ライフサイエンスコーパス: silence

1 d in FABP4/aP2-null macrophages when UCP2 is silenced.

2 enced, whereas MYB33 and MYB65 were strongly silenced.

3 lly inherited in cis, leading to stable gene silencing.

4 higher affinity continually led to stronger silencing.

5 he sequence, restored strong miR159-mediated silencing.

6 trimethylation (H3K9me3) for transcriptional silencing.

7 tain acetylated H3K14ac and H3K27ac for ASS1 silencing.

8 eters as means to reduce heritable transgene silencing.

9 triggers, which together result in HBV gene silencing.

10 ible for histone H2A ubiquitination and gene silencing.

11 n the Drosophila heart using RNAi-based gene silencing.

12 ls of the E2(WT) protein occurred upon ChlR1 silencing.

13 but not HRDE-1, for small RNA-dependent gene silencing.

14 to initiate small-RNA-induced heritable gene silencing.

15 with function of the PRC1 in epigenetic gene silencing.

16 ase ROS1 is also required for d35S::LUC anti-silencing.

17 (H3K27me3) is implicated in epigenetic gene silencing.

18 dissection of MCC generation and checkpoint silencing.

19 essential to ensure prompt and efficient SAC silencing.

20 ate-limiting factors for miRNA-mediated gene silencing.

21 yte contractility, which was rescued by CD36 silencing.

22 ation are not sufficient to cause release of silencing.

23 3 currents were observed upon STIM1 or TRPC1 silencing.

24 n specific transcriptional cascades and gene silencing.

25 with or without SIRT3 enforced expression or silencing.

26 microRNA-guided Argonaute 1 complex and gene silencing.

27 uction, DNA methylation, and transcriptional silencing.

28 RIP13 promote MCC disassembly and checkpoint silencing.

29 ss, HDAC activity contributed to stable gene silencing.

30 We demonstrated marked though distinct anti-silencing activity in the pluripotent state and during P

31 oy activity and seed sequence-dependent gene silencing activity.

32 Importantly, silencing AL L5 feedback reduced visual responses of V1

33 Gene silencing also revealed that Snail enhanced the permeabi

34 nsporter gene revealed that in vitro SLC16A5-silencing altered cellular responses to cisplatin treatm

35 revents the region from becoming permanently silenced and prepares the domain for activation when nee

36 ctivated receptor-3), 2 genes that were also silenced and underexpressed, respectively.

37 nhibition of pluripotency factors since LKB1-silencing and AMPK-inhibition abrogated, while LKB1-over

38 contains a functional RNA duplex with paired silencing and carrier sequences stabilized by a miR-30 s

39 Rapid optogenetic silencing and electrical stimulation indicated that shor

40 This was confirmed by specific LCK gene silencing and ex vivo combined treatment of cells from P

41 s, where DNA methylation associates with the silencing and inaccessibility at promoters.

42 ract antiviral responses, including the gene-silencing and innate immunity machineries.

43 on involve the use of viral vectors prone to silencing and insertional mutagenesis or the use of nonh

44 tion in mobile genetic element (transposons) silencing and maintenance of genome integrity.

45 siRNA inheritance but is required for target silencing and maintenance of siRNA-dependent chromatin o

46 A biogenesis but is essential for transposon silencing and male fertility.

47 Small interfering RNA-mediated PPARalpha silencing and PPARalpha blockade by the antagonist GW647

48 e Mason-Pfizer monkey virus can override the silencing and promote transcription of chimeric proviral

49 ficiency results in impaired transcriptional silencing and repair of DSBs by homologous recombination

50 a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline g

51 on, this change was not associated with gene silencing and was essentially absent in AMLs with DNMT3A

52 ential of HCT116 cells only when alpha1D was silenced, and blocking NCX1/3 increased cytosolic Ca(2+)

53 A combination of phylogenetic analyses, gene silencing, and biochemical analyses coupled with structu

54 ivity of MORC2 is critical for HUSH-mediated silencing, and the most common alteration affecting the

55 e accession, Pla-1, lacked both symptoms and silencing, and was immune to wild-type infectious clones

56 lysis showed that genes affected by TRAF3IP2 silencing are involved in epidermal differentiation, wit

57 mechanisms underlying opposition to Polycomb silencing are poorly understood.

