for the coordinated recruitment of the signalosome and are propagated during B cell spreading.

54 DDB1-induced proteolysis of p27Kip1 requires signalosome and Cul4A, because DDB1 failed to increase t

55 Mice with a functional PKCdelta signalosome and elevated retinoid levels (PKCdelta(+/+)h

56 mmune cells to assemble a CARMA3-Bcl10-MALT1 signalosome and mediate G protein-coupled receptor activ

57 thermore, the feedback inhibition of the BCR signalosome and most of its proteins, as well as most ot

58 ffect of SIRPalpha1 receptor on the EGFRvIII signalosome and phenotypes.

59 ility of ADAP to interact with the NF-kappaB signalosome and regulate NF-kappaB activation.

60 mice with a different status of the PKCdelta signalosome and retinoid levels.

61 ent to the protein kinase C theta (PKCtheta) signalosome and subsequent c-Jun kinase (JNK)-mediated C

62 ignaling cascade as a participant in the LAT signalosome and suggest that the THEMIS-GRB2 complex mig

63 CRADD as a negative regulator of the CARMA1 signalosome and suppressor of Th1- and Th17-mediated inf

64 e endosomal mitogen-activated protein kinase signalosome and terminate signaling.

65 e CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which

66 consequent MR aggregation, forming MR redox signalosomes and mediating redox signaling in CAECs.

67 ssembly of the main constituents of the BCR 'signalosome' and revealed an essential role for CD19, in

68 ed knockdown of DDB1, CSN1 (a subunit of the signalosome), and Cul4A in mammalian cells causes an acc

69 ction in non-membrane-enclosed compartments (signalosomes), and it points to novel potential strategi

70 into which components of the SCF(TIR1), COP9 signalosome, and 26S proteasome are also recruited.

71 KKgamma, the regulatory component of the IKK signalosome, and a requirement for BCL10 in both canonic

72 by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link culli

73 architectural elements: the proteasome, COP9 signalosome, and eukaryotic translation initiation facto

74 ASK1 participated in the IRE1alpha signalosome, and removing ASK1 abrogated the proapoptoti

75 E, beta-arrestin-1 recruitment of a p38 MAPK signalosome, and specific actin bundle formation at the

76 DB1 complex remains associated with the COP9 signalosome, and that interaction is conserved from fiss

77 mblies, including amyloids, various kinds of signalosomes, and cellular granules.

78 actions were proposed, the entire TIR-domain signalosome architecture has not been worked out, possib

79 CARMA1/Bcl10 complex and the endogenous CBM signalosome are filamentous morphologically.

80 events that subsequently turn off the CARMA1 signalosome are unknown.

81 BCR signalosomes are dynamic and transient and are subsequen

82 STAT5 phosphorylated by signalosomes are loaded on kinesins and glide along the

83 ed by the protease activity of the CSN (COP9 signalosome), are required to control ubiquitin ligase a

84 The results identify the endocannabinoid signalosome as a molecular substrate for fragile X syndr

85 energy homeostasis establishes the PKCdelta signalosome as a promising target for therapeutic interv

86 l-regulating kinase-1/MAPK kinase-3/p38 MAPK signalosome assembled on Rab5a and phosphorylated EEA-1

87 transduced by dynamic signaling complexes ("signalosomes") assembled by oligomerizing hub proteins f

88 ) recognition of lipopolysaccharide triggers signalosome assembly among TLR4, sorting (e.g. MyD88 ada

89 t models of T-cell receptor (TCR) triggering signalosome assembly and immune synapse formation invoke

90 eins 5 and 6 (LRP5/6), Dishevelled, and Axin signalosome assembly and provide a more complete model f

91 In addition, ASK1/MKK3/p38 MAPK signalosome assembly appears to occur in a novel manner

92 ly and provide a more complete model for Wnt signalosome assembly both intracellularly and at the mem

93 How Wnt triggers signalosome assembly is unknown.

94 itment, post-translational modifications and signalosome assembly of IL-1 receptor-associated kinase

95 e Wnt co-receptor LRP6, an essential step in signalosome assembly.

