ライフサイエンスコーパス: significant

1 testing, three of the 78 microRNAs remained significant.

2 cy <0.01, (rs3025380 at DBH) was genome-wide significant.

3 rved; strongly suggesting it is biologically significant.

4 es have been demonstrated to be functionally significant.

5 What quantity of change is significant?

6 ll non-clinically relevant but statistically significant (0.2 [SD 1.1] vs 0.1 [1.1], p=0.010) differe

7 n of the blood jet through the valve is most significant (accounting for 99% of the total drop in ste

8 cently advanced in the clinic and have shown significant activity, particularly against tumors driven

9 targets are realized, there could still be a significant adaptation imperative for vulnerable urban p

10 nt of added master alloy, ultrasonics caused significant additional grain refinement compared to that

11 anslatable to industry and thus represents a significant advance in the development of complex macrom

12 erious bacterial infections, and represent a significant advancement toward broader practical deliver

13 The past decade has seen significant advances in understanding of the pathogenesi

14 spatial or polarization dimension and offers significant advantages of rapid reconstruction without h

15 ds/ss nucleic acid solutions, demonstrating significant advantages over current methods.

16 r white British), these differences were not significant after adjusting for age.

17 ns per risk factor, p < 0.0001) and remained significant after adjustment for contemporaneous risk fa

18 No significant aging effect was observed in [(18) F]Nifene

19 Additionally, significant alterations in the expression of well charac

20 Atomic Force Microscopy showed significant alterations to the surface of S. epidermidis

21 tis, and that the protective association was significant among cases of both severe and mild acute pa

22 Spinach is known to contain significant amounts of oxalates, which are toxic and, if

23 ch antimycin-inhibited complex III generates significant amounts of ROS in the presence of Mg(2+) and

24 They contain significant amounts of total dietary fibers (41.69%) and

25 The most significant and uniform correlation between any material

26 rotein, its role in operating this system is significant, and should be understood in detail.

27 ampylobacteriosis, outbreaks, and clinically significant antimicrobial resistance increased.

28 This is significant as auPR curves are argued as suitable metric

29 However, we observed a significant association between the decrease in CTC numb

30 There was no significant association between younger age and risk of

31 The DeePAS revealed a significant association of the rs3750846 SNP at the ARMS

32 A genome-wide significant association was found between ACQ and single

33 hat the efficacy of 9 out of 24 drugs showed significant association with genetic load in a pan-cance

34 not RSV (RR, 0.99; 95% CI, .98-1.01), had a significant association with PEx risk.

35 EBNA3A and EBNA3C showed significant association with repressed and activated gen

36 Our findings indicated no statistically significant associations between either subcortical volu

37 We observed no significant associations between the highest and lowest

38 Fracture analysis revealed significant associations between variation at the WNT16

39 Sixty-seven of 186 genes also have significant asthma-associated methylation changes in nas

40 Organic mixed conductors have garnered significant attention in applications from bioelectronic

41 to increase preterm birth risk has received significant attention worldwide, but the findings are ge

42 tem cell transplantation (HSCT), posing as a significant barrier against the widespread use of HSCTs

43 ts that the RT boost confers a statistically significant benefit in decreasing IBTR across all DCIS a

44 s in bacterial microcompartments might yield significant benefits for pathway flux, as well as for to

45 There was no significant between-group difference in change in patien

46 No statistically significant between-group differences were seen for any

47 MG is explored as a significant biomarker towards the prediction of diabetic

48 , preadolescent stress in mice resulted in a significant blunting of the corticosterone response duri

49 A significant body of evidence suggests that the highly dy

50 As a consequence, a significant body of work now exists on the architecture,

51 Two highly significant CAD loci were identified on chromosome 17q21

52 d biomarker score to predict the presence of significant CAD.

53 A significant challenge of traditional glycan mapping tech

54 ause measuring amorphous structure remains a significant challenge.

55 However, significant challenges exist for structural characteriza

56 d interfacial bone density, as measured by a significant change in bone volume/total volume and trabe

57 This framework also indicates a significant change in dissolution mechanism at [Formula:

58 We found no significant change in prostate cell proliferation in tre

59 -5.6% to -1.0%], P = .004), but there was no significant change in the combined outcome of death or d

60 e stages of polymerase activity and identify significant changes in activity between experiments.