58 and the potential for targeted chemogenetic silencing as a new treatment modality in neuropathic pai

59 ld type does not result in the same level of silencing as direct transformation into the wild type.

60 While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts gl

61 lants, as a factor promoting transcriptional silencing at the transgenic RD29A promoter.

62 HIV MDSC overexpressed B7-H4 and silencing B7-H4 increased the production of IL-2 and IFN

63 Silencing BmAce1 impacted motor control and development

64 Silencing BmAce2 resulted in about 26% mortality, faster

65 rol and development to a greater extent than silencing BmAce2, although both treatment groups suffere

66 These genes were found to be differentially silenced by miR159; MYB81, MYB97, MYB101, MYB104, and DU

67 Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpr

68 Thus, silencing calcium waves in the auditory thalamus induces

69 Silencing CeAL CRF projections in the BNSTDL during cont

70 -induced cell blebbing, with only 20% of the silenced cells developing blebs compared with 53% of the

71 ddition restored ERK phosphorylation in EVI1-silenced cells, suggesting that EVI1 and estradiol signa

72 impaired in both SMI#9-pretreated and RAD6B-silenced cells.

73 n of FosB and Fra1 was increased in TRAF3IP2-silenced cells.

74 the elongation of RNA Pol II and preventing silenced chromatin on the viral genome.

75 chromatin binding proteins involved in gene silencing, chromosome packaging, and chromosome segregat

76 Silencing CNOT3 in colorectal cancer cells resulted in r

77 RNA-induced silencing complex (RISC) is composed of miRNAs and AGO p

78 ranscripts to be degraded by the RNA-induced silencing complex (RISC).

79 el interaction between the major RNA-induced silencing complex component Argounaute-2 (Ago2) and the

80 lex genes (an ovarian steroid-regulated gene silencing complex) in untreated LCLs from women with PMD

81 ed forms that may associate with RNA-induced silencing complexes (RISC).

82 nterneurons, suggesting that their sustained silencing could be causally involved in the development

83 Silencing CSN or desmosome components shifts the balance

84 d: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyocyte-spe

85 Silencing CYLD in hippocampal neurons abolishes NMDA-ind

86 N could self-renew, clonally yielding a TCF1-silenced daughter cell as well as a sibling cell maintai

87 PHD3 silencing decreased hypoxic activation of HIF-1alpha C-t

88 Silencing did not require H3K9me3 or DNA methylation.

89 egulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiqu

90 Egr-1 silencing does not affect levels of cyclin-dependent pro

91 Somatic silencing does not require somatic nuclear RNAi but inst

92 SIR complex-mediated de novo heterochromatic silencing due to the presence of antagonistic histone po

93 valent histone modifications; one allele was silenced during differentiation.

94 They are transcriptionally silenced during early development to protect genome inte

95 nherent danger in cells that lose epigenetic silencing during developmental reprogramming.

96 he A2UCOE is conferred, and whether the anti-silencing effect from the A2UCOE is confined within a co

97 within a core region, we evaluated the anti-silencing effect of different sub-domains.

98 These results demonstrate that Twist1's silencing effect on Foxa1 expression is largely responsi

99 miRNA provides the specificity to guide the silencing effector Argonaute (AGO) protein to target mRN

100 NA structure in MYB33 correlated with strong silencing efficacy; introducing mutations to disrupt eit

101 opose an alternative therapeutic strategy of silencing either of the PKM isoforms along with AMPK in

102 is not a defective pseudogene, but a stably silenced epiallele.

103 Notably, these silencing events often occur within introns of transcrip

104 AMPA receptor (R) synaptic transmission, or silenced excitatory synapses, whereas more prolonged (24

105 Gene silencing experiments targeting alpha1D reduced the migr

106 that these nanoparticles had the ability to silence expression of the alpha-ENaC subunit gene.