96 ction complex activity, but also by impeding signalosome assembly.

97 ps may serve distinct roles in TLR4 and TLR2 signalosome assembly.

98 through B-cell antigen receptor (BCR)-based signalosomes at the B-cell surface.

99 stin2-Ub chimera not only stabilized the ERK signalosomes but also led to their endosomal targeting.

100 , suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions.

101 mechanism to negatively regulate the CARMA1 signalosome by the "death" adaptor protein caspase and r

102 in is directly recruited to the alpha(1D)-AR signalosome by the C-terminal domain of alpha-dystrobrev

103 tochondrial-associated adaptor molecule MAVS signalosome by usurping PCBP2 and the HECT domain E3 lig

104 Furthermore, the CSN4 subunit of the COP9 signalosome co-occupies Rbf target gene promoters with R

105 there are significant differences in how the signalosomes communicate with their cognate receptors.

106 The COP9 signalosome complex (CSN) regulates CRLs by removing the

107 ain binding protein 1), integrated into COP9 signalosome complex (CSN), induces protein instability o

108 isoforms, to the third component of the COP9 signalosome complex (CSN3).

109 sion yeast suggested a role of the Pcu4-Ddb1-signalosome complex in the proteolysis of the replicatio

110 CARD9, a component of the CARD9-Bcl10-MALT1 signalosome complex involved in NF-kappaB translocation.

111 We further show that the signalosome complex is imported into the nucleus in time

112 ma membrane, and the SP-NK(1)R-beta-arrestin signalosome complex trafficked by a dynamin-mediated mec

113 of the cullin-RING E3 ligase-regulating COP9 signalosome complex, attenuates proinflammatory NF-kappa

114 We found that CSN-5, a component of the COP9 signalosome complex, binds to UNC-98 and -96 using the y

115 Jab1, the fifth component of the COP9 signalosome complex, has a central role in the degradati

116 sis is conserved in the mammalian DDB1-Cul4A-signalosome complex.

117 lymphoma translocation gene 1 (MALT1 [CBM]) signalosome complex.

118 d that cocaine activates a DC-SIGN mediated 'signalosome' complex by enhancing its association with L

119 Although one other COP9 signalosome component, CSN-6, also has a Mov34 domain, C

120 ic transcripts by the RNAi pathway, and COP9 signalosome components Csn1 and Csn2, whose role in hete

121 in-protein interactions between Bam and COP9 signalosome components regulate cell fate decisions with

122 amics by enabling phosphorylation of key BCR signalosome components, including the kinases SYK and BT

123 Thus, unlike Btk and other signalosome components, RasGRP1 deficiency selectively a

124 BCL10, MALT1, and other IkappaB kinase (IKK)-signalosome components.

125 of resting B cells where it associates with signalosome components.

126 mRNA splicing, which is independent of other signalosome components.

127 Defects in CD20/BCR signalosome conformation might predispose to the spectru

128 immediate downstream trafficking-associated signalosome, consequently routing KSHV toward lysosomal

129 The constitutively photomorphogenic9 (COP9) signalosome (CSN) acts as a molecular switch of CRLs act

130 tion of free NEDD8 Q40E, inhibiting the COP9 signalosome (CSN) allows Q40E to form only on NEDD8 atta

131 700) portion of the 26S proteasome, the COP9 signalosome (CSN) and a novel complex that includes the

132 CSN3, a component of the multi-protein COP9 signalosome (CSN) complex.

133 e critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL.