61 Kinematic analysis revealed significant changes in several dynamic and static gait p

62 No intervention produced significant changes in VO2 peak, kidney function, or uri

63 =0.009 for within-group changes), whereas no significant changes occurred within the anakinra 2-week

64 lisation and statistical analysis identified significant chemical changes in pet food as a result of

65 Glycans possess significant chemical diversity; glycan binding proteins

66 nts using an anti-O-GlcNAc antibody revealed significant chromatin enrichment of O-GlcNAc-modified pr

67 Tg mice treated with infliximab demonstrated significant clinical and histologic improvement 3 d afte

68 We found significant, coherent and non-cell line specific changes

69 In those with significant comorbidities or those not undergoing surger

70 n the bulk at defects and interfaces lead to significant compositional segregation effects.

71 ar structures, with some proteins undergoing significant conformational change or intermolecular asso

72 d von Willebrand factor A domains undergoing significant conformational changes for affinity regulati

73 t docking of the sorting platform results in significant conformational changes in the needle complex

74 This may be a significant contributor to excessive inflammation seen i

75 We observed a significant correlation between residential radon with b

76 Construct validity was demonstrated via a significant correlation with length of stay (r = 0.586,

77 There were significant correlations between COPD readmission rates

78 rfused, 82% of studies demonstrated positive significant correlations.

79 We find significant cortical entrainment to visual oscillations

80 Lastly, we found significant covariation between the volatile compounds a

81 sheep grazing intensities increased, with a significant cumulative effect occurring during grazing y

82 A significant CYP2A6 genotype x smoking effect was found i

83 (iPET) in daily practice remains a matter of significant debate.

84 owed that ZxAKT1-silenced plants exhibited a significant decline in net uptake of K(+) and Na(+) , re

85 mosomal alignment, which was associated with significant decline in oocyte cleavage and blastocyst de

86 Significant declines in SSB sales, even in this relative

87 A significant decrease in both keratometry readings and sp

88 ting and inoculated with B. cinerea showed a significant decrease in fungal growth after 7days at 5 d

89 1/2 phosphorylation in all tumours, caused a significant decrease in proliferation in 5/23 (22%) tumo

90 FoxM1 levels remained constant, there was a significant decrease of the phosphorylated, likely activ

91 signaling pathways that were able to mediate significant decreases in aggregate levels.

92 After 16 weeks, children who consumed OI had significant decreases in body weight z-score (decrease o

93 antly lower than that of BLS (p<0.05), while significant decreases in the setback and final viscositi

94 none of the cognitive assessment resulted in significant deficits.

95 e that the HAT process is characterized by a significant degree of charge transfer permitted by the p

96 ants were seen in subgroup analyses, with no significant difference according to the indication for a

97 s in the baseline CC, showed a statistically significant difference between both groups (log rank, p

98 In addition color measurements showed a significant difference between the control dough and the

99 .9 (3.0) to 3.2 (3.0) in HC (p=0.38), with a significant difference between the groups (p<0.001).

100 some waste incinerator fly ashes revealed a significant difference between their EPFR contents.

101 The significant difference in k0 is due to a tunneling effec

102 ll P<0.01), more signs of congestion, but no significant difference in left ventricular ejection frac

103 No statistically significant difference in overall survival was observed

104 one for the guideline found no statistically significant difference in the efficacy of second-generat

105 There was no significant difference in the levels of inhibition of UV

106 Results There was no significant difference in the size or shape of ablations

107 ption, but did not result in a statistically significant difference in tumor burden or survival distr

108 lleles or TSLPrs1898671 homozygotes, with no significant difference observed between wildtype and het

109 in uncertain, with estimates ranging from no significant difference to nearly 2 degrees C warmer than

110 A significant difference was observed between the impaired

111 No significant difference was seen between the placebo patc

112 g/L per year to -1.26 g/L per year), but no significant difference was seen in the rate in early-sta

113 avonoids by HPLC-MS and 4861 genes exhibited significant differences at transcript levels by microarr

114 There were no significant differences between groups in patients' grow

115 members compared to controls, there were no significant differences in allele frequencies between af

116 mia who were taking gemfibrozil did not show significant differences in CAL and PD compared with untr

117 There were also significant differences in growth of EFW between countri

118 in Liver Transplant consortium demonstrates significant differences in IC among centers, the importa

119 RNAseq and qPCR confirmed significant differences in mean expression for 10 genes

120 n checklist is demonstrated by statistically significant differences in mean scores between ICUs, bet

121 In the RD analysis, we found no significant differences in MI risk between patients who

122 reated by a general internist, there were no significant differences in overall 30-day mortality rate

123 CL, pHT : 7.70) for 1860 generations, showed significant differences in photosynthesis and growth fro

124 No significant differences in postoperative anterior chambe

125 Significant differences in the community structure were

126 he moderate-severe group (p = 0.008); (3) no significant differences in the mean rod-mediated respons

127 No significant differences were found in the moral distress

128 nce with post hoc analysis for statistically significant differences.