107 (MAPK)-dependent phosphorylation of the RNA-silencing factor HIV TAR-RNA-binding protein (TRBP) prom

108 -mutated lung cancer cell clones were stably silenced for LSD1 expression.

109 siRNA-L2 facilitated significant tumor gene silencing for 7 d after two i.v. doses.

110 ve highlighted great challenges of transgene silencing for transgenic plants facing climate change.

111 is polymerization, but HbF is epigenetically silenced from infancy onward by DNA methyltransferase 1

112 rom different mechanisms to the overall anti-silencing function of the CBX3 element.

113 ncies, explaining their different downstream silencing functions.

114 igibility was restored with the insertion of silence gaps, LRTC in the delta, theta, and low-gamma os

115 a in a receptor-specific fashion to potently silence gene expression and protein secretion.

116 PRCs) are important histone modifiers, which silence gene expression; yet, there exists a subset of P

117 The H3K27me3 mark silences gene expression, while the H3K4me3 mark prevent

118 We use gene silencing, gene expression analysis, genetic mapping and

119 Long double-stranded RNA (dsRNA) can silence genes of matching sequence upon ingestion in man

120 little selectivity for gene upregulation or silenced genes.

121 fying selection relative to CGIs upstream of silenced genes.

122 s the view that DNA elimination in nematodes silences germline-expressed genes.

123 his, we devised a mouse genetics approach to silence glutamatergic signalling only at olivocerebellar

124 Conversely, EVI1 silencing had no effect on constitutive ERK activity in

125 While Hey2 silencing has no effect on radiation-induced EndoMT in v

126 litates SREBP-1 processing in WT mice, while silencing hepatic Osbpl3 reverses the lipogenic phenotyp

127 issive euchromatin with few loci embedded in silenced heterochromatin.

128 Ezh2 activates Id3 while silencing Id2, Prdm1 and Eomes, promoting the expansion

129 fers anti-apoptotic attributes.NF-kappaB p65 silencing identified that these proteins induce TREM-1 i

130 fer from the wild type when consuming plants silenced in AGO1 (a, b, and c), AGO2, AGO4 (a and b), AG

131 Indeed, when CXCR7 was silenced in breast cancer cells, their metastatic abilit

132 AML data set reveals that GLI3 expression is silenced in most AML patient samples, and the GLI3 locus

133 Plants silenced in NaAGO8 expression grew normally but were hig

134 Flowers silenced in NaJAZi are more resistant to tobacco budworm

135 GR expression is silenced in prostate cancer by a combination of AR bindi

136 d in microglia at high levels, expression is silenced in vitro following activation of TLR4 receptor.

137 escent protein (GFP)-reported, RNAi-mediated silencing in a HepG2/GFP-shRNA RNAi sensor line.

138 Accordingly, tensin silencing in AMPK-depleted fibroblasts impedes enhanced

139 HMGB1 silencing in cord blood ECFC-derived cells confirmed its

140 tal liver lysates demonstrated developmental silencing in IGF2BP1.

141 TREM-1 silencing in macrophages exposed to HIV-related proteins

142 ed to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed

143 siRNA-mediated LPP silencing in ovarian tumor-bearing mice improved paclita

144 rgonaute-2 in-vitro, as well as the enhanced silencing in the context of the trivalent N-acetylgalact

145 nd invasion of ovarian cancer cells, whereas silencing in vivo inhibits tumour growth, increases cisp

146 quirements that mirror yeast epigenetic gene silencing in vivo.

147 mouse brains, we demonstrated that LRP1 gene silencing increases expression of proinflammatory mediat

148 SOCS1 silencing inhibited cell migration and invasion as well

149 ASXL3 silencing inhibited proliferation, clonogenicity, and te

150 e macaque brain, we used cortical cooling to silence inputs to posterior IT and compared the findings

151 Despite this evidence of "silencing", intracellular free calcium imaging showed th

152 tions, and our understanding of how they are silenced is in its infancy.

