ライフサイエンスコーパス: significance

1 pathogenic, likely pathogenic, or uncertain significance.

2 r terms relating to statistical and clinical significance.

3 e the hypotheses to be tested cannot achieve significance.

4 lthough the latter did not reach statistical significance.

5 aling and metabolic pathways of pathological significance.

6 oth leucine and valine levels at genome-wide significance.

7 d characterise their clinical and biological significance.

8 ng function, and 15q25.1 reached genome-wide significance.

9 ur findings a high likelihood of physiologic significance.

10 alteration(s), excluding variants of unknown significance.

11 s associated with smoking limit its clinical significance.

12 f either the event or trend analysis reached significance.

13 d with emphysema distribution at genome-wide significance.

14 smaller response failed to reach statistical significance.

15 ining beta-catenin and HMGA1 have functional significance.

16 ustered data were used to assess statistical significance.

17 with the MNP+RUTF meal, which did not reach significance (1.21-fold; 95% CI: 0.92-, 1.61-fold; P = 0

18 proach identified 13 new loci at genome-wide significance, 12 of which were on our previous list of l

19 ariants in locus ADAM12 achieved genome-wide significance, although they did not replicate with publi

20 Both the statistical significance and effect size of the HLA signals were con

21 work is needed to understand the functional significance and fitness consequences for the beetle of

22 evelop, debate still surrounds the energetic significance and physicochemical origins of this class o

23 single variants reaching stringent levels of significance and, despite excellent power, provided litt

24 rative statistics were employed to determine significance, and cost savings were estimated based on o

25 T47 in the alpha1 subunit are of particular significance as their structural modification inhibits a

26 Such differences may have clinical significance, as therapeutic targeting of a signaling pa

27 kov chain beyond reversibility and show that significance at [Formula: see text] is best possible in

28 TOR folate sensing may have broad biological significance because of the critical role of folate in n

29 ather under the changing climate is of great significance but remains challenging which is at least p

30 onsuming to use in practice due to stringent significance criteria commonly seen in these analyses.

31 a Ki-67 of more than 5% (P = 0.004), without significance differences in (18)F-FDG SUVmax Log-rank an

32 myces are of great biological and industrial significance due to their complex morphological developm

33 in the placebo group, but this did not reach significance (estimated marginal mean [95% CI], active,

34 and HC, and across diseases for statistical significance (fold change>/=1.5 and false discovery rate

35 residues have an additional but more modest significance for activity.

36 with cutoff 5.25 had independent prognostic significance for OS, while combined RDW and NLR scores s

37 Our study has important significance for the establishment and manipulation of y

38 s of solid electrolytes are both of critical significance for these devices to operate with high effi

39 inflammatory pain in mice and humans but its significance for visceral pain is unknown.

40 f subpopulations resistant to this treatment.Significance: Illustrating the challenge in treating can

41 diagnosis was monoclonal gammopathy of renal significance in 30 (60%), multiple myeloma in 17 (34%),

42 initial step in determining their functional significance in ageing and osteoarthritis, and provides

43 -rearranged leukemia and suggest its broader significance in AML.

44 ization with microfluidic chips has critical significance in cancer prognosis offering a non-invasive

45 spreading processes on networks is of prime significance in diverse contexts, ranging from the ident

46 Despite its significance in global health, the mechanisms of pathoge

47 tablished, but its pathogenic and prognostic significance in HF with midrange (HFmrEF; EF 40%-50%) an

48 cross lipid bilayer membranes is of profound significance in many biological processes, from the deve

49 te membrane insertion, but the physiological significance in multicellular organisms remains to be re

50 orthy (FPRP <0.2) and approaches genome-wide significance in multivariable analysis (P multivariable

51 roids (odds ratio = 5.05; P = 0.01) retained significance in multivariable analysis.