129 t and chi(2) analysis were used to determine significant differences.

130 While EEG analysis exhibited significant discrepancies between the groups, none of th

131 Conclusion A small but statistically significant dose-dependent T1-weighted signal enhancemen

132 e found that SH2 overexpression results in a significant, dose-dependent increase in EGFR tyrosine ph

133 All approaches have significant drawbacks with respect to stability and effi

134 ial rate of organic carbon correlates with a significant drawdown of atmospheric carbon dioxide (CO2)

135 ut farmed and wild salmonids, constituting a significant economic burden.

136 Our data also revealed the significant effect of hemodynamic shear stress on RBC-in

137 , 1.1 to 6.0; P = .03), whereas there was no significant effect of negative microscopic resection mar

138 A multivariate analysis showed a significant effect of the campaign in the SLSJ region (r

139 or MYCN amplification or diploidy but had no significant effect on OS.

140 The type of carriers had significant effects on the micrometric properties of pro

141 l redesigned segments revealed that the most significant effects were conferred by changes in the con

142 We observed significant enrichments of haloperidol-regulated genes i

143 the catalytic microenvironment, which shows significant esterase activity.

144 antagonistic traits remained substantial and significant even after accounting for all of these proce

145 effect of persistent EBV infection remained significant even after adjustment for all confounding fa

146 Herein we report a significant expansion to the scope of substitution react

147 in skin redness (P = 0.02), correlating with significant expression of genes related to skin barrier

148 ble of adsorbing on the metal surface to any significant extent.

149 ic monolayers are soft materials and display significant fluctuations.

150 Organic aerosol contributes a significant fraction of PM in the United States.

151 spectroscopy reveals that, at pH </= 3.5, a significant fraction of the surface arsenic (30-60%) has

152 These modifications have significant functional consequences as indicated by prof

153 Super-resolution microscopy offers a significant gain in resolution over traditional optical

154 We find many significant gains from promoting rural biogas stoves in

155 Students reported a significant gap between their confidence and their actua

156 Coupled with a significant genetic risk factor for AD, changes in modul

157 We observed no significant group differences in pseudoreference VT or S

158 We identified significant group differences in striatal dopamine trans

159 In addition, there was a significant group effect showing higher tracer uptake in

160 While families reported significant harm, many appreciated the donation attempt.

161 All 3 patients noted significant healing of erosions and plaques starting fro

162 gene (TTK) on chromosome 6q14.1 was the most significant (heterogeneity logarithm of odds score = 3.3

163 AMR-positive patients had more dnDSA with a significant higher frequency of class I, a higher freque

164 Due to its significant homology with the force-activated titin kina

165 els, only death-censored graft loss remained significant (HR, 1.38; 95% CI, 1.12-1.71; overall graft

166 Significant hypoventilation occurred during the inductio

167 n-dependent drug response, which will have a significant impact on cancer precision medicine.

168 Our findings have a significant impact on research related to MPYS-mediated

169 the colour stability of the wines without a significant impact on wine colour.

170 icking receptor CXCR3, which correlated with significant impairment of renal Treg infiltration.

171 icrobial community composition, and may have significant implications for CO2 losses from tropical fo

172 Bispecific antibodies (bsAbs) are of significant importance to the development of novel antib

173 Since initiation of universal NBS for CF, significant improvement has occurred in nutritional stat

174 with breast-conserving therapy, we found no significant improvement in BCSS or OS for women undergoi

175 CSWB-treated samples showed a significant improvement in erythrocyte morphology compar

176 siderable progress in health therapy makes a significant improvement in natural nutraceuticals.

177 honological training resulted in a small but significant improvement in speech comprehension, whereas

178 iezo-phototronic effects together, showing a significant improvement of over 600%.

179 They achieved normal weight by 12 months, a significant improvement over a prescreening cohort of ne

180 Despite significant improvement, molecular and functional readou

181 g tissue, respectively; and were genome-wide significant in a meta-analysis including both identifica

182 .01-0.05, P = .04), with only DRIL remaining significant in multivariate analysis (P = .006).