134 ch desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an associa

135 e COnstitutively Photomorphogenic-9- (COP9-) signalosome (CSN) in somatic support cells disrupted ger

136 The COP9 signalosome (CSN) is a conserved protein complex consist

137 The COP9 signalosome (CSN) is a conserved protein complex known t

138 We discovered that the COP9 signalosome (CSN) is a crucial player in the DSB respons

139 The COP9 signalosome (CSN) is a multi-protein complex that regula

140 The COP9 signalosome (CSN) is an evolutionarily conserved multi-p

141 The COP9 signalosome (CSN) is an evolutionarily conserved multisu

142 The COP9 signalosome (CSN) is an evolutionarily conserved protein

143 The COP9 signalosome (CSN) is an evolutionarily conserved regulat

144 The COP9 signalosome (CSN) is thought to maintain the stability o

145 9 (constitutive photomorphogenesis mutant 9) signalosome (CSN) may regulate the UPS, but this has not

146 COP9 signalosome (CSN) mediates deconjugation of the ubiquiti

147 here that the developmentally regulated COP9 signalosome (CSN) physically interacts with Rbf2 during

148 The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) plays key roles in many biological pro

149 The COP9 signalosome (CSN) promotes the function of SCF-type cull

150 The COP9-Signalosome (CSN) regulates cullin-RING ubiquitin ligase

151 and fly proteins interact with with the COP9 signalosome (CSN) subunit JAB1/CSN5.

152 Here we report that the COP9 signalosome (CSN), a general modulator of diverse cellul

153 Here, we investigated the role of the COP9 signalosome (CSN), a general regulator of protein degrad

154 The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that res

155 ian constitutive photomorphogenesis 9 (COP9) signalosome (CSN), a protein complex involved in embryon

156 d antigen-induced responses require the COP9 signalosome (CSN), a regulator of the ubiquitin-proteaso

157 fication is critically dependent on the COP9 signalosome (CSN), an eight-subunit protein complex cont

158 the zinc metalloprotease subunit of the COP9 signalosome (CSN), which is an important regulator of cu

159 In this study, we show that the COP9 signalosome (CSN)-associated protein CSN5 quantitatively

160 ease following SCF deneddylation by the COP9 signalosome (CSN).

161 lar to those found in components of the COP9 signalosome (CSN).

162 ctivity and gene expression through the COP9 signalosome (CSN).

163 activity is inhibited by binding to the COP9 signalosome (CSN).

164 table to Sirt1-dependent suppression of COP9 signalosome (Csn)5 expression in response to CG-12, lead

165 ated expression of the fifth subunit of COP9 signalosome (CSN5) in early HCC as compared with dysplas

166 or (TCR) ligation assembles a large membrane signalosome, culminating in NF-kappaB activation [1,2].

167 The presence of clathrin and AP2 in the LRP6 signalosomes depended on PtdIns(4,5)P(2), and both clath

168 propagation that differs from the classical, signalosome-dependent pathway.

169 thway and its relationship to the classical, signalosome-dependent signaling pathway are not known.

170 of multivesicular bodies into which the Wnt signalosome/destruction complex becomes localized upon W

171 ctivation, but signaling events that trigger signalosome dissociation from CRL4 have been unclear.

172 Previously, it was unknown how the TLR4 signalosome distinguished between HMGB1 isoforms.

173 By degrading SP and destabilizing endosomal signalosomes, ECE-1 has a dual role in controlling endoc

174 pha-solenoid-like fold and a proteasome COP9/signalosome eIF3 (PCI) module in a right-handed suprahel

175 Eight subunits having PCI (proteasome, COP9 signalosome, eIF3) or MPN (Mpr1, Pad1, amino-terminal) d

176 nate BCR signaling pathway bypasses multiple signalosome elements and terminates in IKKbeta activatio

177 nto large oligomeric signaling complexes, or signalosomes, for signal propagation.

178 res actin reorganization and its role in BCR signalosome formation in mAg- and sAg-stimulated B cells

179 anism by which PtdIns(4,5)P(2) regulates the signalosome formation remains unclear.