52 tory somatic pain in mice and humans but its significance in pain originating from the viscera is unk

53 eeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency sc

54 ification of Lalat as a low GI variety is of significance in the dietary prevention and management of

55 All secondary end points reached statistical significance in the ferric citrate group, including the

56 directionally consistent and reached nominal significance in the validation cohort.

57 ets in oncology, but their clinicopathologic significance in thyroid cancer is unclear.

58 identified 22 loci associated at genome-wide significance, including 13 new associations with COPD.

59 studies of mostly white populations, but its significance is not well established in African American

60 s 3 doses for 6 years, although the clinical significance is unknown.

61 methylation in cord blood at epigenome-wide significance level [false discovery rate (FDR)<0.05].

62 n APOA5 associated with CAD at a genome-wide significance level and provided new insights into pathwa

63 Adopting a cFDR nominal significance level of 0.05, 287 loci were identified for

64 ociated with schizophrenia at the suggestive significance level of 5 x 10(-5).

65 ssociated with 1-year overall mortality at a significance level of P < .10 constructed a multivariate

66 y to target the MYB "addiction" of Ph(+) ALL.Significance: MYB blockade can suppress Philadelphia chr

67 First, a long-standing debate about the significance of aggression in human nature is misconceiv

68 loped a mathematical model to understand the significance of altered levels of SERCA, IP3R, and RyR o

69 Interestingly, we demonstrated that the significance of ASS1 was not restricted to UHCA, but als

70 the fact that we address both the functional significance of attractiveness-related biases and their

71 Here, we review the significance of autophagy as an anoikis resistance pathw

72 Here, we investigated the in vivo significance of BACE1 S-palmitoylation through the analy

73 tion procedure is applied to approximate the significance of Bayesian-type statistics.

74 Purpose To determine the prognostic significance of blasts, and of white and red blood cells

75 indings allow us to interpret the functional significance of cancer associated ZRANB3 mutations.

76 The prognostic significance of CD8A, GLUT1, and COX5B gene expression w

77 To understand the significance of circadian-mediated anticipation in stoma

78 nchiolitis obliterans syndrome; however, the significance of circulating antibodies before transplant

79 studies are required to test the prognostic significance of CNA presence in disease relapse in patie

80 of Deep Learning can be used to identify the significance of different features from physical examina

81 Prognostic significance of each protein was examined by single-mark

82 ion Our study supports the strong prognostic significance of early NPM1m PB-MRD, independent of the c

83 Our results underscore the significance of expanding residential development on mul

84 However, the functional significance of extracellular phosphorylation of specifi

85 tricular tachycardia, showing the functional significance of FXR1 upregulation observed in DCM.

86 these approaches about both the evolutionary significance of gene transfer and the underlying molecul

87 ical function of genes, and the pathological significance of genetic variants in human cardiovascular

88 Collectively, these results emphasize the significance of histone lysine methylation in normal hum

89 However, the functional significance of INS-membrane interaction is not clear.

90 However, the significance of LKB1 mutations in cervical cancer initia

91 shareholders contributes to the statistical significance of local patterns, while homophily always e

92 s of infection, treatment, and public health significance of M. genitalium reviewed at the meeting is

93 or future studies of function and biological significance of m5C in mRNA in mammals.

94 As debates continue over the functional significance of many specific lncRNAs, support grows for

95 We determined the clinical significance of minimal residual disease (MRD) levels as

96 This study investigated the sensory significance of monoterpene glycosides during tasting, b

97 f this study was to elucidate the predictive significance of MPV in CRC.

98 We sought to re-examine the significance of multiple rare variants in patients with

99 h neglects to take account of the positional significance of mutations - the function of a gene is le

100 o be of value in interpreting the functional significance of mutations in the CTLA-4 pathway identifi

101 ave in regulation of NAT expression, and the significance of NATs in response to WS.

102 tive medicine including the current clinical significance of NDs, as well as the challenges that must

103 Clinical significance of only 9.56% of the SNVs is known in ClinV

104 The significance of our research is in examining the suscept

105 th Cd36 and Mertk underscore the physiologic significance of phagocytosis during tissue injury.