153 Calcium signalling silencing is a part of the mechanisms that contribute to

154 of different tissues and virus-induced gene silencing is an efficient way to identify host proteins

155 We previously demonstrated that ASS1 silencing is controlled by HIF-1alpha and Arg starvation

156 We find that silencing is dependent on germline nuclear RNAi factors

157 How target silencing is maintained in subsequent generations is poo

158 lecular basis of transgene susceptibility to silencing is poorly characterized in plants; thus, we ev

159 We found that identity-based silencing is targeted by 21- to 22-nucleotide or 24-nucl

160 bute to the pathogenesis of cancer either by silencing key tumor suppressor genes or by activating on

161 Conversely, JMJD2B silencing led to an enhancement of the DNA-damage driven

162 The higher levels of 18:3n-3 in DGAT1-silencing lines are likely due to the compensatory activ

163 Silencing LZK reduced cell viability and proliferation o

164 s an evolutionarily widespread and versatile silencing mechanism that plays an important role in vari

165 apping and simultaneous function of multiple silencing mechanisms has obscured this area of investiga

166 ts of eukaryotic life, primarily through RNA silencing mechanisms.

167 In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evo

168 Silencing MICU1 in vitro increases oxygen consumption, d

169 evels of MKP-1 and PARP-1 proteins, and that silencing MKP-1 or PARP-1 increased cisplatin sensitivit

170 Silencing MKP-1 promoted PARP-1 ubiquitination, which de

171 Interestingly, Rbfox1 silencing modulates the splicing of the actin-remodeling

172 Silencing MYC expression phenocopied the CSC depletion e

173 tem motor nuclei most prominently, and, when silenced, observed blunting of the ventilatory response

174 These elements drive the translational silencing of a group of chemokine (CC/CXC) and chemokine

175 This study demonstrates that RNAi silencing of a member of the Bone Morphogenetic Protein

176 ion at goal locations to trigger optogenetic silencing of a subset of CA1 pyramidal neurons.

177 Consistent with data in the murine context, silencing of AID in human bone marrow cells skews differ

178 Conversely, silencing of ARHGAP21 enhanced Cdc42 activation and resc

179 Acute silencing of caspase-2 in cultured human cells recapitul

180 In vivo silencing of CLIP170 in C57BL/6 mice by CLIP170-specific

181 e the activation of target cell programs and silencing of donor cell programs.

182 esiRNA silencing of each component suggest that Smad3 and EZH2

183 rotein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repre

184 Further, the silencing of functional HvCERK1 gene in the resistant ge

185 Expression of PsAvh23 or silencing of GmADA2/GmGCN5 resulted in misregulation of

186 ctivation was responsible for mediating gene silencing of IL-27p28 and EBV-induced gene 3.

187 RNAi-mediated gene silencing of il17a in fibrotic mice arrested the progres

188 lect role of BRD4S-BRG1 complexes in genomic silencing of invasive retroelements.

189 Here, we demonstrate that gene silencing of KIND1 decreased keratinocyte proliferation

190 s (CXCL1, CXCL2, CCL3, CCL4, IL6, and CSF3), silencing of major inflammatory intracellular signaling

191 Silencing of Malat1 by Malat1 GapmeR significantly incre

192 CRISPR/Cas9-mediated deletion or silencing of MANTIS with small interfering RNAs or Gapme

193 A knockout, an antagonist, or a local silencing of MKP-1 attenuates depressive-like behaviors,

194 We specifically demonstrate the presence and silencing of MYC, JUN, and SOX2 mRNAs by miR-24 and miR-

195 In vitro, silencing of Nox5 in human mesangial cells was associate

196 ccRCC harboring epigenetic silencing of NSD1 displayed a specific genome-wide methy

197 4-deficient lung fibroblasts is inhibited by silencing of nuclear factor erythroid-derived 2-like 2 (

198 I channels by BTP2 and diethylstilbestrol or silencing of ORAI expression impairs albumin uptake.

199 In end-stage mesothelioma, silencing of p16/Ink4a is sustained and deletion of p19/

200 Small interfering RNA-mediated silencing of parathyroid hormone 2 receptor (PTH2R), the

201 Finally, silencing of PFKFB4-induced apoptosis in p53-deficient c

202 l activity of PKR appears to be complete, as silencing of PKR expression has no impact on viral propa

203 ssion of TRPM2 mutant channel (C1008-->A) or silencing of poly ADP-ribose polymerase in ECs of mice p

204 In RPE19 cells, silencing of PrP(C) decreases ferritin while over-expres

205 Silencing of Rab5 shifts receptor-triggered secretion fr

206 Finally, we show that epigenetic silencing of RAD51C and BRCA1 by promoter methylation is

207 found in a subset of glioblastoma (GBM) and silencing of RanBP6 promoted glioma growth in vivo.