180 5)bisphosphate (PtdIns(4,5)P(2)) production, signalosome formation, and LRP phosphorylation.

181 We evaluated BCR signalosome formation, internalization, and signaling in

182 e of signaling networks, including mAKAPbeta signalosome formation, may constitute an effective thera

183 potential to promote Dvl polymerization and signalosome formation, rather than antagonize it as prev

184 s associated with the BCR but dissociates on signalosome formation.

185 ers, illustrating a key principle underlying signalosome formation.

186 , SIGIRR, and ST2) interfere with TIR domain signalosome formation; 2) major deubiquitinases such as

187 ome shares features with a CARMA1-containing signalosome found in lymphocytes, there are significant

188 ctivation, the CARMA3-containing endothelial signalosome functions completely independent of 3-phosph

189 re likely to cooperate, forming pathways or "signalosomes." Here we report the potential to generate

190 The highly sensitive signalosome identified here provides a regulatory mechan

191 cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and s

192 picua may be an important target of the COP9 signalosome in cancer.

193 ignal complex and the downstream trafficking signalosome in endothelial cells and suggest that simult

194 nto the regulatory role of WHIP-TRIM14-PPP6C signalosome in enhancing RIG-I-mediated viral RNA sensin

195 i, and demonstrate a novel role for the COP9 signalosome in heterochromatin regulation.

196 holamban (PLB), and AKAP18 in a multiprotein signalosome in human sarcoplasmic reticulum (SR).

197 y, endogenous MKK6 was found within the ASK1 signalosome in intact cells and in addition copurified w

198 nalosome, underscoring the importance of the signalosome in mediating one of the most significant pro

199 syndecan-1 as a crucial component of the Wnt signalosome in MM cells, binding Wnts and R-spondins to

200 tegy to identify the components of the MyD88 signalosome in murine macrophages stimulated with lipid

201 However, the role of the CO2-sAC-cAMP-PKA signalosome in regulating COX activity and mitochondrial

202 ein-1 (PELP1) as one of the components of ER signalosome in the cytoplasm.

203 and ERK1/2 and helped IQGAP1 to form a large signalosome in the perinuclear region.

204 Rbf2, suggesting an active role for the COP9 signalosome in transcriptional regulation.

205 est that HSP27, p38, and NFkappaB-p65 form a signalosome in virus-infected cells and influence downst

206 for the first time the existence of a large signalosome in which inputs from the ER, kinases, bone m

207 es the formation of membrane raft (MR) redox signalosomes in a process that depends on a local acid m

208 bits the assembly of immune receptor-induced signalosomes in mast cells.

209 zation, is required for the formation of BCR signalosomes in response to both mAg and sAg.

210 results suggest that FZD receptors may form signalosomes in response to Wnt binding through the CRDs

211 The signalosome includes requisite Galpha(s), Gbetagamma and

212 naling such that ERK phosphorylation becomes signalosome-independent; however, the nature of this new

213 rature review of other manuscripts about the signalosome, inflammasome, apoptosis, or mechanisms of s

214 CSN1), which belongs to the Proteasome, COP9 signalosome, Initiation factor 3 (PCI) domain containing

215 In NOD DNs, alphabeta-TCR signalosomes instead behave like pre-TCRs, resulting in

216 iously undescribed ligand that engages a key signalosome involved in the pathogenesis of human immune

217 Furthermore, the concept of a signalosome involving disease-associated factors, such a

218 paB pathway via the CARD11/BCL10/MALT1 (CBM) signalosome involving key, yet ill-defined roles for lin

219 te CD4(+) T-cells through the formation of a signalosome involving TRAF2/PKC- leading to NF-kB activa

220 kappaB kinase (IKK) beta-subunit of the IKK signalosome is a central target for oxidative inactivati