106 We also discuss the significance of porphyrin-based nanostructures for poten

107 exity to the interpretation as the etiologic significance of results may be unclear (ie, the pneumoni

108 this article was to study the prevalence and significance of sarcopenia in the multimodal management

109 and nonlinear mathematic equations, and the significance of sex was assessed using the Student t tes

110 This demonstrates the significance of surfactants in deteriorating drag reduct

111 However, the strength and significance of the association between dabigatran use a

112 derstanding of the structural and functional significance of the components of the rabies virus repli

113 ven this research attention and the clinical significance of the issue, this article analyzes the ass

114 To test the significance of the latter correlation, we mutated the s

115 ermutation test was applied to determine the significance of the observed square error.

116 The work illustrates the significance of the pellet-based sensing system towards

117 These results highlight the significance of the relative contributions of the dampin

118 ysis leads to a strong overestimation of the significance of the seasonal trends, because multiple te

119 dues in the interface support the functional significance of the structural model and indicate that t

120 rescue medication, both showing statistical significance of the study drug compared to placebo ( P <

121 These studies support the biological significance of the triangular trimer assembly of Abeta

122 However, the detailed functional significance of the vast majority of them remains to be

123 acticality in obtaining motif instances, the significance of their contribution to problem solving is

124 pathogen biology and infectivity although a significance of their interaction remained enigmatic.

125 To establish the pathogenic significance of these abnormalities, we inhibited mitoch

126 We offer literary interpretations of the significance of these anomalies, providing quantitative

127 Although the clinical significance of these findings is yet to be determined,

128 The clinical significance of these potential biomarkers was further t

129 The origin and significance of these profiles remain largely unknown.

130 and alternative splicing, but the functional significance of this evolutionary conserved diversity re

131 ributed cortical regions, yet the functional significance of this extensive thalamocortical connectiv

132 The clinical and immunological significance of this finding is bidirectional in that it

133 (Ca(2+)), but the mechanisms and functional significance of this localized signaling are unknown.

134 Highlighting the significance of this mechanism, we found that ranolazine

135 Furthermore, we demonstrate the functional significance of this rapid transcriptional change using

136 Also, the significance of this regulation in response to chromosom

137 The broad significance of this work is the demonstration of how hi

138 -Armitage trend test was used to examine the significance of trends in mortality from 2006 to 2013.

139 from the cell surface, but the mechanism and significance of uPAR shedding remain obscure.

140 ining the underlying etiology and prognostic significance of VT.

141 Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3,

142 No associations reached genome-wide significance (p>5 x 10(-8)).

143 .0x10(-8)) or an association with suggestive significance (P<1.0x10(-6)) in the discovery set.

144 line score by using paired t tests (level of significance, P < .007).

145 agnosis of hypereosinophilia of undetermined significance, reclassifying some of these cases as eosin

146 aggravating factors for genomic instability.Significance: RUNX3 inactivation in cancer removes an an

147 myeloma or monoclonal gammopathy of unknown significance sequentially underwent dual-energy CT and m

148 celeration across several other target forms.SIGNIFICANCE STATEMENT A compact model of the spatial an

149 reconfiguration of functional brain networks.SIGNIFICANCE STATEMENT A key role of any neuromodulator

150 viable model of auditory stream segregation.SIGNIFICANCE STATEMENT According to the population separ

151 s, even during steady isometric contractions.SIGNIFICANCE STATEMENT Accurate motor actions are made p

152 racterized by declined cognitive flexibility.SIGNIFICANCE STATEMENT Activation of the human default m

153 long-term potentiation (required for Pc-ODP).SIGNIFICANCE STATEMENT Activity-dependent neuronal plast

154 dolescent-specific social learning processes.SIGNIFICANCE STATEMENT Adolescence is a unique developme