183 Diffusion tensor imaging analysis revealed a significant increase in FA in bilateral uncinate fascicu

184 Moreover, a significant increase in hippocampal BDNF was detected in

185 B reporter before and after surgery showed a significant increase in luciferase expression, coincidin

186 oth neonatal and adult THS exposure caused a significant increase in percentage of B-cells and signif

187 Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulati

188 There was a significant increase in the kinetic uptake coefficient o

189 ducing the DPM mass emissions, but lead to a significant increase in the total particle counts due to

190 ncreased proportion of GBS disease in NE and significant increased risk of mortality provides evidenc

191 tinemic maternal state, whereas MIA produced significant increases in proinflammatory cytokines and c

192 hifts in inactivation parameters, leading to significant increases in the magnitude of window current

193 These results suggest that the most significant information used to compute the perceived op

194 ninth day after the expiry date and retained significant inhibitory effects against colon carcinoma (

195 a-salt aerosol bound PFAS, plays a role as a significant input of PFCAs to the Maritime Antarctica.

196 This mechanism adds significant insight into our knowledge of mRNA-specific

197 We found a significant interaction (p=0.051) between type of fracti

198 There was a significant interaction between travel time and major am

199 There was a significant interaction of BCPR with age.

200 No significant interactions between the aortic diameter and

201 There were no significant interactions of genotypes with calcium suppl

202 ic dermatitis and allergic sensitization had significant interactions on both the additive (relative

203 ader cells at the tumor invasion front is of significant interest as these cells may possess a coordi

204 Significant interest has emerged in how inflammation reg

205 g of nonlinear optical quantum devices is of significant interest to enable quantum devices with high

206 profiles (pinteraction=0.007), and exerted a significant ischaemic benefit only in this latter group.

207 We observed a significant ketamine-induced reduction in mGluR5 availab

208 stability of these assemblies is a result of significant levels of cooperative binding that is presen

209 We found significant linear relationships between camera-NDVI and

210 que that efficiently depicts the presence of significant liver fibrosis and, less accurately, mild li

211 ubstoichiometric amount (0.25 equiv) without significant loss of enantioselectivity.

212 We show that this dry air leads to significant low-level sublimation of snowfall.

213 tion or with well matched DNA but exhibits a significant luminescence increase in the presence of a 2

214 (up to 96 % ee) was achieved by exploiting a significant matching effect between the chirality of a c

215 ation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed.

216 There is a significant need to find biomarkers of response to radio

217 A statistically significant negative trend in survival was observed for

218 Conclusion This meta-analysis demonstrates a significant OS benefit and confirms the PFS benefit with

219 ined, and the exits were not associated with significant overall changes in quality or patient experi

220 s different pathogenic properties, there was significant overlap in the most upregulated host genes.

221 The significant overrepresentation of similar groups of DEGs

222 use, whereas ammonia reduction with CRRT was significant (P = 0.007), with IRRT it was not (P = 0.75)

223 Therefore, the trkB.T1 receptor plays a significant pathophysiological role after SCI, and may p

224 No significant performance differences were revealed among

225 lycrystalline silver films which suffer from significant plasmonic losses due to grain boundaries and

226 Our results indicate that a significant portion of a model community's overall metab

227 upport subscale, an NP-PCOCQ subscale, had a significant positive effect on NP role (risk ratio=2.33;

228 he polymer coated CaO2 NP formulation offers significant potential as an in situ method for oxygen ge

229 ature points toward a future UWM that offers significant potential benefits thanks to increased colle

230 AV-mediated muscle-specific gene editing has significant potential for therapy of neuromuscular disor

231 and presence of baseline hemorrhage were all significant predictors of new MA development (P = 0.04,

232 Na(+) and K(+) exhibit a significant preference for the centroid of the aromatic

233 Significant preparation will be needed for a thorough, s

234 n (smaller), and KIT mutation (exon 11) were significant prognostic factors for the probability of su

235 any features of this process remain obscure, significant progress has been made in recent years to de

236 In recent years, significant progress has been made in the understanding

237 Significant progress in meeting the need for FP has been

238 A significant proportion of kidney transplant centers are

239 We also found a significant proportion of Lewy bodies in nigral neurons

240 ments against liposarcoma in recent years, a significant proportion of patients respond only modestly

241 d before transplantation, is detectable in a significant proportion of patients with severe combined

242 Conclusion For the detection of clinically significant prostate cancer, no difference was found in

243 trials only the RV144 vaccine trial elicited significant protection against HIV-1 acquisition, but th

244 ver, the growth of MRSA was inhibited, and a significant protection in mice against the bacterial cha

245 dge to perform rapid detection of clinically significant proteoforms from plasma samples.