221 Here we show that the reconstituted CBM signalosome is a helical filamentous assembly in which s

222 The COP9 signalosome is a large multiprotein complex that consist

223 The OX40 signalosome is formed in membrane microdomains irrespect

224 This signalosome is pirated in the activated B-cell-like subg

225 propose that CD20 dissociation from the BCR signalosome is pivotal to BCR-mediated calcium mobilizat

226 The function of BCR signalosomes is one of the determining factors for the f

227 diacylglycerol lipase-alpha (endocannabinoid signalosome), is disrupted and metabotropic glutamate re

228 e, a key component of the Carma1/Bcl10/MALT1 signalosome, is critical for NF-kappaB signaling in mult

229 We found that CSN6, a subunit of COP9 signalosome, is overexpressed in CRC samples and that CS

230 a2 (PLCgamma2), a key constituent of the BCR signalosome, is stimulated by activated Rac through dire

231 isoform, which targets a different subset of signalosomes, leaves memory undisturbed.

232 ammatory signaling pathways branching at the signalosome level to Mal/MyD88 and TRAM/TRIF pro- and an

233 and holocomplex suggests that TRC8 modulates signalosome levels or compartmentalization.

234 Palpha1 inhibitory receptor and the EGFRvIII signalosome may facilitate the identification of novel t

235 The CARMA1/Bcl10/MALT1 (CBM) signalosome mediates antigen receptor-induced NF-kappaB

236 in naive B cells depends on the function of signalosome mediators; however, prior engagement of CD40

237 The PKCdelta/p66Shc/cytochrome c signalosome might have evolved to effect site-directed o

238 lation and deneddylation, including the COP9 signalosome, Nub1, and enzymes in the neddylation cascad

239 al NF-kappaB by forming a novel Akt(+)NIK(+) signalosome on Rab5(+) endosomes.

240 the formation of the signaling complex, the signalosome, on the IL-7 receptor cytoplasmic domains.

241 adation were found to interact with the ASK1 signalosome once MKK6 activation was completed.

242 These endocannabinoid-producing signalosomes operate in phasic and tonic modes, thereby

243 tal response kinetics suggested that the ABA signalosome partially affects the CO2-induced stomatal r

244 me subunit 5 (CSN5), a component of the COP9 signalosome previously reported to functionally interact

245 est a more complex picture in which distinct signalosomes, previously unrecognized proteins, and newl

246 easing MKK6 binding affinity within the ASK1 signalosome prior to induction of inactivation and degra

247 shed COP9 activity, suggesting that the COP9 signalosome protects Rbf proteins during embryogenesis.

248 The COP9/Signalosome regulates CDT2 stability through CUL4 denedd

249 PC imparts functionality to the alpha(1D)-AR signalosome remains a mystery.

250 The COP9 signalosome removes Nedd8 modifications from the Cullin

251 rate, pre-assembled, ligand-independent GPCR signalosome represents a new paradigm in GPCR signalling

252 s define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral

253 ed repression of CSN5, a subunit of the COP9 signalosome responsible for deneddylation of Cul-1, part

254 ization of BCRs and associated proteins into signalosomes, resulting in BCR-activated calcium entry.

255 proteasome and the promoter-associated COP9 signalosome, serving to extend Rbf protein lifespan and

256 e find that although this CARMA3.Bcl10.MALT1 signalosome shares features with a CARMA1-containing sig

257 hat target the B-cell antigen receptor (BCR) signalosome show clinical efficacy in the treatment of B

258 cilitated the binding of topoIIalpha to COP9 signalosome subunit (Csn)5 by way of topoIIalpha phospho

259 e show that mutations in the Drosophila COP9 signalosome subunit 1b (CSN1b) gene increase the activit

260 Here, we show that the COP9 signalosome subunit 5 (CSN5) is required for activation

261 Moreover, COP9 signalosome subunit 5 (CSN5), a component of the COP9 si

262 We show for the first time that COP9 signalosome subunit 6 (CSN6) associates with COP1 and is

263 ding of p27(kip1) to its inhibitor, the COP9 signalosome subunit jun activation-domain binding protei