155 transform to myelin cells after regeneration.SIGNIFICANCE STATEMENT After injury to peripheral nerves

156 sting extinction of alcohol-seeking behavior.SIGNIFICANCE STATEMENT Alcohol use disorder is a chronic

157 as a general index of cortical excitability.SIGNIFICANCE STATEMENT Alpha-band oscillations are thoug

158 trajectories of functional brain maturation.SIGNIFICANCE STATEMENT Although brain signal variability

159 erioration of this important cell population.SIGNIFICANCE STATEMENT Although injured peripheral nerve

160 sponding under this basic selection pressure.SIGNIFICANCE STATEMENT Among the most basic survival pro

161 ehavior appropriately to nutrient conditions.SIGNIFICANCE STATEMENT Animals adjust behavior in respon

162 d and altered items during periods of threat.SIGNIFICANCE STATEMENT Anxiety and posttraumatic stress

163 may be relevant in some pathological states.SIGNIFICANCE STATEMENT Astrocytes spontaneously release

164 vels and attenuating synaptic deficits in AD.SIGNIFICANCE STATEMENT beta-Site amyloid precursor prote

165 ral responses to predictable sensory streams.SIGNIFICANCE STATEMENT Brain activity can be strongly mo

166 hronization on propagation of neural signals.SIGNIFICANCE STATEMENT By comparing brain tumor patients

167 x, sex chromosome complement, and brain size.SIGNIFICANCE STATEMENT Cerebellar systems are implicated

168 nvariant representations of the visual world.SIGNIFICANCE STATEMENT Combining sensory inputs over tim

169 the pathogenesis of Ube3A/E6AP-dependent ASD.SIGNIFICANCE STATEMENT Copy number variation of the UBE3

170 ources to generate normal neuronal functions.SIGNIFICANCE STATEMENT Critical periods are developmenta

171 ion of dopamine transporters in the striatum.SIGNIFICANCE STATEMENT Delivery of ectopic glial cell li

172 effects on saccade initiation and execution.SIGNIFICANCE STATEMENT Despite a recent surge of interes

173 causally involved in the development of TLE.SIGNIFICANCE STATEMENT Development of temporal lobe epil

174 ne the beginning of the color vision pathway.SIGNIFICANCE STATEMENT Dim-light achromatic vision and b

175 n the neurodegeneration characteristic of PD.SIGNIFICANCE STATEMENT Disruptions or alterations in the

176 lus and idiopathic intracranial hypertension.SIGNIFICANCE STATEMENT Effective disposal of brain cellu

177 y, choice behavior, or cognitive performance.SIGNIFICANCE STATEMENT Engagement of neural regions and

178 atic astrogliosis and seizure susceptibility.SIGNIFICANCE STATEMENT Epilepsy is a common cause of mor

179 o efficient action-selection during foraging.SIGNIFICANCE STATEMENT Evolutionary pressure driving ene

180 e of the auditory processing deficits in FXS.SIGNIFICANCE STATEMENT Fragile X Syndrome (FXS) is the m

181 on and dynamics during growth cone behaviors.SIGNIFICANCE STATEMENT Growth cones are the motile tips

182 ries across experiences during consolidation.SIGNIFICANCE STATEMENT Hippocampal sharp-wave ripples (S

183 o not play a major role in synapse formation.SIGNIFICANCE STATEMENT Human neuroligin genes have been

184 vity supporting increases in task complexity.SIGNIFICANCE STATEMENT Humans have clear limits in their

185 action recognition and action understanding.SIGNIFICANCE STATEMENT Humans tend to interpret the obse

186 g to non-cell-autonomous neurotoxicity in HD.SIGNIFICANCE STATEMENT Huntington's disease (HD) is char

187 duration of D2-inhibited cAMP/cGMP signaling.SIGNIFICANCE STATEMENT In DYT1 transgenic mouse model of

188 role in adaptive sensorimotor prioritization.SIGNIFICANCE STATEMENT In many situations such as fast-m