208 rmine the mechanism for activation-dependent silencing of Rgs10 expression in microglia.

209 Inhibition or silencing of ROCK1 was sufficient to rescue keratinocyte

210 were observed after transient shRNA-mediated silencing of Rps19, but not several other tested ribosom

211 diated heterochromatin formation, epigenetic silencing of S-phase genes and permanent cell cycle arre

212 The silencing of SALL4 in cancer cells decreased the express

213 gestation, H3K27me3-induced transcriptional silencing of select gene targets ensured uterine quiesce

214 alling pathway is repressed by Myt1l through silencing of several members, including Hes1.

215 RNAi-mediated silencing of SLC13A5 expression in two human hepatoma ce

216 ase-2 (SHP-2), and SHP-2 down-regulation via silencing of small interfering RNA in endothelial cells

217 e used to treat disease caused by epigenetic silencing of specific loci.

218 -early gene expression and produced a robust silencing of STN neurons as measured using whole-cell re

219 In vivo silencing of the FETUA gene in BALB/c mice results in a

220 Silencing of the HLA class-I APM is due to histone deace

221 rments proved to be decisive in vivo because silencing of the INSR attenuated clinical symptoms in an

222 Here we show that in rats, genetic silencing of the largest population of brainstem vagal p

223 ulted in potent, dose-dependent, and durable silencing of the mRNA encoding glycolate oxidase and inc

224 by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via tra

225 uired for improved load-bearing capacity and silencing of the spindle assembly checkpoint.

226 Here, we show that the optogenetic silencing of the VH prevented the recall of contextual f

227 Consistent with this model, silencing of TNFalpha and MEKK4 dramatically reduces cys

228 ecture, DNA repair and genome stability, and silencing of transposon and gene expression.

229 ciate with PiwiL2, a protein involved in the silencing of transposons.

230 Silencing of TTP in endometriotic and endometrial epithe

231 or of host defenses consisting of RNAi-based silencing of viral genes.

232 l changes observed following transcriptional silencing of wag31 in M. tuberculosis.

233 anscriptional repression, including at genes silenced on the inactive X chromosome in females.

234 anges in the Fc region have been reported to silence or reduce the effector function of antibodies.

235 Silencing or acute inhibition of the formin mDia1 suppre

236 Interestingly, gene silencing or editing experiments revealed that SNAT7 is

237 dulate MCT1-dependent cancer cell migration, silencing or genetic deletion of MCT1 in vivo inhibited

238 Here, we report that silencing or inhibition of endogenous TAK1 in hepatoma c

239 thine and urea, is induced upon obesity, and silencing or loss of ARG2 markedly suppresses PDA.

240 formation, irrespective of HIF-1 Conversely, silencing or pharmacologic inhibition of LOX activity bl

241 he mechanisms that activate some genes while silencing others are critical to ensure precision in lin

242 e neighboring CGI is unmethylated but remain silenced otherwise.

243 -NS is a NAP that also plays a major role in silencing pathogen genes.

244 ences suggest that various components of RNA silencing pathway are involved in plant defense machiner

245 ng how interdependent targeting of different silencing pathways can potentiate the establishment of o

246 different lengths of the early intermittent silencing phase that largely determine their final life

247 d Rab7 and Rab8 as ICMT substrates that when silenced phenocopy ste14 deficiency.

248 In contrast, the place fields of SPW-R-silenced place cells remapped, and their spatial informa

249 Further experiments showed that ZxAKT1-silenced plants exhibited a significant decline in net u

250 In response to flg22, PLC2-silenced plants maintain wild-type mitogen-activated pro

251 In summary, we demonstrated that silencing PLK2 attenuates HDG-induced podocyte apoptosis

252 (mean change in firing rate: -8.0%), whereas silencing PM L5 feedback suppressed responses of high-SF

253 omatic and heterochromatic lncRNA-based gene silencing processes.