264 eta-arrestin-1 and recruitment of a p38 MAPK signalosome that elicits distinct actin rearrangement at

265 Cofilin within MBn, nucleating a forgetting signalosome that is downstream of dopaminergic inputs th

266 Thus, we have identified a neutrophil Btk signalosome that is involved in a signaling pathway trig

267 together constitute a signaling complex (CBM signalosome) that mediates antigen-dependent activation

268 a pre-assembled, constitutively active GPCR signalosome, that couples the relaxin receptor, relaxin

269 cturally related protein complexes, the COP9 signalosome, the proteasome lid, and the eukaryotic tran

270 HEMIS-mediated recruitment of SHP to the TCR signalosome, THEMIS knock-down increased TCR-induced CD3

271 uncovering a novel vascular role for the CBM signalosome, these findings illustrate that CBM-dependen

272 couple ASK2 S964 phosphorylation to the ASK1 signalosome through dual engagement of 14-3-3.

273 cal cancer cells by associating with the IKK signalosome through IKKalpha.

274 nteracts with several components of the COP9 signalosome through its CARD domain.

275 brane-associated guanylate kinase 1 (CARMA1) signalosome through the coordinated assembly of complexe

276 couples JNK signaling components to the BCR signalosome, thus facilitating JNK activation.

277 udies suggest that DeltaCCDC170 engages Gab1 signalosome to potentiate growth factor signalling and e

278 enotypes revealed a requirement for the COP9 signalosome to prevent ectopic expression of Epidermal g

279 However, the relevance of mAKAPbeta signalosomes to pathological remodeling and heart failur

280 but also orchestrates the targeting of "7TMR signalosomes" to microcompartments within the cell.

281 res an intact endothelial CARMA3.Bcl10.MALT1 signalosome, underscoring the importance of the signalos

282 nucleates a macromolecular complex or a "PKA signalosome." Using the RIIbeta holoenzyme as a prototyp

283 tdIns(4,5)P(2) promotes the assembly of LRP6 signalosomes via the recruitment of AP2 and clathrin and

284 nning ks-vFLIP-induced activation of the IKK signalosome, we have determined the crystal structure of

285 molecules are recruited to the alpha(1D)-AR signalosome, we performed an extensive proteomic analysi

286 onents of the proximal B cell receptor (BCR) signalosome were enriched within teHSP90 complexes.

287 In addition, WNT3A-induced LRP6 signalosomes were primarily localized at cell surfaces,

288 romotes its incorporation into SERCA2/AKAP18 signalosomes, where it regulates a discrete cAMP pool th

289 4 promote the initial assembly of the CARMA1 signalosome, whereas later phosphorylation at S649 trigg

290 sion of the IkappaB kinase (IKK) complex (or signalosome), which involves a physical interaction betw

291 ough stimulus-coupled assembly of the CARMA3 signalosome, which contains the adaptor protein BCL10.

292 ent assembly of the CARMA1-BCL10-MALT1 (CBM) signalosome, which coordinates downstream activation of

293 r the assembly and function of the IRE1alpha signalosome, which forms a positive feedback loop with A

294 A paradigm is the Wnt signalosome, which is assembled by Dishevelled via rever

295 te with alpha(1D)-ARs to create a functional signalosome, which is essential for alpha(1D)-AR regulat

296 activation of the focal adhesion associated signalosome, which triggers Rho GTPase signaling.

297 target cells are sequestered into "circadian signalosomes," whose compositions differ between E and M

298 ation steps modeling the construction of the signalosome with a final sequestered, or high-stability,

299 hypothesis that Nkd1 is recruited to the Wnt signalosome with Dvl2, where it becomes activated to mov

300 cently discovered that alpha(1D)-ARs form a "signalosome" with multiple members of the dystrophin-ass