189 linating diseases such as multiple sclerosis.SIGNIFICANCE STATEMENT In the present study, we show tha

190 mportance of this state for species survival.SIGNIFICANCE STATEMENT Infertility affects 15%-20% of co

191 ignals reflecting a wide variety of odorants.SIGNIFICANCE STATEMENT Inhibitory circuits in the olfact

192 ta-frequency cycles of granule cell activity.SIGNIFICANCE STATEMENT Long-term synaptic plasticity is

193 viable strategy for future drug development.SIGNIFICANCE STATEMENT Memantine and ketamine are NMDA r

194 ve synapse modification in the visual cortex.SIGNIFICANCE STATEMENT Microglia in the visual cortex re

195 visual cortical neurons signal depth from MP.SIGNIFICANCE STATEMENT Motion parallax is a monocular cu

196 pulations involved in beta-amyloid clearance.SIGNIFICANCE STATEMENT Mounting evidence supports the ac

197 to maximize firing output during locomotion.SIGNIFICANCE STATEMENT Nervous system function depends o

198 regulators of the DLK/JNK signaling pathway.SIGNIFICANCE STATEMENT Neuronal degeneration occurs in d

199 l monocarboxylates or by neuronal glycolysis.SIGNIFICANCE STATEMENT Neuronal energy levels are critic

200 t on MAP7 function in neurological disorders.SIGNIFICANCE STATEMENT Neurons communicate with multiple

201 xcitation may contribute to irregular firing.SIGNIFICANCE STATEMENT Neurons embedded in active neural

202 ssessing changes in evoked neuronal activity.SIGNIFICANCE STATEMENT Neurovascular coupling, defined a

203 ght not realizable using either method alone.SIGNIFICANCE STATEMENT Noninvasive recordings of changes

204 cesses by the NRG/ErbB pathway are discussed.SIGNIFICANCE STATEMENT Numerous Neuregulins (NRGs) are g

205 coding of stimulus onset in afferent neurons.SIGNIFICANCE STATEMENT Numerous studies support that hai

206 crucial for the persistence of long-term SRM.SIGNIFICANCE STATEMENT Oxytocin receptors (OXTRs) are ab

207 underlie intrinsic auditory regionalization.SIGNIFICANCE STATEMENT Perception is an active process,

208 tore neurogenesis in human premature infants.SIGNIFICANCE STATEMENT Prematurity results in developmen

209 eurons and increased addiction risk after PE.SIGNIFICANCE STATEMENT Prenatal ethanol exposure (PE) is

210 ng of inputs within the nigrostriatal system.SIGNIFICANCE STATEMENT Prior studies have established th

211 bility and contribute to motor impersistence.SIGNIFICANCE STATEMENT Recent evidence indicates that Hu

212 scillatory reinstatement in memory retrieval.SIGNIFICANCE STATEMENT Recent neurobiological models of

213 ented in chimpanzees or any nonhuman primate.SIGNIFICANCE STATEMENT Recent studies in chimpanzees (Pa

214 ay not be effective in all migraine patients.SIGNIFICANCE STATEMENT Recently, we reported that humani

215 n learning the value of stimuli, not actions.SIGNIFICANCE STATEMENT Reinforcement learning models of

216 n of the saccade with the visual suppression.SIGNIFICANCE STATEMENT Saccades are known to produce a s

217 g saccade generation in dynamic environments.SIGNIFICANCE STATEMENT Saccades are the rapid, ballistic

218 y and altered short-term synaptic plasticity.SIGNIFICANCE STATEMENT Schizophrenia is a profoundly dis

219 distinct circuits in the mouse visual system.SIGNIFICANCE STATEMENT Seeing through two eyes is though

220 at the AIS and throughout the nervous system.SIGNIFICANCE STATEMENT Spectrin cytoskeletons play diver

221 ay thus be a new therapeutic approach to SMA.SIGNIFICANCE STATEMENT Spinal muscular atrophy (SMA) is