254 Upon PARP inhibition, ACLY silencing promotes genomic instability and cell death.

255 We observe that EMT silences protective mucosal interferon (IFN)-I and III p

256 man body contains a set of programmable gene-silencing proteins named Argonaute.

257 ring RNAs (siRNAs) generated from previously silenced regions of the genome.

258 E-cadherin silencing relies on the formation of a complex between t

259 Gene silencing revealed that NaJAZi functions as a flower-spe

260 Gene silencing revealed that STAT4 was required for IL-6 tran

261 -wall muscles or hypodermis, however, enable silencing selectively in the rescued tissue but not in o

262 ar reprogramming requires DNA methylation to silence somatic gene expression and dynamic DNA demethyl

263 aviors and stress calls, whereas optogenetic silencing specifically reduced facial nociception.

264 This was confirmed by silencing STAT3 in macrophages.

265 This nucleation confers a silenced state that is metastably inherited, with memory

266 Nox4 silencing suppressed LPS-induced TNF-alpha and PCNA incr

267 vo Since the TCV CP also serves as the viral silencing suppressor, early translation of the CP from t

268 r immunoassays, and the variant was found to silence T-cell activation in seven of the eight blood do

269 gypti with the engineered yeasts resulted in silenced target gene expression, disrupted neural develo

270 nce, we show that this method can be used to silence the endogenous allele of ataxin 7 and replace it

271 f the 11 AGOs in the N. attenuata genome, we silenced the expression of 10.

272 uced plant endogenous small interfering RNA, silences the AtRAP gene, which encodes a putative RNA bi

273 inactivation by XIST, the noncoding RNA that silences the inactive X.

274 In this article, we report that silencing the INSR in inducible knockdown rats impairs s

275 These defects can be corrected by silencing the mitochondrial calcium uniporter (MCU).

276 d males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female pr

277 matic differentiation, PGCs must transiently silence their genome, an early developmental process tha

278 Silencing thioredoxin-interacting protein abrogated reac

279 emory is then converted to stable epigenetic silencing through separate Polycomb factors, which sprea

280 ethylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DN

281 Yet, how heterochromatin formation, which silences transcription, can proceed by a co-transcriptio

282 ncreased binding of the repressor factor RE1-silencing transcription (also known as neuron-restrictiv

283 RE1 silencing transcription factor (REST) is a transcription

284 ay and that it maintains genome integrity by silencing transposons.

285 anoma development and the potential of SOCS1-silenced tumor cells in raising an effective anti-melano

286 This is surprising, as defective gene silencing underlies developmental abnormalities and dise

287 mploy CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in re

288 lusion, we found that WIF1 is epigenetically silenced via promoter DNA methylation in CS and propose

289 Virus-induced gene silencing (VIGS) and transient expression of Phytophthor

290 Through virus-induced gene silencing (VIGS) in a related crop species, maize (Zea m

291 Virus-induced gene silencing (VIGS) is used extensively for gene function s

292 ion of HIV-infected cells survive infection, silence viral replication, and can reactivate viral prod

293 rming protein Perfringolysin O (PFO), potent silencing was achieved in vitro with no detectable cytot

294 of factors in initiating PIWI-directed gene silencing, we employed a Piwi-interacting RNA (piRNA)-ta

295 To identify genes involved in MeCP2 silencing, we screened a library of 60,000 shRNAs using

296 97, MYB101, MYB104, and DUO1 were all poorly silenced, whereas MYB33 and MYB65 were strongly silenced

297 teristic ring-opening reaction is completely silenced, which explains that the majority of the ring-o

298 COL2A is hypermethylated and silenced, while COL2D is repressed in wild cottons but h

299 akes DNA contacts that are required for gene silencing, while chromosome compaction does not appear t

300 ctivation as well as the maintenance of gene silencing, while H2AX is important in DNA damage repair.