246 (n=4) or after surgical RV revalvulation for significant pulmonary regurgitation (n=21).

247 Although exposure variability showed significant racial/ethnic and regional differences, high

248 Although not statistically significant, rates of BPAR were 2-fold higher in patient

249 on of near wild-type FXN levels, we observed significant recovery of function, associated pathology a

250 The objective is to find a new pathway for significant reduction in CO2 capture energy consumption.

251 for 4 weeks does not result in a clinically significant reduction in fatigue severity in women with

252 In this post hoc study, a highly significant reduction in HPV prevalence 4 years after va

253 r to which the double substitution confers a significant reduction in potency.

254 The deletion of mybA resulted in a very significant reduction in the number and viability of con

255 Furthermore, we report a significant reduction of cerebral amyloid burden and BAC

256 er tonne of suspended solids treated, with a significant reduction of sludge mass (80% reduction of w

257 ecular weights with reduced branching due to significant reductions in beta-hydrogen elimination.

258 ibroblasts to profibrotic stimuli, including significant reductions in cell survival and myofibroblas

259 ast transcriptional regulation, we uncovered significant regulatory variation in individual yeast cel

260 y and UK species abundance data further show significant relationships between diversity estimates de

261 m to efficiently respire nitrate without the significant release of intermediates, such as nitrous ox

262 To date, significant research efforts are underway to understand

263 rimarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or

264 e of the breast and axillary disease, and no significant residual PET avidity.

265 status of these clinical efforts for several significant retinal diseases, describe the challenges in

266 g, nonalcoholic fatty liver disease) or is a significant risk factor, such as reflux esophagitis and

267 sumption, saturated fat and cholesterol were significant risk factors across ethnic/racial population

268 Obesity and type 2 diabetes are significant risk factors for malignancies, being associa

269 Visceral adiposity confers significant risk for developing metabolic disease in obe

270 Animal Welfare Act regulations that carry a significant risk or specific threat to animal welfare.

271 albuminuric BTBR ob/ob mice, indicating its significant role in maintaining podocyte health.

272 We conclude that EEFs can play a significant role in sustainable agricultural production

273 hese results, which underscore a potentially significant role of 5RK in exocytosis, we next amperomet

274 his integrated approach has demonstrated the significant role of the merozoite proteome during erythr

275 of programmable molecular machines may have significant roles in chemical synthesis and molecular ma

276 Significant shifts in composition and function of the or

277 We report 106 genome-wide significant signals that have not been previously identi

278 -approved drug library for agents that share significant similarity in 3D shape and surface electrost

279 ted state, we observe its population through significant solvatochromic shifts in emission wavelength

280 hese results show that microFIPs represent a significant step forward toward the development of impla

281 Despite sequence conservation, there are significant structural differences between microtubules

282 and serve as reservoirs for relapse, showed significant suppression of TEs and interferon pathways.

283 A low but significant target expression in tumor, lung, and stomac

284 ns that are likely to contain TDP-43 and not significant tau pathology.

285 The results indicate that FliG has a significant tendency to form multimers independently of

286 tion of c-Met-Ras-HO-1 axis; and it can have significant therapeutic potential to prevent post-transp

287 se with aligned circular pores, confirming a significant thermal transport degradation with respect t

288 o understand the modes underlying clinically significant tissue reactions to Co, Cr and Ti by analysi

289 ds of resistance (although not statistically significant) to all antimicrobials except nitrofurantoin

290 ckage, which is the first tool for detecting significant transcript isoform switches in time-series d

291 No significant treatment effects were observed for duration

292 n vivo alphaCD20-IL-21 therapy resulted in a significant tumor control in the rituximab-resistant A20

293 17beta-estradiol led to a significant upregulation in pentose phosphate flux and g

294 hway assessment of a single cell could be of significant value for dissecting cellular heterogeneity

295 vailable for over 15 years and are providing significant value to growers.

296 Here we show that a significant variation in the rate of microearthquakes in

297 iring rates of PER interneurons did not show significant velocity modulation.

298 etworks with parallel indenofluorenyl cores, significant volume (64-70%) available for accommodating

299 Esophagectomy is associated with significant weight loss and catabolism, and negatively i

300 ucose levels to the normoglycemic range with significant weight reduction in a high-fat diet (HFD) in