222 d prediction error in Pavlovian conditioning.SIGNIFICANCE STATEMENT Stimuli that positively or negati

223 nputs in the presence of dopamine inhibition.SIGNIFICANCE STATEMENT Substantia nigra dopaminergic neu

224 ng release dependent on stimulation by Ca(2+)SIGNIFICANCE STATEMENT Syntaxin 1A (Syx) is a central pr

225 ility changes in Arc-expressing interneurons.SIGNIFICANCE STATEMENT The accessory olfactory bulb (AOB

226 y, and identifying disorder-specific markers.SIGNIFICANCE STATEMENT The architecture of the functiona

227 gest sex-specific mechanisms of E2 signaling.SIGNIFICANCE STATEMENT The basolateral amygdala (BLA) is

228 change in when they recruit this processing.SIGNIFICANCE STATEMENT The current study provides eviden

229 of feedforward and sensory feedback signals.SIGNIFICANCE STATEMENT The defensive peripersonal space

230 , roles in motor recovery after brain injury.SIGNIFICANCE STATEMENT The dorsal and ventral premotor c

231 ical effects of CBZ on epileptiform activity.SIGNIFICANCE STATEMENT The effects of anti-epileptic dru

232 ictors of vulnerability to neurodegeneration.SIGNIFICANCE STATEMENT The inadequate excitability of mo

233 dulating risk for neuropsychiatric disorders.SIGNIFICANCE STATEMENT The integrin beta3 Leu33Pro codin

234 ons of learned oculomotor plans in the brain.SIGNIFICANCE STATEMENT The mechanism by which humans ada

235 lutamate co-release to inhibit the BA output.SIGNIFICANCE STATEMENT The modulation of the amygdala by

236 times be the source of performance failures.SIGNIFICANCE STATEMENT The performance-monitoring system

237 s to sex differences in hyperalgesic priming.SIGNIFICANCE STATEMENT The present study demonstrates a

238 entially altering reward behavioral outcomes.SIGNIFICANCE STATEMENT The present study identifies a no

239 in the development of direction selectivity.SIGNIFICANCE STATEMENT The proper development of brain c

240 r axonal regeneration after acute CNS injury.SIGNIFICANCE STATEMENT The roles of microglia, the phago

241 vous system evolved to regulate neurogenesis.SIGNIFICANCE STATEMENT The Src family of nonreceptor tyr

242 ions in the vStr and associated limbic areas.SIGNIFICANCE STATEMENT The ventral striatum (vStr) is an

243 tivity phase in the course of preclinical AD.SIGNIFICANCE STATEMENT This article offers a first look

244 accounting for time of day in fMRI protocols.SIGNIFICANCE STATEMENT This is one of the first studies

245 traditionally considered of cerebral origin.SIGNIFICANCE STATEMENT This study examines the biologica

246 herapy (paclitaxel)-induced neuropathic pain.SIGNIFICANCE STATEMENT This work demonstrates that the e

247 otes synaptic recovery in the ischemic brain.SIGNIFICANCE STATEMENT To date, there is no therapeutic

248 itive decline associated with preclinical AD.SIGNIFICANCE STATEMENT Understanding how risk factors fo

249 h the hierarchy of the human auditory cortex.SIGNIFICANCE STATEMENT Using magnetoencephalography reco

250 esses required to generate the shape percept.SIGNIFICANCE STATEMENT Visual objects are recognized thr

251 in learning, attention, and speech disorders.SIGNIFICANCE STATEMENT We characterized the properties o

252 lly dimorphic effects of morphine in the rat.SIGNIFICANCE STATEMENT We demonstrate that periaqueducta

253 s into their origin and functional diversity.SIGNIFICANCE STATEMENT We investigated the in vivo molec

254 ial cause of tactile defensiveness in autism.SIGNIFICANCE STATEMENT We use a novel paradigm of repeti

255 s to abrogate the ensuing cognitive problems.SIGNIFICANCE STATEMENT Whereas seizures have been the ce

256 lls at different stages of brain development.SIGNIFICANCE STATEMENT Zika virus (ZIKV) can cause subst

257 SIGNIFICANCE STATEMENT: Attention involves the selection

258 SIGNIFICANCE STATEMENT: Conceptual or schema congruence

259 SIGNIFICANCE STATEMENT: Decades of research have provide

260 SIGNIFICANCE STATEMENT: Dysfunctional stress responses a

261 SIGNIFICANCE STATEMENT: Food perception and choice depen

262 SIGNIFICANCE STATEMENT: In natural environments, color i

263 SIGNIFICANCE STATEMENT: Neural activity plays a major ro

264 SIGNIFICANCE STATEMENT: Neural control of the dynamic bo

265 SIGNIFICANCE STATEMENT: Neuroimaging studies have identi

266 SIGNIFICANCE STATEMENT: Pitch and timbre are two crucial

267 SIGNIFICANCE STATEMENT: Previous behavioral studies have

268 SIGNIFICANCE STATEMENT: Regional gray matter alterations

269 SIGNIFICANCE STATEMENT: Relapse to cocaine use in a rat

270 SIGNIFICANCE STATEMENT: The DNA damage response (DDR) is

271 SIGNIFICANCE STATEMENT: The hippocampal and oculomotor n

272 SIGNIFICANCE STATEMENT: The KCTD proteins 8, 12, and 16

273 SIGNIFICANCE STATEMENT: The mu-opioid receptor (MOR) loc

274 SIGNIFICANCE STATEMENT: These studies demonstrate that e

275 SIGNIFICANCE STATEMENT: Working memory (WM) is a key com

276 as the related vital processes of industrial significance such as reduction and oxidation of organics

277 further evaluation based on null hypothesis significance testing is doomed to yield a low proportion

278 ed maternal sequence variants of genome-wide significance that replicate in independent data sets.

279 bitors for the many other viral pathogens of significance that require IMPalpha/beta1 in their infect

280 m disorder (ASD), we find strong statistical significance that the affected are more similar to the a

281 which was underpowered to detect genome-wide significance, the evaluation being limited to a single c

282 ty for diminishing bone metastasis formation.Significance: These findings establish an inverse relati

283 e the treatment of this breast cancer subset.Significance: These findings offer a mechanistic rationa

284 lications against chemotherapy-resistant AML.Significance: These findings reveal a mitochondrial meta

285 e amplified by coadministration of sunitinib.Significance: These findings reveal multiple unrecognize

286 a similar degree as PD-1-blocking antibodies.Significance: These findings show how GSK-3 inhibitors t

287 mmunotherapeutic approach for TNBC treatment.Significance: These findings show how upregulation of th

288 ted with a higher risk of future lung cancer.Significance: This large cohort study firmly establishes

289 immune escape via a C3/C5-dependent pathway.Significance: This provocative study suggests that inhib

290 Using a stringent significance threshold (P<7.1 x 10(-9)), GWAS in the AGP

291 eotide polymorphisms (SNPs) that surpassed a significance threshold of P<1x10(-6) for association wit

292 f candidate genes that pass the conventional significance thresholds (e.g. P </= 5 x 10-8).

293 NS5 dimer interface, providing a functional significance to the crystal structure NS5 dimer.

294 using organotypic raft cultures and in vivo significance was assessed via a xenograft mouse model.

295 Although statistical significance was not achieved, blue light filters reduce

296 Statistical significance was replicated for BIRC2 (p = 0.041) and NO

297 No associations of genome-wide significance were detected for CD.

298 integrin alpha6 (ITGA6) reached genome-wide significance with PA (P=1.80x10(-8)), whereas SNPs assoc

299 y with several immune proteins of biological significance, with these interactions resulting in struc

300 increase sensitivity and improve statistical significance without increasing cost.